KEGG   PATHWAY: fca04980
Entry
fca04980                    Pathway                                
Name
Cobalamin transport and metabolism - Felis catus (domestic cat)
Class
Organismal Systems; Digestive system
Pathway map
fca04980  Cobalamin transport and metabolism
fca04980

Organism
Felis catus (domestic cat) [GN:fca]
Gene
101099656  TCN1; transcobalamin-1 [KO:K25741]
101101254  CBLIF; cobalamin binding intrinsic factor isoform X1 [KO:K14615]
101093303  TCN2; transcobalamin-2 [KO:K14619]
101093668  CD320; LOW QUALITY PROTEIN: CD320 antigen [KO:K06734]
101085633  LMBRD1; lysosomal cobalamin transport escort protein LMBD1 isoform X2 [KO:K14617]
101091287  ABCD4; lysosomal cobalamin transporter ABCD4 isoform X1 [KO:K05678] [EC:7.6.2.8]
101090955  MMACHC; cyanocobalamin reductase / alkylcobalamin dealkylase isoform X1 [KO:K14618] [EC:1.16.1.6 2.5.1.151]
101099647  MMADHC; cobalamin trafficking protein CblD isoform X1 [KO:K26006]
101093552  MMAB; corrinoid adenosyltransferase isoform X4 [KO:K00798] [EC:2.5.1.17]
101085459  MMAA; methylmalonic aciduria type A protein, mitochondrial isoform X2 [KO:K07588] [EC:3.6.5.-]
101081046  MMUT; methylmalonyl-CoA mutase, mitochondrial isoform X2 [KO:K01847] [EC:5.4.99.2]
101098359  MTRR; methionine synthase reductase isoform X2 [KO:K00597] [EC:1.16.1.8]
101101166  MTR; methionine synthase isoform X3 [KO:K00548] [EC:2.1.1.13]
101086176  ZNF143; zinc finger protein 143 isoform X3 [KO:K20828]
101097894  ZNF76; zinc finger protein 76 isoform X1 [KO:K20828]
101089996  HCFC1; host cell factor 1 isoform X1 [KO:K14966]
101081180  THAP11; THAP domain-containing protein 11 [KO:K23211]
101091216  PRDX1; peroxiredoxin-1 [KO:K13279] [EC:1.11.1.24]
Compound
C00073  L-Methionine
C00091  Succinyl-CoA
C00101  Tetrahydrofolate
C00155  L-Homocysteine
C00194  Cobamide coenzyme
C00440  5-Methyltetrahydrofolate
C00541  Cob(II)alamin
C01213  (R)-Methylmalonyl-CoA
C02823  Cyanocobalamin
C06409  [Methionine synthase]-cob(II)alamin
C06410  [Methionine synthase]-methylcob(III)alamin
C06453  Methylcobalamin
C08230  Hydroxocobalamin
C22880  [Methionine synthase]-cob(I)alamin
Reference
PMID:35337617
  Authors
Nijland M, Martinez Felices JM, Slotboom DJ, Thangaratnarajah C
  Title
Membrane transport of cobalamin.
  Journal
Vitam Horm 119:121-148 (2022)
DOI:10.1016/bs.vh.2022.01.008
Reference
PMID:35337623
  Authors
Hannibal L, Jacobsen DW
  Title
Intracellular processing of vitamin B(12) by MMACHC (CblC).
  Journal
Vitam Horm 119:275-298 (2022)
DOI:10.1016/bs.vh.2022.02.001
Reference
PMID:35337626
  Authors
Watkins D, Rosenblatt DS
  Title
Inherited defects of cobalamin metabolism.
  Journal
Vitam Horm 119:355-376 (2022)
DOI:10.1016/bs.vh.2022.01.010
Reference
PMID:36422244
  Authors
Kosa M, Galla Z, Lenart I, Barath A, Grecso N, Racz G, Bereczki C, Monostori P
  Title
Vitamin B12 (Cobalamin): Its Fate from Ingestion to Metabolism with Particular Emphasis on Diagnostic Approaches of Acquired Neonatal/Infantile Deficiency  Detected by Newborn Screening.
  Journal
Metabolites 12:metabo12111104 (2022)
DOI:10.3390/metabo12111104
Reference
PMID:20301503
  Authors
Sloan JL, Carrillo N, Adams D, Venditti CP
  Title
Disorders of Intracellular Cobalamin Metabolism.
  Journal
GeneReviews(1993)
Reference
PMID:23539619
  Authors
Gherasim C, Lofgren M, Banerjee R
  Title
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin.
  Journal
J Biol Chem 288:13186-93 (2013)
DOI:10.1074/jbc.R113.458810
Related
pathway
fca00270  Cysteine and methionine metabolism
fca00280  Valine, leucine and isoleucine degradation
fca00670  One carbon pool by folate
fca04144  Endocytosis
fca04977  Vitamin digestion and absorption
KO pathway
ko04980   
LinkDB

DBGET integrated database retrieval system