KEGG   PATHWAY: bue00362
Entry
bue00362                    Pathway                                
Name
Benzoate degradation - Burkholderia sp. RPE67
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
bue00362  Benzoate degradation
bue00362

Module
bue_M00548  Benzene degradation, benzene => catechol [PATH:bue00362]
bue_M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:bue00362]
bue_M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:bue00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Organism
Burkholderia sp. RPE67 [GN:bue]
Gene
BRPE67_DCDS03900  alpha subunit of aromatic ring hydroxylase component of chlorobenzoate 1,2-dioxygenase [KO:K05549] [EC:1.14.12.10 1.14.12.-]
BRPE67_DCDS03910  Beta subunit of aromatic ring hydroxylase component of chlorobenzoate 1,2-dioxygenase [KO:K05550] [EC:1.14.12.10 1.14.12.-]
BRPE67_DCDS03920  electron transfer component of chlorobenzoate 1,2-dioxygenase [KO:K05784] [EC:1.18.1.-]
BRPE67_DCDS03930  Cis-diol dehydrogenase [KO:K05783] [EC:1.3.1.25 1.3.1.-]
BRPE67_DCDS03890  catechol 1,2-dioxygenase [KO:K03381] [EC:1.13.11.1]
BRPE67_ACDS14130  catechol 1,2-dioxygenase [KO:K03381] [EC:1.13.11.1]
BRPE67_CCDS12560  catechol 1,2-dioxygenase [KO:K03381] [EC:1.13.11.1]
BRPE67_ACDS14150  muconate and chloromuconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
BRPE67_DCDS03870  muconate cycloisomerase [KO:K01856] [EC:5.5.1.1]
BRPE67_ECDS02970  putative membrane protein [KO:K03464] [EC:5.3.3.4]
BRPE67_ACDS14140  muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
BRPE67_DCDS03860  muconolactone delta-isomerase [KO:K03464] [EC:5.3.3.4]
BRPE67_ACDS10500  3-oxoadipate enol-lactonase [KO:K01055] [EC:3.1.1.24]
BRPE67_CCDS09030  alpha/beta hydrolase fold protein [KO:K01055] [EC:3.1.1.24]
BRPE67_ACDS01460  alpha/beta hydrolase fold protein [KO:K01055] [EC:3.1.1.24]
BRPE67_ACDS10460  3-oxoacid coA-transferase, A subunit [KO:K01031] [EC:2.8.3.6]
BRPE67_ACDS10470  3-oxoacid coA-transferase, B subunit [KO:K01032] [EC:2.8.3.6]
BRPE67_ACDS02990  acetyl-coA acetyltransferase [KO:K00632] [EC:2.3.1.16]
BRPE67_ACDS14960  beta-ketoadipyl coA thiolase [KO:K07823] [EC:2.3.1.174]
BRPE67_ACDS10480  beta-ketoadipyl coA thiolase [KO:K07823] [EC:2.3.1.174]
BRPE67_CCDS12500  phenol hydrolase assembly protein [KO:K16249]
BRPE67_CCDS12510  methane/phenol/toluene hydroxylase [KO:K16243] [EC:1.14.13.244 1.14.13.243]
BRPE67_CCDS12520  mmoB_dmpM; monooxygenase component MmoB/DmpM [KO:K16244] [EC:1.14.13.244 1.14.13.243]
BRPE67_CCDS12530  phenol hydrolase alpha subunit [KO:K16242] [EC:1.14.13.244 1.14.13.243]
BRPE67_CCDS12540  phenol hydroxylase region [KO:K16245] [EC:1.14.13.244 1.14.13.243]
BRPE67_CCDS12550  phenol 2-monooxygenase [KO:K16246] [EC:1.14.13.244 1.14.13.243]
BRPE67_DCDS08130  amidohydrolase [KO:K14333] [EC:4.1.1.46]
BRPE67_ACDS13040  putative hydratase/decarboxylase [KO:K02554] [EC:4.2.1.80]
BRPE67_DCDS09680  hydratase/decarboxylase [KO:K02554] [EC:4.2.1.80]
BRPE67_FCDS01760  putative membrane protein [KO:K01666] [EC:4.1.3.39]
BRPE67_FCDS01770  putative membrane protein [KO:K04073] [EC:1.2.1.10]
BRPE67_CCDS04330  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
BRPE67_DCDS11250  uncharacterized protein [KO:K01821] [EC:5.3.2.6]
BRPE67_DCDS09140  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
BRPE67_CCDS05760  4-oxalocrotonate tautomerase family enzyme [KO:K01821] [EC:5.3.2.6]
BRPE67_BCDS10700  putative membrane protein [KO:K01821] [EC:5.3.2.6]
BRPE67_CCDS07990  acyloate catabolism-like protein [KO:K01821] [EC:5.3.2.6]
BRPE67_BCDS12640  4-oxalocrotonate tautomerase [KO:K01821] [EC:5.3.2.6]
BRPE67_CCDS06510  intradiol ring-cleavage dioxygenase [KO:K04098] [EC:1.13.11.37]
BRPE67_CCDS00240  benzenetriol dioxygenase [KO:K04098] [EC:1.13.11.37]
BRPE67_CCDS00230  maleylacetate reductase [KO:K00217] [EC:1.3.1.32]
BRPE67_CCDS06500  iron-containing alcohol dehydrogenase [KO:K00217] [EC:1.3.1.32]
BRPE67_DCDS07490  lactaldehyde reductase [KO:K00217] [EC:1.3.1.32]
BRPE67_ECDS03110  iron-containing alcohol dehydrogenase [KO:K00217] [EC:1.3.1.32]
