K03175                      KO                                     
TNF receptor-associated factor 6 [EC:]
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04064  NF-kappa B signaling pathway
map04120  Ubiquitin mediated proteolysis
map04140  Autophagy - animal
map04144  Endocytosis
map04214  Apoptosis - fly
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04657  IL-17 signaling pathway
map04722  Neurotrophin signaling pathway
map04936  Alcoholic liver disease
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03175  TRAF6; TNF receptor-associated factor 6
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04013 MAPK signaling pathway - fly
    K03175  TRAF6; TNF receptor-associated factor 6
   04064 NF-kappa B signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K03175  TRAF6; TNF receptor-associated factor 6
   04140 Autophagy - animal
    K03175  TRAF6; TNF receptor-associated factor 6
  09143 Cell growth and death
   04214 Apoptosis - fly
    K03175  TRAF6; TNF receptor-associated factor 6
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04621 NOD-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04622 RIG-I-like receptor signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
   04657 IL-17 signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K03175  TRAF6; TNF receptor-associated factor 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03175  TRAF6; TNF receptor-associated factor 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03175  TRAF6; TNF receptor-associated factor 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05161 Hepatitis B
    K03175  TRAF6; TNF receptor-associated factor 6
   05160 Hepatitis C
    K03175  TRAF6; TNF receptor-associated factor 6
   05171 Coronavirus disease - COVID-19
    K03175  TRAF6; TNF receptor-associated factor 6
   05162 Measles
    K03175  TRAF6; TNF receptor-associated factor 6
   05168 Herpes simplex virus 1 infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05169 Epstein-Barr virus infection
    K03175  TRAF6; TNF receptor-associated factor 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05132 Salmonella infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05131 Shigellosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05135 Yersinia infection
    K03175  TRAF6; TNF receptor-associated factor 6
   05133 Pertussis
    K03175  TRAF6; TNF receptor-associated factor 6
   05152 Tuberculosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K03175  TRAF6; TNF receptor-associated factor 6
   05140 Leishmaniasis
    K03175  TRAF6; TNF receptor-associated factor 6
   05142 Chagas disease
    K03175  TRAF6; TNF receptor-associated factor 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03175  TRAF6; TNF receptor-associated factor 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K03175  TRAF6; TNF receptor-associated factor 6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K03175  TRAF6; TNF receptor-associated factor 6
