PATHWAY: ko03040 Help
Entry Name Spliceosome
Description After transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, the spliceosome. The standard spliceosome is made up of five small nuclear ribonucleoproteins (snRNPs), U1, U2, U4, U5, and U6 snRNPs, and several spliceosome-associated proteins (SAPs). Spliceosomes are not a simple stable complex, but a dynamic family of particles that assemble on the mRNA precursor and help fold it into a conformation that allows transesterification to proceed. Various spliceosome forms (e.g. A-, B- and C-complexes) have been identified.
Class Genetic Information Processing; TranscriptionBRITE hierarchy
Pathway map Other DBs Orthology K03283 HSPA1_6_8; heat shock 70kDa protein 1/6/8
K06063 SNW1, SKIIP, SKIP; SNW domain-containing protein 1
K09564 PPIE; peptidyl-prolyl isomerase E (cyclophilin E) [EC:5.2.1.8 ]
K09567 PPIH, CYPH; peptidyl-prolyl isomerase H (cyclophilin H) [EC:5.2.1.8 ]
K11086 SNRPB, SMB; small nuclear ribonucleoprotein B and B'
K11087 SNRPD1, SMD1; small nuclear ribonucleoprotein D1
K11088 SNRPD3, SMD3; small nuclear ribonucleoprotein D3
K11091 SNRPA; U1 small nuclear ribonucleoprotein A
K11092 SNRPA1; U2 small nuclear ribonucleoprotein A'
K11093 SNRP70; U1 small nuclear ribonucleoprotein 70kDa
K11094 SNRPB2; U2 small nuclear ribonucleoprotein B''
K11095 SNRPC; U1 small nuclear ribonucleoprotein C
K11096 SNRPD2, SMD2; small nuclear ribonucleoprotein D2
K11097 SNRPE, SME; small nuclear ribonucleoprotein E
K11098 SNRPF, SMF; small nuclear ribonucleoprotein F
K11099 SNRPG, SMG; small nuclear ribonucleoprotein G
K11984 SART1, HAF, SNU66; U4/U6.U5 tri-snRNP-associated protein 1
K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
K12662 PRPF4, PRP4; U4/U6 small nuclear ribonucleoprotein PRP4
K12733 PPIL1; peptidyl-prolyl cis-trans isomerase-like 1 [EC:5.2.1.8 ]
K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3
K12811 DDX46, PRP5; ATP-dependent RNA helicase DDX46/PRP5 [EC:5.6.2.7 ]
K12812 DDX39B, UAP56, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7 ]
K12813 DHX16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 [EC:5.6.2.6 ]
K12814 PRP2; pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2 [EC:5.6.2.6 ]
K12815 DHX38, PRP16; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 [EC:5.6.2.6 ]
K12816 CDC40, PRP17; pre-mRNA-processing factor 17
K12817 PRPF18, PRP18; pre-mRNA-splicing factor 18
K12818 DHX8, PRP22; ATP-dependent RNA helicase DHX8/PRP22 [EC:5.6.2.6 ]
K12819 SLU7; pre-mRNA-processing factor SLU7
K12820 DHX15, PRP43; pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 [EC:5.6.2.6 ]
K12821 PRPF40, PRP40; pre-mRNA-processing factor 40
K12822 RBM25, S164; RNA-binding protein 25
K12823 DDX5, DBP2; ATP-dependent RNA helicase DDX5/DBP2 [EC:5.6.2.7 ]
K12824 TCERG1, CA150; transcription elongation regulator 1
K12825 SF3A1, SAP114; splicing factor 3A subunit 1
K12826 SF3A2, SAP62; splicing factor 3A subunit 2
K12827 SF3A3, SAP61, PRP9; splicing factor 3A subunit 3
K12828 SF3B1, SAP155; splicing factor 3B subunit 1
K12829 SF3B2, SAP145, CUS1; splicing factor 3B subunit 2
K12830 SF3B3, SAP130, RSE1; splicing factor 3B subunit 3
K12831 SF3B4, SAP49; splicing factor 3B subunit 4
K12832 SF3B5, SF3B10; splicing factor 3B subunit 5
K12833 SF3B14; pre-mRNA branch site protein p14
K12834 PHF5A; PHD finger-like domain-containing protein 5A
K12835 DDX42, SF3B125; ATP-dependent RNA helicase DDX42 [EC:5.6.2.7 ]
K12836 U2AF1; splicing factor U2AF 35 kDa subunit
K12837 U2AF2; splicing factor U2AF 65 kDa subunit
K12838 PUF60; poly(U)-binding-splicing factor PUF60
K12839 SMNDC1, SPF30; survival of motor neuron-related-splicing factor 30
K12840 RBM17, SPF45; splicing factor 45
K12841 CHERP; calcium homeostasis endoplasmic reticulum protein
