KEGG   PATHWAY: kpb00290
Entry
kpb00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Klebsiella pneumoniae blaNDM-1
Class
Metabolism; Amino acid metabolism
Pathway map
kpb00290  Valine, leucine and isoleucine biosynthesis
kpb00290

Module
kpb_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:kpb00290]
kpb_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:kpb00290]
kpb_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:kpb00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Klebsiella pneumoniae blaNDM-1 [GN:kpb]
Gene
FH42_17715  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
FH42_07550  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
FH42_21210  isopropylmalate isomerase [KO:K01703] [EC:4.2.1.33 4.2.1.35]
FH42_21205  leuD; isopropylmalate isomerase [KO:K01704] [EC:4.2.1.33 4.2.1.35]
FH42_21215  3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
FH42_17695  acetolactate synthase catalytic subunit [KO:K01652] [EC:2.2.1.6]
FH42_16760  acetolactate synthase catalytic subunit [KO:K01652] [EC:2.2.1.6]
FH42_21230  acetolactate synthase 3 catalytic subunit [KO:K01652] [EC:2.2.1.6]
FH42_11445  acetolactate synthase [KO:K01652] [EC:2.2.1.6]
FH42_12770  hypothetical protein [KO:K01652] [EC:2.2.1.6]
FH42_06395  acetolactate synthase [KO:K01652] [EC:2.2.1.6]
FH42_16755  acetolactate synthase 1 regulatory subunit [KO:K01653] [EC:2.2.1.6]
FH42_21235  ilvH; acetolactate synthase 3 regulatory subunit [KO:K01653] [EC:2.2.1.6]
FH42_17700  ilvM; acetolactate synthase 2 regulatory subunit [KO:K11258] [EC:2.2.1.6]
FH42_17725  ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
FH42_17710  dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
FH42_17705  branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
FH42_16020  avtA; valine--pyruvate aminotransferase [KO:K00835] [EC:2.6.1.66]
FH42_09520  aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
FH42_21220  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
FH42_11095  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
kpb00260  Glycine, serine and threonine metabolism
kpb00280  Valine, leucine and isoleucine degradation
kpb00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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