KEGG   PATHWAY: hvi00982
Entry
hvi00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Homalodisca vitripennis (glassy-winged sharpshooter)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
hvi00982  Drug metabolism - cytochrome P450
hvi00982

Organism
Homalodisca vitripennis (glassy-winged sharpshooter) [GN:hvi]
Gene
124357962  glutathione S-transferase D5-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124368352  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124358654  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124369242  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124371224  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361800  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361941  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124361943  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361944  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124361945  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124373887  LOW QUALITY PROTEIN: glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124363353  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124353840  microsomal glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
124366181  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124355869  glutathione S-transferase theta-2-like [KO:K00799] [EC:2.5.1.18]
124356706  microsomal glutathione S-transferase 3-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367172  glutathione S-transferase 1-1-like [KO:K00799] [EC:2.5.1.18]
124367503  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
124367723  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367830  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367831  glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
124367832  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367833  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124367834  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
124359197  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359713  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359714  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124372366  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124373429  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124373430  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124374570  hematopoietic prostaglandin D synthase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124355503  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366172  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366173  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366369  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366374  glutathione S-transferase-like isoform X1 [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366381  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366382  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366747  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124366896  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367539  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367541  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367542  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124367544  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
124359338  alcohol dehydrogenase class-3 chain L-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
124359339  alcohol dehydrogenase class-3-like [KO:K00121] [EC:1.1.1.284 1.1.1.1]
124354901  aldehyde dehydrogenase, dimeric NADP-preferring [KO:K00129] [EC:1.2.1.5]
124369783  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124369824  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124359966  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124370565  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124372159  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124372952  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124373602  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124362431  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124374548  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124352719  LOW QUALITY PROTEIN: UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124352720  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124352721  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124353662  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124353979  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354323  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354733  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354735  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354736  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354942  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354943  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354945  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354947  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354948  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124354958  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124354959  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124354963  UDP-glucosyltransferase 2-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124365848  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124365857  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124365858  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124355454  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355520  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355521  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124365982  UDP-glycosyltransferase UGT5-like [KO:K00699] [EC:2.4.1.17]
124366202  UDP-glycosyltransferase UGT5-like isoform X1 [KO:K00699] [EC:2.4.1.17]
124355879  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124355885  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356360  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356361  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
124356362  UDP-glucosyltransferase 2-like [KO:K00699] [EC:2.4.1.17]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
LinkDB

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