KEGG   PATHWAY: drg00061
Entry
drg00061                    Pathway                                
Name
Fatty acid biosynthesis - Diaphorobacter ruginosibacter
Class
Metabolism; Lipid metabolism
Pathway map
drg00061  Fatty acid biosynthesis
drg00061

Module
drg_M00082  Fatty acid biosynthesis, initiation [PATH:drg00061]
drg_M00083  Fatty acid biosynthesis, elongation [PATH:drg00061]
drg_M00086  beta-Oxidation, acyl-CoA synthesis [PATH:drg00061]
Other DBs
GO: 0006633
Organism
Diaphorobacter ruginosibacter [GN:drg]
Gene
H9K76_14245  acetyl-CoA carboxylase carboxyltransferase subunit alpha [KO:K01962] [EC:6.4.1.2 2.1.3.15]
H9K76_10260  biotin/lipoyl-binding protein [KO:K02160]
H9K76_10280  accB; acetyl-CoA carboxylase biotin carboxyl carrier protein [KO:K02160]
H9K76_19555  acetyl-CoA carboxylase biotin carboxyl carrier protein [KO:K02160]
H9K76_10285  accC; acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
H9K76_19550  accC; acetyl-CoA carboxylase biotin carboxylase subunit [KO:K01961] [EC:6.4.1.2 6.3.4.14]
H9K76_07950  ATP-grasp domain-containing protein [KO:K01961] [EC:6.4.1.2 6.3.4.14]
H9K76_17320  acetyl-CoA carboxylase carboxyltransferase subunit beta [KO:K01963] [EC:6.4.1.2 2.1.3.15]
H9K76_02450  ATP-grasp domain-containing protein [KO:K11263] [EC:6.4.1.2 6.4.1.3 6.3.4.14]
H9K76_17505  fabD; ACP S-malonyltransferase [KO:K00645] [EC:2.3.1.39]
H9K76_17510  ketoacyl-ACP synthase III [KO:K00648] [EC:2.3.1.180]
H9K76_02715  fabB; beta-ketoacyl-ACP synthase I [KO:K00647] [EC:2.3.1.41]
H9K76_17490  fabF; beta-ketoacyl-ACP synthase II [KO:K09458] [EC:2.3.1.179]
H9K76_09585  fabF; beta-ketoacyl-ACP synthase II [KO:K09458] [EC:2.3.1.179]
H9K76_12540  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
H9K76_17500  fabG; 3-oxoacyl-ACP reductase FabG [KO:K00059] [EC:1.1.1.100]
H9K76_17730  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
H9K76_19000  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
H9K76_01400  SDR family oxidoreductase [KO:K00059] [EC:1.1.1.100]
H9K76_02710  fabA; bifunctional 3-hydroxydecanoyl-ACP dehydratase/trans-2-decenoyl-ACP isomerase [KO:K01716] [EC:4.2.1.59 5.3.3.14]
H9K76_15210  fabZ; 3-hydroxyacyl-ACP dehydratase FabZ [KO:K02372] [EC:4.2.1.59]
H9K76_10345  fabI; enoyl-ACP reductase FabI [KO:K00208] [EC:1.3.1.9 1.3.1.10]
H9K76_10115  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
H9K76_11210  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
H9K76_22000  long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
H9K76_02270  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
H9K76_08205  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
H9K76_09120  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
Compound
C00024  Acetyl-CoA
C00083  Malonyl-CoA
C00154  Palmitoyl-CoA
C00173  Acyl-[acyl-carrier protein]
C00229  Acyl-carrier protein
C00249  Hexadecanoic acid
C00383  Malonate
C00638  Long-chain fatty acid
C00685  3-Oxoacyl-[acyl-carrier protein]
C00693  trans-2,3-Dehydroacyl-[acyl-carrier protein]
C00712  (9Z)-Octadecenoic acid
C01203  Oleoyl-[acyl-carrier protein]
C01209  Malonyl-[acyl-carrier protein]
C01271  (3R)-3-Hydroxyacyl-[acyl-carrier protein]
C01530  Octadecanoic acid
C01571  Decanoic acid
C02679  Dodecanoic acid
C02843  Long-chain acyl-CoA
C03939  Acetyl-[acyl-carrier protein]
C04088  Octadecanoyl-[acyl-carrier protein]
C04180  cis-Dec-3-enoyl-[acp]
C04246  But-2-enoyl-[acyl-carrier protein]
C04618  (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
