KEGG   PATHWAY: cfel04144
Entry
cfel04144                   Pathway                                
Name
Endocytosis - Ctenocephalides felis (cat flea)
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
cfel04144  Endocytosis
cfel04144

Other DBs
GO: 0006897
Organism
Ctenocephalides felis (cat flea) [GN:cfel]
Gene
113374600  ADP-ribosylation factor 6 [KO:K07941]
113377780  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
113387726  phosphatidylinositol 5-phosphate 4-kinase type-2 alpha-like [KO:K00889] [EC:2.7.1.68]
113365320  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like [KO:K00889] [EC:2.7.1.68]
113374026  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113364313  phospholipase D1-like [KO:K01115] [EC:3.1.4.4]
113363958  dynamin [KO:K01528] [EC:3.6.5.5]
113371607  clathrin heavy chain [KO:K04646]
113368465  AP-2 complex subunit alpha-like [KO:K11824]
113384561  AP-2 complex subunit mu [KO:K11826]
113384713  AP-2 complex subunit mu-like [KO:K11826]
113384570  AP-2 complex subunit sigma [KO:K11827]
113385270  AP-2 complex subunit sigma [KO:K11827]
113376142  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
113376942  TGF-beta receptor type-1-like [KO:K04674] [EC:2.7.11.30]
113378781  mothers against decapentaplegic homolog 3-like [KO:K23605]
113378849  mothers against decapentaplegic homolog 3-like [KO:K23605]
113389780  LOW QUALITY PROTEIN: epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
113364040  epidermal growth factor receptor-like [KO:K04361] [EC:2.7.10.1]
113389283  phosphatidylinositol 3-kinase 2-like [KO:K04707] [EC:2.3.2.27]
113389285  uncharacterized protein LOC113389285 [KO:K04707] [EC:2.3.2.27]
113365969  endophilin-A-like isoform X1 [KO:K11247]
113366090  endophilin-A-like [KO:K11247]
113367356  endophilin-A-like [KO:K11247]
113385074  LOW QUALITY PROTEIN: endophilin-B1-like [KO:K11248]
113385095  LOW QUALITY PROTEIN: endophilin-B1-like [KO:K11248]
113371503  amphiphysin isoform X1 [KO:K12562]
113369799  LOW QUALITY PROTEIN: epsin-2-like [KO:K12471]
113370172  epsin-2-like isoform X1 [KO:K12471]
113366857  epidermal growth factor receptor substrate 15-like 1 [KO:K12472]
113376480  E3 ubiquitin-protein ligase Nedd-4 isoform X1 [KO:K10591] [EC:2.3.2.26]
113384398  E3 ubiquitin-protein ligase NRDP1 [KO:K11981] [EC:2.3.2.27]
113374077  E3 ubiquitin-protein ligase SMURF1 [KO:K04678] [EC:2.3.2.26]
113372573  E3 ubiquitin-protein ligase Su(dx)-like isoform X1 [KO:K05633] [EC:2.3.2.26]
113372665  E3 ubiquitin-protein ligase Su(dx)-like [KO:K05633] [EC:2.3.2.26]
113376144  G protein-coupled receptor kinase 1 [KO:K00910] [EC:2.7.11.15]
113369919  G protein-coupled receptor kinase 2 [KO:K08291] [EC:2.7.11.16]
113378001  beta-arrestin-1 [KO:K04439]
113387612  actin-related protein 2 [KO:K17260]
113387695  actin-related protein 2-like [KO:K17260]
113376593  actin-related protein 3 [KO:K18584]
113387531  actin-related protein 2/3 complex subunit 1A [KO:K05757]
113377072  probable actin-related protein 2/3 complex subunit 2 [KO:K05758]
113377686  actin-related protein 2/3 complex subunit 3 [KO:K05756]
113376725  actin-related protein 2/3 complex subunit 4 [KO:K05755]
113372922  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
113373875  actin-related protein 2/3 complex subunit 5-like [KO:K05754]
113372627  heat shock 70 kDa protein cognate 4-like [KO:K03283]
113386851  heat shock protein 70 A1-like isoform X1 [KO:K03283]
113386852  heat shock protein 70 A1-like [KO:K03283]
113363938  heat shock 70 kDa protein cognate 4-like isoform X1 [KO:K03283]
113363952  heat shock 70 kDa protein cognate 4-like isoform X1 [KO:K03283]
113376369  WASH complex subunit 4-like [KO:K18465]
113376370  WASH complex subunit 4-like [KO:K18465]
113366064  WASH complex subunit 5 [KO:K18464]
113368382  WASH complex subunit 3 [KO:K18463]
113377401  F-actin-capping protein subunit alpha-like [KO:K10364]
113370149  F-actin-capping protein subunit alpha-like [KO:K10364]
113366136  F-actin-capping protein subunit beta-like [KO:K10365]
113365880  F-actin-capping protein subunit beta-like [KO:K10365]
113371299  vacuolar protein sorting-associated protein 29-like [KO:K18467]
113371489  vacuolar protein sorting-associated protein 29 [KO:K18467]
113371529  vacuolar protein sorting-associated protein 29 [KO:K18467]
113377479  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
113383220  vacuolar protein sorting-associated protein 35 [KO:K18468]
113377604  sorting nexin-12 [KO:K17918]
113370474  STAM-binding protein-like A [KO:K11866] [EC:3.4.19.12]
113377185  ras-related protein Rab-7a [KO:K07897]
113372336  hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
113387651  signal transducing adapter molecule 1 [KO:K04705]
113388338  signal transducing adapter molecule 1-like [KO:K04705]
113377106  tumor susceptibility gene 101 protein isoform X1 [KO:K12183]
113363395  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
113363929  vacuolar protein sorting-associated protein 28 homolog isoform X1 [KO:K12184]
