Entry Name Type I diabetes mellitus - Monodelphis domestica (gray short-tailed opossum)
Description Type I diabetes mellitus is a disease that results from autoimmune destruction of the insulin-producing beta-cells. Certain beta-cell proteins act as autoantigens after being processed by antigen-presenting cell (APC), such as macrophages and dendritic cells, and presented in a complex with MHC-II molecules on the surface of the APC. Then immunogenic signals from APC activate CD4+ T cells, predominantly of the Th1 subset. Antigen-activated Th1 cells produce IL-2 and IFNgamma. They activate macrophages and cytotoxic CD8+ T cells, and these effector cells may kill islet beta-cells by one or both of two types of mechanisms: (1) direct interactions of antigen-specific cytotoxic T cells with a beta-cell autoantigen-MHC-I complex on the beta-cell, and (2) non-specific inflammatory mediators, such as free radicals/oxidants and cytokines (IL-1, TNFalpha, TNFbeta, IFNgamma).
Class Human Diseases; Endocrine and metabolic diseaseBRITE hierarchy
Pathway map Ortholog table Organism Monodelphis domestica (gray short-tailed opossum) [GN:
mdo ]
Gene 100026858 HLA class II histocompatibility antigen, DM beta chain [KO:K06752 ]
100026007 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
100025990 mamu class II histocompatibility antigen, DR alpha chain-like [KO:K06752 ]
100026088 DLA class II histocompatibility antigen, DR-1 beta chain-like [KO:K06752 ]
100026891 HLA class II histocompatibility antigen, DM alpha chain [KO:K06752 ]
100024589 rano class II histocompatibility antigen, A beta chain-like [KO:K06752 ]
100025909 H-2 class II histocompatibility antigen, E-S beta chain-like [KO:K06752 ]
100025932 RLA class II histocompatibility antigen, DP alpha-1 chain-like [KO:K06752 ]
100026112 H-2 class II histocompatibility antigen, A-U alpha chain-like [KO:K06752 ]
107651119 boLa class II histocompatibility antigen, DQB*0101 beta chain-like [KO:K06752 ]
100026254 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
100026367 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
100026558 H-2 class II histocompatibility antigen, A-R alpha chain-like [KO:K06752 ]
100026802 Modo-UA; patr class I histocompatibility antigen, A-5 alpha chain [KO:K06751 ]
100026822 MODO-UK; HLA class I histocompatibility antigen, A-69 alpha chain-like [KO:K06751 ]
100009719 MHC-I; BOLA class I histocompatibility antigen, alpha chain BL3-7 [KO:K06751 ]
103093835 class I histocompatibility antigen, Gogo-OKO alpha chain-like [KO:K06751 ]
107651418 mamu class I histocompatibility antigen, alpha chain F-like [KO:K06751 ]
103094634 major histocompatibility complex class I-related gene protein-like [KO:K06751 ]
103103471 BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
107651120 RT1 class I histocompatibility antigen, AA alpha chain-like [KO:K06751 ]
103106351 Modo-UT3; H-2 class I histocompatibility antigen, alpha chain-like [KO:K06751 ]
103092123 Modo-UT5; class I histocompatibility antigen, F10 alpha chain-like [KO:K06751 ]
100024719 Mhc-1; BOLA class I histocompatibility antigen, alpha chain BL3-7-like [KO:K06751 ]
751097 MHC-1; major histocompatibility complex class I [KO:K06751 ]
Compound Reference Authors Rabinovitch A, Suarez-Pinzon WL.
Title Cytokines and their roles in pancreatic islet beta-cell destruction and insulin-dependent diabetes mellitus.
Journal Reference Authors Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, Spielman RS, Todd JA, Concannon P
Title Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families.
Journal Reference Authors Davies JL, Kawaguchi Y, Bennett ST, Copeman JB, Cordell HJ, Pritchard LE, Reed PW, Gough SC, Jenkins SC, Palmer SM, et al.
Title A genome-wide search for human type 1 diabetes susceptibility genes.
Journal Reference Authors Fujisawa T, Ikegami H, Kawaguchi Y, Yamato E, Takekawa K, Nakagawa Y, Hamada Y, Ueda H, Shima K, Ogihara T.
Title Class I HLA is associated with age-at-onset of IDDM, while class II HLA confers susceptibility to IDDM.
Journal Reference Authors Jaeckel E, Klein L, Martin-Orozco N, von Boehmer H.
Title Normal incidence of diabetes in NOD mice tolerant to glutamic acid decarboxylase.
Journal Reference Authors Nakayama M, Abiru N, Moriyama H, Babaya N, Liu E, Miao D, Yu L, Wegmann DR, Hutton JC, Elliott JF, Eisenbarth GS.
Title Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice.
Journal Reference Authors Kent SC, Chen Y, Bregoli L, Clemmings SM, Kenyon NS, Ricordi C, Hering BJ, Hafler DA.
Title Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope.
Journal Reference Authors Lieberman SM, DiLorenzo TP.
Title A comprehensive guide to antibody and T-cell responses in type 1 diabetes.
Journal Reference Authors Lord SJ, Rajotte RV, Korbutt GS, Bleackley RC.
Title Granzyme B: a natural born killer.
Journal Related mdo04660 T cell receptor signaling pathway
KO pathway LinkDB All DBs
