PATHWAY: ko00362 Help
Entry Name Benzoate degradation
Class Metabolism; Xenobiotics biodegradation and metabolismBRITE hierarchy
Pathway map Module M00540 Benzoate degradation, cyclohexanecarboxylic acid =>pimeloyl-CoA [PATH:ko00362 ]
M00541 Benzoyl-CoA degradation, benzoyl-CoA => 3-hydroxypimeloyl-CoA [PATH:ko00362 ]
M00547 Benzene/toluene degradation, benzene => catechol / toluene => 3-methylcatechol [PATH:ko00362 ]
M00551 Benzoate degradation, benzoate => catechol / methylbenzoate => methylcatechol [PATH:ko00362 ]
M00568 Catechol ortho-cleavage, catechol => 3-oxoadipate [PATH:ko00362 ]
M00569 Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA [PATH:ko00362 ]
Other DBs Orthology K00074 paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157 ]
K00529 hcaD; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3 ]
K01031 pcaI; 3-oxoadipate CoA-transferase, alpha subunit [EC:2.8.3.6 ]
K01032 pcaJ; 3-oxoadipate CoA-transferase, beta subunit [EC:2.8.3.6 ]
K01615 gcdA; glutaconyl-CoA decarboxylase subunit alpha [EC:7.2.4.5 ]
K01617 dmpH, xylI, nahK; 2-oxo-3-hexenedioate decarboxylase [EC:4.1.1.77 ]
K01857 pcaB; 3-carboxy-cis,cis-muconate cycloisomerase [EC:5.5.1.2 ]
K04107 hcrC, hbaB; 4-hydroxybenzoyl-CoA reductase subunit gamma [EC:1.1.7.1 ]
K04108 hcrA, hbaC; 4-hydroxybenzoyl-CoA reductase subunit alpha [EC:1.1.7.1 ]
K04109 hcrB, hbaD; 4-hydroxybenzoyl-CoA reductase subunit beta [EC:1.1.7.1 ]
K04116 aliA; cyclohexanecarboxylate-CoA ligase [EC:6.2.1.-]
K04117 aliB; cyclohexanecarboxyl-CoA dehydrogenase [EC:1.3.99.-]
K04755 fdx; ferredoxin, 2Fe-2S
K05549 benA-xylX; benzoate/toluate 1,2-dioxygenase subunit alpha [EC:1.14.12.10 1.14.12.-]
K05550 benB-xylY; benzoate/toluate 1,2-dioxygenase subunit beta [EC:1.14.12.10 1.14.12.-]
K05783 benD-xylL; dihydroxycyclohexadiene carboxylate dehydrogenase [EC:1.3.1.25 1.3.1.-]
K05784 benC-xylZ; benzoate/toluate 1,2-dioxygenase reductase component [EC:1.18.1.-]
K07534 badK; cyclohex-1-ene-1-carboxyl-CoA hydratase [EC:4.2.1.-]
K07535 badH; 2-hydroxycyclohexanecarboxyl-CoA dehydrogenase [EC:1.1.1.-]
K07536 badI; 2-ketocyclohexanecarboxyl-CoA hydrolase [EC:3.1.2.-]
K07538 had; 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.1.1.368 ]
K10216 dmpD, xylF; 2-hydroxymuconate-semialdehyde hydrolase [EC:3.7.1.9 ]
K10217 dmpC, xylG, praB; aminomuconate-semialdehyde/2-hydroxymuconate-6-semialdehyde dehydrogenase [EC:1.2.1.32 1.2.1.85 ]
K10218 ligK, galC; 4-hydroxy-4-methyl-2-oxoglutarate aldolase [EC:4.1.3.17 ]
K10219 ligC; 2-hydroxy-4-carboxymuconate semialdehyde hemiacetal dehydrogenase [EC:1.1.1.312 ]
K10621 cmtC, dhbA; 2,3-dihydroxy-p-cumate/2,3-dihydroxybenzoate 3,4-dioxygenase [EC:1.13.11.- 1.13.11.14 ]
K10622 cmtD, dhbB; HCOMODA/2-hydroxy-3-carboxy-muconic semialdehyde decarboxylase [EC:4.1.1.-]
K15514 boxD; 3,4-dehydroadipyl-CoA semialdehyde dehydrogenase [EC:1.2.1.77 ]
K15766 absAa; 2-aminobenzenesulfonate 2,3-dioxygenase subunit alpha [EC:1.14.12.14 ]
K15767 absAb; 2-aminobenzenesulfonate 2,3-dioxygenase subunit beta [EC:1.14.12.14 ]
