KEGG   PATHWAY: crb00999
Entry
crb00999                    Pathway                                
Name
Biosynthesis of various plant secondary metabolites - Capsella rubella (pink shepherd's-purse)
  Including
Crocin biosynthesis, Ginsenoside biosynthesis, Saponin adjuvant biosynthesis, Cannabidiol biosynthesis, Mugineic acid biosynthesis, Pentagalloylglucose biosynthesis, Benzoxazinoid biosynthesis, Gramine biosynthesis, Coumarin biosynthesis, Furanocoumarin biosynthesis, Hordatine biosynthesis, Podophyllotoxin biosynthesis
Class
Metabolism; Biosynthesis of other secondary metabolites
Pathway map
crb00999  Biosynthesis of various plant secondary metabolites
crb00999

Organism
Capsella rubella (pink shepherd's-purse) [GN:crb]
Gene
17878597  beta-amyrin 28-oxidase [KO:K20667] [EC:1.14.14.126]
17882663  S-adenosylmethionine synthase [KO:K00789] [EC:2.5.1.6]
17893672  S-adenosylmethionine synthase 4 [KO:K00789] [EC:2.5.1.6]
17888810  S-adenosylmethionine synthase 2 [KO:K00789] [EC:2.5.1.6]
17887834  S-adenosylmethionine synthase 3 [KO:K00789] [EC:2.5.1.6]
17900607  S-adenosylmethionine synthase 1 [KO:K00789] [EC:2.5.1.6]
17881818  nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
17877070  nicotianamine synthase 2 [KO:K05953] [EC:2.5.1.43]
17880913  LOW QUALITY PROTEIN: nicotianamine synthase 1 [KO:K05953] [EC:2.5.1.43]
17896008  probable nicotianamine synthase 4 [KO:K05953] [EC:2.5.1.43]
17898438  nicotianamine synthase 3 [KO:K05953] [EC:2.5.1.43]
17896534  non-functional NADPH-dependent codeinone reductase 2 [KO:K22374] [EC:1.1.1.285]
111831974  non-functional NADPH-dependent codeinone reductase 2-like [KO:K22374] [EC:1.1.1.285]
17895007  non-functional NADPH-dependent codeinone reductase 2 [KO:K22374] [EC:1.1.1.285]
17892883  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic [KO:K13832] [EC:4.2.1.10 1.1.1.25]
17893009  bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic [KO:K13832] [EC:4.2.1.10 1.1.1.25]
17879555  UDP-glycosyltransferase 84A4 [KO:K23279] [EC:2.4.1.136]
17878132  UDP-glycosyltransferase 84A4 [KO:K23279] [EC:2.4.1.136]
17885191  beta-glucosidase 30 [KO:K01188] [EC:3.2.1.21]
17876017  beta-glucosidase 13 isoform X1 [KO:K01188] [EC:3.2.1.21]
17900477  beta-glucosidase 40 [KO:K01188] [EC:3.2.1.21]
17878313  beta-glucosidase 3 isoform X2 [KO:K01188] [EC:3.2.1.21]
17881086  beta-glucosidase 31 [KO:K01188] [EC:3.2.1.21]
17885414  beta-glucosidase 16 [KO:K01188] [EC:3.2.1.21]
17890328  beta-glucosidase 15 [KO:K01188] [EC:3.2.1.21]
17880107  beta-glucosidase 42 [KO:K01188] [EC:3.2.1.21]
17892131  probable inactive beta-glucosidase 25 [KO:K01188] [EC:3.2.1.21]
17882079  beta-glucosidase 32 [KO:K01188] [EC:3.2.1.21]
17899542  beta-glucosidase 11 isoform X1 [KO:K01188] [EC:3.2.1.21]
111830392  beta-glucosidase 8-like isoform X1 [KO:K01188] [EC:3.2.1.21]
111832471  putative beta-glucosidase 41 [KO:K01188] [EC:3.2.1.21]
17881306  beta-glucosidase 32 [KO:K01188] [EC:3.2.1.21]
17883566  beta-glucosidase 32 [KO:K01188] [EC:3.2.1.21]
17884768  beta-glucosidase 27 [KO:K01188] [EC:3.2.1.21]
17885752  beta-glucosidase 10 [KO:K01188] [EC:3.2.1.21]
17888766  beta-glucosidase 28 [KO:K01188] [EC:3.2.1.21]
17891711  beta-glucosidase 23 [KO:K01188] [EC:3.2.1.21]
17894149  putative beta-glucosidase 5 isoform X1 [KO:K01188] [EC:3.2.1.21]
