KEGG   PATHWAY: mdl04144
Entry
mdl04144                    Pathway                                
Name
Endocytosis - Microplitis demolitor
Description
Endocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins entering through clathrin-dependent endocytosis (CDE) have sequences in their cytoplasmic domains that bind to the APs (adaptor-related protein complexes) and enable their rapid removal from the PM. In addition to APs and clathrin, there are numerous accessory proteins including dynamin. Depending on the various proteins that enter the endosome membrane, these cargoes are sorted to distinct destinations. Some cargoes, such as nutrient receptors, are recycled back to the PM. Ubiquitylated membrane proteins, such as activated growth-factor receptors, are sorted into intraluminal vesicles and eventually end up in the lysosome lumen via multivesicular endosomes (MVEs). There are distinct mechanisms of clathrin-independent endocytosis (CIE) depending upon the cargo and the cell type.
Class
Cellular Processes; Transport and catabolism
Pathway map
mdl04144  Endocytosis
mdl04144

Other DBs
GO: 0006897
Organism
Microplitis demolitor [GN:mdl]
Gene
103578349  ADP-ribosylation factor 6 [KO:K07941]
103579907  phosphatidylinositol 4-phosphate 5-kinase type-1 alpha [KO:K00889] [EC:2.7.1.68]
103580130  phospholipase D1 isoform X1 [KO:K01115] [EC:3.1.4.4]
103571419  dynamin isoform X1 [KO:K01528] [EC:3.6.5.5]
103571342  clathrin light chain isoform X1 [KO:K04644]
103570469  clathrin heavy chain [KO:K04646]
103570459  AP-2 complex subunit alpha [KO:K11824]
103579249  AP-2 complex subunit mu [KO:K11826]
103571828  AP-2 complex subunit sigma [KO:K11827]
103576842  TGF-beta receptor type-1 isoform X1 [KO:K04674] [EC:2.7.11.30]
103569891  uncharacterized protein LOC103569891 isoform X3 [KO:K04679]
103579049  mothers against decapentaplegic homolog 3 [KO:K23605]
103576901  epidermal growth factor receptor isoform X1 [KO:K04361] [EC:2.7.10.1]
103569982  fibroblast growth factor receptor homolog 1-like isoform X1 [KO:K05093] [EC:2.7.10.1]
103577747  E3 ubiquitin-protein ligase CBL-B isoform X1 [KO:K04707] [EC:2.3.2.27]
103575005  endophilin-A isoform X1 [KO:K11247]
103580201  endophilin-B1 isoform X1 [KO:K11248]
103579693  myc box-dependent-interacting protein 1 isoform X1 [KO:K12562]
103570728  epsin-2 isoform X1 [KO:K12471]
103579631  epidermal growth factor receptor substrate 15 isoform X1 [KO:K12472]
103568537  E3 ubiquitin-protein ligase Nedd-4 [KO:K10591] [EC:2.3.2.26]
103569690  TNF receptor-associated factor 6-A [KO:K03175] [EC:2.3.2.27]
103577925  E3 ubiquitin-protein ligase NRDP1 isoform X1 [KO:K11981] [EC:2.3.2.27]
103576578  E3 ubiquitin-protein ligase SMURF2 [KO:K04678] [EC:2.3.2.26]
103578483  E3 ubiquitin-protein ligase Su(dx) [KO:K05633] [EC:2.3.2.26]
103571139  low density lipoprotein receptor adapter protein 1-B-like isoform X1 [KO:K12474]
103575935  uncharacterized protein LOC103575935 [KO:K12475]
103575167  G protein-coupled receptor kinase 1 isoform X1 [KO:K00910] [EC:2.7.11.15]
103578293  G protein-coupled receptor kinase 2 [KO:K08291] [EC:2.7.11.16]
103568155  beta-arrestin-1 isoform X1 [KO:K04439]
103568157  beta-arrestin-1 isoform X1 [KO:K04439]
103572796  neural Wiskott-Aldrich syndrome protein-like [KO:K23612]
103568920  actin-related protein 2 isoform X1 [KO:K17260]
103575752  actin-related protein 3 [KO:K18584]
103578895  actin-related protein 2/3 complex subunit 1A isoform X1 [KO:K05757]
103572713  probable actin-related protein 2/3 complex subunit 2 [KO:K05758]
103578648  actin-related protein 2/3 complex subunit 3-like [KO:K05756]
103577436  actin-related protein 2/3 complex subunit 4 [KO:K05755]
