KEGG   PATHWAY: cfel04150
Entry
cfel04150                   Pathway                                
Name
mTOR signaling pathway - Ctenocephalides felis (cat flea)
Description
The mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 contains mTOR, Raptor, PRAS40, Deptor, mLST8, Tel2 and Tti1. mTORC1 is activated by the presence of growth factors, amino acids, energy status, stress and oxygen levels to regulate several biological processes, including lipid metabolism, autophagy, protein synthesis and ribosome biogenesis. On the other hand, mTORC2, which consists of mTOR, mSin1, Rictor, Protor, Deptor, mLST8, Tel2 and Tti1, responds to growth factors and controls cytoskeletal organization, metabolism and survival.
Class
Environmental Information Processing; Signal transduction
Pathway map
cfel04150  mTOR signaling pathway
cfel04150

Organism
Ctenocephalides felis (cat flea) [GN:cfel]
Gene
113378603  Y+L amino acid transporter 2 [KO:K13780]
113388054  large neutral amino acids transporter small subunit 1-like [KO:K13780]
113365347  large neutral amino acids transporter small subunit 1-like [KO:K13780]
113365780  Y+L amino acid transporter 2 [KO:K13780]
113382800  LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
113382801  LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
113382802  V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]
113384634  V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
113387944  V-type proton ATPase subunit B [KO:K02147]
113364074  V-type proton ATPase subunit B-like [KO:K02147]
113363342  V-type proton ATPase subunit C [KO:K02148]
113374185  V-type proton ATPase subunit D 1 [KO:K02149]
113374205  V-type proton ATPase subunit D 1 [KO:K02149]
113366540  V-type proton ATPase subunit E [KO:K02150]
113382961  V-type proton ATPase subunit F 1 [KO:K02151]
113375470  V-type proton ATPase subunit F 1-like [KO:K02151]
113375476  V-type proton ATPase subunit F 1-like [KO:K02151]
113369793  V-type proton ATPase subunit G-like [KO:K02152]
113370080  V-type proton ATPase subunit G-like [KO:K02152]
113378866  V-type proton ATPase subunit H isoform X1 [KO:K02144]
113382874  ragulator complex protein LAMTOR1-like [KO:K20397]
113383003  ragulator complex protein LAMTOR1-like [KO:K20397]
113377918  ragulator complex protein LAMTOR2-like [KO:K20398]
113364184  ragulator complex protein LAMTOR2-like [KO:K20398]
113378193  ragulator complex protein LAMTOR3 homolog [KO:K04370]
113365488  ragulator complex protein LAMTOR3 homolog [KO:K04370]
113365562  LOW QUALITY PROTEIN: ragulator complex protein LAMTOR3-like [KO:K04370]
113385873  ragulator complex protein LAMTOR4 [KO:K20399]
113370076  ras-related GTP-binding protein A [KO:K16185]
113371678  ras-related GTP-binding protein A [KO:K16185]
113378176  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
113376866  ras-related GTP-binding protein C-like isoform X1 [KO:K16186]
113378594  nucleoporin SEH1-like isoform X1 [KO:K14299]
113378600  LOW QUALITY PROTEIN: nucleoporin SEH1-like [KO:K14299]
113383464  GATOR complex protein WDR24 [KO:K20408]
113372572  GATOR complex protein WDR59-like isoform X1 [KO:K20409]
113373218  LOW QUALITY PROTEIN: GATOR complex protein WDR59-like [KO:K20409]
113384805  protein SEC13 homolog [KO:K14004]
113378647  GATOR complex protein DEPDC5 isoform X1 [KO:K20404]
113384862  GATOR complex protein NPRL2-like [KO:K20405]
113390905  LOW QUALITY PROTEIN: GATOR complex protein NPRL2-like [KO:K20405]
113386026  GATOR complex protein NPRL3 [KO:K20406]
113369803  regulatory-associated protein of mTOR [KO:K07204]
113378831  LOW QUALITY PROTEIN: serine/threonine-protein kinase Tor [KO:K07203] [EC:2.7.11.1]
