KEGG   PATHWAY: bgd02024
Entry
bgd02024                    Pathway                                
Name
Quorum sensing - Burkholderia gladioli BSR3
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
bgd02024  Quorum sensing
bgd02024

Other DBs
GO: 0009372
Organism
Burkholderia gladioli BSR3 [GN:bgd]
Gene
bgla_1g22840  sRNA chaperone Hfq [KO:K03666]
bgla_1g18290  hypothetical protein [KO:K03666]
bgla_1g04760  Anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
bgla_1g04750  Anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
bgla_1g16580  para-aminobenzoate synthase [KO:K01658] [EC:4.1.3.27]
bgla_1p1740  autoinducer synthesis protein [KO:K13061] [EC:2.3.1.184]
bgla_2g11050  AHL synthase [KO:K13061] [EC:2.3.1.184]
bgla_2g07180  Rhamnosyltransferase 1, subunit A [KO:K18100] [EC:2.4.1.-]
bgla_2g07490  Rhamnosyltransferase 1, subunit A [KO:K18100] [EC:2.4.1.-]
bgla_4p1210  glycosyl transferase family protein [KO:K18101] [EC:2.4.1.-]
bgla_2g07500  Glycosyl transferase, family 2 [KO:K18101] [EC:2.4.1.-]
bgla_2g07190  Glycosyl transferase, family 2 [KO:K18101] [EC:2.4.1.-]
bgla_1g07900  Rhamnosyltransferase [KO:K12990] [EC:2.4.1.-]
bgla_2g07210  Rhamnosyltransferase [KO:K12990] [EC:2.4.1.-]
bgla_2g07520  Rhamnosyltransferase [KO:K12990] [EC:2.4.1.-]
bgla_2g24870  phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
bgla_1g06620  hypothetical protein [KO:K01626] [EC:2.5.1.54]
bgla_2g19470  histidine kinase [KO:K07645] [EC:2.7.13.3]
bgla_2g19460  two component transcriptional regulator [KO:K07666]
bgla_1g01910  FlhD [KO:K02403]
bgla_3p0390  transcriptional activator FlhD [KO:K02403]
bgla_2g07950  hypothetical protein [KO:K02403]
bgla_1g01920  FlhC [KO:K02402]
bgla_3p0430  flagellar transcriptional activator FlhC [KO:K02402]
bgla_1g29610  Two component transcriptional regulator, winged helix family protein [KO:K07667]
bgla_1g24990  P-type conjugative transfer ATPase TrbB [KO:K20527] [EC:7.4.2.8]
bgla_1g24980  Conjugal transfer protein TrbC [KO:K20528]
bgla_4p0730  hypothetical protein [KO:K20529]
bgla_1g24970  conjugal transfer protein trbD [KO:K20529]
bgla_4p0740  type IV secretory pathway VirB4 components-like protein [KO:K20530] [EC:7.4.2.8]
bgla_1g24960  ATPase [KO:K20530] [EC:7.4.2.8]
bgla_1g24950  P-type conjugative transfer protein TrbJ [KO:K20266]
bgla_4p0750  type IV secretion system family protein [KO:K20266]
bgla_1g24940  TrbL/VirB6 plasmid conjugal transfer protein [KO:K07344]
bgla_4p0050  hypothetical protein [KO:K20531]
bgla_1g24930  conjugal transfer protein TrbF [KO:K20531]
bgla_4p0060  conjugal transfer protein TrbG/VirB9/CagX [KO:K20532]
bgla_1g24920  P-type conjugative transfer protein TrbG [KO:K20532]
bgla_4p0070  conjugation TrbI family protein [KO:K20533]
bgla_1g24910  conjugation TrbI family protein [KO:K20533]
bgla_2g03340  extracellular solute-binding protein family 1 [KO:K02055]
bgla_2g02970  ABC transporter, periplasmic substrate-binding protein [KO:K02055]
bgla_1g11880  extracellular solute-binding protein [KO:K02055]
bgla_2g10070  extracellular solute-binding protein family 1 [KO:K02055]
bgla_2g15860  extracellular solute-binding protein [KO:K02055]
bgla_2g10100  binding-protein-dependent transport systems inner membrane component [KO:K02053]
bgla_2g15900  binding-protein-dependent transport systems inner membrane component [KO:K02053]
bgla_2g02980  ABC transport system, membrane protein [KO:K02053]
bgla_2g03320  hypothetical protein [KO:K02053]
bgla_1g11860  Binding-protein-dependent transport systems inner membrane component [KO:K02053]
bgla_1g11870  ABC transporter, permease protein [KO:K02053]
bgla_2g02950  binding-protein-dependent transport systems inner membrane component [KO:K02053]
bgla_2g03330  ABC-type spermidine/putrescine transport system, permease component I [KO:K02054]
bgla_2g10110  binding-protein-dependent transport systems inner membrane component [KO:K02054]
bgla_2g15910  binding-protein-dependent transport systems inner membrane component [KO:K02054]
bgla_2g03350  spermidine/putrescine ABC transporter ATPase subunit [KO:K02052]
