KEGG ORTHOLOGY: K03175

ORTHOLOGY: K03175

Entry

K03175                      KO

Symbol

TRAF6

Name

TNF receptor-associated factor 6 [EC:2.3.2.27]

Pathway

map04010

MAPK signaling pathway

map04013

MAPK signaling pathway - fly

map04064

NF-kappa B signaling pathway

map04120

Ubiquitin mediated proteolysis

map04140

Autophagy - animal

map04144

Endocytosis

map04214

Apoptosis - fly

map04380

Osteoclast differentiation

map04620

Toll-like receptor signaling pathway

map04621

NOD-like receptor signaling pathway

map04622

RIG-I-like receptor signaling pathway

map04657

IL-17 signaling pathway

map04722

Neurotrophin signaling pathway

map04936

Alcoholic liver disease

map05130

Pathogenic Escherichia coli infection

map05131

Shigellosis

map05132

Salmonella infection

map05133

Pertussis

map05135

Yersinia infection

map05140

Leishmaniasis

map05142

Chagas disease

map05145

Toxoplasmosis

map05152

Tuberculosis

map05160

Hepatitis C

map05161

Hepatitis B

map05162

Measles

map05168

Herpes simplex virus 1 infection

map05169

Epstein-Barr virus infection

map05170

Human immunodeficiency virus 1 infection

map05171

Coronavirus disease - COVID-19

map05200

Pathways in cancer

map05222

Small cell lung cancer

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

map05417

Lipid and atherosclerosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03175  TRAF6; TNF receptor-associated factor 6
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04013 MAPK signaling pathway - fly
    K03175  TRAF6; TNF receptor-associated factor 6
   04064 NF-kappa B signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K03175  TRAF6; TNF receptor-associated factor 6
   04140 Autophagy - animal
    K03175  TRAF6; TNF receptor-associated factor 6
  09143 Cell growth and death
   04214 Apoptosis - fly
    K03175  TRAF6; TNF receptor-associated factor 6
09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04621 NOD-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04622 RIG-I-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04657 IL-17 signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03175  TRAF6; TNF receptor-associated factor 6
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05161 Hepatitis B
    K03175  TRAF6; TNF receptor-associated factor 6
   05160 Hepatitis C
    K03175  TRAF6; TNF receptor-associated factor 6
   05171 Coronavirus disease - COVID-19
    K03175  TRAF6; TNF receptor-associated factor 6
   05162 Measles
    K03175  TRAF6; TNF receptor-associated factor 6
   05168 Herpes simplex virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05169 Epstein-Barr virus infection
    K03175  TRAF6; TNF receptor-associated factor 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05132 Salmonella infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05131 Shigellosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05135 Yersinia infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05133 Pertussis
    K03175  TRAF6; TNF receptor-associated factor 6
   05152 Tuberculosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05140 Leishmaniasis
    K03175  TRAF6; TNF receptor-associated factor 6
   05142 Chagas disease
    K03175  TRAF6; TNF receptor-associated factor 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03175  TRAF6; TNF receptor-associated factor 6
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K03175  TRAF6; TNF receptor-associated factor 6
   04121 Ubiquitin system
    K03175  TRAF6; TNF receptor-associated factor 6
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03175  TRAF6; TNF receptor-associated factor 6
Membrane trafficking [BR:ko04131]
Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K03175  TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03175  TRAF6; TNF receptor-associated factor 6

Genes

HSA:	7189(TRAF6)

PTR:	451702(TRAF6)

PPS:	100983960(TRAF6)

GGO:	101152087(TRAF6)

PON:	100449432(TRAF6)

NLE:	100595327(TRAF6)

HMH:	116476347(TRAF6)

MCC:	716907(TRAF6)

MCF:	102128596(TRAF6)

MTHB:

126936615

MNI:	105471571(TRAF6)

CSAB:

103237554(TRAF6)

CATY:

105586809(TRAF6)

PANU:

