KEGG   PATHWAY: axx00061
Entry
axx00061                    Pathway                                
Name
Fatty acid biosynthesis - Achromobacter xylosoxidans NCTC10807
Class
Metabolism; Lipid metabolism
Pathway map
axx00061  Fatty acid biosynthesis
axx00061

Module
axx_M00082  Fatty acid biosynthesis, initiation [PATH:axx00061]
axx_M00083  Fatty acid biosynthesis, elongation [PATH:axx00061]
axx_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:axx00061]
Other DBs
GO: 0006633
Organism
Achromobacter xylosoxidans NCTC10807 [GN:axx]
Gene
ERS451415_04432  accA; Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
ERS451415_00634  accB_2; Biotin carboxyl carrier protein of acetyl-CoA carboxylase [KO:K02160]
ERS451415_00213  accB_1; Biotin carboxyl carrier protein of acetyl-CoA carboxylase [KO:K02160]
ERS451415_00635  accC_2; Biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
ERS451415_00214  accC_1; Biotin carboxylase [KO:K01961] [EC:6.4.1.2 6.3.4.14]
ERS451415_01437  accD; Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
ERS451415_01451  fabD; Malonyl CoA-acyl carrier protein transacylase [KO:K00645] [EC:2.3.1.39]
ERS451415_01450  fabH; 3-oxoacyl-[acyl-carrier-protein] synthase 3 [KO:K00648] [EC:2.3.1.180]
ERS451415_06068  pqsD; PQB biosynthetic 3-oxoacyl-[acyl-carrier-protein] synthase III [KO:K00648] [EC:2.3.1.180]
ERS451415_02140  kasA; 3-oxoacyl-[acyl-carrier-protein] synthase 1 [KO:K00647] [EC:2.3.1.41]
ERS451415_02137  fabF_2; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
ERS451415_01454  fabF_1; 3-oxoacyl-[acyl-carrier-protein] synthase 2 [KO:K09458] [EC:2.3.1.179]
ERS451415_03335  fabG_18; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_02336  fabG_14; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_05659  butA; Diacetyl reductase [(S)-acetoin forming] [KO:K00059] [EC:1.1.1.100]
ERS451415_00820  fabG_3; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_04296  fabG_23; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_02138  fabG_11; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_01452  fabG_8; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_02276  fabG_12; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_05640  fabG_32; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_05144  fabG_28; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_00856  fabG_4; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_03960  fabG_21; 3-oxoacyl-[acyl-carrier-protein] reductase FabG [KO:K00059] [EC:1.1.1.100]
ERS451415_02491  fabZ; (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase [KO:K02372] [EC:4.2.1.59]
ERS451415_04955  fabI_2; Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [KO:K00208] [EC:1.3.1.9 1.3.1.10]
ERS451415_00713  fabI_1; Enoyl-[acyl-carrier-protein] reductase [NADH] FabI [KO:K00208] [EC:1.3.1.9 1.3.1.10]
ERS451415_04862  Nitronate monooxygenase [KO:K02371] [EC:1.3.1.9]
ERS451415_02647  Putative reductase YPO4104/y4119/YP_4011 [KO:K00209] [EC:1.3.1.9 1.3.1.44]
ERS451415_00829  fadD_1; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
ERS451415_04301  fadD_7; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
ERS451415_04380  fadD_8; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
ERS451415_05937  Long-chain-fatty-acid--CoA ligase FadD15 [KO:K01897] [EC:6.2.1.3]
ERS451415_03724  Long-chain-fatty-acid--CoA ligase FadD15 [KO:K01897] [EC:6.2.1.3]
ERS451415_00895  fadD_2; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
axx00020  Citrate cycle (TCA cycle)
axx00071  Fatty acid degradation
axx00410  beta-Alanine metabolism
axx00561  Glycerolipid metabolism
axx00564  Glycerophospholipid metabolism
axx00620  Pyruvate metabolism
axx00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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