Entry Name Valine, leucine and isoleucine biosynthesis - Klebsiella pneumoniae Kp52.145
Class Metabolism; Amino acid metabolismBRITE hierarchy
Pathway map kpnk00290 Valine, leucine and isoleucine biosynthesis
Ortholog table Module kpnk_M00019 Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:kpnk00290 ]
Other DBs Organism Klebsiella pneumoniae Kp52.145 [GN:
kpnk ]
Gene BN49_3396 tdcB; highly similar to threonine dehydratase, catabolic from Escherichia coli strain UTI89 - UPEC (tr [KO:K01754 ] [EC:4.3.1.19 ]
BN49_4588 ilvA; highly similar to threonine deaminase from Escherichia coli O7:K1 strain IAI39 - ExPEC (tr [KO:K01754 ] [EC:4.3.1.19 ]
BN49_4262 leuC; highly similar to 3-isopropylmalate dehydratase large subunit from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01703 ] [EC:4.2.1.33 4.2.1.35 ]
BN49_4263 leuD; highly similar to 3-isopropylmalate dehydratase small subunit from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01704 ] [EC:4.2.1.33 4.2.1.35 ]
BN49_4261 leuB; highly similar to 3-isopropylmalate dehydrogenase from Escherichia coli strain UTI89 - UPEC (sp [KO:K00052 ] [EC:1.1.1.85 ]
BN49_1042 unnamed protein product; weakly similar to putative thiamine pyrophosphate enzyme, central domain family from Labrenzia alexandrii. It presents the N-terminal, C-terminal and central domains of thiamine pyrophosphate enzymes, according to Pfam [KO:K01652 ] [EC:2.2.1.6 ]
BN49_3167 budB; highly similar to acetolactate synthase, catabolic from Klebsiella pneumoniae (sp [KO:K01652 ] [EC:2.2.1.6 ]
BN49_0033 ilvB; highly similar to acetolactate synthase from Escherichia coli O111:H-strain 11128 - EHEC (tr [KO:K01652 ] [EC:2.2.1.6 ]
BN49_4592 ilvG; highly similar to acetolactate synthase from Escherichia coli strain SMS-3-5 - SECEC (tr [KO:K01652 ] [EC:2.2.1.6 ]
BN49_0034 ilvN; highly similar to acetolactate synthase isozyme I small subunit from Escherichia coli strain UTI89 - UPEC (tr [KO:K01653 ] [EC:2.2.1.6 ]
BN49_4257 ilvH; highly similar to acetolactate synthase isozyme III small subunit from Escherichia coli O6 (tr [KO:K01653 ] [EC:2.2.1.6 ]
BN49_4591 ilvM; highly similar to acetolactate synthase II, small subunit from Salmonella choleraesuis (tr [KO:K11258 ] [EC:2.2.1.6 ]
BN49_4586 ilvC; highly similar to ketol-acid reductoisomerase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K00053 ] [EC:1.1.1.86 ]
BN49_4589 ilvD; highly similar to dihydroxy-acid dehydratase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01687 ] [EC:4.2.1.9 ]
BN49_4590 ilvE; highly similar to branched-chain-amino-acid aminotransferase from Salmonella typhimurium (sp [KO:K00826 ] [EC:2.6.1.42 ]
BN49_0174 avtA; highly similar to valine--pyruvate aminotransferase from Escherichia coli strain K12 (sp [KO:K00835 ] [EC:2.6.1.66 ]
BN49_3898 unnamed protein product; highly similar to putative aminotransferase from Escherichia coli strain UTI89 - UPEC (tr [KO:K14260 ] [EC:2.6.1.66 2.6.1.2 ]
BN49_4260 leuA2; highly similar to 2-isopropylmalate synthase from Klebsiella pneumoniae subsp. pneumoniae strain ATCC 700721 - MGH 78578 (sp [KO:K01649 ] [EC:2.3.3.13 ]
Compound C00141 3-Methyl-2-oxobutanoic acid
C00233 4-Methyl-2-oxopentanoate
C00671 (S)-3-Methyl-2-oxopentanoic acid
C04181 3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236 (2S)-2-Isopropyl-3-oxosuccinate
C04272 (R)-2,3-Dihydroxy-3-methylbutanoate
C04411 (2R,3S)-3-Isopropylmalate
C06006 (S)-2-Aceto-2-hydroxybutanoate
C06007 (R)-2,3-Dihydroxy-3-methylpentanoate
C06032 D-erythro-3-Methylmalate
C14463 (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference Authors Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
Title Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
Journal Related kpnk00260 Glycine, serine and threonine metabolism
kpnk00280 Valine, leucine and isoleucine degradation
KO pathway LinkDB All DBs