113377509  target of rapamycin complex subunit lst8 [KO:K08266]
113366412  serine/threonine-protein kinase unc-51 [KO:K08269] [EC:2.7.11.1]
113363856  eukaryotic translation initiation factor 4E type 2-like [KO:K03259]
113363857  eukaryotic translation initiation factor 4E type 2-like isoform X1 [KO:K03259]
113377011  eukaryotic translation initiation factor 4E-like isoform X1 [KO:K03259]
113370194  ribosomal protein S6 kinase beta-2 isoform X1 [KO:K04688] [EC:2.7.11.1]
113374345  40S ribosomal protein S6 [KO:K02991]
113376073  STE20-related kinase adapter protein alpha-like [KO:K08271]
113377667  serine/threonine-protein kinase STK11 [KO:K07298] [EC:2.7.11.1]
113369409  protein Mo25 [KO:K08272]
113372595  protein Mo25 [KO:K08272]
113378401  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
113378402  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
113374585  5'-AMP-activated protein kinase catalytic subunit alpha-2-like [KO:K07198] [EC:2.7.11.31]
113369277  GTP-binding protein Rheb homolog [KO:K07208]
113382790  GTP-binding protein Rheb homolog [KO:K07208]
113372413  protein Wnt-1 [KO:K03209]
113382772  protein Wnt-1-like [KO:K00408]
113387605  protein Wnt-5b-like [KO:K00444]
113388368  protein Wnt-5b-like [KO:K00444]
113373606  protein Wnt-6-like [KO:K00445]
113383391  protein Wnt-7b [KO:K00572]
113373604  protein Wnt-10b-like [KO:K01357]
113365343  protein Wnt-10a-like [KO:K01357]
113372331  frizzled isoform X1 [KO:K02432]
113367611  frizzled-4-like [KO:K02354]
113387075  frizzled-2-like [KO:K02375]
113369751  low-density lipoprotein receptor-related protein 6-like [KO:K03068]
113371060  LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 6-like [KO:K03068]
113384707  segment polarity protein dishevelled-like [KO:K02353]
113383528  glycogen synthase kinase-3 beta-like [KO:K03083] [EC:2.7.11.26]
113383529  LOW QUALITY PROTEIN: protein kinase shaggy-like [KO:K03083] [EC:2.7.11.26]
113368099  insulin-like receptor [KO:K04527] [EC:2.7.10.1]
113380212  insulin-like receptor isoform X1 [KO:K04527] [EC:2.7.10.1]
113374030  protein enhancer of sevenless 2B [KO:K04364]
113373081  GTPase HRas [KO:K07827]
113372268  raf homolog serine/threonine-protein kinase Raf isoform X1 [KO:K04365] [EC:2.7.11.1]
113366234  dual specificity mitogen-activated protein kinase kinase dSOR1 [KO:K04368] [EC:2.7.12.2]
113382749  mitogen-activated protein kinase ERK-A [KO:K04371] [EC:2.7.11.24]
113376491  ribosomal protein S6 kinase 2 beta [KO:K04373] [EC:2.7.11.1]
113376446  phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform [KO:K00922] [EC:2.7.1.153]
113387608  3-phosphoinositide-dependent protein kinase 1-like [KO:K06276] [EC:2.7.11.1]
113387829  3-phosphoinositide-dependent protein kinase 1-like isoform X1 [KO:K06276] [EC:2.7.11.1]
113389005  RAC serine/threonine-protein kinase-like isoform X1 [KO:K04456] [EC:2.7.11.1]
113389813  RAC-gamma serine/threonine-protein kinase-like [KO:K04456] [EC:2.7.11.1]
113374558  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
113382734  protein kinase C, brain isozyme-like isoform X1 [KO:K02677] [EC:2.7.11.13]
113382796  protein kinase C, brain isozyme-like isoform X1 [KO:K02677] [EC:2.7.11.13]
Compound
C00020  AMP
C00062  L-Arginine
C00123  L-Leucine
C05981  Phosphatidylinositol-3,4,5-trisphosphate
Reference
PMID:27304501
  Authors
Kennedy BK, Lamming DW
  Title
The Mechanistic Target of Rapamycin: The Grand ConducTOR of Metabolism and Aging.
  Journal
Cell Metab 23:990-1003 (2016)
DOI:10.1016/j.cmet.2016.05.009
Reference
PMID:24556838
  Authors
Shimobayashi M, Hall MN
  Title
Making new contacts: the mTOR network in metabolism and signalling crosstalk.
