KEGG   PATHWAY: bbe02020
Entry
bbe02020                    Pathway                                
Name
Two-component system - Brevibacillus brevis
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
bbe02020  Two-component system
bbe02020

Other DBs
GO: 0000160
Organism
Brevibacillus brevis [GN:bbe]
Gene
BBR47_13940  phoR; two-component sensor histidine kinase [KO:K07636] [EC:2.7.13.3]
BBR47_41930  two-component sensor histidine kinase [KO:K07636] [EC:2.7.13.3]
BBR47_13930  phoP; two-component response regulator [KO:K07658]
BBR47_28750  two-component response regulator [KO:K07658]
BBR47_01730  alkaline phosphatase precursor [KO:K01077] [EC:3.1.3.1]
BBR47_58820  two-component response regulator [KO:K07776]
BBR47_04750  probable phosphate ABC transporter substrate binding protein [KO:K02040]
BBR47_50770  hypothetical protein [KO:K07662]
BBR47_06660  cssS; two-component sensor histidine kinase [KO:K07650] [EC:2.7.13.3]
BBR47_06670  cssR; two-component response regulator [KO:K07770]
BBR47_00090  two-component response regulator [KO:K07770]
BBR47_48260  hypothetical protein [KO:K04771] [EC:3.4.21.107]
BBR47_53350  hag; flagellin [KO:K02406]
BBR47_34540  sigD; RNA polymerase sigma-D factor [KO:K02405]
BBR47_08690  motA; chemotaxis MotA protein [KO:K02556]
BBR47_53150  putative chemotaxis protein [KO:K02556]
BBR47_03850  kdpD; sensor protein [KO:K07646] [EC:2.7.13.3]
BBR47_03820  kdpA; potassium-transporting ATPase A chain [KO:K01546]
BBR47_03830  kdpB; potassium-transporting ATPase B chain [KO:K01547] [EC:7.2.2.6]
BBR47_03840  kdpC; potassium-transporting ATPase C chain [KO:K01548]
BBR47_32280  putative transport protein [KO:K07793]
BBR47_46450  putative transport protein [KO:K07793]
BBR47_11860  putative transport protein [KO:K07793]
BBR47_11850  putative transport protein [KO:K07794]
BBR47_46460  putative transport protein [KO:K07794]
BBR47_32290  putative transport protein [KO:K07794]
BBR47_32300  putative transport protein [KO:K07795]
BBR47_11840  putative transport protein [KO:K07795]
BBR47_24180  resE; two-component sensor histidine kinase [KO:K07651] [EC:2.7.13.3]
BBR47_24170  resD; two-component response regulator [KO:K07775]
BBR47_09280  two-component response regulator [KO:K07775]
BBR47_49800  ctaA; cytochrome aa3 controlling protein [KO:K02259] [EC:1.17.99.9]
BBR47_59120  yycG; two-component sensor histidine kinase [KO:K07652] [EC:2.7.13.3]
BBR47_59130  yycF; two-component response regulator [KO:K07668]
BBR47_04090  two-component response regulator [KO:K07668]
BBR47_12680  two-component response regulator [KO:K07668]
BBR47_14400  two-component response regulator [KO:K07668]
BBR47_00010  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
BBR47_14370  probable ABC transporter ATP binding protein [KO:K11631]
BBR47_14380  probable ABC transporter permease protein [KO:K11632]
BBR47_05440  yxdK; two-component sensor histidine kinase [KO:K11633] [EC:2.7.13.3]
BBR47_05430  yxdJ; two-component response regulator [KO:K11634]
BBR47_05450  yxdL; ABC transporter ATP-binding protein [KO:K11635]
BBR47_05460  yxdM; ABC transporter permease protein [KO:K11636]
BBR47_03540  two-component sensor histidine kinase [KO:K14982] [EC:2.7.13.3]
BBR47_03530  two-component response regulator [KO:K14983]
BBR47_52010  two-component sensor histidine kinase [KO:K18345] [EC:2.7.13.3]
BBR47_57970  two-component response regulator [KO:K18349]
BBR47_12370  conserved hypothetical protein [KO:K08641] [EC:3.4.13.22]
BBR47_05860  probable D,D-peptidase/D,D-carboxypeptidase [KO:K07260] [EC:3.4.17.14]
BBR47_26840  putative D,D-peptidase/D,D-carboxypeptidase [KO:K07260] [EC:3.4.17.14]
BBR47_36730  yodJ; putative D,D-peptidase/D,D-carboxypeptidase [KO:K07260] [EC:3.4.17.14]
BBR47_28030  probable D,D-peptidase/D,D-carboxypeptidase [KO:K07260] [EC:3.4.17.14]
BBR47_06840  conserved hypothetical protein [KO:K18346]
BBR47_25760  hypothetical protein [KO:K18346]
BBR47_05870  ligase [KO:K18856] [EC:6.3.2.35]
BBR47_05880  probable D,D-peptidase/D,D-carboxypeptidase [KO:K18866] [EC:3.4.13.22 3.4.17.14]
BBR47_05890  probable amino acid racemase [KO:K18348] [EC:5.1.1.18 5.1.1.1]
BBR47_09590  two-component sensor histidine kinase [KO:K18940] [EC:2.7.13.3]
BBR47_28060  two-component sensor histidine kinase [KO:K18940] [EC:2.7.13.3]
BBR47_09580  two-component response regulator [KO:K18941]
BBR47_28050  two-component response regulator [KO:K18941]
