KEGG   PATHWAY: mbo00290
Entry
mbo00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Mycobacterium tuberculosis variant bovis AF2122/97
Class
Metabolism; Amino acid metabolism
Pathway map
mbo00290  Valine, leucine and isoleucine biosynthesis
mbo00290

Module
mbo_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:mbo00290]
mbo_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:mbo00290]
mbo_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:mbo00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Mycobacterium tuberculosis variant bovis AF2122/97 [GN:mbo]
Gene
BQ2027_MB1585  ilvA; Probable threonine dehydratase ilvA [KO:K01754] [EC:4.3.1.19]
BQ2027_MB3012C  leuC; PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) [KO:K01703] [EC:4.2.1.33 4.2.1.35]
BQ2027_MB3011C  leuD; PROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (SMALL SUBUNIT) LEUD (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI) [KO:K01704] [EC:4.2.1.33 4.2.1.35]
BQ2027_MB3019C  leuB; probable 3-isopropylmalate dehydrogenase leub (beta-ipm dehydrogenase) (imdh) (3-ipm-dh) [KO:K00052] [EC:1.1.1.85]
BQ2027_MB3028C  ilvB1; acetolactate synthase (large subunit) ilvb1 (acetohydroxy-acid synthase) [KO:K01652] [EC:2.2.1.6]
BQ2027_MB3499C  ilvB2; PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB2 (AHAS) (ACETOHYDROXY-ACID SYNTHASE LARGE SUBUNIT) (ALS) [KO:K01652] [EC:2.2.1.6]
BQ2027_MB3539C  ilvX; PROBABLE ACETOHYDROXYACID SYNTHASE ILVX (ACETOLACTATE SYNTHASE) [KO:K01652] [EC:2.2.1.6]
BQ2027_MB3027C  ilvN; PROBABLE ACETOLACTATE SYNTHASE (SMALL SUBUNIT) ILVN (ACETOHYDROXY-ACID SYNTHASE) (AHAS) (ALS) [KO:K01653] [EC:2.2.1.6]
BQ2027_MB3026C  ilvC; PROBABLE KETOL-ACID REDUCTOISOMERASE ILVC (Acetohydroxy-acid isomeroreductase) (Alpha-keto-beta-hydroxylacil reductoisomerase) [KO:K00053] [EC:1.1.1.86]
BQ2027_MB0195C  ilvD; PROBABLE DIHYDROXY-ACID DEHYDRATASE ILVD (DAD) [KO:K01687] [EC:4.2.1.9]
BQ2027_MB2233C  ilvE; branched-chain amino acid transaminase ilve [KO:K00826] [EC:2.6.1.42]
BQ2027_MB0344C  aspC; PROBABLE ASPARTATE AMINOTRANSFERASE ASPC (TRANSAMINASE A) (ASPAT) [KO:K14260] [EC:2.6.1.66 2.6.1.2]
BQ2027_MB3737  leuA; 2-isopropylmalate synthase leua (alpha-isopropylmalate synthase) (alpha-ipm synthetase) (ipms) [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
mbo00260  Glycine, serine and threonine metabolism
mbo00280  Valine, leucine and isoleucine degradation
mbo00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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