   04121 Ubiquitin system
    K03175  TRAF6; TNF receptor-associated factor 6
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases  RING-type E3 ubiquitin transferase
     K03175  TRAF6; TNF receptor-associated factor 6
Membrane trafficking [BR:ko04131]
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K03175  TRAF6; TNF receptor-associated factor 6
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03175  TRAF6; TNF receptor-associated factor 6
HSA: 7189(TRAF6)
PTR: 451702(TRAF6)
PPS: 100983960(TRAF6)
GGO: 101152087(TRAF6)
PON: 100449432(TRAF6)
NLE: 100595327(TRAF6)
HMH: 116476347(TRAF6)
MCC: 716907(TRAF6)
MCF: 102128596(TRAF6)
MTHB: 126936615
MNI: 105471571(TRAF6)
CSAB: 103237554(TRAF6)
CATY: 105586809(TRAF6)
PANU: 101002649(TRAF6)
TGE: 112607412(TRAF6)
MLEU: 105534673(TRAF6)
RRO: 104658364(TRAF6)
RBB: 108535559(TRAF6)
TFN: 117080232(TRAF6)
PTEH: 111521878(TRAF6)
CANG: 105510802(TRAF6)
CJC: 100395364(TRAF6)
SBQ: 101033308(TRAF6)
CIMI: 108305750(TRAF6)
CSYR: 103263671(TRAF6)
MMUR: 105856828(TRAF6)
LCAT: 123642600(TRAF6)
PCOQ: 105814571(TRAF6)
OGA: 100945817(TRAF6)
MMU: 22034(Traf6)
MCAL: 110290132(Traf6)
MPAH: 110318382(Traf6)
RNO: 311245(Traf6)
MCOC: 116090551(Traf6)
ANU: 117703656(Traf6)
MUN: 110557497(Traf6)
CGE: 100753700(Traf6)
MAUA: 101830563(Traf6)
PROB: 127222196(Traf6)
PLEU: 114710754(Traf6)
MORG: 121440550 121465651(Traf6)
MFOT: 126504640
AAMP: 119814858(Traf6)
NGI: 103749513(Traf6)
HGL: 101697126(Traf6)
CPOC: 100724447(Traf6)
CCAN: 109693564(Traf6)
DORD: 105988129(Traf6)
DSP: 122117775(Traf6)
PLOP: 125361532(Traf6)
NCAR: 124959952
MMMA: 107135761(Traf6)
OCU: 100343190
OPI: 101518298(TRAF6)
TUP: 102482652(TRAF6)
GVR: 103601167(TRAF6)
CFA: 100688110(TRAF6)
CLUD: 112663495(TRAF6)
VVP: 112930471(TRAF6)
VLG: 121471306(TRAF6)
NPO: 129494142(TRAF6)
AML: 100483216(TRAF6)
UMR: 103659308(TRAF6)
UAH: 113265029(TRAF6)
UAR: 123799411(TRAF6)
ELK: 111150027
LLV: 125078866
MPUF: 101691506(TRAF6)
MNP: 132021320(TRAF6)
MLK: 131811444(TRAF6)
NVS: 122912847(TRAF6)
ORO: 101362953(TRAF6)
EJU: 114215395(TRAF6)
ZCA: 113913973(TRAF6)
MLX: 118015773(TRAF6)
NSU: 110576276(TRAF6)
LWW: 102728739(TRAF6)
FCA: 101099750(TRAF6)
PYU: 121043535(TRAF6)
PCOO: 112865434(TRAF6)
PBG: 122483712(TRAF6)
LRUF: 124505383
PTG: 102960157(TRAF6)
PPAD: 109279193(TRAF6)
PUC: 125934537
AJU: 106976941
HHV: 120232555(TRAF6)
BTA: 539124(TRAF6)
BOM: 102285891(TRAF6)
BIU: 109565970
BBUB: 102399580(TRAF6)
BBIS: 104982477(TRAF6)
CHX: 102172830(TRAF6)
OAS: 101107132(TRAF6)
BTAX: 128060227(TRAF6)
ODA: 120876881(TRAF6)
CCAD: 122449806(TRAF6)
MBEZ: 129554762(TRAF6)
SSC: 396629(TRAF6)
CFR: 102520181(TRAF6)
CBAI: 105076500(TRAF6)
CDK: 105106823(TRAF6)
VPC: 102540938(TRAF6)
BACU: 103018592(TRAF6)
LVE: 103088795
OOR: 101277553(TRAF6)
DLE: 111179772(TRAF6)
PCAD: 102993207(TRAF6)
PSIU: 116757663(TRAF6)
NASI: 112404544(TRAF6)
ECB: 100052296(TRAF6)
