KEGG   PATHWAY: dosa03015
Entry
dosa03015                   Pathway                                
Name
mRNA surveillance pathway - Oryza sativa japonica (Japanese rice) (RAPDB)
Description
The mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go decay (NGD). NMD is a mechanism that eliminates mRNAs containing premature translation-termination codons (PTCs). In vertebrates, PTCs trigger efficient NMD when located upstream of an exon junction complex (EJC). Upf3, together with Upf1 and Upf2, may signal the presence of the PTC to the 5'end of the transcript, resulting in decapping and rapid exonucleolytic digestion of the mRNA. In the NSD pathway, which targets mRNAs lacking termination codons, the ribosome is believed to translate through the 3' untranslated region and stall at the end of the poly(A) tail. NSD involves an eRF3-like protein, Ski7p, which is hypothesized to bind the empty A site of the ribosome and recruit the exosome to degrade the mRNA from the 3' end. NGD targets mRNAs with stalls in translation elongation for endonucleolytic cleavage in a process involving the Dom34 and Hbs1 proteins.
Class
Genetic Information Processing; Translation
Pathway map
dosa03015  mRNA surveillance pathway
dosa03015

Other DBs
GO: 0071028
Organism
Oryza sativa japonica (Japanese rice) (RAPDB) [GN:dosa]
Gene
Os03t0347200-01  (RAP-DB) Os03g0347200; Armadillo-type fold domain containing protein. [KO:K12882]
Os02t0612300-01  (RAP-DB) Os02g0612300; Similar to Nuclear cap binding protein subunit 2 (20 kDa nuclear cap binding protein) (NCBP 20 kDa subunit) (CBP20). [KO:K12883]
Os04t0440100-01  (RAP-DB) Os04g0440100; Similar to H0525C06.10 protein. [KO:K14328]
Os03t0809900-01  (RAP-DB) Os03g0809900; Similar to RNA-binding protein 8A (Tsunagi protein). [KO:K12876]
Os05t0140500-01  (RAP-DB) Os05g0140500; RNA binding motif protein 8 family protein. [KO:K12876]
Os12t0287200-01  (RAP-DB) Os12g0287200; Similar to Mago nashi protein. [KO:K12877]
Os08t0107900-01  (RAP-DB) Os08g0107900; Similar to Protein mago nashi. [KO:K12877]
Os01t0639100-01  (RAP-DB) Os01g0639100; Similar to Eukaryotic initiation factor 4A-3 (eIF4A-3) (eIF-4A-3). [KO:K13025] [EC:5.6.2.7]
Os03t0566800-01  (RAP-DB) Os03g0566800; Similar to Eukaryotic initiation factor 4A-3 (eIF4A-3) (eIF-4A-3). [KO:K13025] [EC:5.6.2.7]
Os02t0122000-01  (RAP-DB) Os02g0122000; Similar to P18. [KO:K14324]
Os03t0701900-01  (RAP-DB) Os03g0701900; Similar to Pinin/SDK/memA/ protein conserved region containing protein. [KO:K13114]
Os07t0626200-01  (RAP-DB) Os07g0626200; DNA-binding SAP domain containing protein. [KO:K12875]
Os05t0105900-01  (RAP-DB) Os05g0105900; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14325]
Os01t0959000-01  (RAP-DB) Os01g0959000; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14325]
Os08t0427900-01  (RAP-DB) Os08g0427900; Similar to Hin19 (Fragment). [KO:K12881]
Os07t0237100-00  (RAP-DB) Os07g0237100; RNA recognition motif domain domain containing protein. [KO:K12881]
Os12t0100100-01  (RAP-DB) Os12g0100100; Similar to ALY protein. [KO:K12881]
Os03t0278300-01  (RAP-DB) Os03g0278300; Similar to ALY protein. [KO:K12881]
Os06t0256200-01  (RAP-DB) Os06g0256200; Similar to Keratinocytes proline-rich protein. [KO:K12881]
Os11t0100200-00  (RAP-DB) Os11g0100200; Similar to ALY protein. [KO:K12881]
Os03t0158200-01  (RAP-DB) Os03g0158200; DEAD-like helicase, N-terminal domain containing protein. [KO:K18655] [EC:5.6.2.7]
Os02t0596100-01  (RAP-DB) Os02g0596100; GLE1-like domain containing protein. [KO:K18723]