K16173 acd; glutaryl-CoA dehydrogenase (non-decarboxylating) [EC:1.3.99.32 ]
K16249 dmpK, poxA, tomA0; phenol/toluene 2-monooxygenase (NADH) P0/A0
K18089 todB, tcbAc; benzene/toluene/chlorobenzene dioxygenase ferredoxin component
K18090 todA, tcbAd; benzene/toluene/chlorobenzene dioxygenase ferredoxin reductase component [EC:1.18.1.3 1.18.1.-]
K18365 bphI, xylK, nahM, tesG; 4-hydroxy-2-oxovalerate/4-hydroxy-2-oxohexanoate aldolase [EC:4.1.3.39 4.1.3.43 ]
K19066 E1.3.8.10; cyclohex-1-ene-1-carbonyl-CoA dehydrogenase [EC:1.3.8.10 ]
K19067 E1.3.8.11; cyclohexane-1-carbonyl-CoA dehydrogenase [EC:1.3.8.11 ]
K19515 bamB; benzoyl-CoA reductase subunit BamB [EC:1.3.-.-]
K19516 bamC; benzoyl-CoA reductase subunit BamC [EC:1.3.-.-]
K20509 madB, oadB, gcdB, mmdB; carboxybiotin decarboxylase [EC:7.2.4.1 ]
K22553 CYP199A2; 4-methoxybenzoate monooxygenase (O-demethylating) [EC:1.14.99.15 ]
K23351 gcdC, mmdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma
K23352 gcdD, mmdD; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit delta
K27499 chcB2; cis-4-hydroxycyclohexanecarboxylate dehydrogenase
K27500 chcC1; 4-oxocyclohexanecarboxylate 2-dehydrogenase
K27540 E2.3.1.315; succinyl-CoA:cyclohexane-1-carboxylate CoA transferase
K27672 chcAa; cyclohexane-1-carboxylate 4-trans-hydroxylase
K27673 chcB1; trans-4-hydroxycyclohexanecarboxylate dehydrogenase
K27674 chcC2; 4-oxocyclohex-2-ene-1-carboxylate desaturase
K27848 E2.3.1.318; 3-oxoadipate:acetyl-CoA acetyltransferase
Compound C00596 2-Hydroxy-2,4-pentadienoate
C00682 2-Hydroxymuconate semialdehyde
C01144 (S)-3-Hydroxybutanoyl-CoA
C01163 3-Carboxy-cis,cis-muconate
C01278 2-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C03586 2-Oxo-2,3-dihydrofuran-5-acetate
C03589 4-Hydroxy-2-oxopentanoate
C03671 2-Pyrone-4,6-dicarboxylate
C03676 3-Hydroxy-cis,cis-muconate
C03767 4-Oxocyclohexanecarboxylate
C04091 cis-1,2-Dihydrobenzene-1,2-diol
C04115 4-Carboxy-4-hydroxy-2-oxoadipate
C04324 (1E,3E)-4-Hydroxybuta-1,3-diene-1,2,4-tricarboxylate
C04404 trans-4-Hydroxycyclohexanecarboxylate
C04434 (1E)-4-Oxobut-1-ene-1,2,4-tricarboxylate
C04480 3-Carboxy-2-hydroxymuconate semialdehyde
C04484 4-Carboxy-2-hydroxymuconate semialdehyde
C04553 3-Carboxy-2,5-dihydro-5-oxofuran-2-acetate
C05375 2-Hydroxy-2-hydropyrone-4,6-dicarboxylate
C06035 4-Methylene-2-oxoglutarate
C06321 (1R,6S)-1,6-Dihydroxycyclohexa-2,4-diene-1-carboxylate
C06322 Cyclohexa-1,5-diene-1-carbonyl-CoA
C06333 2-Aminobenzenesulfonate
C06723 6-Carboxyhex-2-enoyl-CoA
C06749 6-Hydroxycyclohex-1-ene-1-carbonyl-CoA
C09809 Cyclohexa-2,5-diene-1-carbonyl-CoA
C09810 Cyclohexa-1,4-diene-1-carbonyl-CoA
C09811 Cyclohex-1-ene-1-carbonyl-CoA
C09812 2-Hydroxycyclohexane-1-carbonyl-CoA
C09813 2-Oxocyclohexane-1-carbonyl-CoA
C09821 6-Oxocyclohex-1-ene-1-carbonyl-CoA
C09822 Cyclohexane-1-carboxylate
C09823 Cyclohexane-1-carbonyl-CoA
C14144 5-Carboxy-2-pentenoyl-CoA
C14610 (S)-5-Oxo-2,5-dihydrofuran-2-acetate
C19682 3,4-Didehydroadipyl-CoA
C19683 3,4-Didehydroadipyl-CoA semialdehyde
