KEGG   PATHWAY: dro04980
Entry
dro04980                    Pathway                                
Name
Cobalamin transport and metabolism - Desmodus rotundus (common vampire bat)
Class
Organismal Systems; Digestive system
Pathway map
dro04980  Cobalamin transport and metabolism
dro04980

Organism
Desmodus rotundus (common vampire bat) [GN:dro]
Gene
112317205  TCN1; transcobalamin-1 [KO:K25741]
112317018  GIF; gastric intrinsic factor [KO:K14615]
112310766  TCN2; transcobalamin-2 [KO:K14619]
112305144  CD320; CD320 antigen [KO:K06734]
112319299  LMBRD1; probable lysosomal cobalamin transporter [KO:K14617]
112311827  ABCD4; ATP-binding cassette sub-family D member 4 isoform X1 [KO:K05678] [EC:7.6.2.8]
112314606  MMACHC; methylmalonic aciduria and homocystinuria type C protein [KO:K14618] [EC:1.16.1.6 2.5.1.151]
112313113  MMADHC; methylmalonic aciduria and homocystinuria type D protein, mitochondrial isoform X1 [KO:K26006]
112310661  MMAB; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial isoform X1 [KO:K00798] [EC:2.5.1.17]
112312629  MMAA; methylmalonic aciduria type A protein, mitochondrial [KO:K07588] [EC:3.6.5.-]
112302141  MUT; methylmalonyl-CoA mutase, mitochondrial [KO:K01847] [EC:5.4.99.2]
112321035  MTRR; methionine synthase reductase isoform X1 [KO:K00597] [EC:1.16.1.8]
112305892  MTR; methionine synthase isoform X1 [KO:K00548] [EC:2.1.1.13]
112303306  ZNF143; zinc finger protein 143 isoform X1 [KO:K20828]
112302133  ZNF76; zinc finger protein 76 isoform X1 [KO:K20828]
112296272  HCFC1; host cell factor 1 [KO:K14966]
112300651  THAP11; THAP domain-containing protein 11 [KO:K23211]
112309363  peroxiredoxin-1-like [KO:K13279] [EC:1.11.1.24]
112314613  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews(1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
dro00270  Cysteine and methionine metabolism
dro00280  Valine, leucine and isoleucine degradation
dro00670  One carbon pool by folate
dro04144  Endocytosis
dro04977  Vitamin digestion and absorption
KO pathway
ko04980   
LinkDB

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