KEGG   PATHWAY: bqb02020
Entry
bqb02020                    Pathway                                
Name
Two-component system - Bradyrhizobium quebecense
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
bqb02020  Two-component system
bqb02020

Other DBs
GO: 0000160
Organism
Bradyrhizobium quebecense [GN:bqb]
Gene
J4P68_0015705  ATP-binding protein [KO:K07636] [EC:2.7.13.3]
J4P68_0015675  phoB; phosphate regulon transcriptional regulator PhoB [KO:K07657]
J4P68_0018710  alkaline phosphatase D family protein [KO:K01113] [EC:3.1.3.1]
J4P68_0015700  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
J4P68_0011815  ATP-binding protein [KO:K07638] [EC:2.7.13.3]
J4P68_0011810  response regulator transcription factor [KO:K07659]
J4P68_0008175  Do family serine endopeptidase [KO:K04771] [EC:3.4.21.107]
J4P68_0033030  Do family serine endopeptidase [KO:K04771] [EC:3.4.21.107]
J4P68_0023105  efflux RND transporter periplasmic adaptor subunit [KO:K07799]
J4P68_0035695  efflux RND transporter periplasmic adaptor subunit [KO:K07799]
J4P68_0038615  efflux RND transporter periplasmic adaptor subunit [KO:K07799]
J4P68_0040030  efflux RND transporter periplasmic adaptor subunit [KO:K07799]
J4P68_0037970  MdtB/MuxB family multidrug efflux RND transporter permease subunit [KO:K07788]
J4P68_0040025  efflux RND transporter permease subunit [KO:K07788]
J4P68_0037975  efflux RND transporter permease subunit [KO:K07789]
J4P68_0040020  efflux RND transporter permease subunit [KO:K07789]
J4P68_0014690  efflux RND transporter permease subunit [KO:K07789]
J4P68_0004150  efflux RND transporter periplasmic adaptor subunit [KO:K07798]
J4P68_0004145  CusA/CzcA family heavy metal efflux RND transporter [KO:K07787]
J4P68_0006160  hypothetical protein [KO:K02406]
J4P68_0007635  flagellin [KO:K02406]
J4P68_0017865  flagellar protein [KO:K02406]
J4P68_0035510  MotA/TolQ/ExbB proton channel family protein [KO:K02556]
J4P68_0010730  DUF4118 domain-containing protein [KO:K07646] [EC:2.7.13.3]
J4P68_0009535  response regulator transcription factor [KO:K07667]
J4P68_0010735  response regulator [KO:K07667]
J4P68_0009555  kdpA; potassium-transporting ATPase subunit KdpA [KO:K01546]
J4P68_0009550  kdpB; potassium-transporting ATPase subunit KdpB [KO:K01547] [EC:7.2.2.6]
J4P68_0009545  K(+)-transporting ATPase subunit C [KO:K01548]
J4P68_0015985  sensor histidine kinase N-terminal domain-containing protein [KO:K07649] [EC:2.7.13.3]
J4P68_0015980  response regulator transcription factor [KO:K07774]
J4P68_0006915  tripartite tricarboxylate transporter permease [KO:K07793]
J4P68_0008215  tripartite tricarboxylate transporter permease [KO:K07793]
J4P68_0006920  tripartite tricarboxylate transporter TctB family protein [KO:K07794]
J4P68_0008220  tripartite tricarboxylate transporter TctB family protein [KO:K07794]
J4P68_0006935  tripartite tricarboxylate transporter substrate binding protein [KO:K07795]
J4P68_0008210  tripartite tricarboxylate transporter substrate binding protein BugD [KO:K07795]
J4P68_0001465  COX15/CtaA family protein [KO:K02259] [EC:1.17.99.9]
J4P68_0020370  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
J4P68_0030350  hypothetical protein [KO:K03739]
J4P68_0016110  sensor histidine kinase [KO:K14980] [EC:2.7.13.3]
J4P68_0016105  response regulator transcription factor [KO:K14981]
J4P68_0002050  M15 family metallopeptidase [KO:K08641] [EC:3.4.13.22]
J4P68_0023765  CoA ester lyase [KO:K01644] [EC:4.1.3.34]
J4P68_0007295  CoA ester lyase [KO:K01644] [EC:4.1.3.34]
J4P68_0018485  CoA ester lyase [KO:K01644] [EC:4.1.3.34]
J4P68_0006530  NAD-dependent malic enzyme [KO:K00027] [EC:1.1.1.38]
J4P68_0032835  nucleotide sugar dehydrogenase [KO:K00066] [EC:1.1.1.132]
J4P68_0007455  histidine kinase [KO:K07675] [EC:2.7.13.3]
J4P68_0005250  response regulator transcription factor [KO:K07689]
J4P68_0000735  response regulator transcription factor [KO:K07689]
J4P68_0029730  serine hydrolase [KO:K01467] [EC:3.5.2.6]
J4P68_0034645  fatty acid desaturase [KO:K10255] [EC:1.14.19.23 1.14.19.45]
J4P68_0002535  spore coat U domain-containing protein [KO:K27078]
J4P68_0002550  spore coat U domain-containing protein [KO:K27078]
J4P68_0002545  molecular chaperone [KO:K07346]
J4P68_0002540  fimbria/pilus outer membrane usher protein [KO:K07347]
J4P68_0023305  Flp family type IVb pilin [KO:K02651]
J4P68_0008490  Flp family type IVb pilin [KO:K02651]