101002649(TRAF6)

TGE:	112607412(TRAF6)

MLEU:

105534673(TRAF6)

RRO:	104658364(TRAF6)

RBB:	108535559(TRAF6)

TFN:	117080232(TRAF6)

PTEH:

111521878(TRAF6)

CANG:

105510802(TRAF6)

CJC:	100395364(TRAF6)

SBQ:	101033308(TRAF6)

CIMI:

108305750(TRAF6)

CSYR:

103263671(TRAF6)

MMUR:

105856828(TRAF6)

LCAT:

123642600(TRAF6)

PCOQ:

105814571(TRAF6)

OGA:	100945817(TRAF6)

MMU:	22034(Traf6)

MCAL:

110290132(Traf6)

MPAH:

110318382(Traf6)

RNO:	311245(Traf6)

MCOC:

116090551(Traf6)

ANU:	117703656(Traf6)

MUN:	110557497(Traf6)

CGE:	100753700(Traf6)

MAUA:

101830563(Traf6)

PROB:

127222196(Traf6)

PLEU:

114710754(Traf6)

MORG:

121440550 121465651(Traf6)

MFOT:

126504640

AAMP:

119814858(Traf6)

NGI:	103749513(Traf6)

HGL:	101697126(Traf6)

CPOC:

100724447(Traf6)

CCAN:

109693564(Traf6)

DORD:

105988129(Traf6)

DSP:	122117775(Traf6)

NCAR:

124959952

OCU:

100343190

OPI:	101518298(TRAF6)

TUP:	102482652(TRAF6)

GVR:	103601167(TRAF6)

CFA:	100688110(TRAF6)

CLUD:

112663495(TRAF6)

VVP:	112930471(TRAF6)

VLG:	121471306(TRAF6)

AML:	100483216(TRAF6)

UMR:	103659308(TRAF6)

UAH:	113265029(TRAF6)

UAR:	123799411(TRAF6)

ELK:

111150027

LLV:

125078866

MPUF:

101691506(TRAF6)

NVS:	122912847(TRAF6)

ORO:	101362953(TRAF6)

EJU:	114215395(TRAF6)

ZCA:	113913973(TRAF6)

MLX:	118015773(TRAF6)

NSU:	110576276(TRAF6)

LWW:	102728739(TRAF6)

FCA:	101099750(TRAF6)

PYU:	121043535(TRAF6)

PBG:	122483712(TRAF6)

LRUF:

124505383

PTG:	102960157(TRAF6)

PPAD:

109279193(TRAF6)

PUC:

125934537

AJU:	106976941(TRAF6)

HHV:	120232555(TRAF6)

BTA:	539124(TRAF6)

BOM:	102285891(TRAF6)

BIU:

109565970

BBUB:

102399580(TRAF6)

BBIS:

104982477(TRAF6)

CHX:	102172830(TRAF6)

OAS:	101107132(TRAF6)

ODA:	120876881(TRAF6)

CCAD:

122449806(TRAF6)

SSC:	396629(TRAF6)

CFR:	102520181(TRAF6)

CBAI:

105076500(TRAF6)

CDK:	105106823(TRAF6)

VPC:	102540938(TRAF6)

BACU:

103018592(TRAF6)

LVE:

103088795

OOR:	101277553(TRAF6)

DLE:	111179772(TRAF6)

PCAD:

102993207(TRAF6)

PSIU:

116757663(TRAF6)

NASI:

112404544(TRAF6)

ECB:	100052296(TRAF6)

EPZ:	103560236(TRAF6)

EAI:	106837480(TRAF6)

MYB:	102250946(TRAF6)

MYD:	102765934(TRAF6)

MMYO:

118665127(TRAF6)

MLF:	102436804(TRAF6)

MNA:	107531990(TRAF6)

PKL:	118712509(TRAF6)

HAI:	109381153(TRAF6)

DRO:	112303407(TRAF6)

SHON:

118983180(TRAF6)

