KEGG   PATHWAY: hbr03008
Entry
hbr03008                    Pathway                                
Name
Ribosome biogenesis in eukaryotes - Hevea brasiliensis (rubber tree)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
hbr03008  Ribosome biogenesis in eukaryotes
hbr03008

Organism
Hevea brasiliensis (rubber tree) [GN:hbr]
Gene
110663937  putative casein kinase II subunit beta-4 [KO:K03115]
110657496  casein kinase II subunit beta-1-like isoform X1 [KO:K03115]
110639399  casein kinase II subunit beta-1-like isoform X1 [KO:K03115]
110635829  putative casein kinase II subunit beta-4 [KO:K03115]
110650130  casein kinase II subunit alpha-2-like isoform X1 [KO:K03097] [EC:2.7.11.1]
110651536  casein kinase II subunit alpha-2-like [KO:K03097] [EC:2.7.11.1]
110665131  casein kinase II subunit alpha-2 isoform X1 [KO:K03097] [EC:2.7.11.1]
110638217  casein kinase II subunit alpha-4, chloroplastic isoform X1 [KO:K03097] [EC:2.7.11.1]
110638242  casein kinase II subunit alpha-4, chloroplastic-like [KO:K03097] [EC:2.7.11.1]
110634354  nucleolar protein 6 isoform X1 [KO:K14544]
110656033  trichohyalin-like isoform X1 [KO:K14545]
110664602  ribosomal RNA-processing protein 7 homolog A-like isoform X1 [KO:K14545]
110670862  trichohyalin-like isoform X1 [KO:K14545]
110646964  WD repeat-containing protein 43-like isoform X1 [KO:K14546]
110660267  WD repeat-containing protein 43 [KO:K14546]
110635907  WD repeat-containing protein 43-like [KO:K14546]
110671356  U3 small nucleolar RNA-associated protein 4-like [KO:K14548]
110665475  protein SLOW WALKER 1 [KO:K14549]
110645257  uncharacterized protein At3g06530 isoform X1 [KO:K14550]
110667107  WD repeat-containing protein 75 [KO:K14552]
110667118  WD repeat-containing protein 75-like [KO:K14552]
110659651  U3 small nucleolar RNA-associated protein 18 homolog [KO:K14553]
110638728  LOW QUALITY PROTEIN: WD repeat-containing protein 36 [KO:K14554]
110647190  transducin beta-like protein 3 isoform X1 [KO:K14555]
110666271  WD repeat-containing protein 3 [KO:K14556]
110633343  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
110635904  periodic tryptophan protein 2-like [KO:K14558]
110642810  U3 small nucleolar ribonucleoprotein protein MPP10 isoform X1 [KO:K14559]
110663683  U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560]
110663691  U3 small nucleolar ribonucleoprotein protein IMP3-like isoform X1 [KO:K14560]
110666568  U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
110666572  U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
110658168  mediator of RNA polymerase II transcription subunit 36a-like isoform X1 [KO:K14563] [EC:2.1.1.-]
110662185  mediator of RNA polymerase II transcription subunit 36a-like [KO:K14563] [EC:2.1.1.-]
110665275  nucleolar protein 56-like [KO:K14564]
110671875  nucleolar protein 56-like isoform X1 [KO:K14564]
110672931  probable nucleolar protein 5-2 isoform X1 [KO:K14565]
110633488  probable nucleolar protein 5-1 [KO:K14565]
110651533  NHP2-like protein 1 [KO:K12845]
110642912  NHP2-like protein 1 [KO:K12845]
110637952  H/ACA ribonucleoprotein complex subunit 4-like isoform X1 [KO:K11131] [EC:5.4.99.-]
110642950  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
110652734  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
110640577  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
110652315  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
110659096  putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 [KO:K11128]
110652583  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
110648538  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
110654274  H/ACA ribonucleoprotein complex subunit 3-like protein [KO:K11130]
110632434  rRNA-processing protein FCF1 homolog [KO:K14566]
110636473  rRNA-processing protein FCF1 homolog [KO:K14566]
110637545  uncharacterized protein C57A7.06 [KO:K14567]