113385317  vacuolar protein sorting-associated protein 37B [KO:K12185]
113369824  vacuolar-sorting protein SNF8-like [KO:K12188]
113369968  vacuolar-sorting protein SNF8-like [KO:K12188]
113385150  vacuolar protein-sorting-associated protein 36-like [KO:K12190]
113385277  LOW QUALITY PROTEIN: vacuolar protein-sorting-associated protein 36 [KO:K12190]
113377178  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
113378047  vacuolar protein-sorting-associated protein 25-like [KO:K12189]
113377499  charged multivesicular body protein 6-like [KO:K12195]
113366243  charged multivesicular body protein 4b [KO:K12194]
113385029  charged multivesicular body protein 3 [KO:K12193]
113366435  charged multivesicular body protein 2a-like [KO:K12191]
113366622  charged multivesicular body protein 2a-like [KO:K12191]
113376777  vacuolar protein sorting-associated protein 4A [KO:K12196]
113377629  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
113377653  charged multivesicular body protein 1b-like [KO:K12197]
113373244  charged multivesicular body protein 1b-like [KO:K12197]
113391324  charged multivesicular body protein 1b-like [KO:K12197]
113377505  charged multivesicular body protein 5-like [KO:K12198]
113377628  charged multivesicular body protein 5-like [KO:K12198]
113380991  IST1 homolog [KO:K19476]
113384871  IST1 homolog [KO:K19476]
113384999  IST1 homolog [KO:K19476]
113378802  programmed cell death 6-interacting protein [KO:K12200]
113363350  maspardin-like [KO:K19367]
113369801  sorting nexin-2-like [KO:K17917]
113368419  sorting nexin-6-like isoform X1 [KO:K17920]
113368420  sorting nexin-6-like isoform X1 [KO:K17920]
113368427  sorting nexin-6-like isoform X1 [KO:K17920]
113368429  sorting nexin-6-like isoform X1 [KO:K17920]
113387597  tyrosine-protein kinase Src64B-like [KO:K05704] [EC:2.7.10.2]
113387699  tyrosine-protein kinase Src64B-like isoform X1 [KO:K05704] [EC:2.7.10.2]
113388555  tyrosine-protein kinase Src64B-like [KO:K05704] [EC:2.7.10.2]
113374558  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
113370091  ras-related protein Rab-5B [KO:K07888]
113366238  LOW QUALITY PROTEIN: rabenosyn-5 [KO:K12481]
113377062  RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
113365941  EH domain-containing protein 3-like [KO:K12483]
113366753  EH domain-containing protein 3-like [KO:K12483]
113368261  EH domain-containing protein 3-like [KO:K12483]
113374052  vacuolar protein sorting-associated protein 45-like isoform X1 [KO:K12479]
113374067  vacuolar protein sorting-associated protein 45-like [KO:K12479]
113387546  ras-related protein Rab-10-like [KO:K07903]
113387552  ras-related protein Rab-10-like [KO:K07903]
113372934  ras-related protein Rab-8A [KO:K07901]
113376649  ras-related protein Rab-35 [KO:K07876]
113374574  ras-related protein Rab-11A [KO:K07904]
113376120  ras-related protein Rab-11A-like [KO:K07904]
113368437  rab11 family-interacting protein 1 isoform X1 [KO:K12484]
113374995  kinesin heavy chain-like [KO:K10396]
113364150  kinesin heavy chain-like [KO:K10396]
113384919  rab11 family-interacting protein 4 isoform X1 [KO:K12485]
113373263  partitioning defective 3 homolog isoform X1 [KO:K04237]
113363804  partitioning defective protein 6-like [KO:K06093]
113363805  partitioning defective protein 6-like [KO:K06093]
113367707  atypical protein kinase C-like [KO:K06069] [EC:2.7.11.13]
113365662  atypical protein kinase C isoform X1 [KO:K06069] [EC:2.7.11.13]
113367786  cdc42 homolog [KO:K04393]
113365683  cdc42 homolog [KO:K04393]
113371641  stromal membrane-associated protein 1 [KO:K12486]
113372880  arfGAP with SH3 domain, ANK repeat and PH domain-containing protein-like [KO:K12488]
113373874  arfGAP with SH3 domain, ANK repeat and PH domain-containing protein-like [KO:K12488]
113369927  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
113372610  centaurin-gamma-1A [KO:K12491]
113374069  centaurin-gamma-1A-like isoform X1 [KO:K12491]
113372571  ADP-ribosylation factor GTPase-activating protein 1-like [KO:K12492]
113373724  LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 1-like [KO:K12492]
113370144  LOW QUALITY PROTEIN: ADP-ribosylation factor GTPase-activating protein 2-like [KO:K12493]
113376787  uncharacterized protein LOC113376787 isoform X1 [KO:K12494]
113377149  uncharacterized protein LOC113377149 [KO:K12495]
113378678  IQ motif and SEC7 domain-containing protein 1-like [KO:K12495]
113372811  cytohesin-1 [KO:K18441]
113387530  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
113377148  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 [KO:K18443]
113387046  ADP-ribosylation factor 1 [KO:K07937]
113376997  ADP-ribosylation factor 2 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
cfel04070  Phosphatidylinositol signaling system
cfel04130  SNARE interactions in vesicular transport
cfel04142  Lysosome
cfel04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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