KEGG   PATHWAY: amou03013
Entry
amou03013                   Pathway                                
Name
Nucleocytoplasmic transport - Anopheles moucheti
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
amou03013  Nucleocytoplasmic transport
amou03013

Other DBs
GO: 0050658
Organism
Anopheles moucheti [GN:amou]
Gene
128297621  aladin-like [KO:K14320]
128304021  uncharacterized protein LOC128304021 [KO:K14321]
128299499  mRNA export factor Gle1 [KO:K18723]
128299009  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
128309703  protein Rae1 [KO:K14298]
128297482  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
128299537  nuclear pore complex protein Nup88 [KO:K14318]
128300318  ran GTPase-activating protein [KO:K14319]
128298552  SUMO-conjugating enzyme UBC9-B-like [KO:K10577]
128309369  SUMO-conjugating enzyme UBC9-B [KO:K10577]
128305247  SUMO-conjugating enzyme UBC9-A-like [KO:K10577]
128298247  small ubiquitin-related modifier 3-like [KO:K12160]
128306346  small ubiquitin-related modifier 3-like isoform X1 [KO:K12160]
128310207  nuclear pore complex protein Nup160 homolog [KO:K14303]
128309381  nuclear pore complex protein Nup75 [KO:K14304]
128310803  protein SEC13 homolog [KO:K14004]
128296870  protein SEC13 homolog [KO:K14004]
128310529  nuclear pore complex protein Nup107 [KO:K14301]
128310403  nuclear pore complex protein Nup133 [KO:K14300]
128303153  nucleoporin seh1 [KO:K14299]
128298067  nucleoporin Nup43 [KO:K14305]
128310040  nucleoporin Nup37 [KO:K14302]
128297631  nuclear pore glycoprotein p62 [KO:K14306]
128305591  nuclear pore complex protein Nup58 [KO:K14307]
128301923  probable nucleoporin Nup54 isoform X1 [KO:K14308]
128301013  nuclear pore complex protein Nup205 [KO:K14310]
128301375  nucleoporin Nup188 [KO:K14311]
128300633  nuclear pore complex protein Nup154 isoform X1 [KO:K14312]
128310565  nuclear pore complex protein Nup93-1 [KO:K14309]
128303641  nucleoporin Nup35 [KO:K14313]
128298927  LOW QUALITY PROTEIN: nucleoporin Ndc1 [KO:K14315]
128303516  nuclear pore membrane glycoprotein 210 [KO:K14314]
128302523  Krueppel homolog 2 [KO:K20724]
128308242  nucleoprotein TPR [KO:K09291]
128301625  importin subunit alpha [KO:K15043]
128301279  importin subunit alpha-3 [KO:K23583]
128305911  importin subunit alpha-7 [KO:K15042]
128304637  importin subunit beta [KO:K14293]
128300736  transportin-1 isoform X1 [KO:K18752]
128310256  transportin-3 isoform X1 [KO:K15436]
128300543  importin-4-like [KO:K20221]
128309290  importin-5 [KO:K20222]
128301845  importin-7 [KO:K20223]
128310295  importin-9 [KO:K20224]
128310242  importin-11 [KO:K25201]
128300639  importin-13 [KO:K25202]
128301663  snurportin-1 [KO:K13151]
128301328  exportin-1 [KO:K14290]
128310078  exportin-2 [KO:K18423]
128297236  exportin-4-like [KO:K25203]
128309489  exportin-5 [KO:K14289]
128299017  ran-binding protein 16 [KO:K18460]
128300407  GTP-binding nuclear protein Ran [KO:K07936]
128299771  elongation factor 1-alpha-like [KO:K03231]
128305616  elongation factor 1-alpha [KO:K03231]
128303245  phosphorylated adapter RNA export protein isoform X1 [KO:K14291]
128309502  nuclear cap-binding protein subunit 1 [KO:K12882]
128309810  nuclear cap-binding protein subunit 2 [KO:K12883]
128300230  60S ribosomal export protein NMD3 [KO:K07562]
128303666  RNA-binding protein 8A [KO:K12876]
128309504  protein mago nashi [KO:K12877]
128305393  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
128305087  apoptotic chromatin condensation inducer in the nucleus [KO:K12875]
128310775  histone deacetylase complex subunit SAP18 [KO:K14324]
128300640  RNA-binding protein with serine-rich domain 1-A [KO:K14325]
128299766  pinin [KO:K13114]
128305064  THO complex subunit 4-A [KO:K12881]
128310357  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
128306438  regulator of nonsense transcripts 2 [KO:K14327]
128297199  nuclear RNA export factor 1-like [KO:K14284]
128304845  NTF2-related export protein [KO:K14285]
128305647  ATP-dependent RNA helicase WM6-like [KO:K12812] [EC:5.6.2.7]
128305979  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
128301559  partner of Y14 and mago [KO:K14294]
128297328  THO complex subunit 1 [KO:K12878]
128304839  THO complex subunit 2 [KO:K12879]
128301990  THO complex subunit 5 homolog [KO:K13174]
128302248  THO complex subunit 6 [KO:K13175]
128307606  THO complex subunit 7 homolog [KO:K13176]
128299627  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
amou03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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