KEGG   PATHWAY: kot02020
Entry
kot02020                    Pathway                                
Name
Two-component system - Kosakonia sp. CCTCC M2018092
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
kot02020  Two-component system
kot02020

Other DBs
GO: 0000160
Organism
Kosakonia sp. CCTCC M2018092 [GN:kot]
Gene
EH164_17300  phoR; phosphate regulon sensor histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
EH164_17305  phoB; phosphate response regulator transcription factor PhoB [KO:K07657]
EH164_17370  alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
EH164_22460  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
EH164_13575  phoQ; two-component system sensor histidine kinase PhoQ [KO:K07637] [EC:2.7.13.3]
EH164_13570  phoP; two-component system response regulator PhoP [KO:K07660]
EH164_13045  phosphatase PAP2 family protein [KO:K09474] [EC:3.1.3.2]
EH164_01535  envZ; two-component system sensor histidine kinase EnvZ [KO:K07638] [EC:2.7.13.3]
EH164_01540  DNA-binding response regulator [KO:K07659]
EH164_07335  ompC; porin [KO:K09475]
EH164_14535  porin [KO:K09476]
EH164_21930  cpxA; envelope stress sensor histidine kinase CpxA [KO:K07640] [EC:2.7.13.3]
EH164_21925  cpxR; envelope stress response regulator transcription factor CpxR [KO:K07662]
EH164_02795  mzrA; EnvZ/OmpR regulon moderator MzrA [KO:K25864]
EH164_12355  rstB; two-component system sensor histidine kinase RstB [KO:K07639] [EC:2.7.13.3]
EH164_12350  rstA; two-component system response regulator RstA [KO:K07661]
EH164_18245  degP; serine endoprotease DegP [KO:K04771] [EC:3.4.21.107]
EH164_18940  creC; two-component system sensor histidine kinase CreC [KO:K07641] [EC:2.7.13.3]
EH164_18945  creB; two-component system response regulator CreB [KO:K07663]
EH164_07915  baeS; two-component system sensor histidine kinase BaeS [KO:K07642] [EC:2.7.13.3]
EH164_07910  baeR; two-component system response regulator BaeR [KO:K07664]
EH164_07935  mdtA; MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit [KO:K07799]
EH164_07930  mdtB; MdtB/MuxB family multidrug efflux RND transporter permease subunit [KO:K07788]
EH164_07925  mdtC; multidrug transporter subunit MdtC [KO:K07789]
EH164_07920  MFS transporter [KO:K18326]
EH164_06130  acrD; multidrug efflux RND transporter permease AcrD [KO:K18324]
EH164_15415  pmrB; two-component system sensor histidine kinase PmrB [KO:K07643] [EC:2.7.13.3]
EH164_15410  two-component system response regulator PmrA [KO:K07771]
EH164_01270  UDP-4-amino-4-deoxy-L-arabinose aminotransferase [KO:K07806] [EC:2.6.1.87]
EH164_16085  copper-binding protein [KO:K07810]
EH164_16075  efflux RND transporter periplasmic adaptor subunit [KO:K07798]
EH164_16070  efflux RND transporter permease subunit [KO:K07787]
EH164_03080  qseC; two-component system sensor histidine kinase QseC [KO:K07645] [EC:2.7.13.3]
EH164_03085  qseB; two-component system response regulator QseB [KO:K07666]
EH164_04940  flhD; flagellar transcriptional regulator FlhD [KO:K02403]
EH164_09250  flhD; flagellar transcriptional regulator FlhD [KO:K02403]
EH164_05105  flhD; flagellar transcriptional regulator FlhD [KO:K02403]
EH164_04945  flhC; flagellar transcriptional regulator FlhC [KO:K02402]
EH164_09255  flhC; flagellar transcriptional regulator FlhC [KO:K02402]
EH164_05100  flhC; flagellar transcriptional regulator FlhC [KO:K02402]
EH164_04970  FliC/FljB family flagellin [KO:K02406]
EH164_12835  flagellin [KO:K02406]
EH164_10220  flagellin FliC [KO:K02406]
EH164_08705  flagellin FliC [KO:K02406]
EH164_08710  flagellin FliC [KO:K02406]
EH164_08715  flagellin FliC [KO:K02406]
EH164_08720  flagellin FliC [KO:K02406]
EH164_04935  RNA polymerase sigma factor FliA [KO:K02405]
EH164_19260  FliA/WhiG family RNA polymerase sigma factor [KO:K02405]
EH164_08790  RNA polymerase sigma factor FliA [KO:K02405]
EH164_04950  motA; flagellar motor stator protein MotA [KO:K02556]
EH164_09260  motA; flagellar motor stator protein MotA [KO:K02556]
EH164_15765  kdbD; two-component system sensor histidine kinase KdbD [KO:K07646] [EC:2.7.13.3]
EH164_15770  kdpE; two-component system response regulator KdpE [KO:K07667]
EH164_15750  kdpA; potassium-transporting ATPase subunit KdpA [KO:K01546]
EH164_15755  kdpB; K(+)-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
EH164_15760  kdpC; potassium-transporting ATPase subunit KdpC [KO:K01548]
EH164_15745  K(+)-transporting ATPase subunit F [KO:K01545]