BBR47_28170  sporulation kinase [KO:K02491] [EC:2.7.13.3]
BBR47_13450  sporulation kinase [KO:K02491] [EC:2.7.13.3]
BBR47_52500  sporulation kinase [KO:K02491] [EC:2.7.13.3]
BBR47_32180  probable two-component sensor histidine kinase [KO:K02491] [EC:2.7.13.3]
BBR47_53060  sporulation kinase [KO:K02491] [EC:2.7.13.3]
BBR47_43740  kinB; sporulation kinase B [KO:K07697] [EC:2.7.13.3]
BBR47_51140  probable two-component sensor histidine kinase [KO:K07697] [EC:2.7.13.3]
BBR47_56690  two-component sensor histidine kinase [KO:K07697] [EC:2.7.13.3]
BBR47_31060  conserved hypothetical protein [KO:K06347]
BBR47_00630  probable two-component sensor histidine kinase [KO:K13533] [EC:2.7.13.3]
BBR47_54900  spo0F; sporulation initiation phosphotransferase F [KO:K02490]
BBR47_18480  spo0B; sporulation initiation phosphotransferase [KO:K06375] [EC:2.7.-.-]
BBR47_23490  spo0A; stage 0 sporulation protein A [KO:K07699]
BBR47_12710  dctS; two-component sensor histidine kinase [KO:K11691] [EC:2.7.13.3]
BBR47_12720  dctR; two-component response regulator [KO:K11692]
BBR47_13780  ytsJ; probable NAD-dependent malic enzyme [KO:K00027] [EC:1.1.1.38]
BBR47_21770  two-component sensor histidine kinase [KO:K07704] [EC:2.7.13.3]
BBR47_21780  two-component response regulator [KO:K07705]
BBR47_07040  natA; Na(+) extrusion ABC transporter ATP binding protein [KO:K09697] [EC:7.2.2.4]
BBR47_07050  natB; Na(+) extrusion ABC transporter permease protein [KO:K09696]
BBR47_39990  hypothetical membrane protein [KO:K07813]
BBR47_21210  two-component response regulator [KO:K07684]
BBR47_29950  probable two-component sensor histidine kinase [KO:K07674] [EC:2.7.13.3]
BBR47_53360  csrA; probable carbon storage regulator [KO:K03563]
BBR47_12890  comP; two-component sensor histidine kinase [KO:K07680] [EC:2.7.13.3]
BBR47_12900  comA; two-component response regulator [KO:K07691]
BBR47_54030  degS; two-component sensor histidine kinase [KO:K07777] [EC:2.7.13.3]
BBR47_54020  degU; two-component response regulator [KO:K07692]
BBR47_07930  desK; two-component sensor histidine kinase [KO:K07778] [EC:2.7.13.3]
BBR47_07940  desR; two-component response regulator [KO:K07693]
BBR47_07920  des; fatty acid desaturase [KO:K10255] [EC:1.14.19.23 1.14.19.45]
BBR47_10070  yvqE; two-component sensor histidine kinase [KO:K11617] [EC:2.7.13.3]
BBR47_10080  yvqC; two-component response regulator [KO:K11618]
BBR47_10060  conserved hypothetical membrane protein [KO:K11622]
BBR47_03990  two-component sensor histidine kinase [KO:K07683] [EC:2.7.13.3]
BBR47_28290  two-component sensor histidine kinase [KO:K07683] [EC:2.7.13.3]
BBR47_04000  two-component response regulator [KO:K07696]
BBR47_28300  two-component response regulator [KO:K07696]
BBR47_01410  hypothetical protein [KO:K02651]
BBR47_01360  hypothetical protein [KO:K02279]
BBR47_05690  hypothetical protein [KO:K02282]
BBR47_01370  putative transcriptional regulator [KO:K02282]
BBR47_05700  conserved hypothetical protein [KO:K02283] [EC:7.4.2.8]
BBR47_01380  conserved hypothetical protein [KO:K02283] [EC:7.4.2.8]
BBR47_01510  hypothetical protein [KO:K02283] [EC:7.4.2.8]
BBR47_05710  conserved hypothetical membrane protein [KO:K12510]
BBR47_01390  hypothetical membrane protein [KO:K12510]
BBR47_01400  hypothetical membrane protein [KO:K12511]
BBR47_05720  conserved hypothetical membrane protein [KO:K12511]
BBR47_33530  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
BBR47_49250  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
BBR47_08740  atoS; two-component sensor histidine kinase [KO:K07710] [EC:2.7.13.3]
BBR47_08750  atoC; two-component response regulator [KO:K07714]
BBR47_20940  probable acetate CoA-transferase subunit A [KO:K01034] [EC:2.8.3.8 2.8.3.9]
BBR47_21900  putative acetate CoA-transferase subunit A [KO:K01034] [EC:2.8.3.8 2.8.3.9]
BBR47_20950  probable acetate CoA-transferase subunit B [KO:K01035] [EC:2.8.3.8 2.8.3.9]
BBR47_21910  putative acetate CoA-transferase subunit B [KO:K01035] [EC:2.8.3.8 2.8.3.9]
BBR47_08760  conserved hypothetical membrane protein [KO:K02106]
BBR47_54990  mmgA; acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BBR47_16650  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BBR47_54580  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BBR47_49980  probable acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BBR47_21950  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BBR47_12650  dctA; probable C4-dicarboxylate ABC transporter permease protein [KO:K11103]