Os01t0549700-01  (RAP-DB) Os01g0549700; Similar to RNA helicase (Fragment). [KO:K12812] [EC:5.6.2.7]
Os01t0550000-01  (RAP-DB) Os01g0550000; DEAD-like helicase, N-terminal domain containing protein. [KO:K12812] [EC:5.6.2.7]
Os03t0262100-01  (RAP-DB) Os03g0262100; Exon junction complex, Pym domain containing protein. [KO:K14294]
Os03t0270200-01  (RAP-DB) Os03g0270200; Hypothetical conserved gene. [KO:K13171]
Os12t0193200-01  (RAP-DB) Os12g0193200; Nucleic acid-binding, OB-fold domain containing protein. [KO:K13917] [EC:2.7.7.50 3.6.1.74]
Os02t0780600-01  (RAP-DB) Os02g0780600; mRNA capping enzyme, large subunit domain containing protein. [KO:K00565] [EC:2.1.1.56]
Os08t0180000-01  (RAP-DB) Os08g0180000; mRNA capping enzyme, large subunit family protein. [KO:K00565] [EC:2.1.1.56]
Os02t0757900-01  (RAP-DB) Os02g0757900; Similar to Poly(A)-binding protein II-like. [KO:K14396]
Os06t0219600-01  (RAP-DB) Os06g0219600; Similar to Poly(A)-binding protein II-like. [KO:K14396]
Os08t0398800-02  (RAP-DB) Os08g0398800; Cleavage and polyadenylation specificity factor, 25 kDa subunit domain containing protein. [KO:K14397]
Os04t0683100-01  (RAP-DB) Os04g0683100; Similar to Cleavage and polyadenylation specificity factor 5. [KO:K14397]
Os08t0490300-01  (RAP-DB) Os08g0490300; RNA recognition motif, glycine rich protein domain containing protein. [KO:K14398]
Os09t0476100-01  (RAP-DB) Os09g0476100; RNA recognition motif, glycine rich protein domain containing protein. [KO:K14398]
Os03t0313300-01  (RAP-DB) Os03g0313300; Poly(A) polymerase, central region domain containing protein. [KO:K14376] [EC:2.7.7.19]
Os06t0558766-00  (RAP-DB) Os06g0558766; Similar to predicted protein. [KO:K14376] [EC:2.7.7.19]
Os02t0227400-01  (RAP-DB) Os02g0227400; Poly(A) polymerase, RNA-binding region domain containing protein. [KO:K14376] [EC:2.7.7.19]
Os04t0588350-00  (RAP-DB) Os04g0588350; Similar to nucleotidyltransferase family protein. [KO:K14376] [EC:2.7.7.19]
Os07t0688500-00  (RAP-DB) Os07g0688500; Similar to Poly. [KO:K14376] [EC:2.7.7.19]
Os02t0217500-01  (RAP-DB) Os02g0217500; Pre-mRNA cleavage complex II Clp1 family protein. [KO:K14399] [EC:2.7.1.78]
Os08t0187700-01  (RAP-DB) Os08g0187700; ENTH/VHS domain containing protein. [KO:K14400]
Os09t0566100-01  (RAP-DB) Os09g0566100; ENTH/VHS domain containing protein. [KO:K14400]
Os09t0569400-01  (RAP-DB) Os09g0569400; Beta-lactamase-like domain containing protein. [KO:K14402]
Os03t0852900-01  (RAP-DB) Os03g0852900; Similar to Cleavage and polyadenylation specificity factor, 73 kDa subunit (CPSF 73 kDa subunit). [KO:K14403] [EC:3.1.27.-]
Os06t0677700-00  (RAP-DB) Os06g0677700; YT521-B-like protein family protein. [KO:K14404]
Os01t0814000-01  (RAP-DB) Os01g0814000; Nuclear fragile X mental retardation-interacting protein 1, conserved domain domain containing protein. [KO:K14404]
Os07t0589400-01  (RAP-DB) Os07g0589400; Similar to Set1 complex component swd2. [KO:K14962]
Os05t0543300-01  (RAP-DB) Os05g0543300; WD40 repeat, region domain containing protein. [KO:K14962]
Os02t0820000-01  (RAP-DB) Os02g0820000; Similar to Serine/threonine protein phosphatase PP1 isozyme 2 (EC 3.1.3.16). [KO:K06269] [EC:3.1.3.16]
Os03t0268000-01  (RAP-DB) Os03g0268000; Similar to Protein phosphatase 1, catalytic gsmms subunit. [KO:K06269] [EC:3.1.3.16]
Os06t0164100-02  (RAP-DB) Os06g0164100; Similar to Serine/threonine protein phosphatase PP1 (EC 3.1.3.16). [KO:K06269] [EC:3.1.3.16]
Os01t0349400-01  (RAP-DB) Os01g0349400; Similar to Serine/threonine protein phosphatase PP1 (EC 3.1.3.16) (Fragment). [KO:K06269] [EC:3.1.3.16]
