KEGG   PATHWAY: ko00362
Entry
ko00362                     Pathway                                
Name
Benzoate degradation
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ko00362  Benzoate degradation
ko00362

Module
M00540  Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA [PATH:ko00362]
M00541  Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA [PATH:ko00362]
M00547  Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:ko00362]
M00548  Benzene degradation, benzene => catechol [PATH:ko00362]
M00551  Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:ko00362]
M00568  Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:ko00362]
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:ko00362]
Other DBs
UMBBD: benz2 benz abs
GO: 0043639
Orthology
K05549  benzoate/toluate 1,2-dioxygenase subunit alpha [EC:1.14.12.10 1.14.12.-]
K05550  benzoate/toluate 1,2-dioxygenase subunit beta [EC:1.14.12.10 1.14.12.-]
K05784  benzoate/toluate 1,2-dioxygenase reductase component [EC:1.18.1.-]
K05783  dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-]
K03381  catechol 1,2-dioxygenase [EC:1.13.11.1]
K01856  muconate cycloisomerase [EC:5.5.1.1]
K03464  muconolactone D-isomerase [EC:5.3.3.4]
K01055  3-oxoadipate enol-lactonase [EC:3.1.1.24]
K14727  3-oxoadipate enol-lactonase / 4-carboxymuconolactone decarboxylase [EC:3.1.1.24 4.1.1.44]
K01031  3-oxoadipate CoA-transferase, alpha subunit [EC:2.8.3.6]
K01032  3-oxoadipate CoA-transferase, beta subunit [EC:2.8.3.6]
K00632  acetyl-CoA acyltransferase [EC:2.3.1.16]
K07823  3-oxoadipyl-CoA thiolase [EC:2.3.1.174]
K27848  3-oxoadipate:acetyl-CoA acetyltransferase [EC:2.3.1.318]
K03268  benzene/toluene/chlorobenzene dioxygenase subunit alpha [EC:1.14.12.3 1.14.12.11 1.14.12.26]
K16268  benzene/toluene/chlorobenzene dioxygenase subunit beta [EC:1.14.12.3 1.14.12.11 1.14.12.26]
K18089  benzene/toluene/chlorobenzene dioxygenase ferredoxin component
K18090  benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component [EC:1.18.1.3 1.18.1.-]
K16269  cis-1,2-dihydrobenzene-1,2-diol/chlorobenzene dihydrodiol dehydrogenase [EC:1.3.1.19 1.3.1.119]
K16249  phenol/toluene 2-monooxygenase (NADH) P0/A0
K16243  phenol/toluene 2-monooxygenase (NADH) P1/A1 [EC:1.14.13.244 1.14.13.243]
K16244  phenol/toluene 2-monooxygenase (NADH) P2/A2 [EC:1.14.13.244 1.14.13.243]
K16242  phenol/toluene 2-monooxygenase (NADH) P3/A3 [EC:1.14.13.244 1.14.13.243]
K16245  phenol/toluene 2-monooxygenase (NADH) P4/A4 [EC:1.14.13.244 1.14.13.243]
K16246  phenol/toluene 2-monooxygenase (NADH) P5/A5 [EC:1.14.13.244 1.14.13.243]
K14333  2,3-dihydroxybenzoate decarboxylase [EC:4.1.1.46]
K00446  catechol 2,3-dioxygenase [EC:1.13.11.2]
K07104  catechol 2,3-dioxygenase [EC:1.13.11.2]
K10621  2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.- 1.13.11.14]
K10622  HCOMODA/2-hydroxy-3-carboxy-muconic semialdehyde decarboxylase [EC:4.1.1.-]
K10216  2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9]
K02554  2-keto-4-pentenoate hydratase [EC:4.2.1.80]
K18364  2-oxopent-4-enoate/cis-2-oxohex-4-enoate hydratase [EC:4.2.1.80 4.2.1.132]
K01666  4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K18365  4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43]
K04073  acetaldehyde dehydrogenase [EC:1.2.1.10]
K18366  acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87]
K10217  aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85]
K15766  2-aminobenzenesulfonate 2,3-dioxygenase subunit alpha [EC:1.14.12.14]