17895027  beta-glucosidase 20 [KO:K01188] [EC:3.2.1.21]
17896770  beta-glucosidase 1 isoform X1 [KO:K01188] [EC:3.2.1.21]
17880398  beta-glucosidase 10 [KO:K01188] [EC:3.2.1.21]
17886863  beta-glucosidase 8 isoform X1 [KO:K01188] [EC:3.2.1.21]
17885685  beta-glucosidase 8 isoform X1 [KO:K01188] [EC:3.2.1.21]
17886922  uncharacterized protein LOC17886922 [KO:K05349] [EC:3.2.1.21]
17883734  uncharacterized protein LOC17883734 isoform X1 [KO:K05349] [EC:3.2.1.21]
17885531  uncharacterized protein LOC17885531 [KO:K05349] [EC:3.2.1.21]
17884994  LOW QUALITY PROTEIN: uncharacterized protein LOC17884994 [KO:K05349] [EC:3.2.1.21]
17884397  uncharacterized protein LOC17884397 [KO:K05349] [EC:3.2.1.21]
17882700  uncharacterized protein LOC17882700 [KO:K05349] [EC:3.2.1.21]
17886413  uncharacterized protein LOC17886413 isoform X1 [KO:K05349] [EC:3.2.1.21]
17895560  beta-glucosidase 46 isoform X1 [KO:K05350] [EC:3.2.1.21]
17894518  beta-glucosidase 45 [KO:K05350] [EC:3.2.1.21]
17894400  beta-glucosidase 45 [KO:K05350] [EC:3.2.1.21]
17893733  beta-glucosidase 44 [KO:K05350] [EC:3.2.1.21]
17880090  beta-glucosidase 47 [KO:K05350] [EC:3.2.1.21]
17893414  beta-glucosidase 43 isoform X1 [KO:K05350] [EC:3.2.1.21]
17893417  feruloyl CoA ortho-hydroxylase 1 [KO:K06892] [EC:1.14.11.61]
17892971  feruloyl CoA ortho-hydroxylase 2 [KO:K23145] [EC:1.14.11.60]
17879967  cytochrome P450 82C4 [KO:K23136] [EC:1.14.14.164]
17899710  pinoresinol reductase 1 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
17878264  pinoresinol reductase 2 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
17898640  pinoresinol reductase 1 [KO:K21568] [EC:1.23.1.1 1.23.1.2 1.23.1.3 1.23.1.4]
17875606  agmatine coumaroyltransferase [KO:K14329] [EC:2.3.1.64 2.3.1.-]
Compound
C00019  S-Adenosyl-L-methionine
C00024  Acetyl-CoA
C00036  Oxaloacetate
C00049  L-Aspartate
C00073  L-Methionine
C00074  Phosphoenolpyruvate
C00078  L-Tryptophan
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00108  Anthranilate
C00179  Agmatine
C00223  p-Coumaroyl-CoA
C00251  Chorismate
C00254  Prephenate
C00323  Caffeoyl-CoA
C00353  Geranylgeranyl diphosphate
C00406  Feruloyl-CoA
C00423  trans-Cinnamate
C00448  trans,trans-Farnesyl diphosphate
C00463  Indole
C00493  Shikimate
C00590  Coniferyl alcohol
C00751  Squalene
C00758  Bergaptol
C00841  Xanthotoxol
C01054  (S)-2,3-Epoxysqualene
C01158  1-O-Galloyl-beta-D-glucose
C01198  3-(2-Hydroxyphenyl)propanoate
C01424  Gallate
C01527  Scopolin
C01557  Bergapten
C01752  Scopoletin
C01772  trans-2-Hydroxycinnamate
C01864  Xanthotoxin
C02162  Isopimpinellin
C02274  Dihydrocoumarin
C02637  3-Dehydroshikimate
C02951  5-Hydroxyxanthotoxin
C03506  Indoleglycerol phosphate
C04498  p-Coumaroylagmatine
C04576  Pentagalloylglucose
C04831  DIMBOA-glucoside
C05158  trans-beta-D-Glucosyl-2-hydroxycinnamate
C05324  Nicotianamine
C05366  (+)-Pinoresinol
C05838  cis-2-Hydroxycinnamate
C05839  cis-beta-D-Glucosyl-2-hydroxycinnamate
C05851  Coumarin
C06098  Zeaxanthin
C06972  Dronabinol
C07578  Cannabidiol
C08304  Gramine
C08307  Hordatine A
C08308  Hordatine B
C08588  Crocetin
C08589  Crocin
C08616  beta-Amyrin
C08942  Echinocystic acid
C08946  Ginsenoside Rg1
C08972  Quillaic acid
C09060  Angelicin
C09263  Esculetin
C09265  Fraxetin
C09276  Marmesin
C09305  Psoralen
C09311  Scoparone
C09315  Umbelliferone
