KEGG   PATHWAY: kpb00230
Entry
kpb00230                    Pathway                                
Name
Purine metabolism - Klebsiella pneumoniae blaNDM-1
Class
Metabolism; Nucleotide metabolism
Pathway map
kpb00230  Purine metabolism
kpb00230

Module
kpb_M00005  PRPP biosynthesis, ribose 5P => PRPP [PATH:kpb00230]
kpb_M00048  De novo purine biosynthesis, PRPP + glutamine => IMP [PATH:kpb00230]
kpb_M00049  Adenine ribonucleotide biosynthesis, IMP => ADP,ATP [PATH:kpb00230]
kpb_M00050  Guanine ribonucleotide biosynthesis, IMP => GDP,GTP [PATH:kpb00230]
kpb_M00053  Deoxyribonucleotide biosynthesis, ADP/GDP/CDP/UDP => dATP/dGTP/dCTP/dUTP [PATH:kpb00230]
Other DBs
GO: 0006163 0042278
Organism
Klebsiella pneumoniae blaNDM-1 [GN:kpb]
Gene
FH42_13505  nudF; ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
FH42_16520  ADP-ribose pyrophosphatase [KO:K01515] [EC:3.6.1.13 3.6.1.-]
FH42_15165  nudE; adenosine nucleotide hydrolase [KO:K08312] [EC:3.6.1.-]
FH42_20725  phosphopentomutase [KO:K01839] [EC:5.4.2.7]
FH42_24595  phosphoglucomutase [KO:K01835] [EC:5.4.2.2]
FH42_07310  ribose-phosphate pyrophosphokinase [KO:K00948] [EC:2.7.6.1]
FH42_09625  amidophosphoribosyltransferase [KO:K00764] [EC:2.4.2.14]
FH42_18295  phosphoribosylamine--glycine ligase [KO:K01945] [EC:6.3.4.13]
FH42_10245  purN; phosphoribosylglycinamide formyltransferase [KO:K11175] [EC:2.1.2.2]
FH42_07910  phosphoribosylglycinamide formyltransferase [KO:K08289] [EC:6.3.1.21]
FH42_10515  phosphoribosylformylglycinamidine synthase [KO:K01952] [EC:6.3.5.3]
FH42_10240  phosphoribosylaminoimidazole synthetase [KO:K01933] [EC:6.3.3.1]
FH42_23330  phosphoribosylaminoimidazole carboxylase [KO:K01589] [EC:6.3.4.18]
FH42_23335  purE; N5-carboxyaminoimidazole ribonucleotide mutase [KO:K01588] [EC:5.4.99.18]
FH42_10170  phosphoribosylaminoimidazole-succinocarboxamide synthase [KO:K01923] [EC:6.3.2.6]
FH42_01505  adenylosuccinate lyase [KO:K01756] [EC:4.3.2.2]
FH42_18300  purH; phosphoribosylaminoimidazolecarboxamide formyltransferase [KO:K00602] [EC:2.1.2.3 3.5.4.10]
FH42_23195  adenine phosphoribosyltransferase [KO:K00759] [EC:2.4.2.7]
FH42_19875  5'-nucleotidase [KO:K01081] [EC:3.1.3.5]
FH42_23250  ushA; 5'-nucleotidase [KO:K11751] [EC:3.1.3.5 3.6.1.45]
FH42_11550  surE; stationary phase survival protein SurE [KO:K03787] [EC:3.1.3.5 3.1.3.6]
FH42_24525  UMP phosphatase [KO:K02566] [EC:3.1.3.5]
FH42_15175  nucleotidase [KO:K20881] [EC:3.1.3.-]
FH42_23230  guanosine kinase [KO:K00892] [EC:2.7.1.73]
FH42_20730  deoD; purine nucleoside phosphorylase [KO:K03784] [EC:2.4.2.1]
FH42_22595  hypothetical protein [KO:K09913] [EC:2.4.2.1 2.4.2.2]
FH42_06670  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
FH42_10690  hypothetical protein [KO:K05810] [EC:2.4.2.1 2.4.2.28 3.5.4.4]
FH42_21500  hypoxanthine phosphoribosyltransferase [KO:K00760] [EC:2.4.2.8]
FH42_10295  inosine-5-monophosphate dehydrogenase [KO:K00088] [EC:1.1.1.205]
FH42_10350  nucleoside diphosphate kinase [KO:K00940] [EC:2.7.4.6]
FH42_20775  yjjX; inositol monophosphatase [KO:K01529] [EC:3.6.1.73]
FH42_12925  nucleoside-triphosphate diphosphatase [KO:K01519] [EC:3.6.1.66]
FH42_22105  xanthine-guanine phosphoribosyltransferase [KO:K00769] [EC:2.4.2.22]
FH42_04935  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
