Entry Name Selenocompound metabolism - Klebsiella pneumoniae subsp. rhinoscleromatis SB3432
Class Metabolism; Metabolism of other amino acidsBRITE hierarchy
Pathway map Organism Klebsiella pneumoniae subsp. rhinoscleromatis SB3432 [GN:
kpr ]
Gene KPR_0191 metB; highly similar to cystathionine gamma-synthase from Escherichia coli strain K12 (sp|P00935) [KO:K01739 ] [EC:2.5.1.48 ]
KPR_0275 metE; highly similar to 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp|A6TGK9) [KO:K00549 ] [EC:2.1.1.14 ]
KPR_0381 metH; highly similar to B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase from Citrobacter sp. 30_2 (tr|C1MFD2) [KO:K00548 ] [EC:2.1.1.13 ]
KPR_1539 metG; highly similar to methionyl-tRNA synthetase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp|A6TBK7) [KO:K01874 ] [EC:6.1.1.10 ]
KPR_2252 selD; highly similar to selenophosphate synthase from Enterobacter sp. (sp|A4W9I2) [KO:K01008 ] [EC:2.7.9.3 ]
KPR_2682 sufS; highly similar to cysteine desulfurase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp|A6TAE4) [KO:K11717 ] [EC:2.8.1.7 4.4.1.16 ]
KPR_2832 malY; highly similar to maltose regulon modulator from Escherichia coli strain UTI89 - UPEC (tr|Q1RBH6) [KO:K14155 ] [EC:4.4.1.13 ]
KPR_3659 trxB; highly similar to thioredoxin reductase from Escherichia coli O6 (tr|Q8FJC8) [KO:K00384 ] [EC:1.8.1.9 ]
KPR_4110 cysN; highly similar to sulfate adenylyltransferase subunit 1 from Escherichia coli O8 strain IAI1 (sp|B7LXG3) [KO:K00956 ] [EC:2.7.7.4 ]
KPR_4111 cysD; highly similar to sulfate adenylyltransferase subunit 2 from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp|A6TD44) [KO:K00957 ] [EC:2.7.7.4 ]
KPR_4459 metC; highly similar to cystathionine beta-lyase from Escherichia coli F11 (tr|B3HTF7) [KO:K01760 ] [EC:4.4.1.13 ]
KPR_4976 selA; highly similar to L-seryl-tRNA(Sec) selenium transferase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp|A6TFJ1) [KO:K01042 ] [EC:2.9.1.1 ]
Compound C05336 Selenomethionyl-tRNA(Met)
C05689 Se-Methyl-L-selenocysteine
C05690 Se-Methylselenomethionine
C05695 gamma-Glutamyl-Se-methylselenocysteine
C06482 L-Selenocysteinyl-tRNA(Sec)
C16638 O-Phosphoseryl-tRNA(Sec)
C18893 1-Methylseleno-N-acetyl-D-galactosamine
C18905 Methylselenocysteine Se-oxide
Reference Authors Hoefig CS, Renko K, Kohrle J, Birringer M, Schomburg L
Title Comparison of different selenocompounds with respect to nutritional value vs. toxicity using liver cells in culture.
Journal Reference Authors McKenzie MJ, Hunter DA, Pathirana R, Watson LM, Joyce NI, Matich AJ, Rowan DD, Brummell DA
Title Accumulation of an organic anticancer selenium compound in a transgenic Solanaceous species shows wider applicability of the selenocysteine methyltransferase transgene from selenium hyperaccumulators.
Journal Reference Authors Pinto JT, Lee JI, Sinha R, MacEwan ME, Cooper AJ
Title Chemopreventive mechanisms of alpha-keto acid metabolites of naturally occurring organoselenium compounds.
Journal Reference Authors Suzuki KT, Kurasaki K, Suzuki N
Title Selenocysteine beta-lyase and methylselenol demethylase in the metabolism of Se-methylated selenocompounds into selenide.
Journal Reference Authors Gromer S, Gross JH
Title Methylseleninate is a substrate rather than an inhibitor of mammalian thioredoxin reductase. Implications for the antitumor effects of selenium.
Journal KO pathway
