KEGG   PATHWAY: mmma03450
Entry
mmma03450                   Pathway                                
Name
Non-homologous end-joining - Marmota marmota marmota (Alpine marmot)
Description
Nonhomologous end joining (NHEJ) eliminates DNA double-strand breaks (DSBs) by direct ligation. NHEJ involves binding of the KU heterodimer to double-stranded DNA ends, recruitment of DNA-PKcs (MRX complex in yeast), processing of ends, and recruitment of the DNA ligase IV (LIG4)-XRCC4 complex, which brings about ligation. A recent study shows that bacteria accomplish NHEJ using just two proteins (Ku and DNA ligase), whereas eukaryotes require many factors. NHEJ repairs DSBs at all stages of the cell cycle, bringing about the ligation of two DNA DSBs without the need for sequence homology, and so is error-prone.
Class
Genetic Information Processing; Replication and repair
Pathway map
mmma03450  Non-homologous end-joining
mmma03450

Other DBs
GO: 0006303
Organism
Marmota marmota marmota (Alpine marmot) [GN:mmma]
Gene
107135904  Fen1; flap endonuclease 1 [KO:K04799] [EC:3.1.-.-]
107138395  Xrcc5; X-ray repair cross-complementing protein 5 [KO:K10885]
107138711  Nhej1; non-homologous end-joining factor 1 isoform X2 [KO:K10980]
107140434  Dclre1c; protein artemis isoform X1 [KO:K10887] [EC:3.1.-.-]
107140911  Lig4; DNA ligase 4 [KO:K10777] [EC:6.5.1.1]
107142378  Prkdc; DNA-dependent protein kinase catalytic subunit isoform X2 [KO:K06642] [EC:2.7.11.1]
107145928  Mre11; double-strand break repair protein MRE11 [KO:K10865]
107146213  Polm; DNA-directed DNA/RNA polymerase mu isoform X3 [KO:K03513] [EC:2.7.7.7]
107148117  Rad50; DNA repair protein RAD50 [KO:K10866] [EC:3.6.-.-]
107149818  Poll; DNA polymerase lambda isoform X2 [KO:K03512] [EC:2.7.7.7 4.2.99.-]
107149977  Dntt; DNA nucleotidylexotransferase isoform X1 [KO:K00977] [EC:2.7.7.31]
107152334  Xrcc4; DNA repair protein XRCC4 isoform X2 [KO:K10886]
Reference
PMID:16971555
  Authors
Gennery AR.
  Title
Primary immunodeficiency syndromes associated with defective DNA double-strand break repair.
  Journal
Br Med Bull 77-78:71-85 (2006)
DOI:10.1093/bmb/ldl006
Reference
PMID:17589524
  Authors
Zhang Y, Hefferin ML, Chen L, Shim EY, Tseng HM, Kwon Y, Sung P, Lee SE, Tomkinson AE.
  Title
Role of Dnl4-Lif1 in nonhomologous end-joining repair complex assembly and suppression of homologous recombination.
  Journal
Nat Struct Mol Biol 14:639-46 (2007)
DOI:10.1038/nsmb1261
Reference
PMID:16895466
  Authors
Wyman C, Kanaar R.
  Title
DNA double-strand break repair: all's well that ends well.
  Journal
Annu Rev Genet 40:363-83 (2006)
DOI:10.1146/annurev.genet.40.110405.090451
Reference
PMID:15578053
  Authors
Weller GR, Brandt VL, Roth DB.
  Title
Doing more with less in bacterial DNA repair.
  Journal
Nat Struct Mol Biol 11:1158-9 (2004)
DOI:10.1038/nsmb1204-1158
Reference
PMID:12215643
  Authors
Weller GR, Kysela B, Roy R, Tonkin LM, Scanlan E, Della M, Devine SK, Day JP, Wilkinson A, d'Adda di Fagagna F, Devine KM, Bowater RP, Jeggo PA, Jackson SP, Doherty AJ.
  Title
Identification of a DNA nonhomologous end-joining complex in bacteria.
  Journal
Science 297:1686-9 (2002)
DOI:10.1126/science.1074584
Reference
PMID:17506672
  Authors
Pitcher RS, Brissett NC, Doherty AJ.
  Title
Nonhomologous end-joining in bacteria: a microbial perspective.
  Journal
Annu Rev Microbiol 61:259-82 (2007)
DOI:10.1146/annurev.micro.61.080706.093354
KO pathway
ko03450   

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