EH164_02360  arcB; aerobic respiration two-component sensor histidine kinase ArcB [KO:K07648] [EC:2.7.13.3]
EH164_18930  arcA; two-component system response regulator ArcA [KO:K07773]
EH164_00005  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
EH164_16390  TonB-dependent siderophore receptor [KO:K19611]
EH164_03355  response regulator [KO:K07702]
EH164_03375  citC; [citrate (pro-3S)-lyase] ligase [KO:K01910] [EC:6.2.1.22]
EH164_03380  citD; citrate lyase acyl carrier protein [KO:K01646]
EH164_03385  citE; citrate (pro-3S)-lyase subunit beta [KO:K01644] [EC:4.1.3.34]
EH164_03390  citF; citrate lyase subunit alpha [KO:K01643] [EC:2.8.3.10]
EH164_03395  citX; citrate lyase holo-[acyl-carrier protein] synthase [KO:K05964] [EC:2.7.7.61]
EH164_03400  citG; triphosphoribosyl-dephospho-CoA synthase CitG [KO:K05966] [EC:2.4.2.52]
EH164_10040  dcuS; two-component system sensor histidine kinase DcuS [KO:K07701] [EC:2.7.13.3]
EH164_10035  dcuR; two-component system response regulator DcuR [KO:K07703]
EH164_11805  NAD-dependent malic enzyme [KO:K00027] [EC:1.1.1.38]
EH164_10530  narX; nitrate/nitrite two-component system sensor histidine kinase NarX [KO:K07673] [EC:2.7.13.3]
EH164_10525  narL; two-component system response regulator NarL [KO:K07684]
EH164_10540  nitrate reductase subunit alpha [KO:K00370] [EC:1.7.5.1 1.7.99.-]
EH164_10545  narH; nitrate reductase subunit beta [KO:K00371] [EC:1.7.5.1 1.7.99.-]
EH164_10555  narI; respiratory nitrate reductase subunit gamma [KO:K00374] [EC:1.7.5.1 1.7.99.-]
EH164_10550  narJ; nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
EH164_11525  fdnG; formate dehydrogenase-N subunit alpha [KO:K08348] [EC:1.17.5.3]
EH164_11845  fdnG; formate dehydrogenase-N subunit alpha [KO:K08348] [EC:1.17.5.3]
EH164_11530  fdxH; formate dehydrogenase subunit beta [KO:K08349]
EH164_11840  fdxH; formate dehydrogenase subunit beta [KO:K08349]
EH164_11535  formate dehydrogenase-N subunit gamma [KO:K08350]
EH164_11835  formate dehydrogenase-N subunit gamma [KO:K08350]
EH164_20235  fumarate reductase (quinol) flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
EH164_20240  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00245] [EC:1.3.5.1]
EH164_20245  frdC; fumarate reductase subunit FrdC [KO:K00246]
EH164_20250  frdD; fumarate reductase subunit FrdD [KO:K00247]
EH164_18080  rcsF; Rcs stress response system protein RcsF [KO:K06080]
EH164_07320  rcsC; two-component system sensor histidine kinase RcsC [KO:K07677] [EC:2.7.13.3]
EH164_07330  rcsD; phosphotransferase RcsD [KO:K07676] [EC:2.7.13.3]
EH164_08600  rcsA; transcriptional regulator RcsA [KO:K07781]
EH164_07325  rcsB; transcriptional regulator RcsB [KO:K07687]
EH164_17215  DNA-binding response regulator [KO:K07687]
EH164_17240  response regulator [KO:K07687]
EH164_17880  barA; two-component sensor histidine kinase BarA [KO:K07678] [EC:2.7.13.3]
EH164_08830  uvrY; two-component system response regulator UvrY [KO:K07689]
EH164_08820  sdiA; transcriptional regulator SdiA [KO:K07782]
EH164_04610  csrA; carbon storage regulator [KO:K03563]
EH164_16460  fimZ; fimbriae biosynthesis transcriptional regulator FimZ [KO:K07688]
EH164_09300  SCPU domain-containing protein [KO:K27078]
EH164_09285  SCPU domain-containing protein [KO:K27078]
EH164_09280  SCPU domain-containing protein [KO:K27078]
EH164_09290  molecular chaperone [KO:K07346]
EH164_16480  fimC; molecular chaperone FimC [KO:K07346]
EH164_19560  molecular chaperone [KO:K07346]
EH164_19555  fimbrial biogenesis outer membrane usher protein [KO:K07347]
EH164_09295  fimbrial biogenesis outer membrane usher protein [KO:K07347]
EH164_16475  fimD; outer membrane usher protein FimD [KO:K07347]
EH164_18225  glnD; bifunctional uridylyltransferase/uridylyl-removing protein GlnD [KO:K00990] [EC:2.7.7.59]
EH164_05650  nitrogen regulatory protein P-II [KO:K04751]
EH164_22100  nitrogen regulation protein NR(II) [KO:K07708] [EC:2.7.13.3]
EH164_22105  nitrogen regulation protein NR(I) [KO:K07712]
EH164_22095  glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
EH164_03890  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
EH164_00980  dicarboxylate/amino acid:cation symporter [KO:K11103]
EH164_02395  RNA polymerase factor sigma-54 [KO:K03092]
EH164_05635  two component system sensor histidine kinase QseE/GlrK [KO:K07711] [EC:2.7.13.3]
