KEGG   PATHWAY: mesc00260
Entry
mesc00260                   Pathway                                
Name
Glycine, serine and threonine metabolism - Manihot esculenta (cassava)
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
mesc00260  Glycine, serine and threonine metabolism
mesc00260

Module
mesc_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:mesc00260]
mesc_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:mesc00260]
mesc_M00555  Betaine biosynthesis, choline => betaine [PATH:mesc00260]
mesc_M00621  Glycine cleavage system [PATH:mesc00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Manihot esculenta (cassava) [GN:mesc]
Gene
110626838  aspartokinase 2, chloroplastic isoform X1 [KO:K00928] [EC:2.7.2.4]
110606612  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
110628249  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
110606744  bifunctional aspartokinase/homoserine dehydrogenase 1, chloroplastic [KO:K12524] [EC:2.7.2.4 1.1.1.3]
110600765  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
110621944  homoserine kinase [KO:K00872] [EC:2.7.1.39]
110626891  threonine synthase, chloroplastic [KO:K01733] [EC:4.2.3.1]
110603978  threonine synthase 1, chloroplastic [KO:K01733] [EC:4.2.3.1]
110622871  probable low-specificity L-threonine aldolase 1 isoform X1 [KO:K01620] [EC:4.1.2.48]
110621097  probable low-specificity L-threonine aldolase 1 [KO:K01620] [EC:4.1.2.48]
110601861  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
110604068  serine hydroxymethyltransferase 3, chloroplastic [KO:K00600] [EC:2.1.2.1]
110606415  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
110628494  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
110610302  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
110619493  serine hydroxymethyltransferase 7 [KO:K00600] [EC:2.1.2.1]
110630137  serine hydroxymethyltransferase, mitochondrial [KO:K00600] [EC:2.1.2.1]
110602559  serine hydroxymethyltransferase 4 [KO:K00600] [EC:2.1.2.1]
110607048  serine hydroxymethyltransferase 7 isoform X1 [KO:K00600] [EC:2.1.2.1]
110609356  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110600432  serine--glyoxylate aminotransferase [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
110614212  glycerate dehydrogenase [KO:K15893] [EC:1.1.1.29]
110628293  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
110614536  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
110614547  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
110614991  glyoxylate/hydroxypyruvate reductase HPR3 [KO:K15919] [EC:1.1.1.79 1.1.1.81]
110607034  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
110604617  2,3-bisphosphoglycerate-dependent phosphoglycerate mutase 1 [KO:K01834] [EC:5.4.2.11]
110629418  phosphoglycerate mutase-like protein 4 isoform X1 [KO:K15634] [EC:5.4.2.11]
110623085  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
110620860  2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
110612515  D-glycerate 3-kinase, chloroplastic isoform X1 [KO:K15918] [EC:2.7.1.31]
110619437  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110624863  D-3-phosphoglycerate dehydrogenase 1, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110607931  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110615782  D-3-phosphoglycerate dehydrogenase 3, chloroplastic [KO:K00058] [EC:1.1.1.95 1.1.1.399]
110600099  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
110609055  phosphoserine aminotransferase 2, chloroplastic [KO:K00831] [EC:2.6.1.52]
110630719  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
110616955  phosphoserine phosphatase, chloroplastic isoform X1 [KO:K01079] [EC:3.1.3.3]
110599894  copper methylamine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
110610728  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
110609489  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
110628926  copper methylamine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
110628686  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
110601188  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
110602601  primary amine oxidase [KO:K00276] [EC:1.4.3.21]
110617532  copper methylamine oxidase isoform X1 [KO:K00276] [EC:1.4.3.21]
110604177  glycine dehydrogenase (decarboxylating), mitochondrial [KO:K00281] [EC:1.4.4.2]
110605214  aminomethyltransferase, mitochondrial [KO:K00605] [EC:2.1.2.10]
110611729  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
110602122  dihydrolipoyl dehydrogenase 2, chloroplastic isoform X1 [KO:K00382] [EC:1.8.1.4]
110612238  dihydrolipoyl dehydrogenase 1, mitochondrial [KO:K00382] [EC:1.8.1.4]
110601243  glycine cleavage system H protein, mitochondrial [KO:K02437]
110618689  glycine cleavage system H protein 2, mitochondrial [KO:K02437]
110623541  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110630530  alanine--glyoxylate aminotransferase 2 homolog 1, mitochondrial [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110620548  alanine--glyoxylate aminotransferase 2 homolog 2, mitochondrial isoform X1 [KO:K00827] [EC:2.6.1.44 2.6.1.40]
110627295  glutamate--glyoxylate aminotransferase 2 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
110629550  glutamate--glyoxylate aminotransferase 2 isoform X1 [KO:K14272] [EC:2.6.1.4 2.6.1.2 2.6.1.44]
110618115  choline monooxygenase, chloroplastic isoform X1 [KO:K00499] [EC:1.14.15.7]
110617997  betaine aldehyde dehydrogenase 1, chloroplastic [KO:K00130] [EC:1.2.1.8]
110613709  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110626659  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110626662  aldehyde dehydrogenase family 7 member B4 [KO:K14085] [EC:1.2.1.31 1.2.1.8 1.2.1.3]
110602977  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110610511  probable sarcosine oxidase [KO:K00306] [EC:1.5.3.1 1.5.3.7]
110622516  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
110621316  threonine dehydratase biosynthetic, chloroplastic [KO:K01754] [EC:4.3.1.19]
110608698  serine racemase isoform X1 [KO:K12235] [EC:5.1.1.18]
110608699  serine racemase [KO:K12235] [EC:5.1.1.18]
110614711  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
110619508  tryptophan synthase alpha chain [KO:K01695] [EC:4.2.1.20]
110611958  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
110603067  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
110603068  tryptophan synthase beta chain 1 [KO:K01696] [EC:4.2.1.20]
110600768  tryptophan synthase beta chain 1 isoform X1 [KO:K01696] [EC:4.2.1.20]
110610110  tryptophan synthase beta chain 2 [KO:K06001] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
mesc00010  Glycolysis / Gluconeogenesis
mesc00020  Citrate cycle (TCA cycle)
mesc00230  Purine metabolism
mesc00250  Alanine, aspartate and glutamate metabolism
mesc00270  Cysteine and methionine metabolism
mesc00290  Valine, leucine and isoleucine biosynthesis
mesc00300  Lysine biosynthesis
mesc00330  Arginine and proline metabolism
mesc00460  Cyanoamino acid metabolism
mesc00470  D-Amino acid metabolism
mesc00564  Glycerophospholipid metabolism
mesc00600  Sphingolipid metabolism
mesc00620  Pyruvate metabolism
mesc00630  Glyoxylate and dicarboxylate metabolism
mesc00640  Propanoate metabolism
mesc00860  Porphyrin metabolism
mesc00920  Sulfur metabolism
KO pathway
ko00260   
LinkDB

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