110667159  ribosomal RNA small subunit methyltransferase nep-1-like isoform X1 [KO:K14568] [EC:2.1.1.260]
110667161  ribosomal RNA small subunit methyltransferase mra1-like [KO:K14568] [EC:2.1.1.260]
110666882  ribosome biogenesis protein BMS1 homolog isoform X1 [KO:K14569]
110669239  RNA cytidine acetyltransferase 1-like [KO:K14521] [EC:2.3.1.-]
110643293  RNA cytidine acetyltransferase 1-like [KO:K14521] [EC:2.3.1.-]
110632640  RNA cytidine acetyltransferase 1-like isoform X1 [KO:K14521] [EC:2.3.1.-]
110660281  probable RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
110647913  uncharacterized protein LOC110647913 isoform X1 [KO:K01164] [EC:3.1.26.5]
110655030  uncharacterized protein LOC110655030 isoform X1 [KO:K03538] [EC:3.1.26.5]
110644413  probable ribonuclease P/MRP protein subunit POP5 isoform X1 [KO:K03537] [EC:3.1.26.5]
110673734  probable ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
110651306  uncharacterized protein LOC110651306 isoform X1 [KO:K03539] [EC:3.1.26.5]
110665362  uncharacterized protein LOC110665362 [KO:K03539] [EC:3.1.26.5]
110635638  probable ribonuclease P protein subunit 3 [KO:K03539] [EC:3.1.26.5]
110669086  small RNA degrading nuclease 3-like isoform X1 [KO:K14570] [EC:3.1.-.-]
110673563  small RNA degrading nuclease 3-like isoform X1 [KO:K14570] [EC:3.1.-.-]
110641397  small RNA degrading nuclease 5 isoform X1 [KO:K14570] [EC:3.1.-.-]
110670345  oligoribonuclease isoform X1 [KO:K13288] [EC:3.1.-.-]
110659152  oligoribonuclease-like [KO:K13288] [EC:3.1.-.-]
110673776  5'-3' exoribonuclease 3-like isoform X1 [KO:K12619] [EC:3.1.13.-]
110666356  5'-3' exoribonuclease 3-like isoform X1 [KO:K12619] [EC:3.1.13.-]
110649164  nucleolar GTP-binding protein 1 isoform X1 [KO:K06943]
110638991  nucleolar GTP-binding protein 1-like [KO:K06943]
110633847  nucleolar GTP-binding protein 1-like [KO:K06943]
110641969  nuclear/nucleolar GTPase 2-like [KO:K14537]
110641973  nuclear/nucleolar GTPase 2-like [KO:K14537]
110643223  nuclear/nucleolar GTPase 2-like [KO:K14537]
110671809  guanine nucleotide-binding protein-like NSN1 [KO:K14538]
110633324  guanine nucleotide-binding protein-like NSN1 [KO:K14538]
110636303  cell division control protein 48 homolog C [KO:K14571]
110641539  midasin isoform X1 [KO:K14572]
110647777  RNA-binding protein 28 [KO:K14573]
110644365  RNA-binding protein NOB1-like [KO:K11883]
110643519  LOW QUALITY PROTEIN: RNA-binding protein NOB1-like [KO:K11883]
110657386  GTP-binding nuclear protein Ran-3-like [KO:K07936]
110654066  GTP-binding nuclear protein Ran-3 isoform X1 [KO:K07936]
110637327  GTP-binding nuclear protein Ran-3 [KO:K07936]
110636051  GTP-binding nuclear protein Ran-3-like [KO:K07936]
110660407  protein EXPORTIN 1A-like isoform X1 [KO:K14290]
110667676  protein EXPORTIN 1A [KO:K14290]
110647524  60S ribosomal export protein NMD3-like [KO:K07562]
110637179  60S ribosomal export protein NMD3-like [KO:K07562]
110637180  60S ribosomal export protein NMD3-like [KO:K07562]
110634198  60S ribosomal export protein NMD3-like isoform X1 [KO:K07562]
110669897  eukaryotic translation initiation factor 6-2-like [KO:K03264]
110669851  eukaryotic translation initiation factor 6-2-like [KO:K03264]
110672877  eukaryotic translation initiation factor 6-2 isoform X1 [KO:K03264]
110661414  ribosome maturation protein SBDS isoform X1 [KO:K14574]
110671285  elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
110637260  GTPase LSG1-2 [KO:K14539] [EC:3.6.1.-]
110667324  adenylate kinase isoenzyme 6 homolog [KO:K18532] [EC:2.7.4.3]
110671896  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
110651754  serine/threonine-protein kinase rio2-like isoform X1 [KO:K07179] [EC:2.7.11.1]
110637278  serine/threonine-protein kinase rio2-like [KO:K07179] [EC:2.7.11.1]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
hbr03010  Ribosome
KO pathway
ko03008   
LinkDB

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