KEGG   PATHWAY: ldc00982
Entry
ldc00982                    Pathway                                
Name
Drug metabolism - cytochrome P450 - Leptinotarsa decemlineata (Colorado potato beetle)
Class
Metabolism; Xenobiotics biodegradation and metabolism
Pathway map
ldc00982  Drug metabolism - cytochrome P450
ldc00982

Organism
Leptinotarsa decemlineata (Colorado potato beetle) [GN:ldc]
Gene
111514056  glutathione S-transferase D1-like [KO:K00799] [EC:2.5.1.18]
111506313  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111515104  uncharacterized protein LOC111515104 [KO:K00799] [EC:2.5.1.18]
111515116  uncharacterized protein LOC111515116 [KO:K00799] [EC:2.5.1.18]
111515122  glutathione S-transferase 1 [KO:K00799] [EC:2.5.1.18]
111515176  glutathione S-transferase D7-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111515202  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515214  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515223  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515375  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515376  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111515377  glutathione S-transferase D5-like [KO:K00799] [EC:2.5.1.18]
111506563  prostaglandin E synthase-like [KO:K00799] [EC:2.5.1.18]
111516160  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111507461  glutathione S-transferase theta-1-like [KO:K00799] [EC:2.5.1.18]
111517560  glutathione S-transferase omega-1-like [KO:K00799] [EC:2.5.1.18]
111508100  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111509100  microsomal glutathione S-transferase 1-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111509471  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111509532  glutathione S-transferase 1-like [KO:K00799] [EC:2.5.1.18]
111509814  glutathione S-transferase D2-like isoform X1 [KO:K00799] [EC:2.5.1.18]
111504113  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111513855  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111514898  glutathione S-transferase-like [KO:K04097] [EC:5.3.99.2 2.5.1.18]
111506142  alcohol dehydrogenase class-3 [KO:K00121] [EC:1.1.1.284 1.1.1.1]
111515135  fatty aldehyde dehydrogenase-like [KO:K00129] [EC:1.2.1.5]
111515823  aldehyde dehydrogenase, dimeric NADP-preferring-like [KO:K00129] [EC:1.2.1.5]
111516030  aldehyde dehydrogenase, dimeric NADP-preferring-like [KO:K00129] [EC:1.2.1.5]
111507112  aldehyde dehydrogenase, dimeric NADP-preferring-like [KO:K00129] [EC:1.2.1.5]
111506342  probable flavin-containing monoamine oxidase A isoform X1 [KO:K00274] [EC:1.4.3.4]
111510977  UDP-glucuronosyltransferase 1-10-like isoform X1 [KO:K00699] [EC:2.4.1.17]
111511174  UDP-glucuronosyltransferase 2B10-like [KO:K00699] [EC:2.4.1.17]
111512940  UDP-glucuronosyltransferase 2B7-like [KO:K00699] [EC:2.4.1.17]
111513316  UDP-glucuronosyltransferase 2B30-like [KO:K00699] [EC:2.4.1.17]
111504789  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
111514251  UDP-glucuronosyltransferase 1-8-like [KO:K00699] [EC:2.4.1.17]
111515672  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
111506694  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
111506695  UDP-glucuronosyltransferase 2B31-like [KO:K00699] [EC:2.4.1.17]
111516487  UDP-glucuronosyltransferase 2B13-like [KO:K00699] [EC:2.4.1.17]
111516529  UDP-glucuronosyltransferase 2B9-like [KO:K00699] [EC:2.4.1.17]
111516574  putative UDP-glucuronosyltransferase ugt-47 [KO:K00699] [EC:2.4.1.17]
111506945  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
111506946  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
111507891  UDP-glucuronosyltransferase 2B20-like [KO:K00699] [EC:2.4.1.17]
