KEGG   PATHWAY: htb00260
Entry
htb00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Hymenobacter tibetensis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
htb00260  Glycine, serine and threonine metabolism
htb00260

Module
htb_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:htb00260]
htb_M00621  Glycine cleavage system [PATH:htb00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Hymenobacter tibetensis [GN:htb]
Gene
MTX78_06275  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MTX78_07855  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MTX78_10030  aspartate kinase [KO:K00928] [EC:2.7.2.4]
MTX78_22175  thrA; bifunctional aspartate kinase/homoserine dehydrogenase I [KO:K12524] [EC:2.7.2.4 1.1.1.3]
MTX78_20125  aspartate-semialdehyde dehydrogenase [KO:K00133] [EC:1.2.1.11]
MTX78_20195  homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
MTX78_22180  homoserine kinase [KO:K00872] [EC:2.7.1.39]
MTX78_22185  thrC; threonine synthase [KO:K01733] [EC:4.2.3.1]
MTX78_04260  threonine synthase [KO:K01733] [EC:4.2.3.1]
MTX78_15670  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K01620] [EC:4.1.2.48]
MTX78_22815  serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
MTX78_21920  gpmI; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [KO:K15633] [EC:5.4.2.12]
MTX78_09750  phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MTX78_16825  serA; phosphoglycerate dehydrogenase [KO:K00058] [EC:1.1.1.95 1.1.1.399]
MTX78_08415  aminotransferase class V-fold PLP-dependent enzyme [KO:K00831] [EC:2.6.1.52]
MTX78_10070  SDR family NAD(P)-dependent oxidoreductase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
MTX78_11175  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00639] [EC:2.3.1.29]
MTX78_00915  kbl; glycine C-acetyltransferase [KO:K00639] [EC:2.3.1.29]
MTX78_01210  gcvP; aminomethyl-transferring glycine dehydrogenase [KO:K00281] [EC:1.4.4.2]
MTX78_17380  gcvT; glycine cleavage system aminomethyltransferase GcvT [KO:K00605] [EC:2.1.2.10]
MTX78_06480  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MTX78_01325  lpdA; dihydrolipoyl dehydrogenase [KO:K00382] [EC:1.8.1.4]
MTX78_20645  gcvH; glycine cleavage system protein GcvH [KO:K02437]
MTX78_02910  CDP-alcohol phosphatidyltransferase family protein [KO:K17103] [EC:2.7.8.8]
MTX78_11530  sdaAB; L-serine ammonia-lyase, iron-sulfur-dependent subunit beta [KO:K01752] [EC:4.3.1.17]
MTX78_02040  sdaAA; L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha [KO:K01752] [EC:4.3.1.17]
MTX78_05675  ilvA; threonine ammonia-lyase IlvA [KO:K01754] [EC:4.3.1.19]
MTX78_08710  trpA; tryptophan synthase subunit alpha [KO:K01695] [EC:4.2.1.20]
MTX78_08705  trpB; tryptophan synthase subunit beta [KO:K01696] [EC:4.2.1.20]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
htb00010  Glycolysis / Gluconeogenesis
htb00020  Citrate cycle (TCA cycle)
htb00230  Purine metabolism
htb00250  Alanine, aspartate and glutamate metabolism
htb00270  Cysteine and methionine metabolism
htb00290  Valine, leucine and isoleucine biosynthesis
htb00300  Lysine biosynthesis
htb00330  Arginine and proline metabolism
htb00460  Cyanoamino acid metabolism
htb00470  D-Amino acid metabolism
htb00564  Glycerophospholipid metabolism
htb00600  Sphingolipid metabolism
htb00620  Pyruvate metabolism
htb00630  Glyoxylate and dicarboxylate metabolism
htb00640  Propanoate metabolism
htb00680  Methane metabolism
htb00860  Porphyrin metabolism
htb00920  Sulfur metabolism
KO pathway
ko00260   
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