KEGG   PATHWAY: mesc00290
Entry
mesc00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Manihot esculenta (cassava)
Class
Metabolism; Amino acid metabolism
Pathway map
mesc00290  Valine, leucine and isoleucine biosynthesis
mesc00290

Module
mesc_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mesc00290]
mesc_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mesc00290]
mesc_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mesc00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Manihot esculenta (cassava) [GN:mesc]
Gene
110622516  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
110621316  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
110602289  3-isopropylmalate dehydratase large subunit, chloroplastic [KO:K01703] [EC:4.2.1.33 4.2.1.35]
110611159  3-isopropylmalate dehydratase large subunit, chloroplastic isoform X1 [KO:K01703] [EC:4.2.1.33 4.2.1.35]
110611160  3-isopropylmalate dehydratase large subunit, chloroplastic [KO:K01703] [EC:4.2.1.33 4.2.1.35]
110629216  3-isopropylmalate dehydratase small subunit 1 [KO:K01704] [EC:4.2.1.33 4.2.1.35]
110626790  3-isopropylmalate dehydrogenase, chloroplastic [KO:K00052] [EC:1.1.1.85]
110617115  acetolactate synthase 3, chloroplastic [KO:K01652] [EC:2.2.1.6]
110600767  acetolactate synthase 2, chloroplastic [KO:K01652] [EC:2.2.1.6]
110604799  LOW QUALITY PROTEIN: acetolactate synthase 1, chloroplastic-like [KO:K01652] [EC:2.2.1.6]
110627279  acetolactate synthase small subunit 1, chloroplastic isoform X2 [KO:K01653] [EC:2.2.1.6]
110626109  acetolactate synthase small subunit 2, chloroplastic [KO:K01653] [EC:2.2.1.6]
110605359  ketol-acid reductoisomerase, chloroplastic [KO:K00053] [EC:1.1.1.86]
110629306  ketol-acid reductoisomerase, chloroplastic [KO:K00053] [EC:1.1.1.86]
110603740  ketol-acid reductoisomerase, chloroplastic [KO:K00053] [EC:1.1.1.86]
110601862  dihydroxy-acid dehydratase, chloroplastic [KO:K01687] [EC:4.2.1.9]
110610627  dihydroxy-acid dehydratase, chloroplastic isoform X1 [KO:K01687] [EC:4.2.1.9]
110628991  branched-chain amino acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
110628677  branched-chain amino acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
110614661  branched-chain-amino-acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
110614665  branched-chain-amino-acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
110605897  branched-chain-amino-acid aminotransferase 2, chloroplastic isoform X1 [KO:K00826] [EC:2.6.1.42]
110606928  branched-chain amino acid aminotransferase 2, chloroplastic [KO:K00826] [EC:2.6.1.42]
110612751  2-isopropylmalate synthase 2, chloroplastic isoform X1 [KO:K01649] [EC:2.3.3.13]
110626508  2-isopropylmalate synthase 2, chloroplastic isoform X1 [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
mesc00260  Glycine, serine and threonine metabolism
mesc00280  Valine, leucine and isoleucine degradation
mesc00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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