103571006  actin-related protein 2/3 complex subunit 5-like protein [KO:K05754]
103569981  major heat shock 70 kDa protein Ab-like [KO:K03283]
103572015  heat shock protein 68-like [KO:K03283]
103570478  heat shock protein 68-like [KO:K03283]
103573832  heat shock 70 kDa protein cognate 4 [KO:K03283]
103580508  major heat shock 70 kDa protein Ab-like [KO:K03283]
103578052  WASH complex subunit 7 [KO:K18465]
103573084  WASH complex subunit strumpellin [KO:K18464]
103580118  WASH complex subunit FAM21-like isoform X1 [KO:K18462]
103573681  WAS protein family homolog 1 [KO:K18461]
103577538  WASH complex subunit CCDC53 [KO:K18463]
103577853  F-actin-capping protein subunit alpha [KO:K10364]
103575516  F-actin-capping protein subunit beta [KO:K10365]
103570924  vacuolar protein sorting-associated protein 29 [KO:K18467]
103579462  vacuolar protein sorting-associated protein 26B-like [KO:K18466]
103578915  vacuolar protein sorting-associated protein 35 isoform X1 [KO:K18468]
103570022  sorting nexin-12 [KO:K17918]
103570445  STAM-binding protein-like [KO:K11866] [EC:3.4.19.12]
103579406  ras-related protein Rab-7a [KO:K07897]
103574126  hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]
103573570  signal transducing adapter molecule 1 [KO:K04705]
103570397  tumor susceptibility gene 101 protein [KO:K12183]
103571013  multivesicular body subunit 12A isoform X1 [KO:K12186]
103571529  vacuolar protein sorting-associated protein 28 homolog [KO:K12184]
103570201  vacuolar protein sorting-associated protein 37B [KO:K12185]
103577594  vacuolar protein sorting-associated protein 37A isoform X1 [KO:K12185]
103578929  vacuolar-sorting protein SNF8 [KO:K12188]
103571268  vacuolar protein-sorting-associated protein 36 [KO:K12190]
103577857  vacuolar protein-sorting-associated protein 25 [KO:K12189]
103575146  charged multivesicular body protein 6 [KO:K12195]
103569874  charged multivesicular body protein 4b [KO:K12194]
103580317  charged multivesicular body protein 3 [KO:K12193]
103570228  charged multivesicular body protein 2a [KO:K12191]
103570219  charged multivesicular body protein 7 [KO:K15053]
103572757  vacuolar protein sorting-associated protein 4B [KO:K12196]
103571664  vacuolar protein sorting-associated protein VTA1 homolog [KO:K12199]
103576833  charged multivesicular body protein 1b [KO:K12197]
103579502  charged multivesicular body protein 5 [KO:K12198]
103569826  IST1 homolog [KO:K19476]
103569800  programmed cell death 6-interacting protein [KO:K12200]
103579229  maspardin [KO:K19367]
103573337  cation-independent mannose-6-phosphate receptor [KO:K06564]
103568443  sorting nexin-2 [KO:K17917]
103574982  sorting nexin-6 isoform X2 [KO:K17920]
103579737  tyrosine-protein kinase Src64B isoform X1 [KO:K05704] [EC:2.7.10.2]
103575406  ras-like GTP-binding protein Rho1 isoform X1 [KO:K04513]
103574490  caveolin-3 [KO:K12959]
103576885  ras-related protein Rab-5B [KO:K07889]
103569788  rab GTPase-binding effector protein 1 [KO:K12480]
103573815  rabenosyn-5 [KO:K12481]
103570431  RUN and FYVE domain-containing protein 2 isoform X1 [KO:K12482]
103579894  EH domain-containing protein 3 [KO:K12483]
103569581  vacuolar protein sorting-associated protein 45 [KO:K12479]
103571763  sorting nexin-4 [KO:K17919]
103578155  ras-related protein Rab-10 [KO:K07903]
103573167  ras-related protein Rab-8A isoform X1 [KO:K07901]
103577038  ras-related protein Rab-35 [KO:K07876]
103571708  ras-related protein Rab-11A [KO:K07904]
103575996  rab11 family-interacting protein 2 [KO:K12484]
103577507  kinesin heavy chain isoform X1 [KO:K10396]
103579517  rab11 family-interacting protein 4 isoform X1 [KO:K12485]