EPZ: 103560236(TRAF6)
EAI: 106837480(TRAF6)
MYB: 102250946(TRAF6)
MYD: 102765934(TRAF6)
MMYO: 118665127(TRAF6)
MLF: 102436804(TRAF6)
PKL: 118712509(TRAF6)
EFUS: 103290874(TRAF6)
MNA: 107531990(TRAF6)
DRO: 112303407(TRAF6)
SHON: 118983180(TRAF6)
AJM: 119036455(TRAF6)
PDIC: 114500758(TRAF6)
PHAS: 123809979(TRAF6)
MMF: 118628151(TRAF6)
PPAM: 129080456(TRAF6)
HAI: 109381153(TRAF6)
RFQ: 117030261(TRAF6)
PALE: 102886476(TRAF6)
PGIG: 120606104(TRAF6)
PVP: 105290063(TRAF6)
RAY: 107499247(TRAF6)
MJV: 108390300(TRAF6)
TOD: 119255354(TRAF6)
SARA: 101543216(TRAF6)
LAV: 100671471(TRAF6)
TMU: 101345331
ETF: 101658809(TRAF6)
DNM: 101438500(TRAF6)
MDO: 100010055(TRAF6)
GAS: 123251329(TRAF6)
SHR: 100922331(TRAF6)
AFZ: 127542124
PCW: 110192620(TRAF6)
OAA: 100077058(TRAF6)
GGA: 423163(TRAF6)
PCOC: 116229116(TRAF6)
MGP: 100544809(TRAF6)
CJO: 107314700(TRAF6)
TPAI: 128085633(TRAF6)
LMUT: 125694458(TRAF6)
NMEL: 110401104(TRAF6)
APLA: 101802411(TRAF6)
ACYG: 106044346(TRAF6)
CATA: 118250786(TRAF6)
AFUL: 116489674(TRAF6)
TGU: 100229606(TRAF6)
LSR: 110484454(TRAF6)
SCAN: 103826724(TRAF6)
PMOA: 120512561(TRAF6)
OTC: 121344869(TRAF6)
PRUF: 121360996(TRAF6)
GFR: 102040197(TRAF6)
FAB: 101817601(TRAF6)
OMA: 130253546(TRAF6)
PHI: 102105183(TRAF6)
PMAJ: 107206210(TRAF6)
CCAE: 111930105(TRAF6)
CCW: 104693976(TRAF6)
CBRC: 103620910(TRAF6)
ETL: 114056738(TRAF6)
ZAB: 102065554(TRAF6)
ACHL: 103802335(TRAF6)
SVG: 106851517(TRAF6)
MMEA: 130578096(TRAF6)
HRT: 120754032(TRAF6)
FPG: 101912003(TRAF6)
FCH: 102058044(TRAF6)
CLV: 102083770(TRAF6)
EGZ: 104134046(TRAF6)
NNI: 104019573
PCRI: 104023738(TRAF6)
PLET: 104618120(TRAF6)
EHS: 104502487(TRAF6)
PCAO: 104039330(TRAF6)
ACUN: 113481145(TRAF6)
TALA: 104369526(TRAF6)
PADL: 103921676(TRAF6)
AFOR: 103901553(TRAF6)
ACHC: 115353383(TRAF6)
HALD: 104316940(TRAF6)
HLE: 104843213(TRAF6)
AGEN: 126049491
GCL: 127017259
CCRI: 104154446(TRAF6)
CSTI: 104556332(TRAF6)
CMAC: 104480420(TRAF6)
MUI: 104548272(TRAF6)
BREG: 104641124(TRAF6)
FGA: 104070053(TRAF6)
GSTE: 104254122(TRAF6)
LDI: 104350177(TRAF6)
MNB: 103776764(TRAF6)
OHA: 104330076(TRAF6)
NNT: 104402000(TRAF6)
SHAB: 115606662(TRAF6)
DPUB: 104304786(TRAF6)
PGUU: 104457452(TRAF6)
ACAR: 104523193(TRAF6)
CPEA: 104388407(TRAF6)
AVIT: 104277489(TRAF6)
CVF: 104295805(TRAF6)
RTD: 128908737(TRAF6)
CUCA: 104056322(TRAF6)
TEO: 104382441(TRAF6)
BRHI: 104495856(TRAF6)
AAM: 106498355(TRAF6)
AROW: 112960908(TRAF6)
NPD: 112943501(TRAF6)
TGT: 104574137(TRAF6)
SCAM: 104152881(TRAF6)
ASN: 102368234(TRAF6)
AMJ: 102572036(TRAF6)
CPOO: 109321438(TRAF6)
GGN: 109298950(TRAF6)
PSS: 102463398(TRAF6)
CMY: 102938959(TRAF6)
CCAY: 125637892(TRAF6)
DCC: 119856996(TRAF6)
CPIC: 101953645(TRAF6)
TST: 117877000(TRAF6)
CABI: 116839265(TRAF6)
MRV: 120404545(TRAF6)
ACS: 100561211(traf6)
ASAO: 132768609(TRAF6)
PVT: 110090250(TRAF6)
SUND: 121929536(TRAF6)
PBI: 103052063(TRAF6)
PMUR: 107293338(TRAF6)
CTIG: 120301920(TRAF6)
TSR: 106556967(TRAF6)
PGUT: 117665476(TRAF6)