C19684 2,3-Epoxy-2,3-dihydrobenzoyl-CoA
C22885 cis-4-Hydroxycyclohexane-1-carboxylate
C22887 4-Oxocyclohex-2-ene-1-carboxylate
C22920 4-Oxocyclohex-2,5-dienecarboxylate
Reference Authors Carmona M, Zamarro MT, Blazquez B, Durante-Rodriguez G, Juarez JF, Valderrama JA, Barragan MJ, Garcia JL, Diaz E
Title Anaerobic catabolism of aromatic compounds: a genetic and genomic view.
Journal Reference Authors Hara H, Masai E, Miyauchi K, Katayama Y, Fukuda M.
Title Characterization of the 4-carboxy-4-hydroxy-2-oxoadipate aldolase gene and operon structure of the protocatechuate 4,5-cleavage pathway genes in Sphingomonas paucimobilis SYK-6.
Journal Reference Authors Maruyama K, Shibayama T, Ichikawa A, Sakou Y, Yamada S, Sugisaki H.
Title Cloning and characterization of the genes encoding enzymes for the protocatechuate meta-degradation pathway of Pseudomonas ochraceae NGJ1.
Journal Reference Authors Mampel J, Ruff J, Junker F, Cook AM.
Title The oxygenase component of the 2-aminobenzenesulfonate dioxygenase system from Alcaligenes sp. strain O-1.
Journal Reference Authors Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM.
Title Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid.
Journal Reference Authors Harwood CS, Gibson J.
Title Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?
Journal Reference Authors Peters F, Shinoda Y, McInerney MJ, Boll M.
Title Cyclohexa-1,5-diene-1-carbonyl-coenzyme A (CoA) hydratases of Geobacter metallireducens and Syntrophus aciditrophicus: Evidence for a common benzoyl-CoA degradation pathway in facultative and strict anaerobes.
Journal Reference Authors Cowles CE, Nichols NN, Harwood CS.
Title BenR, a XylS homologue, regulates three different pathways of aromatic acid degradation in Pseudomonas putida.
Journal Reference Authors Smith MA, Weaver VB, Young DM, Ornston LN.
Title Genes for chlorogenate and hydroxycinnamate catabolism (hca) are linked to functionally related genes in the dca-pca-qui-pob-hca chromosomal cluster of Acinetobacter sp. strain ADP1.
Journal Reference Authors Kuntze K, Shinoda Y, Moutakki H, McInerney MJ, Vogt C, Richnow HH, Boll M
Title 6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.
Journal Reference Authors Pelletier DA, Harwood CS
Title 2-Hydroxycyclohexanecarboxyl coenzyme A dehydrogenase, an enzyme characteristic of the anaerobic benzoate degradation pathway used by Rhodopseudomonas palustris.
Journal Reference Authors Elshahed MS, Bhupathiraju VK, Wofford NQ, Nanny MA, McInerney MJ
Title Metabolism of benzoate, cyclohex-1-ene carboxylate, and cyclohexane carboxylate by "Syntrophus aciditrophicus" strain SB in syntrophic association with H(2)-using microorganisms.
Journal Reference Authors Nogales J, Canales A, Jimenez-Barbero J, Serra B, Pingarron JM, Garcia JL, Diaz E
Title Unravelling the gallic acid degradation pathway in bacteria: the gal cluster from Pseudomonas putida.
Journal Related ko00010 Glycolysis / Gluconeogenesis
ko00361 Chlorocyclohexane and chlorobenzene degradation