111507895  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
111517685  UDP-glucuronosyltransferase 2B4-like [KO:K00699] [EC:2.4.1.17]
111517690  UDP-glucuronosyltransferase 2B33-like [KO:K00699] [EC:2.4.1.17]
111508063  UDP-glucuronosyltransferase 2A3-like isoform X1 [KO:K00699] [EC:2.4.1.17]
111508065  UDP-glucuronosyltransferase 2B2-like [KO:K00699] [EC:2.4.1.17]
111508810  UDP-glucuronosyltransferase 1-3-like [KO:K00699] [EC:2.4.1.17]
111508948  UDP-glucuronosyltransferase 2B15-like [KO:K00699] [EC:2.4.1.17]
111508953  UDP-glucuronosyltransferase 2B1-like [KO:K00699] [EC:2.4.1.17]
Compound
C01471  Acrolein
C01516  Morphine
C05011  Hydroxytamoxifen
C06174  Codeine
C06754  Chloroacetaldehyde
C06868  Carbamazepine
C07047  Ifosfamide
C07073  Lidocaine
C07108  Tamoxifen
C07163  Methadone
C07185  Valproic acid
C07492  Oxcarbazepine
C07493  10-Hydroxycarbazepine
C07495  Dihydroxycarbazepine
C07496  Carbamazepine-10,11-epoxide
C07501  Felbamate
C07572  Citalopram
C07643  4-Hydroxycyclophosphamide
C07644  4-Ketocyclophosphamide
C07645  Aldophosphamide
C07646  Carboxyphosphamide
C07647  Phosphoramide mustard
C07888  Cyclophosphamide
C08012  Levomethadyl acetate
C11004  2,6-Dimethylaniline
C11583  4-Glutathionyl cyclophosphamide
C11785  Normorphine
C16544  alpha-Hydroxytamoxifen
C16545  Tamoxifen N-oxide
C16546  N-Desmethyltamoxifen
C16547  Endoxifen
C16548  N,N-Didesmethyltamoxifen
C16549  alpha-Hydroxy-N-desmethyltamoxifen
C16550  Dechloroethylcyclophosphamide
C16551  Alcophosphamide
C16552  Nornitrogen mustard
C16553  4-Hydroxyifosfamide
C16554  4-Ketoifosfamide
C16555  2-Dechloroethylifosfamide
C16556  Aldoifosfamide
C16557  Carboxyifosfamide
C16558  Alcoifosfamide
C16559  Isophosphoramide mustard
C16560  3-Hydroxylidocaine
C16561  Monoethylglycinexylidide
C16569  Glycinexylidide
C16570  4-Hydroxy-2,6-dimethylaniline
C16571  2-Amino-3-methylbenzoate
C16572  3-Hydroxymonoethylglycinexylidide
C16576  Norcodeine
C16577  Codeine-6-glucuronide
C16578  Morphine-6-glucuronide
C16582  2-Hydroxyfelbamate
C16584  p-Hydroxyfelbamate
C16586  2-Phenyl-1,3-propanediol monocarbamate
C16587  3-Carbamoyl-2-phenylpropionaldehyde
C16591  3-Carbamoyl-2-phenylpropionic acid
C16592  Atropaldehyde
C16595  4-Hydroxy-5-phenyltetrahydro-1,3-oxazin-2-one
C16596  5-Phenyl-1,3-oxazinane-2,4-dione
C16601  2-Hydroxycarbamazepine
C16602  3-Hydroxycarbamazepine
C16603  2,3-Dihydroxycarbamazepine
C16604  2-Hydroxyiminostilbene
C16605  2H-Dibenz[b,f]azepin-2-one
C16606  Carbamazepine-o-quinone
C16607  Citalopram N-oxide
C16608  Demethylcitalopram
C16609  Didemethylcitalopram
C16610  Citalopram propionic acid
C16612  Citalopram aldehyde
C16643  Morphine-3-glucuronide
C16648  2-n-Propyl-4-pentenoic acid
C16649  4-Hydroxyvalproic acid
C16650  5-Hydroxyvalproic acid
C16651  3-Hydroxyvalproic acid
C16652  3-Oxovalproic acid
C16653  2-n-Propyl-2-pentenoic acid
C16654  2-n-Propyl-3-pentenoic acid
C16655  2-n-Propyl-4-oxopentanoic acid
C16656  2-Propyl-2,4-pentadienoic acid
C16657  2-Propylsuccinic acid
C16658  2-Propylglutaric acid
C16659  2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
C16660  2-Ethyl-5-methyl-3,3-diphenyl-1-pyrroline
C16661  L-alpha-Acetyl-N-normethadol
C16662  L-alpha-Acetyl-N,N-dinormethadol
D00195  Codeine (USP)
D00252  Carbamazepine (JP18/USP/INN)
D00343  Ifosfamide (JAN/USP/INN)
D00358  Lidocaine (JP18/USP/INN)
D00399  Valproic acid (USP)
D00533  Oxcarbazepine (JAN/USP/INN)
D00536  Felbamate (USPINN)
D04716  Levomethadyl acetate (USAN)
D07704  Citalopram (USP/INN)
D07760  Cyclophosphamide (INN)
D08195  Methadone (BAN)
D08233  Morphine (BAN)
D08559  Tamoxifen (INN)
Reference
  Authors
Kato R, Kamatari T (eds).