Os08t0455600-01  (RAP-DB) Os08g0455600; Similar to Serine/threonine protein phosphatase PP1-alpha catalytic subunit (EC 3.1.3.16) (PP-1A). Splice isoform 1. [KO:K06269] [EC:3.1.3.16]
Os12t0168200-01  (RAP-DB) Os12g0168200; RNA polymerase II subunit A, C-terminal domain phosphatase domain containing protein. [KO:K15544] [EC:3.1.3.16]
Os03t0754900-01  (RAP-DB) Os03g0754900; Similar to Cleavage stimulation factor, 50 kDa subunit. [KO:K14406]
Os06t0698400-01  (RAP-DB) Os06g0698400; RNA recognition motif domain domain containing protein. [KO:K14407]
Os06t0248200-01  (RAP-DB) Os06g0248200; Hypothetical conserved gene. [KO:K14407]
Os11t0176100-01  (RAP-DB) Os11g0176100; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14407]
Os12t0571900-01  (RAP-DB) Os12g0571900; Tetratricopeptide-like helical domain containing protein. [KO:K14408]
Os07t0693900-01  (RAP-DB) Os07g0693900; HEAT domain containing protein. [KO:K06100]
Os01t0945800-01  (RAP-DB) Os01g0945800; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14411]
Os07t0584500-01  (RAP-DB) Os07g0584500; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14411]
Os05t0376000-00  (RAP-DB) Os05g0376000; Hypothetical conserved gene. [KO:K14411]
Os10t0470900-01  (RAP-DB) Os10g0470900; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14411]
Os07t0124600-01  (RAP-DB) Os07g0124600; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14411]
Os11t0637700-01  (RAP-DB) Os11g0637700; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K14411]
Os09t0279500-01  (RAP-DB) Os09g0279500; Similar to Plastid-specific 30S ribosomal protein 2, chloroplast precursor (PSRP- 2). [KO:K13126]
Os08t0314800-01  (RAP-DB) Os08g0314800; Similar to Poly(A)-binding protein. [KO:K13126]
Os03t0278500-01  (RAP-DB) Os03g0278500; Nucleotide-binding, alpha-beta plait domain containing protein. [KO:K13126]
Os04t0682400-01  (RAP-DB) Os04g0682400; Similar to H0124B04.13 protein. [KO:K13126]
Os06t0589700-01  (RAP-DB) Os06g0589700; Similar to Poly(A)-binding protein (Fragment). [KO:K13126]
Os09t0115400-01  (RAP-DB) Os09g0115400; Similar to Poly(A)-binding protein. [KO:K13126]
Os04t0504800-01  (RAP-DB) Os04g0504800; Similar to Poly(A)-binding protein. [KO:K13126]
Os03t0702800-01  (RAP-DB) Os03g0702800; Similar to Eukaryotic peptide chain release factor subunit 1 (eRF1) (Eukaryotic release factor 1) (TB3-1) (Cl1 protein). [KO:K03265]
Os05t0373900-01  (RAP-DB) Os05g0373900; Similar to Eukaryotic peptide chain release factor subunit 1 (eRF1) (Eukaryotic release factor 1) (TB3-1) (Cl1 protein). [KO:K03265]
Os07t0587400-01  (RAP-DB) Os07g0587400; Similar to Eukaryotic peptide chain release factor subunit 1-3 (eRF1-3) (Eukaryotic release factor 1-3) (Omnipotent suppressor protein 1 homolog 3) (SUP1 homolog 3). [KO:K03265]
Os01t0939500-00  (RAP-DB) Os01g0939500; Similar to Eukaryotic peptide chain release factor subunit 1-2 (eRF1-2) (Eukaryotic release factor 1-2) (Omnipotent suppressor protein 1 homolog 2) (SUP1 homolog 2). [KO:K03265]
Os04t0270100-01  (RAP-DB) Os04g0270100; Similar to GTP-binding protein. [KO:K03267]
Os02t0456500-01  (RAP-DB) Os02g0456500; Similar to GTP-binding protein. [KO:K03267]
Os07t0495900-01  (RAP-DB) Os07g0495900; Similar to low-level beta-amylase 1. [KO:K14326] [EC:5.6.2.5 5.6.2.3]
Os08t0305300-01  (RAP-DB) Os08g0305300; Protein prenyltransferase domain containing protein. [KO:K14409]
Os03t0805300-01  (RAP-DB) Os03g0805300; Similar to Phosphoprotein phosphatase 2A isoform 4. [KO:K04382] [EC:3.1.3.16]