AJM:	119036455(TRAF6)

PDIC:

114500758(TRAF6)

PHAS:

123809979(TRAF6)

MMF:	118628151(TRAF6)

RFQ:	117030261(TRAF6)

PALE:

102886476(TRAF6)

PGIG:

120606104(TRAF6)

PVP:	105290063(TRAF6)

RAY:	107499247(TRAF6)

MJV:	108390300(TRAF6)

TOD:	119255354(TRAF6)

SARA:

101543216(TRAF6)

LAV:	100671471(TRAF6)

TMU:

101345331

ETF:	101658809(TRAF6)

DNM:	101438500(TRAF6)

MDO:	100010055(TRAF6)

GAS:	123251329(TRAF6)

SHR:	100922331(TRAF6)

AFZ:

127542124

PCW:	110192620(TRAF6)

OAA:	100077058(TRAF6)

GGA:	423163(TRAF6)

PCOC:

116229116(TRAF6)

MGP:	100544809(TRAF6)

CJO:	107314700(TRAF6)

NMEL:

110401104(TRAF6)

APLA:

101802411(TRAF6)

ACYG:

106044346(TRAF6)

AFUL:

116489674(TRAF6)

TGU:	100229606(TRAF6)

LSR:	110484454(TRAF6)

SCAN:

103826724(TRAF6)

PMOA:

120512561(TRAF6)

OTC:	121344869(TRAF6)

PRUF:

121360996(TRAF6)

GFR:	102040197(TRAF6)

FAB:	101817601(TRAF6)

PHI:	102105183(TRAF6)

PMAJ:

107206210(TRAF6)

CCAE:

111930105(TRAF6)

CCW:	104693976(TRAF6)

CBRC:

103620910(TRAF6)

ETL:	114056738(TRAF6)

ZAB:	102065554(TRAF6)

ACHL:

103802335(TRAF6)

SVG:	106851517(TRAF6)

FPG:	101912003(TRAF6)

FCH:	102058044(TRAF6)

CLV:	102083770(TRAF6)

EGZ:	104134046(TRAF6)

NNI:

104019573

PLET:

104618120(TRAF6)

PCRI:

104023738(TRAF6)

PCAO:

104039330(TRAF6)

ACUN:

113481145(TRAF6)

TALA:

104369526(TRAF6)

PADL:

103921676(TRAF6)

AFOR:

103901553(TRAF6)

ACHC:

115353383(TRAF6)

HALD:

104316940(TRAF6)

HLE:	104843213(TRAF6)

AGEN:

126049491

GCL:

127017259

CCRI:

104154446(TRAF6)

CSTI:

104556332(TRAF6)

EHS:	104502487(TRAF6)

CMAC:

104480420(TRAF6)

MUI:	104548272(TRAF6)

FGA:	104070053(TRAF6)

GSTE:

104254122(TRAF6)

LDI:	104350177(TRAF6)

MNB:	103776764(TRAF6)

OHA:	104330076(TRAF6)

NNT:	104402000(TRAF6)

SHAB:

115606662(TRAF6)

DPUB:

104304786(TRAF6)

PGUU:

104457452(TRAF6)

ACAR:

104523193(TRAF6)

CPEA:

104388407(TRAF6)

AVIT:

104277489(TRAF6)

CVF:	104295805(TRAF6)

CUCA:

104056322(TRAF6)

TEO:	104382441(TRAF6)

BRHI:

104495856(TRAF6)

AAM:	106498355(TRAF6)

AROW:

112960908(TRAF6)

NPD:	112943501(TRAF6)

TGT:	104574137(TRAF6)

DNE:	112981786 112983104

SCAM:

104152881(TRAF6)

ASN:	102368234(TRAF6)

AMJ:	102572036(TRAF6)

CPOO:

109321438(TRAF6)

GGN:	109298950(TRAF6)

PSS:	102463398(TRAF6)

CMY:	102938959(TRAF6)

CPIC:

101953645(TRAF6)

TST:	117877000(TRAF6)

CABI:

116839265(TRAF6)

MRV:	120404545(TRAF6)

ACS:	100561211(traf6)

PVT:	110090250(TRAF6)

SUND:

121929536(TRAF6)

PBI:	103052063(TRAF6)

PMUR:

107293338(TRAF6)

CTIG:

120301920(TRAF6)

TSR:	106556967(TRAF6)

PGUT:

117665476(TRAF6)

VKO:	123026693(TRAF6)

PMUA:

114600173(TRAF6)

ZVI:	118089981(TRAF6)

GJA:	107116985(TRAF6)

STOW:

125434925

XLA:	444777(traf6.L) 734929(traf6.S)

XTR:	493524(traf6)

NPR:	108787821(TRAF6)

RTEM:

120917068(TRAF6)

BBUF:

120980714(TRAF6)

BGAR:

122920378(TRAF6)

DRE:	554561(traf6)

SRX:	107707871 107730254

SANH:

107694091 107696643

SGH:	107562521 107596425(traf6) 107596428

CCAR:

109065463 109093401(traf6)

CAUA:

113051336 113106240

CGIB:

127961861 128016621

PPRM:

120469276(traf6)

MAMB:

125265141(traf6)

CIDE:

127515905

MASI:

127411867 127443482

IPU:	108259200(traf6)

PHYP:

113540966(traf6)

SMEO:

124379888(traf6)

TFD:	113636662(traf6)

AMEX:

103021325(traf6)

EEE:	113579696(traf6)

TRU:	101071368(traf6)

TNG:	GSTEN00018197G001

LCO:	104920634(traf6)

NCC:	104948752(traf6)

CGOB:

115025996(traf6)

ELY:	117257648(traf6)

EFO:	125900030(traf6)

PLEP:

121946204(traf6)

SLUC:

116043440(traf6)

ECRA:

117948342(traf6)

ESP:	116689192(traf6)

PFLV:

114552813(traf6)

GAT:	100174890(traf6)

PPUG:

119228078(traf6)

MSAM:

119889757(traf6)

CUD:	121513662(traf6)

ALAT:

119017781(traf6)

MZE:	101469001(traf6)

ONL:	100703551(traf6)

OAU:	116329465(traf6)

OLA:	101161132(traf6)

OML:	112161172(traf6)

XMA:	102220826(traf6)

XCO:	114142760(traf6)

XHE:	116718296(traf6)

PRET:

103462724(traf6)

PFOR:

103153578(traf6)

PLAI:

106965102(traf6)

PMEI:

106907132(traf6)

GAF:	122845565(traf6)

CVG:	107099447(traf6)

CTUL:

119773575(traf6)

GMU:	124866796(traf6)

NFU:	107383589(traf6)

KMR:	108234801(traf6)

ALIM:

106523547(traf6)

NWH:	119430243(traf6)

AOCE:

111571002(traf6)

MCEP:

125005122(traf6)

CSEM:

103378810(traf6)

POV:	109637261(traf6)

SSEN:

122772221(traf6)

HHIP:

117754467(traf6)

HSP:	118106693(traf6)

LCF:

108887802

SDU:	111223588(traf6)

SLAL:

111644323(traf6)

XGL:	120788717(traf6)

HCQ:	109525774(traf6)

SSCV:

125967623

BPEC:

110162549(traf6)

MALB:

109965061(traf6)

BSPL:

114852159(traf6)

SASA:

106562692 106592035

STRU:

115166780 115203637

OTW:	112247822(traf6)

OMY:	110506216 110506983

OGO:	124026357 124027860 124033071

ONE:

115117991

SALP:

112077783(traf6)

CCLU:

121546400(traf6)

ELS:	105025313(traf6)

SFM:	108934700 108942315(traf6)

PKI:	111841418 111859511

AANG:

118215287(traf6)

LOC:	102684182(traf6)

PSPA:

121294705 121329873

ARUT:

117432247 117435117

PSEX:

120523208(traf6)

LCM:	102353931(TRAF6)

CMK:	103186026(traf6)

RTP:	109936672(traf6)

CPLA:

122557956(traf6)

BFO:

118414689

BBEL:

109461774 109486976

CIN:	778949(zf(traf/ring)-3)

SCLV:

120333900

SPU:	115925587 584052 585060

APLC:

110975424 110980832

SKO:	100372970 102804654

DME:	Dmel_CG10961(Traf6)

DER:

6550517

DSE:

6620179

DSI:	Dsimw501_GD16124(Dsim_GD16124)

DYA:	Dyak_GE17475

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14410

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

MDE:

SCAC:

LCQ:

LSQ:	119603964 119610751

HIS:

119654244

AGA:	AgaP_AGAP003004

ACOZ:

AARA:

ASTE:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

MDL:

FAS:

DAM:

AGIF:

CCIN:

TCA:	661716(Traf2)

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_202662

BANY:

NIQ:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:	105382485 105389114

API:

DNX:

AGS:

RMD:

BTAB:

DCI:	103510016 103518718 103518719

CLEC:

106670044

HHAL:

106683518

NLU:

111046887

PHU:	Phum_PHUM129280

FOC:

TPAL:

ZNE:

CSEC:

FCD:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

ISC:	IscW_ISCW011773 IscW_ISCW012083

DSV:	119431184 119431190 119431191 119431501 119431504 119431513 119434840 119435759 119445711 119452482 119452766 119456125 119464243 119465194 119465198 119465226 119465264 119465265 125939969

DFR:

124495251

CSCU:

111628924

HRO:	HELRODRAFT_194130

LGI:	LOTGIDRAFT_154170 LOTGIDRAFT_208992

PCAN:

112560472 112573637

BGT:	106068706 106079650

GAE:

121380421

HRF:	124110829 124115067

HRJ:	124281779 124291770

CRG:	105325127 105346921 105348659

MYI:	110449364 110453157

PMAX:

117327240

MMER:

123563068

DPOL:

127866356

OBI:	106878692 106883380

OSN:	115213801 115214503

LAK:	106154806 106168821

NVE:

5520915

EPA:	110238205 110238648 110251240 110254378

ATEN:

116305601 116307960

ADF:	107330393 107332219 107345490 107354397 107355733 107355734 107355736 107355817 107355819

AMIL:

114953101 114953110 114953111 114953112 114953114 114953204 114953216 114957717

PDAM:

113665766 113665768 113679218 113685897

SPIS:

111329931 111329938 111330715 111334989 111339679 111344690 111345112 111345955

DGT:	114526503 114527425

XEN:	124434071 124448725 124449673 124449678 124453815 124458537

TTT:	THITE_2123400

MGR:

MGG_03256

FGR:	FGSG_11967

FPU:	FPSE_00766

FVR:	FVEG_09651

FOX:	FOXG_11139

MAW:

MAC_05764

MAJ:

MAA_01724

CMT:

CCM_08969

PLJ:	VFPFJ_07301

DPP:	DICPUDRAFT_147424 DICPUDRAFT_18410 DICPUDRAFT_39824 DICPUDRAFT_39837 DICPUDRAFT_40987 DICPUDRAFT_44485 DICPUDRAFT_49369 DICPUDRAFT_7370 DICPUDRAFT_91159

» show all

Reference

PMID:19713527

Authors

Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK

Title

The E3 ligase TRAF6 regulates Akt ubiquitination and activation.

Journal

Science 325:1134-8 (2009)
DOI:10.1126/science.1175065

Sequence

[hsa:7189]

Reference

PMID:8837778

Authors

Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV

Title

TRAF6 is a signal transducer for interleukin-1.

Journal

Nature 383:443-6 (1996)
DOI:10.1038/383443a0

Sequence

[hsa:7189]

LinkDB

DBGET integrated database retrieval system