KEGG   PATHWAY: mun04721
Entry
mun04721                    Pathway                                
Name
Synaptic vesicle cycle - Meriones unguiculatus (Mongolian gerbil)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
mun04721  Synaptic vesicle cycle
mun04721

Other DBs
GO: 0016079 0048488
Organism
Meriones unguiculatus (Mongolian gerbil) [GN:mun]
Gene
110539483  Syt1; synaptotagmin-1 isoform X1 [KO:K15290]
110539811  Cltc; clathrin heavy chain 1 isoform X2 [KO:K04646]
110542756  Slc1a2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
110543308  [KO:K02152]
110545376  Slc6a3; sodium-dependent dopamine transporter [KO:K05036]
110545640  Nsf; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
110545715  Atp6v0d1; V-type proton ATPase subunit d 1 [KO:K02146]
110545836  Cacna1a; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
110546058  Slc6a13; sodium- and chloride-dependent GABA transporter 2 isoform X2 [KO:K05046]
110546059  Atp6v1e1; V-type proton ATPase subunit E 1 [KO:K02150]
110546069  [KO:K05045]
110546613  Cplx4; complexin-4 [KO:K15295]
110546702  Slc6a7; sodium-dependent proline transporter [KO:K05040]
110546776  Ap2a1; AP-2 complex subunit alpha-1 isoform X2 [KO:K11824]
110546835  Slc17a7; vesicular glutamate transporter 1 [KO:K12302]
110547014  Slc1a1; excitatory amino acid transporter 3 isoform X1 [KO:K05612]
110547113  Tcirg1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
110547125  Unc13b; protein unc-13 homolog B isoform X6 [KO:K15293]
110547515  Atp6v0a4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
110547820  Atp6v0e1; V-type proton ATPase subunit e 1 [KO:K02153]
110548920  Slc6a1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
110548942  Slc6a11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
110549155  Rab3a; ras-related protein Rab-3A [KO:K07882]
110549195  Unc13a; protein unc-13 homolog A isoform X1 [KO:K15293]
110549387  Ap2m1; AP-2 complex subunit mu [KO:K11826]
110550166  Stx2; syntaxin-2 isoform X1 [KO:K08486]
110550886  Atp6v0a1; V-type proton ATPase 116 kDa subunit a 1 isoform X4 [KO:K02154]
110551236  Atp6v1b1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
110551565  Slc6a5; sodium- and chloride-dependent glycine transporter 2 isoform X1 [KO:K05038]
110551728  Vamp2; vesicle-associated membrane protein 2 [KO:K13504]
110552258  Slc18a2; synaptic vesicular amine transporter isoform X1 [KO:K08155]
110552276  Atp6v1c2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
110552341  Atp6v1e2; V-type proton ATPase subunit E 2 [KO:K02150]
110552460  Dnm2; dynamin-2 isoform X5 [KO:K23484]
110552651  Ap2s1; AP-2 complex subunit sigma isoform X1 [KO:K11827]
110552691  Atp6v0a2; V-type proton ATPase 116 kDa subunit a 2 [KO:K02154]
110552916  Slc6a9; sodium- and chloride-dependent glycine transporter 1 isoform X2 [KO:K05038]
110552933  Atp6v0b; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
110553030  Atp6v0c; V-type proton ATPase 16 kDa proteolipid subunit c isoform X1 [KO:K02155]
110553625  Cplx1; complexin-1 [KO:K15294]
110553662  Slc17a8; vesicular glutamate transporter 3 [KO:K12302]
110553817  Clta; clathrin light chain A isoform X1 [KO:K04644]
110553921  Ap2a2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
110554061  Cltb; clathrin light chain B isoform X1 [KO:K04645]
110554066  Cplx2; complexin-2 [KO:K15294]
110555206  Napa; alpha-soluble NSF attachment protein [KO:K15296]
110555673  Ap2b1; AP-2 complex subunit beta isoform X1 [KO:K11825]
110556304  Atp6v1g1; V-type proton ATPase subunit G 1 [KO:K02152]
110556936  Rims1; regulating synaptic membrane exocytosis protein 1 isoform X1 [KO:K15291]
110557052  Atp6v1d; V-type proton ATPase subunit D [KO:K02149]
110557632  Atp6v1b2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
110557633  Slc18a1; chromaffin granule amine transporter [KO:K08155]
110558542  Cplx3; complexin-3 [KO:K15295]
110559189  Atp6v0e2; V-type proton ATPase subunit e 2 [KO:K02153]
110559452  Slc6a4; sodium-dependent serotonin transporter [KO:K05037]
110559787  Stx1b; syntaxin-1B isoform X1 [KO:K08486]
110559869  Slc1a6; excitatory amino acid transporter 4 [KO:K05617]
110560128  Atp6v1g2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
110560151  Atp6v1g3; V-type proton ATPase subunit G 3 [KO:K02152]
110560648  Dnm1; dynamin-1 isoform X9 [KO:K01528] [EC:3.6.5.5]
110560761  Atp6v1a; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
110560827  Snap25; synaptosomal-associated protein 25 isoform X1 [KO:K18211]
110561295  Slc17a6; vesicular glutamate transporter 2 [KO:K12302]
110561620  Slc18a3; vesicular acetylcholine transporter [KO:K14636]
110563057  Cacna1b; voltage-dependent N-type calcium channel subunit alpha-1B isoform X1 [KO:K04849]
110564016  Slc1a7; excitatory amino acid transporter 5 [KO:K05618]
110564275  Atp6v1c1; V-type proton ATPase subunit C 1 isoform X1 [KO:K02148]
110564278  Stxbp1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
110564417  Atp6v1f; V-type proton ATPase subunit F [KO:K02151]
110564479  Atp6v1h; V-type proton ATPase subunit H isoform X1 [KO:K02144]
110564510  Unc13c; protein unc-13 homolog C isoform X1 [KO:K15293]
110564598  Stx3; syntaxin-3 isoform X3 [KO:K08486]
110564792  Dnm3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
110565374  Slc6a2; sodium-dependent noradrenaline transporter [KO:K05035]
110565630  Slc1a3; excitatory amino acid transporter 1 [KO:K05614]
110565723  Atp6v0d2; V-type proton ATPase subunit d 2 [KO:K02146]
110565877  Slc32a1; vesicular inhibitory amino acid transporter [KO:K15015]
110566638  Stx1a; syntaxin-1A [KO:K04560]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
mun04144  Endocytosis
mun04724  Glutamatergic synapse
mun04725  Cholinergic synapse
mun04726  Serotonergic synapse
mun04727  GABAergic synapse
mun04728  Dopaminergic synapse
KO pathway
ko04721   

DBGET integrated database retrieval system