BBR47_52430  sigL; RNA polymerase sigma-54 factor [KO:K03092]
BBR47_24690  cheR; chemotaxis protein methyltransferase [KO:K00575] [EC:2.1.1.80]
BBR47_08630  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_11740  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_44110  putative heme-based signal transducer protein [KO:K03406]
BBR47_00460  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_10860  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_10300  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_04250  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_16050  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_22660  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_43070  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_43530  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_43690  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_46660  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_48640  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_51270  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_55530  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_55720  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_02990  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_56440  putative methyl-accepting chemotaxis protein [KO:K03406]
BBR47_58900  probable methyl-accepting chemotaxis protein [KO:K03406]
BBR47_34580  cheW; chemotaxis protein CheW [KO:K03408]
BBR47_40300  probable chemotaxis protein [KO:K03408]
BBR47_34590  cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
BBR47_34690  cheY; chemotaxis response protein [KO:K03413]
BBR47_05540  probable two-component response regulator [KO:K03413]
BBR47_05550  probable two-component response regulator [KO:K03413]
BBR47_49430  probable two-component response regulator [KO:K03413]
BBR47_57060  probable two-component response regulator [KO:K03413]
BBR47_34600  cheB; protein glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
BBR47_11450  conserved hypothetical protein [KO:K10914]
BBR47_29690  probable transcriptional regulator [KO:K10914]
BBR47_29700  transcriptional regulator [KO:K10914]
BBR47_12200  two-component sensor histidine kinase [KO:K07717] [EC:2.7.13.3]
BBR47_27400  glnK; two-component sensor histidine kinase [KO:K07717] [EC:2.7.13.3]
BBR47_09170  two-component sensor histidine kinase [KO:K07717] [EC:2.7.13.3]
BBR47_12210  two-component response regulator [KO:K07719]
BBR47_27410  glnL; two-component response regulator [KO:K07719]
BBR47_09180  two-component response regulator [KO:K07719]
BBR47_22510  ylaM; probable glutaminase [KO:K01425] [EC:3.5.1.2]
BBR47_27390  glsA; glutaminase [KO:K01425] [EC:3.5.1.2]
BBR47_27380  sodium/amino acid symporter [KO:K11626]
BBR47_06780  probable two-component sensor histidine kinase [KO:K07718] [EC:2.7.13.3]
BBR47_58070  probable two-component sensor histidine kinase [KO:K07718] [EC:2.7.13.3]
BBR47_06770  probable two-component response regulator [KO:K07720]
BBR47_58060  probable two-component response regulator [KO:K07720]
BBR47_42310  probable transcriptional regulator [KO:K07720]
BBR47_15550  probable two-component response regulator [KO:K07720]
BBR47_45980  cydA; cytochrome d ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
BBR47_03660  cbdA; cytochrome d oxidase subunit I [KO:K00425] [EC:7.1.1.7]
BBR47_45970  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
BBR47_03650  cbdB; cytochrome bd-I oxidase subunit II [KO:K00426] [EC:7.1.1.7]
BBR47_08730  ptpA; low molecular weight protein-tyrosine-phosphatase [KO:K25307] [EC:3.1.3.48]
BBR47_54670  mnaA; UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
BBR47_16470  putative UDP-glucose/GDP-mannose dehydrogenase [KO:K02472] [EC:1.1.1.336]
BBR47_53420  flgM; negative regulator of flagellin synthesis [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
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Related
pathway
bbe00190  Oxidative phosphorylation
bbe00550  Peptidoglycan biosynthesis
bbe00910  Nitrogen metabolism
bbe02030  Bacterial chemotaxis
bbe02040  Flagellar assembly
bbe03070  Bacterial secretion system
KO pathway
ko02020   
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