BRPE67_BCDS13490  protocatechuate 3,4-dioxygenase, alpha subunit [KO:K00448] [EC:1.13.11.3]
BRPE67_BCDS13480  protocatechuate 3,4-dioxygenase, beta subunit [KO:K00449] [EC:1.13.11.3]
BRPE67_ACDS10490  3-carboxy-cis,cis-muconate cycloisomerase [KO:K01857] [EC:5.5.1.2]
BRPE67_BCDS04890  fumarate lyase [KO:K01857] [EC:5.5.1.2]
BRPE67_ACDS10510  4-carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
BRPE67_CCDS09020  putative carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
BRPE67_ACDS04360  carboxymuconolactone decarboxylase [KO:K01607] [EC:4.1.1.44]
BRPE67_BCDS04970  amidohydrolase 2 [KO:K10220] [EC:4.2.1.83]
BRPE67_DCDS11740  amidohydrolase [KO:K10220] [EC:4.2.1.83]
BRPE67_DCDS11730  4-carboxy-4-hydroxy-2-oxoadipate aldolase/oxaloacetate decarboxylase [KO:K10218] [EC:4.1.3.17]
BRPE67_DCDS01240  ferredoxin reductase [KO:K00529] [EC:1.18.1.3]
BRPE67_DCDS01310  FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00529] [EC:1.18.1.3]
BRPE67_DCDS08190  FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00529] [EC:1.18.1.3]
BRPE67_DCDS05000  FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00529] [EC:1.18.1.3]
BRPE67_CCDS00760  FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00529] [EC:1.18.1.3]
BRPE67_DCDS06720  FAD-dependent pyridine nucleotide-disulfide oxidoreductase [KO:K00529] [EC:1.18.1.3]
BRPE67_DCDS01250  ferredoxin [KO:K04755]
BRPE67_ACDS16970  ferredoxin, 2Fe-2S type, ISC system [KO:K04755]
BRPE67_DCDS04990  ferredoxin [KO:K04755]
BRPE67_BCDS08780  4-hydroxybenzoate 3-monooxygenase [KO:K00481] [EC:1.14.13.2]
BRPE67_CCDS09420  3-hydroxybenzoate-6-hydroxylase [KO:K22270] [EC:1.14.13.24]
BRPE67_DCDS02310  thioesterase superfamily protein [KO:K01075] [EC:3.1.2.23]
BRPE67_DCDS03830  thioesterase superfamily protein [KO:K01075] [EC:3.1.2.23]
BRPE67_ACDS14030  putative uncharacterized protein [KO:K01075] [EC:3.1.2.23]
BRPE67_DCDS08010  short-chain dehydrogenase/reductase [KO:K07535] [EC:1.1.1.-]
BRPE67_ACDS12750  short chain enoyl-coA hydratase / 3-hydroxyacyl-coA dehydrogenase [KO:K07516] [EC:1.1.1.35]
BRPE67_ACDS02980  3-hydroxyacyl-coA dehydrogenase NAD-binding protein [KO:K07516] [EC:1.1.1.35]
BRPE67_CCDS01670  short chain enoyl-coA hydratase / 3-hydroxyacyl-coA dehydrogenase [KO:K07516] [EC:1.1.1.35]
BRPE67_ACDS22280  acyl-coA dehydrogenase domain protein [KO:K00252] [EC:1.3.8.6]
BRPE67_ACDS23810  enoyl-coA hydratase [KO:K01692] [EC:4.2.1.17]
BRPE67_CCDS03140  enoyl-coA hydratase/isomerase [KO:K01692] [EC:4.2.1.17]
BRPE67_ACDS14950  3-hydroxybutyryl-coA dehydrogenase [KO:K00074] [EC:1.1.1.157]
BRPE67_ACDS17260  3-hydroxy-acyl-coA dehydrogenase [KO:K00074] [EC:1.1.1.157]
BRPE67_BCDS14220  3-hydroxyacyl-coA dehydrogenase [KO:K00074] [EC:1.1.1.157]
BRPE67_ACDS15720  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_DCDS07570  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_CCDS11680  acetyl-coA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_FCDS01720  putative membrane protein [KO:K00626] [EC:2.3.1.9]
BRPE67_ACDS12770  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_DCDS13380  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_ACDS15660  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_ACDS16550  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
BRPE67_ACDS00960  acetyl-coA acetyltransferase [KO:K00626] [EC:2.3.1.9]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C03767  4-Oxocyclohexanecarboxylate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04404  trans-4-Hydroxycyclohexanecarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
C22885  cis-4-Hydroxycyclohexane-1-carboxylate
C22887  4-Oxocyclohex-2-ene-1-carboxylate
C22920  4-Oxocyclohex-2,5-dienecarboxylate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
bue00010  Glycolysis / Gluconeogenesis
bue00020  Citrate cycle (TCA cycle)
bue00350  Tyrosine metabolism
bue00360  Phenylalanine metabolism
bue00361  Chlorocyclohexane and chlorobenzene degradation
bue00627  Aminobenzoate degradation
bue00790  Folate biosynthesis
KO pathway
ko00362   
LinkDB

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