Os06t0574500-01  (RAP-DB) Os06g0574500; Protein phosphatase 2A. [KO:K04382] [EC:3.1.3.16]
Os02t0217600-01  (RAP-DB) Os02g0217600; Similar to Isoform 2 of Serine/threonine-protein phosphatase PP2A-3 catalytic subunit. [KO:K04382] [EC:3.1.3.16]
Os03t0167700-01  (RAP-DB) Os03g0167700; Similar to Serine/threonine protein phosphatase PP2A-3 catalytic subunit (EC 3.1.3.16). [KO:K04382] [EC:3.1.3.16]
Os09t0249700-01  (RAP-DB) Os09g0249700; Protein phosphatase 2A A subunit (Phosphatase 2A regulatory A subunit). [KO:K03456]
Os02t0617600-01  (RAP-DB) Os02g0617600; Protein phosphatase 2A, regulatory subunit PR55 domain containing protein. [KO:K04354]
Os02t0224200-01  (RAP-DB) Os02g0224200; Similar to Ser/Thr specific protein phosphatase 2A B regulatory subunit beta isoform. [KO:K04354]
Os01t0600200-01  (RAP-DB) Os01g0600200; Ser/Thr specific protein phosphatase 2A B regulatory subunit beta isoform. [KO:K04354]
Os02t0191700-00  (RAP-DB) Os02g0191700; EF-HAND 2 domain containing protein. [KO:K11583]
Os05t0149800-01  (RAP-DB) Os05g0149800; EF-Hand type domain containing protein. [KO:K11583]
Os10t0476600-01  (RAP-DB) Os10g0476600; Similar to Protein phosphatase 2A 62 kDa B'' regulatory subunit (Protein phosphatase 2A 62 kDa B regulatory subunit) (Protein phosphatase 2A alpha). [KO:K11583]
Os07t0274800-01  (RAP-DB) Os07g0274800; Similar to Protein phosphatase 2A B' regulatory subunit. [KO:K11584]
Os08t0122000-01  (RAP-DB) Os08g0122000; Similar to Protein phosphatase 2A B' regulatory subunit. [KO:K11584]
Os03t0844500-01  (RAP-DB) Os03g0844500; Similar to Protein phosphatase 2A B' regulatory subunit. [KO:K11584]
Os03t0681800-00  (RAP-DB) Os03g0681800; Protein phosphatase 2A, regulatory B subunit, B56 domain containing protein. [KO:K11584]
Os09t0542700-00  (RAP-DB) Os09g0542700; Protein phosphatase 2A, regulatory B subunit, B56 family protein. [KO:K11584]
Os05t0178400-01  (RAP-DB) Os05g0178400; Similar to Protein phosphatase 2A B'kappa subunit. [KO:K11584]
Os05t0555100-01  (RAP-DB) Os05g0555100; Similar to Protein phosphatase 2A B'kappa subunit. [KO:K11584]
Os04t0485100-01  (RAP-DB) Os04g0485100; Similar to Protein phosphatase 2A B' regulatory subunit. [KO:K11584]
Os01t0116600-01  (RAP-DB) Os01g0116600; Protein synthesis factor, GTP-binding domain containing protein. [KO:K14416]
Os04t0596500-02  (RAP-DB) Os04g0596500; Translation elongation factor EFTu/EF1A, C-terminal domain containing protein. [KO:K14416]
Reference
PMID:15040442
  Authors
Maquat LE
  Title
Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics.
  Journal
Nat Rev Mol Cell Biol 5:89-99 (2004)
DOI:10.1038/nrm1310
Reference
PMID:16723977
  Authors
Amrani N, Sachs MS, Jacobson A
  Title
Early nonsense: mRNA decay solves a translational problem.
  Journal
Nat Rev Mol Cell Biol 7:415-25 (2006)
DOI:10.1038/nrm1942
Reference
PMID:17183357
  Authors
Eulalio A, Behm-Ansmant I, Izaurralde E
  Title
P bodies: at the crossroads of post-transcriptional pathways.
  Journal
Nat Rev Mol Cell Biol 8:9-22 (2007)
DOI:10.1038/nrm2080
Reference
PMID:18158581
  Authors
Mandel CR, Bai Y, Tong L
  Title
Protein factors in pre-mRNA 3'-end processing.
  Journal
Cell Mol Life Sci 65:1099-122 (2008)
DOI:10.1007/s00018-007-7474-3
Reference
PMID:16715045
  Authors
Clement SL, Lykke-Andersen J
  Title
No mercy for messages that mess with the ribosome.
  Journal
Nat Struct Mol Biol 13:299-301 (2006)
DOI:10.1038/nsmb0406-299
Related
pathway
dosa03013  Nucleocytoplasmic transport
dosa03018  RNA degradation
dosa03040  Spliceosome
KO pathway
ko03015   
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