J4P68_0032665  Flp family type IVb pilin [KO:K02651]
J4P68_0023295  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
J4P68_0034205  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
J4P68_0040105  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
J4P68_0023290  type II and III secretion system protein family protein [KO:K02280]
J4P68_0024900  type II and III secretion system protein family protein [KO:K02280]
J4P68_0034250  type II and III secretion system protein family protein [KO:K02280]
J4P68_0040110  type II and III secretion system protein family protein [KO:K02280]
J4P68_0023280  AAA family ATPase [KO:K02282]
J4P68_0034210  AAA family ATPase [KO:K02282]
J4P68_0040120  AAA family ATPase [KO:K02282]
J4P68_0023275  CpaF family protein [KO:K02283] [EC:7.4.2.8]
J4P68_0034215  CpaF family protein [KO:K02283] [EC:7.4.2.8]
J4P68_0023270  type II secretion system F family protein [KO:K12510]
J4P68_0034220  type II secretion system F family protein [KO:K12510]
J4P68_0023265  type II secretion system F family protein [KO:K12511]
J4P68_0034225  type II secretion system F family protein [KO:K12511]
J4P68_0028695  pilus assembly protein TadG-related protein [KO:K27080]
J4P68_0020845  [protein-PII] uridylyltransferase [KO:K00990] [EC:2.7.7.59]
J4P68_0001305  P-II family nitrogen regulator [KO:K04751]
J4P68_0039665  nitrogen regulation protein NR(II) [KO:K07708] [EC:2.7.13.3]
J4P68_0039660  ntrC; nitrogen regulation protein NR(I) [KO:K07712]
J4P68_0036430  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
J4P68_0037525  glutamine synthetase beta-grasp domain-containing protein [KO:K01915] [EC:6.3.1.2]
J4P68_0015805  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
J4P68_0001310  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
J4P68_0039655  PAS domain-containing sensor histidine kinase [KO:K13598] [EC:2.7.13.3]
J4P68_0039650  sigma-54 dependent transcriptional regulator [KO:K13599]
J4P68_0025965  nifA; nif-specific transcriptional activator NifA [KO:K02584]
J4P68_0011290  CoA transferase subunit A [KO:K01034] [EC:2.8.3.8 2.8.3.9]
J4P68_0011295  3-oxoacid CoA-transferase subunit B [KO:K01035] [EC:2.8.3.8 2.8.3.9]
J4P68_0007675  TIGR00366 family protein [KO:K02106]
J4P68_0022325  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0022980  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0002850  thiolase domain-containing protein [KO:K00626] [EC:2.3.1.9]
J4P68_0026905  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0007705  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0028860  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0031840  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0035815  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0035890  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0011040  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0021065  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
J4P68_0024380  dctA; C4-dicarboxylate transporter DctA [KO:K11103]
J4P68_0031130  dicarboxylate/amino acid:cation symporter [KO:K11103]
J4P68_0036905  dicarboxylate/amino acid:cation symporter [KO:K11103]
J4P68_0038055  dicarboxylate/amino acid:cation symporter [KO:K11103]
J4P68_0019755  rpoN; RNA polymerase factor sigma-54 [KO:K03092]
J4P68_0010170  protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
J4P68_0017845  protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
J4P68_0027000  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0031825  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0032110  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0035460  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0013195  PAS domain-containing methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0013320  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0013325  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0016180  methyl-accepting chemotaxis protein [KO:K03406]
J4P68_0010185  chemotaxis protein CheW [KO:K03408]
J4P68_0017855  chemotaxis protein CheW [KO:K03408]
J4P68_0010190  hybrid sensor histidine kinase/response regulator [KO:K03407] [EC:2.7.13.3]
J4P68_0017860  hybrid sensor histidine kinase/response regulator [KO:K03407] [EC:2.7.13.3]
J4P68_0010180  response regulator [KO:K03413]
J4P68_0011900  response regulator [KO:K03413]
J4P68_0017850  response regulator [KO:K03413]
J4P68_0010175  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