APRI: 131187423(TRAF6)
PTEX: 113440701(TRAF6)
NSS: 113410230(TRAF6)
VKO: 123026693(TRAF6)
PMUA: 114600173(TRAF6)
PRAF: 128416982(TRAF6)
ZVI: 118089981(TRAF6)
HCG: 128341705(TRAF6)
GJA: 107116985(TRAF6)
STOW: 125434925
EMC: 129323951(TRAF6)
XLA: 444777(traf6.L) 734929(traf6.S)
XTR: 493524(traf6)
NPR: 108787821(TRAF6)
RTEM: 120917068(TRAF6)
BBUF: 120980714(TRAF6)
BGAR: 122920378(TRAF6)
MUO: 115468800(TRAF6)
GSH: 117351994(TRAF6)
DRE: 554561(traf6)
CCAR: 109065463 109093401(traf6)
PTET: 122349485(traf6)
LROH: 127168474(traf6)
OMC: 131543819(traf6)
PPRM: 120469276(traf6)
RKG: 130077123(traf6)
MAMB: 125265141(traf6)
CIDE: 127515905
TROS: 130561567(traf6)
TDW: 130427828(traf6)
MANU: 129447218(traf6)
IPU: 108259200
IFU: 128603046(traf6)
PHYP: 113540966(traf6)
SMEO: 124379888(traf6)
TFD: 113636662(traf6)
TVC: 132838745(traf6)
AMEX: 103021325(traf6)
CMAO: 118817529(traf6)
EEE: 113579696(traf6)
CHAR: 105889045(traf6) 105913349
TRU: 101071368(traf6)
TFS: 130515755(traf6)
LCO: 104920634(traf6)
NCC: 104948752(traf6)
TBEN: 117471647(traf6)
CGOB: 115025996(traf6)
PGEO: 117463949(traf6)
GACU: 117549320(traf6)
EMAC: 134863706(traf6)
ELY: 117257648(traf6)
EFO: 125900030(traf6)
PLEP: 121946204(traf6)
SLUC: 116043440(traf6)
ECRA: 117948342(traf6)
ESP: 116689192(traf6)
PFLV: 114552813(traf6)
GAT: 100174890(traf6)
PPUG: 119228078(traf6)
AFB: 129101016(traf6)
CLUM: 117749526(traf6)
PSWI: 130192387(traf6)
MSAM: 119889757(traf6)
SCHU: 122870990(traf6)
CUD: 121513662(traf6)
ALAT: 119017781(traf6)
MZE: 101469001(traf6)
ONL: 100703551(traf6)
OAU: 116329465(traf6)
OLA: 101161132(traf6)
OML: 112161172(traf6)
CSAI: 133458825(traf6)
XMA: 102220826(traf6)
XCO: 114142760(traf6)
XHE: 116718296(traf6)
PRET: 103462724(traf6)
PFOR: 103153578(traf6)
PLAI: 106965102(traf6)
PMEI: 106907132(traf6)
GAF: 122845565(traf6)
PPRL: 129364077(traf6)
CVG: 107099447(traf6)
CTUL: 119773575(traf6)
GMU: 124866796(traf6)
NFU: 107383589(traf6)
KMR: 108234801(traf6)
ALIM: 106523547(traf6)
NWH: 119430243(traf6)
AOCE: 111571002(traf6)
MCEP: 125005122(traf6)
CSEM: 103378810(traf6)
POV: 109637261(traf6)
SSEN: 122772221(traf6)
HHIP: 117754467(traf6)
HSP: 118106693(traf6)
SMAU: 118302102(traf6)
LCF: 108887802
SDU: 111223588(traf6)
SLAL: 111644323(traf6)
XGL: 120788717(traf6)
HCQ: 109525774(traf6)
SSCV: 125967623
SBIA: 133498402(traf6)
PEE: 133399116(traf6)
PTAO: 133471939(traf6)
BPEC: 110162549(traf6)
MALB: 109965061(traf6)
BSPL: 114852159(traf6)
SJO: 128382417(traf6)
OTW: 112247822(traf6)
ONE: 115117991
OKI: 109877755(traf6) 116365776
OKE: 118381203(traf6)
SALP: 112077783(traf6)
CCLU: 121546400(traf6)
ELS: 105025313(traf6)
SFM: 108934700 108942315(traf6)
AANG: 118215287(traf6)
LOC: 102684182(traf6)
PSEX: 120523208(traf6)
LCM: 102353931(TRAF6)
CMK: 103186026(traf6) 121852210
RTP: 109936672(traf6)
CPLA: 122557956(traf6)
HOC: 132824362(traf6)
LERI: 129705871(traf6)
PMRN: 116945680(TRAF6)
LRJ: 133351359
BFO: 118414689
