KEGG   PATHWAY: paev00350
Entry
paev00350                   Pathway                                
Name
Tyrosine metabolism - Pseudomonas aeruginosa PAO1-VE13
Class
Metabolism; Amino acid metabolism
Pathway map
paev00350  Tyrosine metabolism
paev00350

Module
paev_M00044  Tyrosine degradation, tyrosine => homogentisate [PATH:paev00350]
paev_M00533  Homoprotocatechuate degradation, homoprotocatechuate => 2-oxohept-3-enedioate [PATH:paev00350]
Other DBs
GO: 0006570
Organism
Pseudomonas aeruginosa PAO1-VE13 [GN:paev]
Gene
N297_2028  [KO:K01826] [EC:5.3.3.10]
N297_2070  maiA; maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
N297_2071  fahA; fumarylacetoacetase [KO:K01555] [EC:3.7.1.2]
N297_2072  hmgA; homogentisate 1,2-dioxygenase [KO:K00451] [EC:1.13.11.5]
N297_2541  gtdA; gentisate 1,2-dioxygenase [KO:K00450] [EC:1.13.11.4]
N297_2542  [KO:K16165] [EC:3.7.1.20]
N297_2544  maiA; maleylacetoacetate isomerase [KO:K01800] [EC:5.2.1.2]
N297_2603  [KO:K00817] [EC:2.6.1.9]
N297_271  gabD; succinate-semialdehyde dehydrogenase [NADP+] [KO:K00135] [EC:1.2.1.16 1.2.1.79 1.2.1.20]
N297_3252  [KO:K00832] [EC:2.6.1.57]
N297_3276  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
N297_3753  [KO:K00121] [EC:1.1.1.284 1.1.1.1]
N297_4203  [KO:K00146] [EC:1.2.1.39]
N297_4221  hpaB; 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component [KO:K00483] [EC:1.14.14.9]
N297_4222  hpaC; 4-hydroxyphenylacetate 3-monooxygenase, reductase component [KO:K00484] [EC:1.5.1.36]
N297_4253  hpaG; isomerase/decarboxylase [KO:K05921] [EC:4.1.1.68 5.3.3.-]
N297_4254  hpaG; isomerase/decarboxylase [KO:K05921] [EC:4.1.1.68 5.3.3.-]
N297_4255  hpaE; 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase [KO:K00151] [EC:1.2.1.60]
N297_4256  hpaD; 3,4-dihydroxyphenylacetate 2,3-dioxygenase [KO:K00455] [EC:1.13.11.15]
N297_4257  hpcD; 5-carboxymethyl-2-hydroxymuconate Delta-isomerase [KO:K01826] [EC:5.3.3.10]
N297_4259  hpaH; 2-oxo-hepta-3-ene-1,7-dioic acid hydratase [KO:K02509] [EC:4.2.1.-]
N297_4260  hpaI; 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [KO:K02510] [EC:4.1.2.52]
N297_432  [KO:K00274] [EC:1.4.3.4]
N297_4592  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
N297_5613  [KO:K13953] [EC:1.1.1.1]
N297_893  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
N297_898  [KO:K00813] [EC:2.6.1.1]
Compound
C00022  Pyruvate
C00042  Succinate
C00082  L-Tyrosine
C00122  Fumarate
C00146  Phenol
C00164  Acetoacetate
C00232  Succinate semialdehyde
C00355  3,4-Dihydroxy-L-phenylalanine
C00483  Tyramine
C00530  Hydroquinone
C00544  Homogentisate
C00547  L-Noradrenaline
C00628  2,5-Dihydroxybenzoate
C00642  4-Hydroxyphenylacetate
C00788  L-Adrenaline
C00811  4-Coumarate
C00822  Dopaquinone
C01036  4-Maleylacetoacetate
C01060  3,5-Diiodo-L-tyrosine
C01061  4-Fumarylacetoacetate
C01161  3,4-Dihydroxyphenylacetate
C01179  3-(4-Hydroxyphenyl)pyruvate
C01384  Maleic acid
C01693  L-Dopachrome
C01829  Thyroxine
C01850  Rosmarinate
C02167  Maleylpyruvate
C02442  N-Methyltyramine
C02465  Triiodothyronine
C02514  3-Fumarylpyruvate
