KEGG   PATHWAY: kpb00260
Entry
kpb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Klebsiella pneumoniae blaNDM-1
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
kpb00260  Glycine, serine and threonine metabolism
kpb00260

Module
kpb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:kpb00260]
kpb_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:kpb00260]
kpb_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:kpb00260]
kpb_M00555  Betaine biosynthesis, choline => betaine [PATH:kpb00260]
kpb_M00621  Glycine cleavage system [PATH:kpb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Klebsiella pneumoniae blaNDM-1 [GN:kpb]
Gene
FH42_18390  aspartate kinase [KO:K00928] [EC:2.7.2.4]
FH42_20820  thrA; aspartate kinase [KO:K12524] [EC:2.7.2.4 1.1.1.3]
FH42_17525  metL; aspartate kinase [KO:K12525] [EC:2.7.2.4 1.1.1.3]
FH42_04900  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FH42_15330  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
FH42_20825  serine kinase [KO:K00872] [EC:2.7.1.39]
FH42_20830  threonine synthase [KO:K01733] [EC:4.2.3.1]
FH42_00210  threonine aldolase [KO:K01620] [EC:4.1.2.48]
FH42_10485  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
FH42_01130  ghrA; bifunctional glyoxylate/hydroxypyruvate reductase A [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FH42_10900  2-hydroxyacid dehydrogenase [KO:K12972] [EC:1.1.1.79 1.1.1.81]
FH42_15910  bifunctional glyoxylate/hydroxypyruvate reductase B [KO:K00090] [EC:1.1.1.79 1.1.1.81 1.1.1.215]
FH42_13975  glycerate kinase [KO:K00865] [EC:2.7.1.165]
FH42_11665  glycerate kinase [KO:K00865] [EC:2.7.1.165]
FH42_04465  glycerate kinase [KO:K00865] [EC:2.7.1.165]
FH42_02155  hydroxypyruvate reductase [KO:K11529] [EC:2.7.1.165]
FH42_24855  gpmA; phosphoglyceromutase [KO:K01834] [EC:5.4.2.11]
FH42_20780  phosphoglycerate mutase [KO:K15634] [EC:5.4.2.11]
FH42_16135  phosphoglyceromutase [KO:K15633] [EC:5.4.2.12]
FH42_22170  oxidoreductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FH42_24220  dihydrofolate reductase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FH42_12710  D-3-phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
FH42_00575  3-phosphoserine/phosphohydroxythreonine aminotransferase [KO:K00831] [EC:2.6.1.52]
FH42_20745  serB; phosphoserine phosphatase [KO:K01079] [EC:3.1.3.3]
FH42_03860  malonic semialdehyde reductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
FH42_16160  2-amino-3-ketobutyrate CoA ligase [KO:K00639] [EC:2.3.1.29]
FH42_16155  tdh; L-threonine 3-dehydrogenase [KO:K00060] [EC:1.1.1.103]
FH42_03230  tynA; tyramine oxidase [KO:K00276] [EC:1.4.3.21]
FH42_12665  glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
FH42_12675  gcvT; glycine cleavage system protein T [KO:K00605] [EC:2.1.2.10]
FH42_22200  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
FH42_21420  dihydrolipoamide dehydrogenase [KO:K00382] [EC:1.8.1.4]
FH42_12670  glycine cleavage system protein H [KO:K02437]
FH42_10650  pssA; phosphatidylserine synthase [KO:K00998] [EC:2.7.8.8]
FH42_23945  choline dehydrogenase [KO:K00108] [EC:1.1.99.1]
FH42_23950  betaine-aldehyde dehydrogenase [KO:K00130] [EC:1.2.1.8]
FH42_13310  cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
FH42_13315  cystathionine beta-lyase [KO:K01758] [EC:4.4.1.1]
FH42_07735  serine dehydratase [KO:K01752] [EC:4.3.1.17]
FH42_11720  serine dehydratase [KO:K01752] [EC:4.3.1.17]
FH42_17715  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
FH42_07550  threonine dehydratase [KO:K01754] [EC:4.3.1.19]
FH42_16795  D-serine dehydratase [KO:K01753] [EC:4.3.1.18]
FH42_20490  aldolase [KO:K01753] [EC:4.3.1.18]
FH42_12235  racemase [KO:K25316] [EC:5.1.1.10]
FH42_02160  tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
FH42_02165  tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
FH42_05045  diaminobutyrate--2-oxoglutarate aminotransferase [KO:K00836] [EC:2.6.1.76]
FH42_05050  2,4-diaminobutyrate decarboxylase [KO:K13745] [EC:4.1.1.86]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
kpb00010  Glycolysis / Gluconeogenesis
kpb00020  Citrate cycle (TCA cycle)
kpb00230  Purine metabolism
kpb00250  Alanine, aspartate and glutamate metabolism
kpb00270  Cysteine and methionine metabolism
kpb00290  Valine, leucine and isoleucine biosynthesis
kpb00300  Lysine biosynthesis
kpb00330  Arginine and proline metabolism
kpb00460  Cyanoamino acid metabolism
kpb00470  D-Amino acid metabolism
kpb00564  Glycerophospholipid metabolism
kpb00600  Sphingolipid metabolism
kpb00620  Pyruvate metabolism
kpb00630  Glyoxylate and dicarboxylate metabolism
kpb00640  Propanoate metabolism
kpb00680  Methane metabolism
kpb00860  Porphyrin metabolism
kpb00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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