Entry |
|
Name |
Scrapie conformation PrPSc to PRNP-PI3K-NOX2 signaling pathway
|
Definition |
PRNP* -> CAV -> FYN -> PI3K -> PRKCD -> NOX2 -> ROS |
Expanded |
5621v1 -> (857,858,859) -> 2534 -> (5290,5291,5293) -> 5580 -> ((1536+1535+4689+653361+4688+(5879,5880)) -> (C00027,C00704) |
Class |
|
Type |
Variant
|
Pathway |
|
Disease |
|
Gene |
2534 | FYN; FYN proto-oncogene, Src family tyrosine kinase |
5290 | PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha |
5291 | PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta |
5293 | PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta |
5580 | PRKCD; protein kinase C delta |
1536 | CYBB; cytochrome b-245 beta chain |
1535 | CYBA; cytochrome b-245 alpha chain |
4689 | NCF4; neutrophil cytosolic factor 4 |
653361 | NCF1; neutrophil cytosolic factor 1 |
4688 | NCF2; neutrophil cytosolic factor 2 |
5879 | RAC1; Rac family small GTPase 1 |
5880 | RAC2; Rac family small GTPase 2 |
|
Variant |
5621v1 (PRNP*) PRNP scrapie conformation
|
Metabolite |
|
Reference |
|
Authors |
Schneider B, Pietri M, Pradines E, Loubet D, Launay JM, Kellermann O, Mouillet-Richard S |
Title |
Understanding the neurospecificity of Prion protein signaling. |
Journal |
|
Reference |
|
Authors |
Hirsch TZ, Hernandez-Rapp J, Martin-Lanneree S, Launay JM, Mouillet-Richard S |
Title |
PrP(C) signalling in neurons: from basics to clinical challenges. |
Journal |
|
Reference |
|
Authors |
Marella M, Gaggioli C, Batoz M, Deckert M, Tartare-Deckert S, Chabry J |
Title |
Pathological prion protein exposure switches on neuronal mitogen-activated protein kinase pathway resulting in microglia recruitment. |
Journal |
|
Reference |
|
Authors |
Didonna A |
Title |
Prion protein and its role in signal transduction. |
Journal |
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LinkDB |
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