J4P68_0033090  ATP-binding protein [KO:K07716] [EC:2.7.13.3]
J4P68_0035160  ATP-binding protein [KO:K07716] [EC:2.7.13.3]
J4P68_0002185  PleD family two-component system response regulator [KO:K02488] [EC:2.7.7.65]
J4P68_0032560  ATP-binding protein [KO:K11357] [EC:2.7.13.3]
J4P68_0002190  response regulator [KO:K11443]
J4P68_0005785  response regulator [KO:K13587] [EC:2.7.13.3]
J4P68_0010195  histidine phosphotransferase [KO:K13588]
J4P68_0010130  response regulator transcription factor [KO:K13584]
J4P68_0012905  response regulator [KO:K13589]
J4P68_0007845  TRAP transporter substrate-binding protein [KO:K11688]
J4P68_0007840  TRAP transporter small permease [KO:K11689]
J4P68_0007835  TRAP transporter large permease subunit [KO:K11690]
J4P68_0027720  PAS domain S-box protein [KO:K14986] [EC:2.7.13.3]
J4P68_0027715  response regulator [KO:K14987]
J4P68_0025250  cyclic nucleotide-binding domain-containing protein [KO:K15861]
J4P68_0027590  helix-turn-helix domain-containing protein [KO:K15861]
J4P68_0011245  helix-turn-helix domain-containing protein [KO:K15861]
J4P68_0012470  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
J4P68_0012475  ABC transporter permease subunit [KO:K10002]
J4P68_0012480  amino acid ABC transporter permease [KO:K10003]
J4P68_0012485  amino acid ABC transporter substrate-binding protein [KO:K10001]
J4P68_0000720  amino acid ABC transporter substrate-binding protein [KO:K10001]
J4P68_0020260  amino acid ABC transporter substrate-binding protein [KO:K10001]
J4P68_0007040  Crp/Fnr family transcriptional regulator [KO:K10914]
J4P68_0017740  Crp/Fnr family transcriptional regulator [KO:K10914]
J4P68_0006645  Crp/Fnr family transcriptional regulator [KO:K10914]
J4P68_0010585  Crp/Fnr family transcriptional regulator [KO:K10914]
J4P68_0035855  glsA; glutaminase A [KO:K01425] [EC:3.5.1.2]
J4P68_0020750  ActS/PrrB/RegB family redox-sensitive histidine kinase [KO:K15011] [EC:2.7.13.3]
J4P68_0021510  ATP-binding protein [KO:K15011] [EC:2.7.13.3]
J4P68_0020745  ActR/PrrA/RegA family redox response regulator transcription factor [KO:K15012]
J4P68_0021505  response regulator transcription factor [KO:K15012]
J4P68_0029125  petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
J4P68_0029130  cytochrome b N-terminal domain-containing protein [KO:K00410]
J4P68_0023220  cytochrome c family protein [KO:K08738]
J4P68_0003850  hypothetical protein [KO:K08738]
J4P68_0038845  c-type cytochrome [KO:K08738]
J4P68_0011950  c-type cytochrome [KO:K08738]
J4P68_0012245  cytochrome c family protein [KO:K08738]
J4P68_0017220  c-type cytochrome [KO:K08738]
J4P68_0021550  c-type cytochrome [KO:K08738]
J4P68_0027750  ccoN; cytochrome-c oxidase, cbb3-type subunit I [KO:K00404] [EC:7.1.1.9]
J4P68_0027755  ccoO; cytochrome-c oxidase, cbb3-type subunit II [KO:K00405]
J4P68_0027760  cbb3-type cytochrome c oxidase subunit 3 [KO:K00407]
J4P68_0027765  ccoP; cytochrome-c oxidase, cbb3-type subunit III [KO:K00406]
J4P68_0016745  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
J4P68_0016750  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
J4P68_0032365  TolC family outer membrane protein [KO:K12340]
J4P68_0039720  TolC family outer membrane protein [KO:K12340]
J4P68_0032775  polysaccharide export protein [KO:K01991]
J4P68_0034385  polysaccharide export protein [KO:K01991]
J4P68_0001500  polysaccharide export protein [KO:K01991]
J4P68_0020390  polysaccharide export protein [KO:K01991]
J4P68_0039515  low molecular weight phosphatase family protein [KO:K25307] [EC:3.1.3.48]
J4P68_0001495  Wzz/FepE/Etk N-terminal domain-containing protein [KO:K16692] [EC:2.7.10.3]
J4P68_0025130  pectinesterase family protein [KO:K01051] [EC:3.1.1.11]
J4P68_0010965  glycoside hydrolase family 5 protein [KO:K01179] [EC:3.2.1.4]
J4P68_0012355  glycoside hydrolase family 5 protein [KO:K01179] [EC:3.2.1.4]
J4P68_0033940  FecR domain-containing protein [KO:K07165]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
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  Title
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Related
pathway
bqb00190  Oxidative phosphorylation
bqb00550  Peptidoglycan biosynthesis
bqb00910  Nitrogen metabolism
bqb02030  Bacterial chemotaxis
bqb02040  Flagellar assembly
bqb03070  Bacterial secretion system
KO pathway
ko02020   
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