KEGG   PATHWAY: llm00550
Entry
llm00550                    Pathway                                
Name
Peptidoglycan biosynthesis - Lactococcus lactis subsp. cremoris MG1363
Description
Peptidoglycan is a macromolecule made of long aminosugar strands cross-linked by short peptides. It forms the cell wall in bacteria surrounding the cytoplasmic membrane. The glycan strands are typically comprised of repeating N-acetylglucosamine (GlcNAc) and N-acetylmuramic acid (MurNAc) disaccharides. Each MurNAc is linked to a peptide of three to five amino acid residues. Disaccharide subunits are first assembled on the cytoplasmic side of the bacterial membrane on a polyisoprenoid anchor (lipid I and II). Polymerization of disaccharide subunits by transglycosylases and cross-linking of glycan strands by transpeptidases occur on the other side of the membrane. Bacterial cell wall biosynthesis inhibitors form a major class of antibiotics.
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
llm00550  Peptidoglycan biosynthesis
llm00550

Organism
Lactococcus lactis subsp. cremoris MG1363 [GN:llm]
Gene
llmg_0326  murA1; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
llmg_0517  murA2; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [KO:K00790] [EC:2.5.1.7]
llmg_1329  murB; MurB protein [KO:K00075] [EC:1.3.1.98]
llmg_2316  murC; UDP-N-acetyl muramate-alanine ligase [KO:K01924] [EC:6.3.2.8]
llmg_0912  murD; MurD protein [KO:K01925] [EC:6.3.2.9]
llmg_0360  D-alanine-D-alanine ligase [KO:K01921] [EC:6.3.2.4]
llmg_0361  murF; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase [KO:K01929] [EC:6.3.2.10]
llmg_1486  dgkA; DgkA protein [KO:K00887] [EC:2.7.1.66]
llmg_2415  uppS; UPP synthetase [KO:K00806] [EC:2.5.1.31]
llmg_2476  bacA; bacitracin resistance protein [KO:K06153] [EC:3.6.1.27]
llmg_1678  mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [KO:K01000] [EC:2.7.8.13]
llmg_0913  murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [KO:K02563] [EC:2.4.1.227]
llmg_0511  ponA; putative penicillin-binding protein 1a [KO:K05366] [EC:2.4.99.28 3.4.16.4]
llmg_2392  pbp2A; Penicillin-binding protein 2a [KO:K12555] [EC:2.4.99.28 3.4.16.4]
llmg_2560  dacA; DacA protein [KO:K07258] [EC:3.4.16.4]
llmg_1578  dacB; DacB protein [KO:K07260] [EC:3.4.17.14]
llmg_1989  murE; UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase [KO:K05362] [EC:6.3.2.7]
llmg_1465  murC2; putative UDP-N-acetylmuramyl tripeptide synthetase [KO:K23393] [EC:6.3.5.13]
llmg_1466  cobQ; cobyric acid synthase [KO:K07009] [EC:6.3.5.13]
llmg_2352  murM; putative peptidoglycan branched peptide synthesis protein [KO:K05363] [EC:2.3.2.10]
llmg_0402  pbp1B; Penicillin-binding protein 1B [KO:K03693]
llmg_0358  pbp2B; penicillin-binding protein 2B [KO:K00687]
llmg_1679  pbpX; penicillin-binding protein [KO:K12556]
Compound
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00133  D-Alanine
C00448  trans,trans-Farnesyl diphosphate
C00692  UDP-N-acetylmuramoyl-L-alanyl-D-glutamate
C00993  D-Alanyl-D-alanine
C01050  UDP-N-acetylmuramate
C01212  UDP-N-acetylmuramoyl-L-alanine
C04574  di-trans,poly-cis-Undecaprenyl diphosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C04702  UDPMurNAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)
C04851  MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol
C04877  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimelate
C04882  UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine
C05892  UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine
C05893  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine
C05894  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine
C05895  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine
C05896  Crosslinked peptidoglycan
C05897  Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C05898  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine
C17541  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)-D-alanyl-D-alanine
C17542  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)3-D-alanyl-D-alanine
C17549  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl-L-alanyl)-D-alanyl-D-alanine
C17550  Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-(L-alanyl)-D-alanyl-D-alanine
C17556  di-trans,poly-cis-Undecaprenyl phosphate
C17558  di-trans,poly-cis-Undecaprenol
C22053  UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Reference
PMID:18081839
  Authors
Bouhss A, Trunkfield AE, Bugg TD, Mengin-Lecreulx D
  Title
The biosynthesis of peptidoglycan lipid-linked intermediates.
  Journal
FEMS Microbiol Rev 32:208-33 (2008)
DOI:10.1111/j.1574-6976.2007.00089.x
Reference
PMID:18077448
  Authors
Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG
  Title
Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.
  Journal
J Biol Chem 283:6402-17 (2008)
DOI:10.1074/jbc.M708105200
Reference
PMID:18266853
  Authors
Barreteau H, Kovac A, Boniface A, Sova M, Gobec S, Blanot D
  Title
Cytoplasmic steps of peptidoglycan biosynthesis.
  Journal
FEMS Microbiol Rev 32:168-207 (2008)
DOI:10.1111/j.1574-6976.2008.00104.x
Reference
PMID:11699883
  Authors
van Heijenoort J
  Title
Recent advances in the formation of the bacterial peptidoglycan monomer unit.
  Journal
Nat Prod Rep 18:503-19 (2001)
DOI:10.1039/a804532a
Reference
PMID:11320055
  Authors
van Heijenoort  J
  Title
Formation of the glycan chains in the synthesis of bacterial peptidoglycan.
  Journal
Glycobiology 11:25R-36R (2001)
DOI:10.1093/glycob/11.3.25R
Related
pathway
llm00470  D-Amino acid metabolism
llm00520  Amino sugar and nucleotide sugar metabolism
llm00900  Terpenoid backbone biosynthesis
KO pathway
ko00550   
LinkDB

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