FH42_05115  glutamine amidotransferase [KO:K01951] [EC:6.3.5.2]
FH42_10290  guaA; GMP synthase [KO:K01951] [EC:6.3.5.2]
FH42_21355  guanosine 5'-monophosphate oxidoreductase [KO:K00364] [EC:1.7.1.7]
FH42_04990  guanine deaminase [KO:K01487] [EC:3.5.4.3]
FH42_09780  dCMP deaminase [KO:K01487] [EC:3.5.4.3]
FH42_16330  gmk; guanylate kinase [KO:K00942] [EC:2.7.4.8]
FH42_09330  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
FH42_11045  ribonucleotide-diphosphate reductase subunit alpha [KO:K00525] [EC:1.17.4.1]
FH42_09335  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
FH42_11050  ribonucleotide-diphosphate reductase subunit beta [KO:K00526] [EC:1.17.4.1]
FH42_19600  ribonucleoside-triphosphate reductase [KO:K21636] [EC:1.1.98.6]
FH42_21720  dgt; deoxyguanosinetriphosphate triphosphohydrolase [KO:K01129] [EC:3.1.5.1]
FH42_09525  5'-nucleotidase [KO:K08722] [EC:3.1.3.89]
FH42_16340  (p)ppGpp synthetase [KO:K01139] [EC:2.7.6.5 3.1.7.2]
FH42_17760  guanosine polyphosphate pyrophosphohydrolase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
FH42_10255  exopolyphosphatase [KO:K01524] [EC:3.6.1.11 3.6.1.40]
FH42_11650  relA; (p)ppGpp synthetase [KO:K00951] [EC:2.7.6.5]
FH42_17890  cyaA; adenylate cyclase [KO:K05851] [EC:4.6.1.1]
FH42_19250  adenylosuccinate synthetase [KO:K01939] [EC:6.3.4.4]
FH42_05895  adenosine deaminase [KO:K01488] [EC:3.5.4.4]
FH42_08330  AMP nucleosidase [KO:K01241] [EC:3.2.2.4]
FH42_11710  LOG family protein [KO:K06966] [EC:3.2.2.10 3.2.2.-]
FH42_08885  adenine deaminase [KO:K01486] [EC:3.5.4.2]
FH42_19405  cpdB; 2', 3'-cyclic nucleotide 2'-phosphodiesterase [KO:K01119] [EC:3.1.4.16 3.1.3.6]
FH42_23220  adk; adenylate kinase [KO:K00939] [EC:2.7.4.3]
FH42_11645  mazG; nucleoside triphosphate hydrolase [KO:K04765] [EC:3.6.1.9]
FH42_13495  hypothetical protein [KO:K03651] [EC:3.1.4.53]
FH42_19815  3',5'-cyclic-nucleotide phosphodiesterase [KO:K03651] [EC:3.1.4.53]
FH42_21045  apaH; diadenosine tetraphosphatase [KO:K01525] [EC:3.6.1.41]
FH42_11580  adenylylsulfate kinase [KO:K00860] [EC:2.7.1.25]
FH42_11585  cysN; sulfate adenylyltransferase subunit 1 [KO:K00956] [EC:2.7.7.4]
FH42_11590  sulfate adenylyltransferase subunit 2 [KO:K00957] [EC:2.7.7.4]
FH42_04315  monooxygenase [KO:K16839] [EC:1.14.13.113]
FH42_04330  5-hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
FH42_23380  hydroxyisourate hydrolase [KO:K07127] [EC:3.5.2.17]
FH42_04325  OHCU decarboxylase [KO:K16840] [EC:4.1.1.97]
FH42_04975  Asp/Glu racemase [KO:K16841] [EC:5.1.99.3]
FH42_04970  allantoinase [KO:K16842] [EC:3.5.2.5]
FH42_04840  allantoate amidohydrolase [KO:K02083] [EC:3.5.3.9]
FH42_04845  aminotransferase V [KO:K00839] [EC:2.6.1.112]
FH42_13610  ureC; urease subunit alpha [KO:K01428] [EC:3.5.1.5]
FH42_13605  ureB; urease subunit beta [KO:K01429] [EC:3.5.1.5]
FH42_13600  ureA; urease subunit gamma [KO:K01430] [EC:3.5.1.5]
FH42_04885  amidase [KO:K22601] [EC:2.1.3.5]
FH42_04875  gamma-glutamyltransferase [KO:K22602] [EC:3.5.1.126]
Compound
C00002  ATP
C00008  ADP
C00011  CO2
C00014  Ammonia
C00020  AMP
C00035  GDP
C00037  Glycine
C00039  DNA
C00044  GTP
C00046  RNA
C00048  Glyoxylate
C00053  3'-Phosphoadenylyl sulfate
C00054  Adenosine 3',5'-bisphosphate
C00059  Sulfate
C00064  L-Glutamine
C00081  ITP
C00086  Urea