bgla_2g02960  ABC transporter, ATP-binding protein [KO:K02052]
bgla_1g11850  AABC transporter, ATP-binding protein [KO:K02052]
bgla_2g10140  spermidine/putrescine ABC transporter ATPase subunit [KO:K02052]
bgla_2g15920  spermidine/putrescine ABC transporter ATPase subunit [KO:K02052]
bgla_1g00710  Branched-chain amino acid ABC transporter, periplasmic branched-chain amino acid-binding protein [KO:K01999]
bgla_1g00750  Extracellular ligand-binding receptor [KO:K01999]
bgla_1g00760  branched-chain amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K01999]
bgla_1g02200  Amino acid ABC transporter, periplasmic amino acid-binding protein, putative [KO:K01999]
bgla_1g01010  putative periplasmic substrate-binding protein [KO:K01999]
bgla_2g04540  extracellular ligand-binding receptor [KO:K01999]
bgla_2g04930  Extracellular ligand-binding receptor [KO:K01999]
bgla_2g28100  putative periplasmic solute-binding protein [KO:K01999]
bgla_2g29470  Extracellular ligand-binding receptor [KO:K01999]
bgla_1g07150  Extracellular ligand-binding receptor [KO:K01999]
bgla_1g29350  Extracellular ligand-binding receptor [KO:K01999]
bgla_2g24730  Extracellular ligand-binding receptor [KO:K01999]
bgla_2g05490  hypothetical protein [KO:K01999]
bgla_2g06620  Extracellular ligand-binding receptor [KO:K01999]
bgla_2g13420  Extracellular ligand-binding receptor [KO:K01999]
bgla_1g00720  ABC branched-chain amino acid family transporter, inner membrane subunit [KO:K01997]
bgla_1g00770  inner-membrane translocator [KO:K01997]
bgla_1g32010  ABC branched-chain amino acid family transporter, inner membrane subunit [KO:K01997]
bgla_2g29460  inner-membrane translocator [KO:K01997]
bgla_1g17230  branched-chain amino acid ABC transporter, permease protein [KO:K01997]
bgla_1g00780  ABC transporter related protein [KO:K01995 K01998]
bgla_1g17240  ABC transporter, permease/ATP-binding protein [KO:K01995 K01998]
bgla_1g00730  Putative branched-chain amino acid ABC transporter integral membrane subunit [KO:K01998]
bgla_2g29450  inner-membrane translocator [KO:K01998]
bgla_1g32000  Inner-membrane translocator [KO:K01998]
bgla_1g00690  branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
bgla_1g31990  Branched-chain amino acid ABC transporter, ATP-binding protein [KO:K01995]
bgla_2g29440  high-affinity branched-chain amino acid transport ATP-binding protein BRAF 6 [KO:K01995]
bgla_1g00790  ABC branched-chain amino acid family transporter, ATPase subunit [KO:K01996]
bgla_1g00700  ABC transporter related protein [KO:K01996]
bgla_2g29430  Cell division ATP-binding protein FtsE [KO:K01996]
bgla_1g17250  branched-chain amino acid ABC transporter, ATP-binding protein, putative [KO:K01996]
bgla_1g31980  ABC transporter related protein [KO:K01996]
bgla_1g19730  AttM/AiiB family protein [KO:K13075] [EC:3.1.1.81]
bgla_2g11070  quorum sensing LuxR family sensor regulator [KO:K19666]
bgla_2g25190  Propeptide peptidase M4 and M36 [KO:K20274]
bgla_2g00530  putative hemagglutinin/hemolysin-related protein [KO:K20276]
bgla_2g00540  putative hemagglutinin/hemolysin-related protein [KO:K20276]
bgla_3p0160  hypothetical protein [KO:K20276]
bgla_1g13080  Fucose-binding lectin II [KO:K20277]
bgla_1g18310  AMP-dependent synthetase and ligase [KO:K01897] [EC:6.2.1.3]
bgla_1g04870  AMP-dependent synthetase and ligase [KO:K01897] [EC:6.2.1.3]
bgla_1g32660  AMP-binding domain protein [KO:K01897] [EC:6.2.1.3]
bgla_1g32460  Putative regulatory protein [KO:K10914]
bgla_1g32970  Transcriptional regulator np20 [KO:K09823]
bgla_2g01610  putative ferric uptake regulator, Fur family protein [KO:K09823]
bgla_1g11630  IclR family regulatory protein [KO:K20329]
bgla_2g09030  DNA binding protein [KO:K20330]
bgla_1g04570  Trp-1 [KO:K20331] [EC:2.1.1.349]
bgla_1g04580  Putative GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
bgla_2g11000  GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
bgla_1g04590  WD-repeat protein [KO:K20332]
bgla_1g04600  hypothetical protein [KO:K20333]
