Entry Name Hippo signaling pathway - multiple species
Description Hippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evolution, with related forms described in animals and fungi. In Drosophila and mammals, Hippo/MST co-operate with Mats/Mob1 and Salvador/WW45 to activate Warts/LATS, which negatively regulates Yorkie/YAP. Yorkie/YAP interact with Scalloped/TEAD to promote gene transcriptions and control organ size through the balance between cell proliferation and apoptosis. In C. elegans, WTS-1 YAP-1 EGL-44 axis is conserved and regulates thermotolerance and healthy lifespan. In S. cerevisiae, the LATS-related Dbf2 or Dbf20 kinase in complex with Mob1 controls mitotic exit and cytokinesis, and the Hippo/MST family of kinases, STE-20, modulates Tec1, the putative yeast TEAD ortholog.
Class Environmental Information Processing; Signal transductionBRITE hierarchy
Pathway map ko04392 Hippo signaling pathway - multiple species
Other DBs Orthology K04412 STK3, MST2; serine/threonine kinase 3
K06684 DBF2; cell cycle protein kinase DBF2 [EC:2.7.11.-]
K06685 MOB1, Mats; MOB kinase activator 1
K08791 LATS1_2, Wts; serine/threonine-protein kinase LATS1/2 [EC:2.7.11.1 ]
K09448 TEAD; transcriptional enhancer factor
K09850 RASSF1; Ras association domain-containing protein 1
K09851 RASSF2_4; Ras association domain-containing protein 2/4
K09854 RASSF6; Ras association domain-containing protein 6
K16507 DCHS1_2, PCDH16_23; protocadherin-16/23
K16669 FAT4; protocadherin Fat 4
K16682 AJUBA, LIMD1, WTIP; LIM domain-containing protein
K16686 SAV1, Sav; scaffold protein salvador
K16687 YAP1, Yki; transcriptional coactivator YAP1
K16820 WWTR1, TAZ; WW domain-containing transcription regulator protein 1
K16821 FRMD1; FERM domain-containing protein 1
K16822 FRMD6; FERM domain-containing protein 6
Reference Authors Hilman D, Gat U
Title The evolutionary history of YAP and the hippo/YAP pathway.
Journal Reference Authors Varelas X
Title The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease.
Journal Reference Authors Zhao B, Tumaneng K, Guan KL
Title The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal.
Journal Reference Authors Halder G, Johnson RL
Title Hippo signaling: growth control and beyond.
Journal Reference Authors Pan D
Title The hippo signaling pathway in development and cancer.
Journal Reference Authors Zhao B, Li L, Lei Q, Guan KL
Title The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version.
Journal Reference Authors Fausti F, Di Agostino S, Sacconi A, Strano S, Blandino G
Title Hippo and rassf1a Pathways: A Growing Affair.
Journal Reference Authors Gogl G, Schneider KD, Yeh BJ, Alam N, Nguyen Ba AN, Moses AM, Hetenyi C, Remenyi A, Weiss EL
Title The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism.
Journal Reference Authors Iwasa H, Maimaiti S, Kuroyanagi H, Kawano S, Inami K, Timalsina S, Ikeda M, Nakagawa K, Hata Y
Title Yes-associated protein homolog, YAP-1, is involved in the thermotolerance and aging in the nematode Caenorhabditis elegans.
Journal Reference Authors Yang Z, Hata Y
Title What is the Hippo pathway? Is the Hippo pathway conserved in Caenorhabditis elegans?
Journal Reference Authors Hotz M, Barral Y
Title The Mitotic Exit Network: new turns on old pathways.
Journal Reference Authors Rock JM, Lim D, Stach L, Ogrodowicz RW, Keck JM, Jones MH, Wong CC, Yates JR 3rd, Winey M, Smerdon SJ, Yaffe MB, Amon A
Title Activation of the yeast Hippo pathway by phosphorylation-dependent assembly of signaling complexes.
Journal Reference Authors Hergovich A, Hemmings BA
Title Hippo signalling in the G2/M cell cycle phase: lessons learned from the yeast MEN and SIN pathways.
Journal Reference Authors Wang Y, Abu Irqeba A, Ayalew M, Suntay K
Title Sumoylation of transcription factor Tec1 regulates signaling of mitogen-activated protein kinase pathways in yeast.
Journal Related ko04011 MAPK signaling pathway - yeast
ko04391 Hippo signaling pathway - fly