C04619  (3R)-3-Hydroxydecanoyl-[acyl-carrier protein]
C04620  (3R)-3-Hydroxyoctanoyl-[acyl-carrier protein]
C04633  (3R)-3-Hydroxypalmitoyl-[acyl-carrier protein]
C04688  (3R)-3-Hydroxytetradecanoyl-[acyl-carrier protein]
C05223  Dodecanoyl-[acyl-carrier protein]
C05744  Acetoacetyl-[acp]
C05745  Butyryl-[acp]
C05746  3-Oxohexanoyl-[acp]
C05747  (3R)-3-Hydroxyhexanoyl-[acyl-carrier protein]
C05748  trans-Hex-2-enoyl-[acp]
C05749  Hexanoyl-[acp]
C05750  3-Oxooctanoyl-[acp]
C05751  trans-Oct-2-enoyl-[acp]
C05752  Octanoyl-[acp]
C05753  3-Oxodecanoyl-[acp]
C05754  trans-Dec-2-enoyl-[acp]
C05755  Decanoyl-[acp]
C05756  3-Oxododecanoyl-[acp]
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05758  trans-Dodec-2-enoyl-[acp]
C05759  3-Oxotetradecanoyl-[acp]
C05760  trans-Tetradec-2-enoyl-[acp]
C05761  Tetradecanoyl-[acp]
C05762  3-Oxohexadecanoyl-[acp]
C05763  trans-Hexadec-2-enoyl-[acp]
C05764  Hexadecanoyl-[acp]
C06423  Octanoic acid
C06424  Tetradecanoic acid
C08362  (9Z)-Hexadecenoic acid
C16219  3-Oxostearoyl-[acp]
C16220  (3R)-3-Hydroxyoctadecanoyl-[acyl-carrier protein]
C16221  (2E)-Octadecenoyl-[acp]
C16520  Hexadecenoyl-[acyl-carrier protein]
C20683  Long-chain acyl-[acyl-carrier protein]
C20794  n-7 Unsaturated acyl-[acyl-carrier protein]
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
Reference
  Authors
Zhang YM, Marrakchi H, White SW, Rock CO.
  Title
The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase.
  Journal
J Lipid Res 44:1-10 (2003)
DOI:10.1194/jlr.R200016-JLR200
Reference
  Authors
Voelker T, Kinney AJ.
  Title
VARIATIONS IN THE BIOSYNTHESIS OF SEED-STORAGE LIPIDS.
  Journal
Annu Rev Plant Physiol Plant Mol Biol 52:335-361 (2001)
DOI:10.1146/annurev.arplant.52.1.335
Reference
  Authors
Barker GC, Larson TR, Graham IA, Lynn JR, King GJ.
  Title
Novel insights into seed fatty acid synthesis and modification pathways from genetic diversity and quantitative trait Loci analysis of the Brassica C genome.
  Journal
Plant Physiol 144:1827-42 (2007)
DOI:10.1104/pp.107.096172
Reference
  Authors
Bowman CE, Wolfgang MJ
  Title
Role of the malonyl-CoA synthetase ACSF3 in mitochondrial metabolism.
  Journal
Adv Biol Regul 71:34-40 (2019)
DOI:10.1016/j.jbior.2018.09.002
Reference
  Authors
Venkatesan R, Sah-Teli SK, Awoniyi LO, Jiang G, Prus P, Kastaniotis AJ, Hiltunen JK, Wierenga RK, Chen Z
  Title
Insights into mitochondrial fatty acid synthesis from the structure of heterotetrameric 3-ketoacyl-ACP reductase/3R-hydroxyacyl-CoA dehydrogenase.
  Journal
Nat Commun 5:4805 (2014)
DOI:10.1038/ncomms5805
Reference
  Authors
Hiltunen JK, Chen Z, Haapalainen AM, Wierenga RK, Kastaniotis AJ
  Title
Mitochondrial fatty acid synthesis--an adopted set of enzymes making a pathway of major importance for the cellular metabolism.
  Journal
Prog Lipid Res 49:27-45 (2010)
DOI:10.1016/j.plipres.2009.08.001
Reference
  Authors
Kastaniotis AJ, Autio KJ, Keratar JM, Monteuuis G, Makela AM, Nair RR, Pietikainen LP, Shvetsova A, Chen Z, Hiltunen JK
  Title
Mitochondrial fatty acid synthesis, fatty acids and mitochondrial physiology.
  Journal
Biochim Biophys Acta Mol Cell Biol Lipids 1862:39-48 (2017)
DOI:10.1016/j.bbalip.2016.08.011
Related
pathway
drg00020  Citrate cycle (TCA cycle)
drg00071  Fatty acid degradation
drg00410  beta-Alanine metabolism
drg00561  Glycerolipid metabolism
drg00564  Glycerophospholipid metabolism
drg00620  Pyruvate metabolism
drg00785  Lipoic acid metabolism
KO pathway
ko00061   
LinkDB

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