KEGG   NETWORK: N00984
Entry
N00984                      Network                                
Name
mGluR5-Ca2+ -apoptotic pathway
Definition
Glutamate -> GRM5 -> GNAQ -> PLCB -> IP3 -> ITPR -> Ca2+ -- MCU -> Ca2+(mito) -- MPTP -> CYCS == APAF1 -> CASP9 -> (CASP3,CASP7)
  Expanded
C00025 -> 2915 -> 2776 -> (23236,5330,5331,5332) -> C01245 -> (3708,3709,3710) -> C00076 -- 90550 -> C00076 -- (7416,7417,7419,291,292,293,83447) -> 54205 == 317 -> 842 -> (836,840)
Class
nt06528 Calcium signaling
nt06460 Alzheimer disease
nt06464 Amyotrophic lateral sclerosis
nt06461 Huntington disease
nt06462 Spinocerebellar ataxia
nt06465 Prion disease
nt06466 Pathways of neurodegeneration
Type
Reference
Pathway
hsa04724  Glutamatergic synapse
hsa04210  Apoptosis
hsa04720  Long-term potentiation
Gene
2915  GRM5; glutamate metabotropic receptor 5
2776  GNAQ; G protein subunit alpha q
23236  PLCB1; phospholipase C beta 1
5330  PLCB2; phospholipase C beta 2
5331  PLCB3; phospholipase C beta 3
5332  PLCB4; phospholipase C beta 4
3708  ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709  ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710  ITPR3; inositol 1,4,5-trisphosphate receptor type 3
90550  MCU; mitochondrial calcium uniporter
7416  VDAC1; voltage dependent anion channel 1
7417  VDAC2; voltage dependent anion channel 2
7419  VDAC3; voltage dependent anion channel 3
291  SLC25A4; solute carrier family 25 member 4
292  SLC25A5; solute carrier family 25 member 5
293  SLC25A6; solute carrier family 25 member 6
83447  SLC25A31; solute carrier family 25 member 31
54205  CYCS; cytochrome c, somatic
317  APAF1; apoptotic peptidase activating factor 1
842  CASP9; caspase 9
836  CASP3; caspase 3
840  CASP7; caspase 7
Metabolite
C00025  L-Glutamate
C01245  D-myo-Inositol 1,4,5-trisphosphate
C00076  Calcium cation
C00076  Calcium cation
Reference
PMID:11413485
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
PMID:31655116
  Authors
Sushma, Mondal AC
  Title
Role of GPCR signaling and calcium dysregulation in Alzheimer's disease.
  Journal
Mol Cell Neurosci 101:103414 (2019)
DOI:10.1016/j.mcn.2019.103414
Reference
PMID:28867646
  Authors
Penna E, Espino J, De Stefani D, Rizzuto R
  Title
The MCU complex in cell death.
  Journal
Cell Calcium 69:73-80 (2018)
DOI:10.1016/j.ceca.2017.08.008
Reference
PMID:29409699
  Authors
Giorgi C, Danese A, Missiroli S, Patergnani S, Pinton P
  Title
Calcium Dynamics as a Machine for Decoding Signals.
  Journal
Trends Cell Biol 28:258-273 (2018)
DOI:10.1016/j.tcb.2018.01.002
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