KEGG   PATHWAY: kpb00740
Entry
kpb00740                    Pathway                                
Name
Riboflavin metabolism - Klebsiella pneumoniae blaNDM-1
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
kpb00740  Riboflavin metabolism
kpb00740

Module
kpb_M00125  Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD [PATH:kpb00740]
Other DBs
GO: 0006771
Organism
Klebsiella pneumoniae blaNDM-1 [GN:kpb]
Gene
FH42_02260  ribA; GTP cyclohydrolase [KO:K01497] [EC:3.5.4.25]
FH42_22760  ribD; 5-amino-6-(5-phosphoribosylamino)uracil reductase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
FH42_25435  sugar phosphatase [KO:K20861] [EC:3.1.3.102 3.1.3.104]
FH42_17920  flavin mononucleotide phosphatase [KO:K20862] [EC:3.1.3.102 3.1.3.104]
FH42_13535  ribB; 3,4-dihydroxy-2-butanone 4-phosphate synthase [KO:K02858] [EC:4.1.99.12]
FH42_22765  ribH; 6,7-dimethyl-8-ribityllumazine synthase [KO:K00794] [EC:2.5.1.78]
FH42_06110  riboflavin synthase subunit alpha [KO:K00793] [EC:2.5.1.9]
FH42_20905  hypothetical protein [KO:K11753] [EC:2.7.1.26 2.7.7.2]
FH42_24175  3-phytase [KO:K01093] [EC:3.1.3.26 3.1.3.2]
FH42_18540  class B acid phosphatase [KO:K03788] [EC:3.1.3.2]
FH42_01895  acid phosphatase [KO:K09474] [EC:3.1.3.2]
FH42_20415  hpaC; 4-hydroxyphenylacetate 3-monooxygenase [KO:K00484] [EC:1.5.1.36]
FH42_18055  fre; FMN reductase [KO:K05368] [EC:1.5.1.41]
FH42_00745  NAD(P)H-dependent FMN reductase [KO:K00299] [EC:1.5.1.38]
FH42_08870  hydroxyethylthiazole kinase [KO:K00878] [EC:2.7.1.50]
FH42_13505  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
FH42_16520  ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
FH42_01520  phosphatase [KO:K12152] [EC:3.6.1.-]
FH42_09620  3-octaprenyl-4-hydroxybenzoate carboxy-lyase [KO:K03186] [EC:2.5.1.129]
FH42_11510  phenolic acid decarboxylase [KO:K03186] [EC:2.5.1.129]
Compound
C00016  FAD
C00044  GTP
C00061  FMN
C00199  D-Ribulose 5-phosphate
C00235  Dimethylallyl diphosphate
C00255  Riboflavin
C00474  Ribitol
C01007  Reduced riboflavin
C01268  5-Amino-6-(5'-phosphoribosylamino)uracil
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C01352  FADH2
C01390  Prenol
C01727  Lumichrome
C01847  Reduced FMN
C03114  Dimethylbenzimidazole
C04332  6,7-Dimethyl-8-(D-ribityl)lumazine
C04454  5-Amino-6-(5'-phospho-D-ribitylamino)uracil
C04732  5-Amino-6-(1-D-ribitylamino)uracil
C05995  7-Hydroxy-6-methyl-8-ribityllumazine
C15556  L-3,4-Dihydroxybutan-2-one 4-phosphate
C15563  2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C18910  2,5-Diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one
C21214  Dimethylallyl phosphate
C21215  Prenylated FMNH2
Reference
PMID:12136096
  Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
  Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
  Journal
Nucleic Acids Res 30:3141-51 (2002)
DOI:10.1093/nar/30.14.3141
Reference
PMID:11856310
  Authors
Fischer M, Haase I, Feicht R, Richter G, Gerhardt S, Changeux JP, Huber R, Bacher A.
  Title
Biosynthesis of riboflavin: 6,7-dimethyl-8-ribityllumazine synthase of Schizosaccharomyces pombe.
  Journal
Eur J Biochem 269:519-26 (2002)
DOI:10.1046/j.0014-2956.2001.02674.x
Reference
PMID:12867427
  Authors
Haase I, Fischer M, Bacher A, Schramek N.
  Title
Temperature-dependent presteady state kinetics of lumazine synthase from the hyperthermophilic eubacterium Aquifex aeolicus.
  Journal
J Biol Chem 278:37909-15 (2003)
DOI:10.1074/jbc.M303090200
Reference
PMID:16042598
  Authors
Fischer M, Romisch W, Illarionov B, Eisenreich W, Bacher A.
  Title
Structures and reaction mechanisms of riboflavin synthases of eubacterial and archaeal origin.
  Journal
Biochem Soc Trans 33:780-4 (2005)
DOI:10.1042/BST0330780
Related
pathway
kpb00030  Pentose phosphate pathway
kpb00040  Pentose and glucuronate interconversions
kpb00230  Purine metabolism
kpb00860  Porphyrin metabolism
kpb00900  Terpenoid backbone biosynthesis
KO pathway
ko00740   
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