C02515  3-Iodo-L-tyrosine
C03063  2-Oxohept-3-enedioate
C03077  4-Chlorophenylacetate
C03758  Dopamine
C03765  4-Hydroxyphenylacetaldehyde
C03964  (R)-3-(4-Hydroxyphenyl)lactate
C04043  3,4-Dihydroxyphenylacetaldehyde
C04045  3-(3,4-Dihydroxyphenyl)pyruvate
C04052  5-Carboxy-2-oxohept-3-enedioate
C04185  5,6-Dihydroxyindole-2-carboxylate
C04186  5-Carboxymethyl-2-hydroxymuconate
C04368  3-Amino-3-(4-hydroxyphenyl)propanoate
C04642  2-Hydroxy-5-carboxymethylmuconate semialdehyde
C04796  4-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C04797  5-(L-Alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde
C05338  4-Hydroxyphenylacetyl-CoA
C05350  2-Hydroxy-3-(4-hydroxyphenyl)propenoate
C05576  3,4-Dihydroxyphenylethyleneglycol
C05577  3,4-Dihydroxymandelaldehyde
C05578  5,6-Dihydroxyindole
C05579  Indole-5,6-quinone
C05580  3,4-Dihydroxymandelate
C05581  3-Methoxy-4-hydroxyphenylacetaldehyde
C05582  Homovanillate
C05583  3-Methoxy-4-hydroxyphenylglycolaldehyde
C05584  3-Methoxy-4-hydroxymandelate
C05585  Gentisate aldehyde
C05587  3-Methoxytyramine
C05588  L-Metanephrine
C05589  L-Normetanephrine
C05593  3-Hydroxyphenylacetate
C05594  3-Methoxy-4-hydroxyphenylethyleneglycol
C05595  4-Hydroxyphenylacetylglutamic acid
C05596  p-Hydroxyphenylacetylglycine
C05600  2-Hydroxyhepta-2,4-dienedioate
C05604  2-Carboxy-2,3-dihydro-5,6-dihydroxyindole
C06044  4-Hydroxyphenylethanol
C06046  Salidroside
C06047  Stizolobate
C06048  Stizolobinate
C06199  Hordenine
C06201  2,4-Dihydroxyhept-2-enedioate
C10447  3,4-Dihydroxyphenylpropanoate
C17935  Cysteinyldopa
C17936  Phaeomelanin
C17937  Eumelanin
C17938  5,6-Indolequinone-2-carboxylic acid
C22038  (R)-3-(3,4-Dihydroxyphenyl)lactate
C23042  Atromentin
Reference
PMID:8550403
  Authors
Prieto MA, Diaz E, Garcia JL.
  Title
Molecular characterization of the 4-hydroxyphenylacetate catabolic pathway of Escherichia coli W: engineering a mobile aromatic degradative cluster.
  Journal
J Bacteriol 178:111-20 (1996)
DOI:10.1128/JB.178.1.111-120.1996
Reference
PMID:1194238
  Authors
Sparnins VL, Dagley S.
  Title
Alternative routes of aromatic catabolism in Pseudomonas acidovorans and Pseudomonas putida: gallic acid as a substrate and inhibitor of dioxygenases.
  Journal
J Bacteriol 124:1374-81 (1975)
DOI:10.1128/JB.124.3.1374-1381.1975
Reference
PMID:18435614
  Authors
Ito S, Wakamatsu K
  Title
Chemistry of mixed melanogenesis--pivotal roles of dopaquinone.
  Journal
Photochem Photobiol 84:582-92 (2008)
DOI:10.1111/j.1751-1097.2007.00238.x
Reference
PMID:11171088
  Authors
Olivares C, Jimenez-Cervantes C, Lozano JA, Solano F, Garcia-Borron JC
  Title
The 5,6-dihydroxyindole-2-carboxylic acid (DHICA) oxidase activity of human tyrosinase.
  Journal
Biochem J 354:131-9 (2001)
DOI:10.1042/bj3540131
Related
pathway
paev00020  Citrate cycle (TCA cycle)
paev00360  Phenylalanine metabolism
paev00400  Phenylalanine, tyrosine and tryptophan biosynthesis
paev00620  Pyruvate metabolism
paev00650  Butanoate metabolism
KO pathway
ko00350   

DBGET integrated database retrieval system