Entry Name Hippo signaling pathway - fly
Description Hippo signaling is an evolutionarily conserved signaling pathway that controls organ size during development from flies to humans. The core of the drosophila pathway is a kinase cascade consisting of four proteins including Hippo, Salvador, Warts and Mats. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the transcriptional co-activator Yorkie, thereby promoting cell apoptosis and restricting organ size overgrowth. When the Hippo pathway is inactivated, Yorkie translocates into the nucleus to bind to transcriptional factors to promote cell growth and proliferation.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map ko04391 Hippo signaling pathway - fly
Other DBs Orthology K03209 WNT1; wingless-type MMTV integration site family, member 1
K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
K04237 PARD3; partitioning defective protein 3
K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
K04377 MYC; Myc proto-oncogene protein
K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16 ]
K04412 STK3, MST2; serine/threonine kinase 3
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24 ]
K04676 SMAD1; mothers against decapentaplegic homolog 1
K05628 RERE; arginine-glutamic acid dipeptide repeats protein
K05692 ACTB_G1; actin beta/gamma 1
K06091 MPP5, PALS1; MAGUK p55 subfamily member 5
K06093 PARD6; partitioning defective protein 6
K06094 LLGL; lethal(2) giant larvae protein
K06095 MPDZ, MUPP1, Patj; multiple PDZ domain protein
K06626 CCNE; G1/S-specific cyclin-E1
K06630 YWHAE; 14-3-3 protein epsilon
K06685 MOB1, Mats; MOB kinase activator 1
K08791 LATS1_2, Wts; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1 ]
K09448 TEAD; transcriptional enhancer factor
K09851 RASSF2_4; Ras association domain-containing protein 2/4
K10149 TP63; tumor protein p63
K12076 DLG1; disks large protein 1
K16175 SCRIB; protein scribble
K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
K16507 DCHS1_2, PCDH16_23; protocadherin-16/23
K16669 FAT4; protocadherin Fat 4
K16672 HTH; homeobox protein homothorax
K16673 LIX1L; LIX1-like protein
K16674 FJX1; four-jointed box protein 1
K16676 LPP; lipoma-prefererred partner
K16682 AJUBA, LIMD1, WTIP; LIM domain-containing protein
K16686 SAV1, Sav; scaffold protein salvador
K16687 YAP1, Yki; transcriptional coactivator YAP1
K24050 DLG5; discs large protein 5
Reference Authors Halder G, Johnson RL
Title Hippo signaling: growth control and beyond.
Journal Reference Authors Zhao B, Li L, Lei Q, Guan KL
Title The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
Journal Reference Authors Pan D
Title The hippo signaling pathway in development and cancer.
Journal Reference Authors Schroeder MC, Halder G
Title Regulation of the Hippo pathway by cell architecture and mechanical signals.
Journal Reference Authors Zhao B, Tumaneng K, Guan KL
Title The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
Journal Reference Authors Yin M, Zhang L
Title Hippo signaling: a hub of growth control, tumor suppression and pluripotency maintenance.
Journal Reference Authors Chan SW, Lim CJ, Chen L, Chong YF, Huang C, Song H, Hong W
Title The Hippo pathway in biological control and cancer development.
Journal Reference Authors Hilman D, Gat U
Title The evolutionary history of YAP and the hippo/YAP pathway.
Journal Reference Authors Zhao B, Lei QY, Guan KL
Title The Hippo-YAP pathway: new connections between regulation of organ size and cancer.
Journal Reference Authors Badouel C, Garg A, McNeill H
Title Herding Hippos: regulating growth in flies and man.
Journal Reference Authors Zhang L, Yue T, Jiang J
Title Hippo signaling pathway and organ size control.
Journal Reference Authors Harvey K, Tapon N
Title The Salvador-Warts-Hippo pathway - an emerging tumour-suppressor network.
Journal Reference Authors Kango-Singh M, Singh A
Title Regulation of organ size: insights from the Drosophila Hippo signaling pathway.
Journal Reference Authors Sun G, Irvine KD
Title Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors.
Journal Reference Authors Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
Title Hippo and rassf1a Pathways: A Growing Affair.
Journal Reference Authors Oh H, Irvine KD
Title Yorkie: the final destination of Hippo signaling.
Journal Reference Authors Buttitta LA, Edgar BA
Title How size is controlled: from Hippos to Yorkies.
Journal Reference Authors Chen L, Loh PG, Song H
Title Structural and functional insights into the TEAD-YAP complex in the Hippo signaling pathway.
Journal Reference Authors Oh H, Reddy BV, Irvine KD
Title Phosphorylation-independent repression of Yorkie in Fat-Hippo signaling.
Journal Reference Authors Badouel C, McNeill H
Title Apical junctions and growth control in Drosophila.
Journal Related
