KEGG   PATHWAY: bceo02024
Entry
bceo02024                   Pathway                                
Name
Quorum sensing - Burkholderia cenocepacia H111
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
bceo02024  Quorum sensing
bceo02024

Other DBs
GO: 0009372
Organism
Burkholderia cenocepacia H111 [GN:bceo]
Gene
I35_1797  hfQ; RNA-binding protein Hfq [KO:K03666]
I35_1436  RNA-binding protein Hfq / domain of unknown function [KO:K03666]
I35_0389  trpE; Anthranilate synthase, aminase component [KO:K01657] [EC:4.1.3.27]
I35_0388  trpG; Anthranilate synthase, amidotransferase component [KO:K01658] [EC:4.1.3.27]
I35_5747  cepI; N-acyl-L-homoserine lactone synthetase cepI [KO:K13061] [EC:2.3.1.184]
I35_6233  rhlA; RhlA, 3-(3-hydroxyalkanoyloxy)alkanoic acids (HAAs) synthase [KO:K18100] [EC:2.4.1.-]
I35_6231  rhlB; RhlB, TDP-rhamnosyltransferase 1 [KO:K18101] [EC:2.4.1.-]
I35_6229  rhlC; RhlC, TDP-rhamnosyltransferase 2 [KO:K12990] [EC:2.4.1.-]
I35_6642  aroG; 2-keto-3-deoxy-D-arabino-heptulosonate-7-phospha t e synthase I alpha [KO:K01626] [EC:2.5.1.54]
I35_0592  aroG; 2-keto-3-deoxy-D-arabino-heptulosonate-7-phospha t e synthase I alpha [KO:K01626] [EC:2.5.1.54]
I35_0131  flhD; Flagellar transcriptional activator FlhD [KO:K02403]
I35_0132  flhC; Flagellar transcriptional activator FlhC [KO:K02402]
I35_2303  kdpE; DNA-binding response regulator KdpE [KO:K07667]
I35_1655  ABC transporter substrate-binding protein [KO:K02055]
I35_1114  ABC-type Fe3+ transport system, periplasmic component [KO:K02055]
I35_4562  Spermidine/putrescine-binding periplasmic protein [KO:K02055]
I35_5531  Spermidine/putrescine-binding periplasmic protein [KO:K02055]
I35_4873  ABC transporter, periplasmic spermidine putrescine-binding protein PotD (TC 3.A.1.11.1) [KO:K02055]
I35_1658  ABC transporter permease protein [KO:K02053]
I35_1112  ABC transporter permease protein [KO:K02053]
I35_1113  Molybdenum transport system permease protein ModB (TC 3.A.1.8.1) [KO:K02053]
I35_4566  ABC-type spermidine/putrescine transport system,permease component II [KO:K02053]
I35_4875  Spermidine Putrescine ABC transporter permease component potC (TC_3.A.1.11.1) [KO:K02053]
I35_1657  ABC transporter permease protein [KO:K02054]
I35_4567  ABC-type spermidine/putrescine transport system,permease component I [KO:K02054]
I35_4874  Spermidine Putrescine ABC transporter permease component PotB (TC 3.A.1.11.1) [KO:K02054]
I35_1656  aglK; ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [KO:K02052]
I35_1111  Maltose maltodextrin transport ATP-binding protein malK [KO:K02052]
I35_4568  ABC-type spermidine/putrescine transport systems,ATPase components [KO:K02052]
I35_4872  Putrescine transport ATP-binding protein PotA (TC 3.A.1.11.1) [KO:K02052]
I35_2274  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_4178  leucine ABC transporter subunit substrate-binding protein [KO:K01999]
I35_5066  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_6142  Extracellular ligand-binding receptor [KO:K01999]
I35_7138  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_0019  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_0022  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_0045  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_0158  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_2547  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_1037  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_5160  amiC; Urea ABC transporter, urea binding protein [KO:K01999]
I35_4402  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_4506  Branched-chain amino acid ABC transporter, amino acid-binding protein (TC 3.A.1.4.1) [KO:K01999]
I35_7057  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_5341  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_6406  Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
I35_2568  High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) [KO:K01997]
I35_1319  livH; High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) [KO:K01997]
I35_6141  livH; High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) [KO:K01997]
I35_7139  High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) [KO:K01997]
I35_0020  High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) [KO:K01997]
I35_0023  High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) [KO:K01997]
I35_4507  High-affinity branched-chain amino acid transport system permease protein LivH (TC 3.A.1.4.1) / Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) [KO:K01997 K01998]
I35_0024  ABC-type branched-chain amino acid transport systems, ATPase component [KO:K01995 K01998]
I35_7140  Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) [KO:K01998]
I35_1320  livM; Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) [KO:K01998]
I35_6140  livM; Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) [KO:K01998]
I35_0021  Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) [KO:K01998]
I35_2567  Branched-chain amino acid transport system permease protein LivM (TC 3.A.1.4.1) [KO:K01998]
I35_1321  livG; Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) [KO:K01995]
I35_6139  livG; Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) [KO:K01995]
I35_7141  Urea ABC transporter, ATPase protein UrtD [KO:K01995]
I35_0017  Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) [KO:K01995]
I35_2566  Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) [KO:K01995]
I35_4508  Branched-chain amino acid transport ATP-binding protein LivG (TC 3.A.1.4.1) [KO:K01995]