bgla_1g04610  Putative deaminase [KO:K11752] [EC:3.5.4.26 1.1.1.193]
bgla_1g08660  Pyrimidine reductase, riboflavin biosynthesis [KO:K11752] [EC:3.5.4.26 1.1.1.193]
bgla_1g04550  hypothetical protein [KO:K09936]
bgla_2g17800  hypothetical protein [KO:K09936]
bgla_2g17810  hypothetical protein [KO:K09936]
bgla_2g06440  inner membrane protein YdcZ [KO:K09936]
bgla_1g04540  Probable RND efflux membrane-fusion protein precursor [KO:K18306]
bgla_1g04530  Probable RND efflux transporter [KO:K18307]
bgla_1g04520  Putative outer membrane protein OprM precursor [KO:K18139]
bgla_1g33040  RND efflux system, outer membrane lipoprotein, NodT [KO:K18139]
bgla_2g04790  RND efflux system, outer membrane lipoprotein, NodT [KO:K18139]
bgla_2g25990  oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580]
bgla_2g26000  oligopeptide transport system permease protein [KO:K15581]
bgla_2g26010  oligopeptide ABC transporter, permease protein [KO:K15582]
bgla_2g26020  oligopeptide ABC transporter, ATP-binding protein [KO:K15583]
bgla_2g26030  peptide ABC transporter, ATP-binding protein [KO:K10823]
bgla_2g08170  putative periplasmic solute-binding protein [KO:K02035]
bgla_2g12260  ABC transporter, periplasmic substrate-binding protein [KO:K02035]
bgla_2g12270  ABC-type dipeptide transport system,periplasmic component [KO:K02035]
bgla_2g12250  dipeptide/oligopeptide/nickel ABC transporter inner membrane protein [KO:K02033]
bgla_2g08180  binding-protein-dependent transport systems inner membrane component [KO:K02033]
bgla_2g12240  ABC transporter, permease protein [KO:K02034]
bgla_2g08190  putative binding-protein-dependent transport system protein [KO:K02034]
bgla_2g08200  ABC transporter related protein [KO:K02031 K02032]
bgla_2g12230  ABC dipeptide/oligopeptide/nickel family transporter, ATPase subunit [KO:K02031]
bgla_2g12220  ABC transporter system, ATP-binding protein [KO:K02032]
bgla_1g38830  Putative inner membrane protein translocase component YidC [KO:K03217]
bgla_2g12790  Serine metalloprotease MrpA [KO:K14645] [EC:3.4.21.-]
bgla_2g01650  Serine metalloprotease [KO:K14645] [EC:3.4.21.-]
bgla_1g02790  Translocase [KO:K03073]
bgla_1g29300  preprotein translocase subunit SecG [KO:K03075]
bgla_1g03230  Preprotein translocase SecY [KO:K03076]
bgla_1g06450  Preprotein translocase, YajC subunit [KO:K03210]
bgla_1g05080  Preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
bgla_1g35050  Signal recognition particle-docking protein FtsY [KO:K03110]
bgla_1g35450  Protein-export protein SecB [KO:K03071]
bgla_1g05290  Signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
bgla_2g19140  Non-hemolytic phospholipase C [KO:K01114] [EC:3.1.4.3]
bgla_1g11300  Phospholipase C [KO:K01114] [EC:3.1.4.3]
bgla_2g13970  Phosphoesterase family protein [KO:K01114] [EC:3.1.4.3]
bgla_2g28640  phospholipase c precursor protein [KO:K01114] [EC:3.1.4.3]
bgla_1g19600  Phospholipase C [KO:K01114] [EC:3.1.4.3]
bgla_2g01470  phospholipase C [KO:K01114] [EC:3.1.4.3]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
  Authors
Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  Journal
Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
  Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  Title
Quinolones: from antibiotics to autoinducers.
  Journal
FEMS Microbiol Rev 35:247-74 (2011)
DOI:10.1111/j.1574-6976.2010.00247.x
Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
DOI:10.1111/j.1365-2958.2009.06906.x
Reference
PMID:7665477
  Authors
Beck von Bodman S, Farrand SK
  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
  Journal
J Bacteriol 177:5000-8 (1995)
DOI:10.1128/JB.177.17.5000-5008.1995
Reference
PMID:19761612
  Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
DOI:10.1186/1471-2164-10-441
Reference
PMID:16041013
  Authors
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  Journal
Infect Immun 73:4982-92 (2005)
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Related
pathway
bgd02040  Flagellar assembly
KO pathway
ko02024   
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