C10556  Deoxypodophyllotoxin
C10557  Dihydroanhydropodorhizol
C10646  Lariciresinol
C10682  Matairesinol
C10784  Cannabidiolic acid
C10874  Podophyllotoxin
C11130  3-Hydroxyindolin-2-one
C12312  Indolin-2-one
C15485  2'-Deoxymugineic acid
C15486  3''-Deamino-3''-oxonicotianamine
C15500  Mugineic acid
C15501  3-Epihydroxymugineic acid
C15502  3-Epihydroxy-2'-deoxymugineic acid
C15769  HBOA
C15770  DIBOA
C15772  DIBOA-glucoside
C17055  Picrocrocin
C17062  Safranal
C17148  Oleanolic acid
C17513  trans-Crocetin (beta-D-glucosyl) (beta-D-gentibiosyl) ester
C18062  TRIBOA-glucoside
C18079  Isoscopoletin
C18080  Osthenol
C18083  Demethylsuberosin
C18167  Secoisolariciresinol
C18325  Feruloylagmatine
C19707  (+)-Columbianetin
C19730  Crocetin dialdehyde
C19731  (3S)-3-Hydroxycyclocitral
C19829  Dammarenediol-II
C19867  beta-D-Glucosyl crocetin
C19868  Bis(beta-D-glucosyl) crocetin
C19869  beta-D-Gentiobiosyl crocetin
C20406  Cannabigerolate
C20413  3,5,7-Trioxododecanoyl-CoA
C20417  2,4-Dihydroxy-6-pentylbenzoate
C20454  (-)-Lariciresinol
C20455  (-)-Pinoresinol
C20456  (+)-Secoisolariciresinol
C20713  Ginsenoside Rb1
C20715  Protopanaxadiol
C20716  Protopanaxatriol
C20725  Ginsenoside Rd
C20778  Ginsenoside Rg3
C20779  Ginsenoside F2
C20780  Ginsenoside F1
C20894  beta-Citraurin
C21183  Bursehernin
C21184  (-)-5'-Demethylyatein
C21191  Pluviatolide
C21459  6-Hydroxyferuloyl-CoA
C21601  3-(Aminomethyl)indole
C21602  (1H-Indol-3-yl)-N-methylmethanamine
C21903  Delta9-Tetrahydrocannabinolate
C22007  Sideretin
C22070  2,4-Dihydroxycinnamoyl-CoA
C22127  Ginsenoside C-K
C22128  (20S)-Ginsenoside Rh2
C22129  Ginsenoside Rh1
C22152  Bergamottin
C22153  Epoxybergamottin
C22156  6',7'-Dihydroxybergamottin
C22438  3,5-Dehydroshikimate
C22444  5,8-Dihydroxypsoralen
C22445  8-Hydroxybergapten
C22452  6,7,8-Trihydroxycoumarin
C22652  Quillaic acid 3-O-beta-D-glucuronide
C22653  Quillaic acid 3-O-beta-D-galactosyl-1,2-beta-D-glucuronide
C22654  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22655  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide
C22656  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22657  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-fucoside
C22658  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22659  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22660  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22661  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22662  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22663  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-xylosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22664  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22665  Quillaic acid 3-O-alpha-L-rhamnosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide-28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-alpha-L-rhamnosyl-1,2-beta-D-fucoside
C22666  Quillaic acid 3-O-beta-D-xylosyl-1,3-(beta-D-galactosyl-1,2)-beta-D-glucuronide 28-O-beta-D-apiosyl-1,3-beta-D-xylosyl-1,4-(beta-D-glucosyl-1,3)-alpha-L-rhamnosyl-1,2-(alpha-L-rhamnosyl-1,3)-4-O-acetyl-beta-D-fucoside
Reference
PMID:22569263
  Authors
Nagatoshi M, Terasaka K, Owaki M, Sota M, Inukai T, Nagatsu A, Mizukami H
  Title
UGT75L6 and UGT94E5 mediate sequential glucosylation of crocetin to crocin in Gardenia jasminoides.
