KEGG   PATHWAY: mcro00984
Entry
mcro00984                   Pathway                                
Name
Steroid degradation - Mycolicibacterium crocinum
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
mcro00984  Steroid degradation
mcro00984

Other DBs
GO: 0006707
Organism
Mycolicibacterium crocinum [GN:mcro]
Gene
MI149_07495  GMC family oxidoreductase [KO:K03333] [EC:1.1.3.6]
MI149_06755  NAD-dependent epimerase/dehydratase family protein [KO:K16045] [EC:1.1.1.145 5.3.3.1]
MI149_16585  cytochrome P450 [KO:K15981] [EC:1.14.15.29]
MI149_25630  cytochrome P450 [KO:K15981] [EC:1.14.15.29]
MI149_26220  cytochrome P450 [KO:K15981] [EC:1.14.15.29]
MI149_26065  cytochrome P450 [KO:K16046] [EC:1.14.15.28]
MI149_07090  cytochrome P450 [KO:K16046] [EC:1.14.15.28]
MI149_15390  3-ketosteroid-delta-1-dehydrogenase [KO:K05898] [EC:1.3.99.4]
MI149_21560  FAD-binding protein [KO:K05898] [EC:1.3.99.4]
MI149_26175  3-oxosteroid 1-dehydrogenase [KO:K05898] [EC:1.3.99.4]
MI149_15275  FAD-binding protein [KO:K05898] [EC:1.3.99.4]
MI149_15395  3-ketosteroid-9-alpha-hydroxylase subunit A [KO:K15982] [EC:1.14.15.30]
MI149_21050  Rieske 2Fe-2S domain-containing protein [KO:K15982] [EC:1.14.15.30]
MI149_26115  3-ketosteroid-9-alpha-hydroxylase subunit A [KO:K15982] [EC:1.14.15.30]
MI149_00375  aromatic ring-hydroxylating dioxygenase subunit alpha [KO:K15982] [EC:1.14.15.30]
MI149_25025  Rieske (2Fe-2S) protein [KO:K15982] [EC:1.14.15.30]
MI149_15520  ferredoxin--NADP reductase [KO:K15983] [EC:1.14.15.30]
MI149_26370  ferredoxin--NADP reductase [KO:K15983] [EC:1.14.15.30]
MI149_11665  ferredoxin--NADP reductase [KO:K15983] [EC:1.14.15.30]
MI149_13770  acyl-CoA dehydrogenase [KO:K16047] [EC:1.14.14.12]
MI149_15515  acyl-CoA dehydrogenase family protein [KO:K16047] [EC:1.14.14.12]
MI149_15565  acyl-CoA dehydrogenase family protein [KO:K16047] [EC:1.14.14.12]
MI149_26365  flavin-dependent monooxygenase [KO:K16047] [EC:1.14.14.12]
MI149_26355  flavin reductase family protein [KO:K16048] [EC:1.5.1.-]
MI149_15510  bphC; biphenyl-2,3-diol 1,2-dioxygenase [KO:K16049] [EC:1.13.11.25]
MI149_15560  bphC; biphenyl-2,3-diol 1,2-dioxygenase [KO:K16049] [EC:1.13.11.25]
MI149_26360  VOC family protein [KO:K16049] [EC:1.13.11.25]
MI149_09950  alpha/beta fold hydrolase [KO:K16050] [EC:3.7.1.17]
MI149_21470  FadD3 family acyl-CoA ligase [KO:K18687] [EC:6.2.1.41]
MI149_26310  fadD3; 3-((3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl)propanoate--CoA ligase FadD3 [KO:K18687] [EC:6.2.1.41]
MI149_25770  ketosteroid isomerase family protein [KO:K01822] [EC:5.3.3.1]
MI149_26100  nuclear transport factor 2 family protein [KO:K01822] [EC:5.3.3.1]
MI149_06590  nuclear transport factor 2 family protein [KO:K01822] [EC:5.3.3.1]
Compound
C00187  Cholesterol
C00280  Androstenedione
C00535  Testosterone
C00599  Cholest-4-en-3-one
C00674  5alpha-Androstane-3,17-dione
C01227  Dehydroepiandrosterone
C04793  3,4-Dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C04844  3-Hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate
C07635  Epiandrosterone
C11354  2-Hydroxy-cis-hex-2,4-dienoate
C14909  9alpha-Hydroxyandrosta-1,4-diene-3,17-dione
C19944  3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione
C20144  Androsta-1,4-diene-3,17-dione
C20199  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate
C20252  5-Androstene-3,17-dione
C20838  3-[(3aS,4S,7aS)-7a-Methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
C20839  (25R)-3-Oxocholest-4-en-26-oate
C21076  Delta4-Dafachronic acid
Reference
PMID:21924910
  Authors
Ouellet H, Johnston JB, de Montellano PR
  Title
Cholesterol catabolism as a therapeutic target in Mycobacterium tuberculosis.