106693678  partitioning defective 3 homolog [KO:K04237]
103570623  partitioning defective protein 6 [KO:K06093]
103578646  atypical protein kinase C [KO:K06069] [EC:2.7.11.13]
103575682  cdc42 homolog [KO:K04393]
103571982  stromal membrane-associated protein 1 isoform X1 [KO:K12486]
103574818  ARF GTPase-activating protein GIT1 isoform X1 [KO:K12487]
103568262  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [KO:K12488]
103575336  arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [KO:K12489]
103572316  centaurin-gamma-1A [KO:K12491]
103574321  ADP-ribosylation factor GTPase-activating protein 1 isoform X1 [KO:K12492]
103574628  ADP-ribosylation factor GTPase-activating protein 2 [KO:K12493]
103579357  PH and SEC7 domain-containing protein 2 isoform X1 [KO:K12494]
103568957  IQ motif and SEC7 domain-containing protein 1 isoform X1 [KO:K12495]
103573986  cytohesin-1 [KO:K18441]
103580667  brefeldin A-inhibited guanine nucleotide-exchange protein 1 [KO:K18442]
103573468  Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 isoform X1 [KO:K18443]
103578032  ADP-ribosylation factor 1 [KO:K07937]
103574486  ADP-ribosylation factor 2 [KO:K07939]
Compound
C00035  GDP
C00044  GTP
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
C04637  1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
C05981  Phosphatidylinositol-3,4,5-trisphosphate
C11556  1-Phosphatidyl-1D-myo-inositol 3,5-bisphosphate
Reference
PMID:19007773
  Authors
Acconcia F, Sigismund S, Polo S
  Title
Ubiquitin in trafficking: the network at work.
  Journal
Exp Cell Res 315:1610-8 (2009)
DOI:10.1016/j.yexcr.2008.10.014
Reference
PMID:18647649
  Authors
Donaldson JG, Porat-Shliom N, Cohen LA
  Title
Clathrin-independent endocytosis: a unique platform for cell signaling and PM remodeling.
  Journal
Cell Signal 21:1-6 (2009)
DOI:10.1016/j.cellsig.2008.06.020
Reference
PMID:15261671
  Authors
Sorkin A
  Title
Cargo recognition during clathrin-mediated endocytosis: a team effort.
  Journal
Curr Opin Cell Biol 16:392-9 (2004)
DOI:10.1016/j.ceb.2004.06.001
Reference
PMID:19325624
  Authors
Raiborg C, Stenmark H
  Title
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
  Journal
Nature 458:445-52 (2009)
DOI:10.1038/nature07961
Reference
PMID:20110990
  Authors
Scita G, Di Fiore PP
  Title
The endocytic matrix.
  Journal
Nature 463:464-73 (2010)
DOI:10.1038/nature08910
Reference
PMID:15687999
  Authors
Le Roy C, Wrana JL
  Title
Clathrin- and non-clathrin-mediated endocytic regulation of cell signalling.
  Journal
Nat Rev Mol Cell Biol 6:112-26 (2005)
DOI:10.1038/nrm1571
Reference
PMID:19924646
  Authors
Jovic M, Sharma M, Rahajeng J, Caplan S
  Title
The early endosome: a busy sorting station for proteins at the crossroads.
  Journal
Histol Histopathol 25:99-112 (2010)
DOI:10.14670/HH-25.99
Reference
PMID:16203612
  Authors
Pietiainen VM, Marjomaki V, Heino J, Hyypia T
  Title
Viral entry, lipid rafts and caveosomes.
  Journal
Ann Med 37:394-403 (2005)
DOI:10.1080/07853890510011976
Reference
PMID:19696797
  Authors
Grant BD, Donaldson JG
  Title
Pathways and mechanisms of endocytic recycling.
  Journal
Nat Rev Mol Cell Biol 10:597-608 (2009)
DOI:10.1038/nrm2755
Reference
PMID:22193161
  Authors
Cullen PJ, Korswagen HC
  Title
Sorting nexins provide diversity for retromer-dependent trafficking events.
  Journal
Nat Cell Biol 14:29-37 (2012)
DOI:10.1038/ncb2374
Related
pathway
mdl04070  Phosphatidylinositol signaling system
mdl04130  SNARE interactions in vesicular transport
mdl04142  Lysosome
mdl04350  TGF-beta signaling pathway
KO pathway
ko04144   
LinkDB

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