K15767  2-aminobenzenesulfonate 2,3-dioxygenase subunit beta [EC:1.14.12.14]
K01821  4-oxalocrotonate tautomerase [EC:5.3.2.6]
K01617  2-oxo-3-hexenedioate decarboxylase [EC:4.1.1.77]
K20941  gamma-resorcylate decarboxylase [EC:4.1.1.103]
K20942  resorcinol 4-hydroxylase (FADH2) [EC:1.14.14.27]
K20943  resorcinol 4-hydroxylase (NADPH) [EC:1.14.13.219]
K20944  resorcinol 4-hydroxylase (NADH) [EC:1.14.13.220]
K04098  hydroxyquinol 1,2-dioxygenase [EC:1.13.11.37]
K00217  maleylacetate reductase [EC:1.3.1.32]
K00448  protocatechuate 3,4-dioxygenase, alpha subunit [EC:1.13.11.3]
K00449  protocatechuate 3,4-dioxygenase, beta subunit [EC:1.13.11.3]
K01857  3-carboxy-cis,cis-muconate cycloisomerase [EC:5.5.1.2]
K01607  4-carboxymuconolactone decarboxylase [EC:4.1.1.44]
K14334  carboxy-cis,cis-muconate cyclase [EC:5.5.1.5]
K04100  protocatechuate 4,5-dioxygenase, alpha chain [EC:1.13.11.8]
K04101  protocatechuate 4,5-dioxygenase, beta chain [EC:1.13.11.8]
K10219  2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312]
K10221  2-pyrone-4,6-dicarboxylate lactonase [EC:3.1.1.57]
K16514  4-oxalomesaconate tautomerase [EC:5.3.2.8]
K10220  4-oxalmesaconate hydratase [EC:4.2.1.83]
K16515  4-oxalomesaconate hydratase [EC:4.2.1.83]
K10218  4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17]
K07824  benzoate 4-monooxygenase [EC:1.14.14.92]
K22553  4-methoxybenzoate monooxygenase (O-demethylating) [EC:1.14.99.15]
K27672  cyclohexane-1-carboxylate 4-trans-hydroxylase [EC:1.14.15.40]
K00529  3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K04755  ferredoxin, 2Fe-2S
K27673  trans-4-hydroxycyclohexanecarboxylate dehydrogenase [EC:1.1.1.226]
K27499  cis-4-hydroxycyclohexanecarboxylate dehydrogenase [EC:1.1.1.438]
K27500  4-oxocyclohexanecarboxylate 2-dehydrogenase [EC:1.17.3.5]
K27674  4-oxocyclohex-2-ene-1-carboxylate desaturase
K00481  p-hydroxybenzoate 3-monooxygenase [EC:1.14.13.2]
K19065  3-hydroxybenzoate 4-monooxygenase [EC:1.14.13.23]
K22270  3-hydroxybenzoate 6-monooxygenase [EC:1.14.13.24]
K04105  4-hydroxybenzoate-CoA ligase [EC:6.2.1.27 6.2.1.25]
K20458  3-hydroxybenzoate/4-hydroxybenzoate---CoA ligase [EC:6.2.1.37 6.2.1.27]
K01075  4-hydroxybenzoyl-CoA thioesterase [EC:3.1.2.23]
K04107  4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1]
K04108  4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1]
K04109  4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1]
K04110  benzoate-CoA ligase [EC:6.2.1.25]
K04112  benzoyl-CoA reductase subunit C [EC:1.3.7.8]
K04113  benzoyl-CoA reductase subunit B [EC:1.3.7.8]
K04114  benzoyl-CoA reductase subunit A [EC:1.3.7.8]
K04115  benzoyl-CoA reductase subunit D [EC:1.3.7.8]
K19515  benzoyl-CoA reductase subunit BamB [EC:1.3.-.-]
K19516  benzoyl-CoA reductase subunit BamC [EC:1.3.-.-]
K07537  cyclohexa-1,5-dienecarbonyl-CoA hydratase [EC:4.2.1.100]
K07538  6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.1.1.368]
K07539  6-oxocyclohex-1-ene-carbonyl-CoA hydrolase [EC:3.7.1.21]
K19066  cyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.3.8.10]
K19067  cyclohexane-1-carbonyl-CoA dehydrogenase [EC:1.3.8.11]
K04116  cyclohexanecarboxylate-CoA ligase [EC:6.2.1.-]
K27540  succinyl-CoA:cyclohexane-1-carboxylate CoA transferase [EC:2.3.1.315]
K04117  cyclohexanecarboxyl-CoA dehydrogenase [EC:1.3.99.-]
K07534  cyclohex-1-ene-1-carboxyl-CoA hydratase [EC:4.2.1.-]
K07535  2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-]
