KEGG PATHWAY: gfs04145

KEGG

PATHWAY: gfs04145

Entry

gfs04145                    Pathway

Name

Phagosome - Glossina fuscipes (tsetse fly)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Glossina fuscipes (tsetse fly) [GN:gfs]

Gene

syntaxin-7 [KO:K08488]

actin-85C-like [KO:K05692]

actin-5C [KO:K05692]

syntaxin-18 [KO:K08492]

vesicle-trafficking protein SEC22b-B [KO:K08517]

ras-related protein Rab-5B [KO:K07889]

phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]

hepatocyte growth factor-regulated tyrosine kinase substrate isoform X1 [KO:K12182]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]

LOW QUALITY PROTEIN: V-type proton ATPase catalytic subunit A-like [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B [KO:K02147]

V-type proton ATPase subunit C [KO:K02148]

V-type proton ATPase subunit D-like [KO:K02149]

V-type proton ATPase subunit D 1 [KO:K02149]

V-type proton ATPase subunit E [KO:K02150]

V-type proton ATPase subunit F-like [KO:K02151]

V-type proton ATPase subunit F 1 [KO:K02151]

V-type proton ATPase subunit G [KO:K02152]

V-type proton ATPase subunit e-like [KO:K02153]

V-type proton ATPase subunit e [KO:K02153]

V-type proton ATPase subunit e 2-like [KO:K02153]

V-type proton ATPase 116 kDa subunit a1 isoform X1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a1-like [KO:K02154]

V-type proton ATPase 116 kDa subunit a [KO:K02154]

V-type proton ATPase subunit d 1 [KO:K02146]

V-type proton ATPase subunit H isoform X1 [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]

V-type proton ATPase 21 kDa proteolipid subunit-like [KO:K03661]

V-type proton ATPase subunit S1-like [KO:K03662]

V-type proton ATPase subunit S1 [KO:K03662]

ras-related protein rab7 [KO:K07897]

LOW QUALITY PROTEIN: dynein heavy chain, cytoplasmic [KO:K10413]

LOW QUALITY PROTEIN: cytoplasmic dynein 2 heavy chain 1 [KO:K10414]

cytoplasmic dynein 1 intermediate chain isoform X1 [KO:K10415]

cytoplasmic dynein 1 light intermediate chain 2-like isoform X1 [KO:K10416]

cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]

tubulin alpha-3 chain [KO:K07374]

tubulin alpha-1 chain [KO:K07374]

tubulin alpha-2/alpha-4 chain [KO:K07374]

tubulin alpha-4 chain [KO:K07374]

tubulin beta-1 chain [KO:K07375]

tubulin beta-3 chain [KO:K07375]

probable tubulin beta chain CG32396 [KO:K07375]

tubulin beta chain isoform X1 [KO:K07375]

tubulin beta-2 chain-like [KO:K07375]

tubulin beta-2 chain [KO:K07375]

tubulin beta-2 chain-like [KO:K07375]

lysosome-associated membrane glycoprotein 1 [KO:K06528]

putative 1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]

nitric oxide synthase [KO:K13240] [EC:1.14.13.39]

cathepsin L [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha [KO:K10956]

protein transport protein Sec61 subunit beta [KO:K09481]

protein transport protein Sec61 gamma-2 subunit [KO:K07342]

calreticulin [KO:K08057]

calnexin isoform X1 [KO:K08054]

integrin beta-PS isoform X1 [KO:K05719]

cartilage oligomeric matrix protein isoform X1 [KO:K04659]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-related protein Rac1 [KO:K04392]

ras-like GTP-binding protein RhoL isoform X1 [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Lysosome

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system