EH164_05645  glrR; two-component system response regulator GlrR [KO:K07715]
EH164_09310  cheR; protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
EH164_05020  methyltransferase domain-containing protein [KO:K00575] [EC:2.1.1.80]
EH164_13125  chemotaxis protein [KO:K03406]
EH164_20065  methyl-accepting chemotaxis protein [KO:K03406]
EH164_13485  HAMP domain-containing protein [KO:K03406]
EH164_04770  HAMP domain-containing protein [KO:K03406]
EH164_13420  methyl-accepting chemotaxis protein [KO:K03406]
EH164_01215  methyl-accepting chemotaxis protein [KO:K03406]
EH164_05900  transcription factor [KO:K03406]
EH164_05905  methyl-accepting chemotaxis protein [KO:K03406]
EH164_06350  methyl-accepting chemotaxis protein [KO:K03406]
EH164_10505  methyl-accepting chemotaxis protein [KO:K03406]
EH164_03180  HAMP domain-containing protein [KO:K03406]
EH164_11960  methyl-accepting chemotaxis protein [KO:K03406]
EH164_04930  HAMP domain-containing protein [KO:K05874]
EH164_19995  HAMP domain-containing protein [KO:K05874]
EH164_19160  methyl-accepting chemotaxis protein [KO:K05874]
EH164_12010  HAMP domain-containing protein [KO:K05874]
EH164_19885  HAMP domain-containing protein [KO:K05874]
EH164_02865  HAMP domain-containing protein [KO:K05875]
EH164_09305  methyl-accepting chemotaxis protein II [KO:K05875]
EH164_20085  HAMP domain-containing protein [KO:K05875]
EH164_04240  HAMP domain-containing protein [KO:K05875]
EH164_11500  HAMP domain-containing protein [KO:K05875]
EH164_11255  HAMP domain-containing protein [KO:K05876]
EH164_19425  HAMP domain-containing protein [KO:K05876]
EH164_02860  PAS domain S-box protein [KO:K03776]
EH164_11790  PAS domain S-box protein [KO:K03776]
EH164_04965  cheW; chemotaxis protein CheW [KO:K03408]
EH164_09275  cheW; chemotaxis protein CheW [KO:K03408]
EH164_09270  cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
EH164_09320  cheY; chemotaxis protein CheY [KO:K03413]
EH164_05010  cheY; chemotaxis protein CheY [KO:K03413]
EH164_09315  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
EH164_05015  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
EH164_07200  chemotaxis signal transduction protein CheV [KO:K03415]
EH164_22415  response regulator [KO:K14978]
EH164_22410  two component system response regulator [KO:K14979]
EH164_15955  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
EH164_15950  gltK; glutamate/aspartate ABC transporter permease GltK [KO:K10002]
EH164_15945  amino acid ABC transporter permease [KO:K10003]
EH164_15940  amino acid ABC transporter substrate-binding protein [KO:K10001]
EH164_01730  cAMP-activated global transcriptional regulator CRP [KO:K10914]
EH164_10825  enoyl-CoA hydratase [KO:K13816]
EH164_12005  glutaminase [KO:K01425] [EC:3.5.1.2]
EH164_15655  cydA; cytochrome bd-I ubiquinol oxidase subunit CydA [KO:K00425] [EC:7.1.1.7]
EH164_10120  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
EH164_11400  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
EH164_15650  cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
EH164_10125  cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
EH164_11395  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
EH164_15645  cydX; cytochrome bd-I oxidase subunit CydX [KO:K00424] [EC:7.1.1.7]
EH164_03010  tolC; outer membrane channel protein TolC [KO:K12340]
EH164_07985  polysaccharide export protein [KO:K01991]
EH164_07990  low molecular weight protein-tyrosine-phosphatase Wzb [KO:K25307] [EC:3.1.3.48]
EH164_07995  tyrosine-protein kinase Wzc [KO:K16692] [EC:2.7.10.3]
EH164_21545  UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) [KO:K01791] [EC:5.1.3.14]
EH164_21540  UDP-N-acetyl-D-mannosamine dehydrogenase [KO:K02472] [EC:1.1.1.336]
EH164_03210  pectinesterase A [KO:K01051] [EC:3.1.1.11]
EH164_15470  putative acyl-CoA thioester hydrolase [KO:K01051] [EC:3.1.1.11]
EH164_04865  flgM; flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
EH164_13910  flgM; anti-sigma-28 factor FlgM [KO:K02398]
EH164_19275  flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
PMID:15601704
  Authors
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Related
pathway
kot00190  Oxidative phosphorylation
kot00550  Peptidoglycan biosynthesis
kot00910  Nitrogen metabolism
kot02030  Bacterial chemotaxis
kot02040  Flagellar assembly
kot03070  Bacterial secretion system
KO pathway
ko02020   
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