K07536  2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-]
K04118  pimeloyl-CoA dehydrogenase [EC:1.3.1.62]
K01782  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase [EC:1.1.1.35 4.2.1.17 5.1.2.3]
K01825  3-hydroxyacyl-CoA dehydrogenase / enoyl-CoA hydratase / 3-hydroxybutyryl-CoA epimerase / enoyl-CoA isomerase [EC:1.1.1.35 4.2.1.17 5.1.2.3 5.3.3.8]
K07516  3-hydroxyacyl-CoA dehydrogenase [EC:1.1.1.35]
K16173  glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32]
K01615  glutaconyl-CoA decarboxylase subunit alpha [EC:7.2.4.5]
K20509  carboxybiotin decarboxylase [EC:7.2.4.1]
K23351  glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
K23352  glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
K00252  glutaryl-CoA dehydrogenase [EC:1.3.8.6]
K01692  enoyl-CoA hydratase [EC:4.2.1.17]
K13767  enoyl-CoA hydratase [EC:4.2.1.17]
K00074  3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00626  acetyl-CoA C-acetyltransferase [EC:2.3.1.9]
K15511  benzoyl-CoA 2,3-epoxidase subunit A [EC:1.14.13.208]
K15512  benzoyl-CoA 2,3-epoxidase subunit B [EC:1.14.13.208]
K15514  3,4-dehydroadipyl-CoA semialdehyde dehydrogenase [EC:1.2.1.77]
K15513  benzoyl-CoA-dihydrodiol lyase [EC:4.1.2.44]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00084  Acetaldehyde
C00090  Catechol
C00091  Succinyl-CoA
C00146  Phenol
C00156  4-Hydroxybenzoate
C00180  Benzoate
C00196  2,3-Dihydroxybenzoate
C00230  3,4-Dihydroxybenzoate
C00332  Acetoacetyl-CoA
C00512  Benzoyl-CoA
C00527  Glutaryl-CoA
C00530  Hydroquinone
C00587  3-Hydroxybenzoate
C00596  2-Hydroxy-2,4-pentadienoate
C00628  2,5-Dihydroxybenzoate
C00682  2-Hydroxymuconate semialdehyde
C00846  3-Oxoadipate
C00877  Crotonoyl-CoA
C01063  Pimeloyl-CoA
C01144  (S)-3-Hydroxybutanoyl-CoA
C01163  3-Carboxy-cis,cis-muconate
C01278  2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C01407  Benzene
C01751  Resorcinol
C02222  2-Maleylacetate
C02232  3-Oxoadipyl-CoA
C02411  Glutaconyl-1-CoA
C02480  cis,cis-Muconate
C02501  2-Hydroxymuconate
C02519  4-Methoxybenzoate
C02814  Benzene-1,2,4-triol
C02949  4-Hydroxybenzoyl-CoA
C03453  gamma-Oxalocrotonate
C03586  2-Oxo-2,3-dihydrofuran-5-acetate
C03589  4-Hydroxy-2-oxopentanoate
C03671  2-Pyrone-4,6-dicarboxylate
C03676  3-Hydroxy-cis,cis-muconate
C03767  4-Oxocyclohexanecarboxylate
C04091  cis-1,2-Dihydrobenzene-1,2-diol
C04115  4-Carboxy-4-hydroxy-2-oxoadipate
C04324  (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04404  trans-4-Hydroxycyclohexanecarboxylate
C04434  (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480  3-Carboxy-2-hydroxymuconate semialdehyde
C04484  4-Carboxy-2-hydroxymuconate semialdehyde
C04553  3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375  2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06033  Parapyruvate
C06035  4-Methylene-2-oxoglutarate
C06321  (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322  Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333  2-Aminobenzenesulfonate
C06336  3-Sulfocatechol
C06714  3-Hydroxypimeloyl-CoA
C06715  3-Oxopimeloyl-CoA
C06723  6-Carboxyhex-2-enoyl-CoA
C06749  6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809  Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810  Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811  Cyclohex-1-ene-1-carbonyl-CoA
C09812  2-Hydroxycyclohexane-1-carbonyl-CoA
C09813  2-Oxocyclohexane-1-carbonyl-CoA
C09821  6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822  Cyclohexane-1-carboxylate