K12842 SR140; U2-associated protein SR140
K12843 PRPF3, PRP3; U4/U6 small nuclear ribonucleoprotein PRP3
K12844 PRPF31; U4/U6 small nuclear ribonucleoprotein PRP31
K12845 SNU13, NHP2L; U4/U6 small nuclear ribonucleoprotein SNU13
K12846 SNRNP27; U4/U6.U5 tri-snRNP-associated protein 3
K12847 USP39, SAD1; U4/U6.U5 tri-snRNP-associated protein 2
K12848 SNU23; U4/U6.U5 tri-snRNP component SNU23
K12849 PRPF38A; pre-mRNA-splicing factor 38A
K12850 PRPF38B; pre-mRNA-splicing factor 38B
K12851 PRP38; pre-mRNA-splicing factor 38
K12852 EFTUD2; 116 kDa U5 small nuclear ribonucleoprotein component
K12853 SNU114; 114 kDa U5 small nuclear ribonucleoprotein component
K12854 SNRNP200, BRR2; pre-mRNA-splicing helicase BRR2 [EC:5.6.2.6 ]
K12855 PRPF6, PRP6; pre-mRNA-processing factor 6
K12856 PRPF8, PRP8; pre-mRNA-processing factor 8
K12857 SNRNP40, PRP8BP; Prp8 binding protein
K12858 DDX23, PRP28; ATP-dependent RNA helicase DDX23/PRP28 [EC:5.6.2.7 ]
K12859 TXNL4A, DIB1; U5 snRNP protein, DIM1 family
K12860 CDC5L, CDC5, CEF1; pre-mRNA-splicing factor CDC5/CEF1
K12861 BCAS2; pre-mRNA-splicing factor SPF27
K12862 PLRG1, PRL1, PRP46; pleiotropic regulator 1
K12864 CTNNBL1; beta-catenin-like protein 1
K12865 PQBP1, NPW38; polyglutamine-binding protein 1
K12866 WBP11, NPWBP; WW domain-binding protein 11
K12867 SYF1, XAB2; pre-mRNA-splicing factor SYF1
K12868 SYF2; pre-mRNA-splicing factor SYF2
K12869 CRN, CRNKL1, CLF1, SYF3; crooked neck
K12870 ISY1; pre-mRNA-splicing factor ISY1
K12871 CCDC12; coiled-coil domain-containing protein 12
K12872 RBM22, SLT11; pre-mRNA-splicing factor RBM22/SLT11
K12873 BUD31, G10; bud site selection protein 31
K12874 AQR; intron-binding protein aquarius
K12875 ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus
K12876 RBM8A, Y14; RNA-binding protein 8A
K12877 MAGOH; protein mago nashi
K12878 THOC1; THO complex subunit 1
K12879 THOC2; THO complex subunit 2
K12880 THOC3; THO complex subunit 3
K12881 THOC4, ALY; THO complex subunit 4
K12882 NCBP1, CBP80; nuclear cap-binding protein subunit 1
K12883 NCBP2, CBP20; nuclear cap-binding protein subunit 2
K12884 HNRNPC; heterogeneous nuclear ribonucleoprotein C1/C2
K12885 RBMX, HNRNPG; heterogeneous nuclear ribonucleoprotein G
K12886 HNRNPK; heterogeneous nuclear ribonucleoprotein K
K12887 HNRNPM; heterogeneous nuclear ribonucleoprotein M
K12888 HNRNPU; heterogeneous nuclear ribonucleoprotein U
K12889 PCBP1; poly(rC)-binding protein 1
K12890 SRSF1, SFRS1, ASF, SF2; serine/arginine-rich splicing factor 1
K12891 SRSF2_8, SFRS2A_B; serine/arginine-rich splicing factor 2/8
K12892 SRSF3, SFRS3; serine/arginine-rich splicing factor 3
K12893 SRSF4_5_6, SFRS4_5_6; serine/arginine-rich splicing factor 4/5/6
K12896 SRSF7, SFRS7; serine/arginine-rich splicing factor 7
K12897 TRA2; transformer-2 protein
K12900 SRSF10, FUSIP1; serine/arginine-rich splicing factor 10
K13098 TLS, FUS; RNA-binding protein FUS
K14276 U1snRNA; U1 spliceosomal RNA
K14277 U2snRNA; U2 spliceosomal RNA
K14278 U4snRNA; U4 spliceosomal RNA
K14279 U5snRNA; U5 spliceosomal RNA
K14280 U6snRNA; U6 spliceosomal RNA
K19604 RP9, PAP-1; retinitis pigmentosa 9 protein
K21123 SRSF9, SFRS9; serine/arginine-rich splicing factor 9
Reference Authors Wahl MC, Will CL, Luhrmann R
Title The spliceosome: design principles of a dynamic RNP machine.
Journal Reference Authors Morris DP, Greenleaf AL
Title The splicing factor, Prp40, binds the phosphorylated carboxyl-terminal domain of RNA polymerase II.
Journal Reference Authors Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW
Title Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors.
Journal Reference Authors Ritchie DB, Schellenberg MJ, MacMillan AM
Title Spliceosome structure: piece by piece.
Journal