CIN: 778949(zf(traf/ring)-3)
SCLV: 120333900
DME: Dmel_CG10961(Traf6)
DER: 6550517
DSE: 6620179
DSI: Dsimw501_GD16124(Dsim_GD16124)
DSR: 110179707
DPO: 4814971
DPE: 6598159
DMN: 108164693
DWI: 6641099
DGR: 6565995
DAZ: 108617878
DNV: 108655545
DHE: 111594992
DVI: 6632039
CCAT: 101456087
BOD: 106618464
BDR: 105232033
RZE: 108364599
AOQ: 129239603
TDA: 119669766
MDE: 101890213
SCAC: 106087456
LCQ: 111674929
GFS: 119641147
ECOE: 129948038
HIS: 119654244
AGA: 1272949
ACOZ: 120961031
AARA: 120897145
AMER: 121600145
ASTE: 118503584
AFUN: 125765449
AMOU: 128310802
AALI: 118459068
BCOO: 119071533
AME: 551819
ACER: 107994913
ALAB: 122713429
ADR: 102675349
AFLR: 100867190
BIM: 100744070
BBIF: 117215675
BVK: 117238330
BVAN: 117164721
BTER: 100647374
BAFF: 126914697
BPYO: 122566488
BPAS: 132909841
FVI: 122538191
CCAL: 108622235
OBB: 114881674
OLG: 117609805
MGEN: 117219535
NMEA: 116428933
CGIG: 122405097
SOC: 105198280
MPHA: 105833603
AEC: 105149418
ACEP: 105625455
PBAR: 105422477
VEM: 105567281
HST: 105190721
DQU: 106742594
CFO: 105257286
FEX: 115238130
LHU: 105676050
PGC: 109851970
OBO: 105280100
PCF: 106788531
PFUC: 122518063
VPS: 122628097
VCRB: 124422504
VVE: 124947452
LHT: 122501544
LBD: 127281180
MDL: 103569690
FAS: 105267067
DAM: 107039233
AGIF: 122854142
VCAN: 122405899
CCIN: 107268152
DSM: 124412632
NPT: 124220832
NFB: 124184215
NLO: 107222633
NVG: 124306602
AROA: 105694090
TCA: 661716(Traf2)
DPA: 109541363
SOY: 115874728
AGRG: 126741656
ATD: 109597958
CSET: 123309084
AGB: 108911878
LDC: 111504407
NVL: 108556858
APLN: 108733106
OTU: 111413061
BMOR: 100862757
BMAN: 114241799
BANY: 112046594
MJU: 123866044
NIQ: 126768147
VCD: 124544401
MCIX: 123670312
PMAC: 106715656
PPOT: 106103347
PXU: 106113379
PRAP: 111001407
PBX: 123711294
PNAP: 125059331
ZCE: 119833545
CCRC: 123692171
LSIN: 126976964
HAW: 110371014
HZE: 124632749
TNL: 113507105
SLIU: 111358584
OFU: 114364070
PGW: 126366285
CCRN: 123299236
API: 100575177
DNX: 107165263
AGS: 114120558
RMD: 113560984
ACOO: 126843453
DVT: 126900212
BTAB: 109044603
CLEC: 106670044
HHAL: 106683518
NLU: 111046887
HVI: 124364591
FOC: 113213546
TPAL: 117647796
ZNE: 110826527
CSEC: 111863746
FCD: 110850863
PVM: 113823573
PJA: 122259149
PCHN: 125035846
PMOO: 119594067
HAME: 121877642
PCLA: 123761643
CQD: 128686024
PTRU: 123518241
ESN: 127010133
HAZT: 108680316
EAF: 111700075
LSM: 121126234
TCF: 131889650
PPOI: 119107386
DFR: 124495251
CSCU: 111628924
LPOL: 106469125
GAE: 121380421
PMAX: 117327240
MMER: 123563068
DPOL: 127866356
NVE: 5520915
HSY: 130612339
MGR: MGG_03256
MAW: MAC_05764
MAJ: MAA_01724
CMT: CCM_08969
 » show all
Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK
The E3 ligase TRAF6 regulates Akt ubiquitination and activation.
Science 325:1134-8 (2009)
Cao Z, Xiong J, Takeuchi M, Kurama T, Goeddel DV
TRAF6 is a signal transducer for interleukin-1.
Nature 383:443-6 (1996)

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