I35_7142  Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_1322  livF; Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_6138  livF; Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_4509  Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_0018  Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_0025  Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_2565  Branched-chain amino acid transport ATP-binding protein LivF (TC 3.A.1.4.1) [KO:K01996]
I35_5745  cepR; transcriptional regulator cepR [KO:K19666]
I35_4186  cepR2; transcriptional activator protein CepR2 [KO:K20540]
I35_4475  rpfF; BDSF synthase rpfF [KO:K13816]
I35_4474  rpfR; Cis-2-dodecenoic acid receptor RpfR [KO:K14051] [EC:3.1.4.52]
I35_7447  zmpA; zinc metalloprotease ZmpA [KO:K20273]
I35_6198  zmpB; family M4 metallo peptidase [KO:K20274]
I35_7309  aidA; nematocidal protein AidA [KO:K20275]
I35_7308  AidA [KO:K20275]
I35_6025  bapA; Large repetitive protein [KO:K20276]
I35_4182  bclB; lectin [KO:K20277]
I35_4183  bclC; lectin [KO:K20277]
I35_4184  bclA; lectin [KO:K20277]
I35_5962  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
I35_1439  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
I35_0401  fadD; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
I35_7779  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
I35_2629  Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
I35_2612  transcriptional regulator, Crp/Fnr family [KO:K10914]
I35_7657  cAMP-binding proteins-catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [KO:K10914]
I35_2669  Zinc uptake regulation protein ZUR [KO:K09823]
I35_1074  bapR; transcriptional regulator, IclR family [KO:K20329]
I35_5758  Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [KO:K20330]
I35_5751  GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
I35_0819  ribD; Diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
I35_6188  Integral membrane protein [KO:K09936]
I35_1587  RND efflux system, outer membrane lipoprotein CmeC [KO:K18139]
I35_7887  oprB; multidrug efflux system outer membrane protein [KO:K18139]
I35_2677  efflux system outer membrane protein [KO:K18139]
I35_7756  RND efflux system, outer membrane lipoprotein CmeC [KO:K18139]
I35_5969  Outer membrane protein [KO:K18139]
I35_4845  Outer membrane protein [KO:K18139]
I35_6613  oppA; Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein OppA (TC 3.A.1.5.1) [KO:K15580]
I35_6612  oppB; Oligopeptide transport system permease protein OppB (TC 3.A.1.5.1) [KO:K15581]
I35_6611  oppC; Oligopeptide transport system permease protein OppC (TC 3.A.1.5.1) [KO:K15582]
I35_6610  oppD; Oligopeptide transport ATP-binding protein OppD (TC 3.A.1.5.1) [KO:K15583]
I35_6609  oppF; Oligopeptide transport ATP-binding protein OppF (TC 3.A.1.5.1) [KO:K10823]
I35_7491  ABC-type dipeptide transport system, periplasmic component [KO:K02035]
I35_7492  ABC-type dipeptide transport system, periplasmic component [KO:K02035]
I35_7407  ABC-type dipeptide transport system, periplasmic component [KO:K02035]
I35_5637  ABC-type dipeptide transport system, periplasmic component [KO:K02035]
I35_5645  Dipeptide-binding ABC transporter; putative hemin-binding lipoprotein [KO:K02035]
I35_7493  Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) [KO:K02033]
I35_7408  Peptide ABC transporter, permease protein [KO:K02033]
I35_5646  dppB; Dipeptide transport system permease protein DppB (TC 3.A.1.5.2) [KO:K02033]
I35_7494  Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) [KO:K02034]
I35_7409  Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) [KO:K02034]
I35_5647  dppC; Dipeptide transport system permease protein DppC (TC 3.A.1.5.2) [KO:K02034]
I35_7495  ABC transporter ATP-binding protein [KO:K02031 K02032]
I35_7410  ATPase components of various ABC-type transport systems, contain duplicated ATPase [KO:K02031 K02032]
I35_5648  dppD; Dipeptide transport ATP-binding protein DppD (TC 3.A.1.5.2) [KO:K02031]
I35_5649  dppF; Dipeptide transport ATP-binding protein DppF (TC 3.A.1.5.2) [KO:K02032]
I35_3240  yidC; Inner membrane protein translocase component YidC, long form [KO:K03217]
I35_5615  Extracellular protease precursor [KO:K14645] [EC:3.4.21.-]
I35_0210  secE; Preprotein translocase subunit SecE (TC 3.A.5.1.1) [KO:K03073]
I35_2269  secG; Preprotein translocase subunit SecG (TC 3.A.5.1.1) [KO:K03075]
I35_0244  secY; Preprotein translocase secY subunit (TC 3.A.5.1.1) [KO:K03076]
I35_0572  yajC; Preprotein translocase subunit YajC (TC 3.A.5.1.1) [KO:K03210]
I35_0422  secA; Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1) [KO:K03070] [EC:7.4.2.8]
I35_2876  Signal recognition particle receptor protein FtsY (alpha subunit) [KO:K03110]
I35_2924  secB; Protein export cytoplasm chaperone protein (SecB,maintains protein to be exported in unfolded state) [KO:K03071]
I35_0442  ffh; Signal recognition particle, subunit Ffh SRP54 [KO:K03106] [EC:3.6.5.4]
I35_6328  Phospholipase C [KO:K01114] [EC:3.1.4.3]
I35_6605  Phospholipase C 4 precursor [KO:K01114] [EC:3.1.4.3]
I35_5328  Acid phosphatase [KO:K01114] [EC:3.1.4.3]
I35_3222  Phospholipase C 4 precursor [KO:K01114] [EC:3.1.4.3]
I35_1038  plcN; Phospholipase C [KO:K01114] [EC:3.1.4.3]
I35_4315  Phospholipase C [KO:K01114] [EC:3.1.4.3]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
  Authors
Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  Journal
Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
  Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  Title
Quinolones: from antibiotics to autoinducers.
  Journal
FEMS Microbiol Rev 35:247-74 (2011)
DOI:10.1111/j.1574-6976.2010.00247.x
Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
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Related
pathway
bceo02040  Flagellar assembly
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ko02024   
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