  Title
[Drug Metabolism] (In Japanese)
  Journal
Tokyo Kagaku Dojin (2000)
Reference
  Authors
Gjerde J, Kisanga ER, Hauglid M, Holm PI, Mellgren G, Lien EA.
  Title
Identification and quantification of tamoxifen and four metabolites in serum by liquid chromatography-tandem mass spectrometry.
  Journal
J Chromatogr A 1082:6-14 (2005)
DOI:10.1016/j.chroma.2005.01.004
Reference
  Authors
Buck MB, Coller JK, Murdter TE, Eichelbaum M, Knabbe C.
  Title
TGFbeta2 and TbetaRII are valid molecular biomarkers for the antiproliferative effects of tamoxifen and tamoxifen metabolites in breast cancer cells.
  Journal
Breast Cancer Res Treat 107:15-24 (2008)
DOI:10.1007/s10549-007-9526-7
Reference
  Authors
Rodriguez-Antona C, Ingelman-Sundberg M.
  Title
Cytochrome P450 pharmacogenetics and cancer.
  Journal
Oncogene 25:1679-91 (2006)
DOI:10.1038/sj.onc.1209377
Reference
  Authors
Zhang J, Tian Q, Yung Chan S, Chuen Li S, Zhou S, Duan W, Zhu YZ.
  Title
Metabolism and transport of oxazaphosphorines and the clinical implications.
  Journal
Drug Metab Rev 37:611-703 (2005)
DOI:10.1080/03602530500364023
Reference
  Authors
Kosel M, Amey M, Aubert AC, Baumann P.
  Title
In vitro metabolism of citalopram by monoamine oxidase B in human blood.
  Journal
Eur Neuropsychopharmacol 11:75-8 (2001)
DOI:10.1016/S0924-977X(00)00128-0
Reference
  Authors
Olesen OV, Linnet K.
  Title
Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes.
  Journal
Pharmacology 59:298-309 (1999)
DOI:10.1159/000028333
Reference
PMID:9698084
  Authors
Rochat B, Kosel M, Boss G, Testa B, Gillet M, Baumann P.
  Title
Stereoselective biotransformation of the selective serotonin reuptake inhibitor citalopram and its demethylated metabolites by monoamine oxidases in human liver.
  Journal
Biochem Pharmacol 56:15-23 (1998)
DOI:10.1016/S0006-2952(98)00008-2
Reference
  Authors
David AW, Thomas LL, William OF.
  Title
Foye's Principles of Medicinal Chemistry (5th ed)
  Journal
Lippincott Williams & Wilkins (2002)
Reference
  Authors
Oda Y, Kharasch ED.
  Title
Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
  Journal
J Pharmacol Exp Ther 298:1021-32 (2001)
Reference
  Authors
Wang JS, Backman JT, Taavitsainen P, Neuvonen PJ, Kivisto KT.
  Title
Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans.
  Journal
Drug Metab Dispos 28:959-65 (2000)
Reference
  Authors
Dieckhaus CM, Thompson CD, Roller SG, Macdonald TL.
  Title
Mechanisms of idiosyncratic drug reactions: the case of felbamate.
  Journal
Chem Biol Interact 142:99-117 (2002)
DOI:10.1016/S0009-2797(02)00057-1
Reference
  Authors
Pearce RE, Lu W, Wang Y, Uetrecht JP, Correia MA, Leeder JS
  Title
Pathways of carbamazepine bioactivation in vitro. III. The role of human cytochrome P450 enzymes in the formation of 2,3-dihydroxycarbamazepine.
  Journal
Drug Metab Dispos 36:1637-49 (2008)
DOI:10.1124/dmd.107.019562
Reference
  Authors
Pearce RE, Vakkalagadda GR, Leeder JS.
  Title
Pathways of carbamazepine bioactivation in vitro I. Characterization of human cytochromes P450 responsible for the formation of 2- and 3-hydroxylated metabolites.
  Journal
Drug Metab Dispos 30:1170-9 (2002)
DOI:10.1124/dmd.30.11.1170
Reference
  Authors
Kumar S, Wong H, Yeung SA, Riggs KW, Abbott FS, Rurak DW.
  Title
Disposition of valproic acid in maternal, fetal, and newborn sheep. II: metabolism and renal elimination.
  Journal
Drug Metab Dispos 28:857-64 (2000)
Reference
  Authors
Bernad T, Joachim M.
  Title
Hydrolysis in Drug and Prodrug Metabolism: Chemistry, Biochemistry, and Enzymology
  Journal
Wiley-VCH (2003)
KO pathway
ko00982   
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