C09823  Cyclohexane-1-carbonyl-CoA
C14144  5-Carboxy-2-pentenoyl-CoA
C14610  (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682  3,4-Didehydroadipyl-CoA
C19683  3,4-Didehydroadipyl-CoA semialdehyde
C19684  2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C21298  2,6-Dihydroxybenzoate
C22885  cis-4-Hydroxycyclohexane-1-carboxylate
C22887  4-Oxocyclohex-2-ene-1-carboxylate
C22920  4-Oxocyclohex-2,5-dienecarboxylate
Reference
  Authors
Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
  Title
Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
  Journal
Microbiol Mol Biol Rev 73:71-133 (2009)
DOI:10.1128/MMBR.00021-08
Reference
  Authors
Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
  Title
Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
  Journal
J Bacteriol 185:41-50 (2003)
DOI:10.1128/JB.185.1.41-50.2003
Reference
  Authors
Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
  Title
Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
  Journal
Biosci Biotechnol Biochem 68:1434-41 (2004)
DOI:10.1271/bbb.68.1434
Reference
  Authors
Mampel J, Ruff J, Junker F, Cook AM.
  Title
The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
  Journal
Microbiology 145 ( Pt 11):3255-64 (1999)
DOI:10.1099/00221287-145-11-3255
Reference
PMID:8002948
  Authors
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
  Title
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
  Journal
Biochem J 300 ( Pt 2):429-36 (1994)
DOI:10.1042/bj3000429
Reference
PMID:8990279
  Authors
Harwood CS, Gibson J.
  Title
Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
  Journal
J Bacteriol 179:301-9 (1997)
DOI:10.1128/JB.179.2.301-309.1997
Reference
  Authors
Peters F, Shinoda Y, McInerney MJ, Boll M.
  Title
Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
  Journal
J Bacteriol 189:1055-60 (2007)
DOI:10.1128/JB.01467-06
Reference
  Authors
Cowles CE, Nichols NN, Harwood CS.
  Title
BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
  Journal
J Bacteriol 182:6339-46 (2000)
DOI:10.1128/JB.182.22.6339-6346.2000
Reference
  Authors
Smith MA, Weaver VB, Young DM, Ornston LN.
  Title
Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
  Journal
Appl Environ Microbiol 69:524-32 (2003)
DOI:10.1128/AEM.69.1.524-532.2003
Reference
  Authors
Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
  Title
6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
  Journal
Environ Microbiol 10:1547-56 (2008)
DOI:10.1111/j.1462-2920.2008.01570.x
Reference
  Authors
Pelletier DA, Harwood CS
  Title
2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
  Journal
J Bacteriol 182:2753-60 (2000)
DOI:10.1128/JB.182.10.2753-2760.2000
Reference
  Authors
Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
  Title
Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
  Journal
Appl Environ Microbiol 67:1728-38 (2001)
DOI:10.1128/AEM.67.4.1728-1738.2001
Reference
  Authors
Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
  Title
Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
  Journal
Mol Microbiol 79:359-74 (2011)
DOI:10.1111/j.1365-2958.2010.07448.x
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00020  Citrate cycle (TCA cycle)
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00361  Chlorocyclohexane and chlorobenzene degradation
ko00627  Aminobenzoate degradation
ko00790  Folate biosynthesis
LinkDB

DBGET integrated database retrieval system