  Journal
Nat Rev Mol Cell Biol 15:155-62 (2014)
DOI:10.1038/nrm3757
Reference
PMID:25242279
  Authors
Huang K, Fingar DC
  Title
Growing knowledge of the mTOR signaling network.
  Journal
Semin Cell Dev Biol 36:79-90 (2014)
DOI:10.1016/j.semcdb.2014.09.011
Reference
PMID:26269525
  Authors
Bockaert J, Marin P
  Title
mTOR in Brain Physiology and Pathologies.
  Journal
Physiol Rev 95:1157-87 (2015)
DOI:10.1152/physrev.00038.2014
Reference
PMID:26185979
  Authors
Caron A, Richard D, Laplante M
  Title
The Roles of mTOR Complexes in Lipid Metabolism.
  Journal
Annu Rev Nutr 35:321-48 (2015)
DOI:10.1146/annurev-nutr-071714-034355
Reference
PMID:26658722
  Authors
Shimobayashi M, Hall MN
  Title
Multiple amino acid sensing inputs to mTORC1.
  Journal
Cell Res 26:7-20 (2016)
DOI:10.1038/cr.2015.146
Reference
PMID:24698685
  Authors
Bar-Peled L, Sabatini DM
  Title
Regulation of mTORC1 by amino acids.
  Journal
Trends Cell Biol 24:400-6 (2014)
DOI:10.1016/j.tcb.2014.03.003
Reference
PMID:26046644
  Authors
Fingar DC
  Title
Rag Ubiquitination Recruits a GATOR1: Attenuation of Amino Acid-Induced mTORC1 Signaling.
  Journal
Mol Cell 58:713-5 (2015)
DOI:10.1016/j.molcel.2015.05.029
Reference
PMID:26700098
  Authors
Cai H, Dong LQ, Liu F
  Title
Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.
  Journal
Trends Pharmacol Sci 37:303-17 (2016)
DOI:10.1016/j.tips.2015.11.011
Reference
PMID:24842496
  Authors
Eyre TA, Collins GP, Goldstone AH, Cwynarski K
  Title
Time now to TORC the TORC? New developments in mTOR pathway inhibition in lymphoid malignancies.
  Journal
Br J Haematol 166:336-51 (2014)
DOI:10.1111/bjh.12945
Reference
PMID:23465396
  Authors
Jewell JL, Guan KL
  Title
Nutrient signaling to mTOR and cell growth.
  Journal
Trends Biochem Sci 38:233-42 (2013)
DOI:10.1016/j.tibs.2013.01.004
Reference
PMID:23421405
  Authors
Wood TL, Bercury KK, Cifelli SE, Mursch LE, Min J, Dai J, Macklin WB
  Title
mTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development.
  Journal
ASN Neuro 5:e00108 (2013)
DOI:10.1042/AN20120092
Reference
PMID:23694989
  Authors
Kim SG, Buel GR, Blenis J
  Title
Nutrient regulation of the mTOR complex 1 signaling pathway.
  Journal
Mol Cells 35:463-73 (2013)
DOI:10.1007/s10059-013-0138-2
Reference
PMID:19812304
  Authors
Laplante M, Sabatini DM
  Title
mTOR signaling at a glance.
  Journal
J Cell Sci 122:3589-94 (2009)
DOI:10.1242/jcs.051011
Reference
PMID:16756488
  Authors
Alessi DR, Sakamoto K, Bayascas JR
  Title
LKB1-dependent signaling pathways.
  Journal
Annu Rev Biochem 75:137-63 (2006)
DOI:10.1146/annurev.biochem.75.103004.142702
Reference
PMID:27027448
  Authors
Dan HC, Antonia RJ, Baldwin AS
  Title
PI3K/Akt promotes feedforward mTORC2 activation through IKKalpha.
  Journal
Oncotarget 7:21064-75 (2016)
DOI:10.18632/oncotarget.8383
Reference
PMID:28283069
  Authors
Saxton RA, Sabatini DM
  Title
mTOR Signaling in Growth, Metabolism, and Disease.
  Journal
Cell 168:960-976 (2017)
DOI:10.1016/j.cell.2017.02.004
Related
pathway
cfel00561  Glycerolipid metabolism
cfel04140  Autophagy - animal
KO pathway
ko04150   
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