C00104  IDP
C00117  D-Ribose 5-phosphate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00130  IMP
C00131  dATP
C00144  GMP
C00147  Adenine
C00169  Carbamoyl phosphate
C00206  dADP
C00209  Oxalate
C00212  Adenosine
C00224  Adenylyl sulfate
C00242  Guanine
C00262  Hypoxanthine
C00286  dGTP
C00288  HCO3-
C00294  Inosine
C00301  ADP-ribose
C00330  Deoxyguanosine
C00360  dAMP
C00361  dGDP
C00362  dGMP
C00366  Urate
C00385  Xanthine
C00387  Guanosine
C00499  Allantoate
C00559  Deoxyadenosine
C00575  3',5'-Cyclic AMP
C00603  (S)-Ureidoglycolate
C00620  alpha-D-Ribose 1-phosphate
C00655  Xanthosine 5'-phosphate
C00700  XTP
C00802  Oxalureate
C00942  3',5'-Cyclic GMP
C01228  Guanosine 3',5'-bis(diphosphate)
C01260  P1,P4-Bis(5'-adenosyl)tetraphosphate
C01261  P1,P4-Bis(5'-guanosyl) tetraphosphate
C01344  dIDP
C01345  dITP
C01367  3'-AMP
C01444  Oxamate
C01762  Xanthosine
C02091  (S)-Ureidoglycine
C02348  (R)(-)-Allantoin
C02350  (S)-Allantoin
C02353  2',3'-Cyclic AMP
C02718  N-Formiminoglycine
C03090  5-Phosphoribosylamine
C03373  Aminoimidazole ribotide
C03483  Adenosine tetraphosphate
C03614  Inosine 5'-tetraphosphate
C03794  N6-(1,2-Dicarboxyethyl)-AMP
C03838  5'-Phosphoribosylglycinamide
C04051  5-Amino-4-imidazolecarboxyamide
C04376  5'-Phosphoribosyl-N-formylglycinamide
C04392  P1,P4-Bis(5'-xanthosyl) tetraphosphate
C04494  Guanosine 3'-diphosphate 5'-triphosphate
C04640  2-(Formamido)-N1-(5'-phosphoribosyl)acetamidine
C04677  1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide
C04734  1-(5'-Phosphoribosyl)-5-formamido-4-imidazolecarboxamide
C04751  1-(5-Phospho-D-ribosyl)-5-amino-4-imidazolecarboxylate
C04823  1-(5'-Phosphoribosyl)-5-amino-4-(N-succinocarboxamide)-imidazole
C05239  5-Aminoimidazole
C05512  Deoxyinosine
C05513  Urate-3-ribonucleoside
C05515  5-Ureido-4-imidazole carboxylate
C05516  5-Amino-4-imidazole carboxylate
C05993  Acetyl adenylate
C06193  Guanosine 3'-phosphate
C06194  2',3'-Cyclic GMP
C06195  Imidazolone
C06196  2'-Deoxyinosine 5'-phosphate
C06197  P1,P3-Bis(5'-adenosyl) triphosphate
C06433  5'-Benzoylphosphoadenosine
C06435  5'-Butyrylphosphoinosine
C11821  5-Hydroxyisourate
C12248  5-Hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate
C15667  5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole
C22395  N6-Succino-2-amino-2'-deoxyadenylate
C22441  dZMP
C22442  dZDP
C22443  dZTP
C22499  8-Hydroxyadenine
C22500  2,8-Dihydroxyadenine
Reference
PMID:10601204
  Authors
Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
  Title
Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
  Journal
J Bacteriol 181:7479-84 (1999)
DOI:10.1128/JB.181.24.7479-7484.1999
Reference
PMID:10986234
  Authors
Xi H, Schneider BL, Reitzer L.
  Title
Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage.
  Journal
J Bacteriol 182:5332-41 (2000)
DOI:10.1128/JB.182.19.5332-5341.2000
Related
pathway
kpb00030  Pentose phosphate pathway
kpb00220  Arginine biosynthesis
kpb00250  Alanine, aspartate and glutamate metabolism
kpb00260  Glycine, serine and threonine metabolism
kpb00340  Histidine metabolism
kpb00630  Glyoxylate and dicarboxylate metabolism
kpb00730  Thiamine metabolism
kpb00740  Riboflavin metabolism
kpb00790  Folate biosynthesis
KO pathway
ko00230   
LinkDB

DBGET integrated database retrieval system