KEGG PATHWAY: gpb00790

PATHWAY: gpb00790

Entry

gpb00790                    Pathway

Name

Folate biosynthesis - Gamma proteobacterium HdN1

Class

Metabolism; Metabolism of cofactors and vitamins

Pathway map

gpb00790

Folate biosynthesis

Module

gpb_M00126

Tetrahydrofolate biosynthesis, GTP => THF [PATH:gpb00790]

gpb_M00880

Molybdenum cofactor biosynthesis, GTP => molybdenum cofactor [PATH:gpb00790]

Other DBs

GO:

0046656

Organism

Gamma proteobacterium HdN1 [GN:gpb]

Gene

HDN1F_29370

folE; GTP cyclohydrolase I [KO:K01495] [EC:3.5.4.16]

HDN1F_24260

GTP cyclohydrolase I, FolE [KO:K01495] [EC:3.5.4.16]

HDN1F_29230

Conserved hypothetical protein [KO:K09007] [EC:3.5.4.16]

HDN1F_32050

phoD; Phosphodiesterase I [KO:K01113] [EC:3.1.3.1]

HDN1F_27600

folB; Dihydroneopterin aldolase [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]

HDN1F_20020

folK1; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [KO:K00950] [EC:2.7.6.3]

HDN1F_27610

folK2; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [KO:K00950] [EC:2.7.6.3]

HDN1F_04330

hppK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase [KO:K00950] [EC:2.7.6.3]

HDN1F_08590

dhpS; Dihydropteroate synthase (FolP) [KO:K00796] [EC:2.5.1.15]

HDN1F_01410

dfrA; Dihydrofolate reductase (FolA) [KO:K00287] [EC:1.5.1.3]

HDN1F_16310

folC; Folylpolyglutamate synthase [KO:K11754] [EC:6.3.2.12 6.3.2.17]

HDN1F_25420

ribAB; Riboflavin biosynthesis bifunctional protein : GTP cyclohydrolase ii and 3,4-dihydroxy-2-butanone-4-phosphate synthase [KO:K14652] [EC:4.1.99.12 3.5.4.25]

HDN1F_16830

pabB; similar to para-aminobenzoate synthase component I [KO:K01665] [EC:2.6.1.85]

HDN1F_33330

pabC; 4-amino-4-deoxychorismate lyase [KO:K02619] [EC:4.1.3.38]

HDN1F_04320

oxidoreductase, short chain dehydrogenase/reductase family [KO:K13938] [EC:1.5.1.50 1.5.1.3]

HDN1F_20710

phhB; pterin-4-alpha-carbinolamine dehydratase [KO:K01724] [EC:4.2.1.96]

HDN1F_32860

Putative radical activating enzyme [KO:K10026] [EC:4.3.99.3]

HDN1F_32870

exsB; ExsB protein [KO:K06920] [EC:6.3.4.20]

HDN1F_29540

queF; 7-cyano-7-deazaguanine reductase [KO:K06879] [EC:1.7.1.13]

HDN1F_13290

moaA; Molybdenum cofactor biosynthesis protein A [KO:K03639] [EC:4.1.99.22]

HDN1F_34460

moaC; Molybdenum cofactor biosynthesis protein C [KO:K03637] [EC:4.6.1.17]

HDN1F_34480

moaE; Molybdenum cofactor biosynthesis protein E [KO:K03635] [EC:2.8.1.12]

HDN1F_09480

mog; Molybdopterin biosynthesis Mog protein [KO:K03638] [EC:2.7.7.75]

HDN1F_09490

moeA; Molybdopterin binding domain [KO:K03750] [EC:2.10.1.1]

HDN1F_28480

hypothetical protein [KO:K03752] [EC:2.7.7.77]

Compound

C00044

GTP

C00101

Tetrahydrofolate

C00119

5-Phospho-alpha-D-ribose 1-diphosphate

C00156

4-Hydroxybenzoate

C00251

Chorismate

C00266

Glycolaldehyde

C00268

Dihydrobiopterin

C00272

Tetrahydrobiopterin

C00415

Dihydrofolate

C00504

Folate

C00568

4-Aminobenzoate

C00835

Sepiapterin

C00921

Dihydropteroate

C01217

5,6,7,8-Tetrahydromethanopterin

C01300

6-(Hydroxymethyl)-7,8-dihydropterin

C01304

2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one

C02587

Pyrimidodiazepine

C02953

7,8-Dihydrobiopterin

C03541

THF-polyglutamate

C03684

6-Pyruvoyltetrahydropterin

C04244

6-Lactoyl-5,6,7,8-tetrahydropterin

C04807

6-Hydroxymethyl-7,8-dihydropterin diphosphate

C04874

7,8-Dihydroneopterin

C04895

7,8-Dihydroneopterin 3'-triphosphate

C05922

Formamidopyrimidine nucleoside triphosphate

C05923

2,5-Diaminopyrimidine nucleoside triphosphate

C05924

Molybdopterin

C05925

Dihydroneopterin phosphate

C05926

Neopterin

C05927

7,8-Dihydromethanopterin

C06148

2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine

C06313

Biopterin

C09332

THF-L-glutamate

C11355

4-Amino-4-deoxychorismate

C15522

4a-Hydroxytetrahydrobiopterin

C15996

7-Cyano-7-carbaguanine

C16675

7-Aminomethyl-7-carbaguanine

C18237

Molybdoenzyme molybdenum cofactor

C18239

Precursor Z

C18802

Tetrahydrosarcinapterin

C19848

Adenylated molybdopterin

C19871

Guanylyl molybdenum cofactor

C20239

6-Carboxy-5,6,7,8-tetrahydropterin

C20248

7-Carboxy-7-carbaguanine

C20264

L-threo-Tetrahydrobiopterin

C20559

4-(beta-D-Ribofuranosyl)aniline 5'-phosphate

C20562

N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate

C20566

7,8-Dihydroneopterin 2'-phosphate

C20567

7,8-Dihydroneopterin 2',3'-cyclic phosphate

C21007

5,6,7,8-Tetrahydromonapterin

C21008

7,8-Dihydromonapterin

C21065

7,8-Dihydroxanthopterin

C21094

7,8-Dihydromonapterin 3'-triphosphate

C21107

4-(beta-D-Ribofuranosyl)phenol 5'-phosphate

C21310

(8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate

C21485

Cytidylyl molybdenum cofactor

C21486

Thio-molybdenum cofactor

C21640

6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin

Reference

Authors

Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).

Title

[Cellular Functions and Metabolic Maps] (In Japanese)

Journal

Tokyo Kagaku Dojin (1997)

Reference

PMID:19675644

Authors

Schwarz G, Mendel RR, Ribbe MW

Title

Molybdenum cofactors, enzymes and pathways.

Journal

Nature 460:839-47 (2009)
DOI:10.1038/nature08302

Reference

PMID:16632608

Authors

Hanzelmann P, Schindelin H

Title

Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.

Journal

Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103

Reference

PMID:18092812

Authors

Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H

Title

Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.

Journal

Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g

Reference

PMID:12571226

Authors

Wuebbens MM, Rajagopalan KV

Title

Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.

Journal

J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200

Reference

PMID:21867484