  Journal
FEBS Lett 586:1055-61 (2012)
DOI:10.1016/j.febslet.2012.03.003
Reference
PMID:17544411
  Authors
Taura F, Sirikantaramas S, Shoyama Y, Yoshikai K, Shoyama Y, Morimoto S
  Title
Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativa.
  Journal
FEBS Lett 581:2929-34 (2007)
DOI:10.1016/j.febslet.2007.05.043
Reference
PMID:9952442
  Authors
Higuchi K, Suzuki K, Nakanishi H, Yamaguchi H, Nishizawa NK, Mori S
  Title
Cloning of nicotianamine synthase genes, novel genes involved in the biosynthesis of phytosiderophores.
  Journal
Plant Physiol 119:471-80 (1999)
DOI:10.1104/pp.119.2.471
Reference
PMID:7622460
  Authors
Ma JF, Shinada T, Matsuda C, Nomoto K
  Title
Biosynthesis of phytosiderophores, mugineic acids, associated with methionine cycling.
  Journal
J Biol Chem 270:16549-54 (1995)
DOI:10.1074/jbc.270.28.16549
Reference
PMID:33346890
  Authors
Tahara K, Nishiguchi M, Funke E, Miyazawa SI, Miyama T, Milkowski C
  Title
Dehydroquinate dehydratase/shikimate dehydrogenases involved in gallate biosynthesis of the aluminum-tolerant tree species Eucalyptus camaldulensis.
  Journal
Planta 253:3 (2020)
DOI:10.1007/s00425-020-03516-w
Reference
PMID:26558757
  Authors
Dugrand-Judek A, Olry A, Hehn A, Costantino G, Ollitrault P, Froelicher Y, Bourgaud F.
  Title
The Distribution of Coumarins and Furanocoumarins in Citrus Species Closely Matches Citrus Phylogeny and Reflects the Organization of Biosynthetic Pathways.
  Journal
PLoS One 10:e0142757 (2015)
DOI:10.1371/journal.pone.0142757
Reference
PMID:15009205
  Authors
Hehmann M, Lukacin R, Ekiert H, Matern U
  Title
Furanocoumarin biosynthesis in Ammi majus L. Cloning of bergaptol O-methyltransferase.
  Journal
Eur J Biochem 271:932-40 (2004)
DOI:10.1111/j.1432-1033.2004.03995.x
Reference
PMID:26359402
  Authors
Lau W, Sattely ES
  Title
Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone.
  Journal
Science 349:1224-8 (2015)
DOI:10.1126/science.aac7202
Reference
PMID:36952412
  Authors
Reed J, Orme A, El-Demerdash A, Owen C, Martin LBB, Misra RC, Kikuchi S, Rejzek M, Martin AC, Harkess A, Leebens-Mack J, Louveau T, Stephenson MJ, Osbourn A.
  Title
Elucidation of the pathway for biosynthesis of saponin adjuvants from the soapbark tree.
  Journal
Science 379:1252-1264 (2023)
DOI:10.1126/science.adf3727
Related
pathway
crb00010  Glycolysis / Gluconeogenesis
crb00020  Citrate cycle (TCA cycle)
crb00270  Cysteine and methionine metabolism
crb00400  Phenylalanine, tyrosine and tryptophan biosynthesis
crb00900  Terpenoid backbone biosynthesis
crb00940  Phenylpropanoid biosynthesis
KO pathway
ko00999   
LinkDB

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