  Journal
Trends Microbiol 19:530-9 (2011)
DOI:10.1016/j.tim.2011.07.009
Reference
PMID:17264217
  Authors
Van der Geize R, Yam K, Heuser T, Wilbrink MH, Hara H, Anderton MC, Sim E, Dijkhuizen L, Davies JE, Mohn WW, Eltis LD
  Title
A gene cluster encoding cholesterol catabolism in a soil actinomycete provides insight into Mycobacterium tuberculosis survival in macrophages.
  Journal
Proc Natl Acad Sci U S A 104:1947-52 (2007)
DOI:10.1073/pnas.0605728104
Reference
PMID:22045806
  Authors
Thomas ST, VanderVen BC, Sherman DR, Russell DG, Sampson NS
  Title
Pathway profiling in Mycobacterium tuberculosis: elucidation of cholesterol-derived catabolite and enzymes that catalyze its metabolism.
  Journal
J Biol Chem 286:43668-78 (2011)
DOI:10.1074/jbc.M111.313643
Reference
PMID:20889498
  Authors
Driscoll MD, McLean KJ, Levy C, Mast N, Pikuleva IA, Lafite P, Rigby SE, Leys D, Munro AW
  Title
Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen.
  Journal
J Biol Chem 285:38270-82 (2010)
DOI:10.1074/jbc.M110.164293
Reference
PMID:20843794
  Authors
Johnston JB, Ouellet H, Ortiz de Montellano PR
  Title
Functional redundancy of steroid C26-monooxygenase activity in Mycobacterium tuberculosis revealed by biochemical and genetic analyses.
  Journal
J Biol Chem 285:36352-60 (2010)
DOI:10.1074/jbc.M110.161117
Reference
PMID:17630785
  Authors
Yang X, Dubnau E, Smith I, Sampson NS
  Title
Rv1106c from Mycobacterium tuberculosis is a 3beta-hydroxysteroid dehydrogenase.
  Journal
Biochemistry 46:9058-67 (2007)
DOI:10.1021/bi700688x
Reference
PMID:19875455
  Authors
Lack NA, Yam KC, Lowe ED, Horsman GP, Owen RL, Sim E, Eltis LD
  Title
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism.
  Journal
J Biol Chem 285:434-43 (2010)
DOI:10.1074/jbc.M109.058081
Reference
PMID:19843168
  Authors
Kreit J, Sampson NS
  Title
Cholesterol oxidase: physiological functions.
  Journal
FEBS J 276:6844-56 (2009)
DOI:10.1111/j.1742-4658.2009.07378.x
Reference
PMID:21056662
  Authors
Horinouchi M, Hayashi T, Kudo T
  Title
Steroid degradation in Comamonas testosteroni.
  Journal
J Steroid Biochem Mol Biol 129:4-14 (2012)
DOI:10.1016/j.jsbmb.2010.10.008
Reference
PMID:20554032
  Authors
Horinouchi M, Kurita T, Hayashi T, Kudo T
  Title
Steroid degradation genes in Comamonas testosteroni TA441: Isolation of genes encoding a Delta4(5)-isomerase and 3alpha- and 3beta-dehydrogenases and evidence for a 100 kb steroid degradation gene hot spot.
  Journal
J Steroid Biochem Mol Biol 122:253-63 (2010)
DOI:10.1016/j.jsbmb.2010.06.002
Related
pathway
mcro00100  Steroid biosynthesis
mcro00622  Xylene degradation
KO pathway
ko00984   
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