KEGG   PATHWAY: mmyo03008
Entry
mmyo03008                   Pathway                                
Name
Ribosome biogenesis in eukaryotes - Myotis myotis (greater mouse-eared bat)
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
mmyo03008  Ribosome biogenesis in eukaryotes
mmyo03008

Organism
Myotis myotis (greater mouse-eared bat) [GN:mmyo]
Gene
118679647  CSNK2B; casein kinase II subunit beta [KO:K03115]
118674082  CSNK2A2; casein kinase II subunit alpha' isoform X1 [KO:K03097] [EC:2.7.11.1]
118663040  CSNK2A1; casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
118676987  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
118667389  NOL6; nucleolar protein 6 isoform X1 [KO:K14544]
118650354  RRP7A; ribosomal RNA-processing protein 7 homolog A isoform X1 [KO:K14545]
118667461  WD repeat-containing protein 43 [KO:K14546]
118669143  WDR43; WD repeat-containing protein 43 isoform X1 [KO:K14546]
118674398  UTP4; U3 small nucleolar RNA-associated protein 4 homolog isoform X1 [KO:K14548]
118656603  UTP15; U3 small nucleolar RNA-associated protein 15 homolog isoform X1 [KO:K14549]
118678719  HEATR1; HEAT repeat-containing protein 1 isoform X1 [KO:K14550]
118661513  WDR75; WD repeat-containing protein 75 [KO:K14552]
118671316  UTP18; U3 small nucleolar RNA-associated protein 18 homolog isoform X1 [KO:K14553]
118656474  WDR36; WD repeat-containing protein 36 isoform X1 [KO:K14554]
118656188  TBL3; transducin beta-like protein 3 isoform X1 [KO:K14555]
118672683  WDR3; WD repeat-containing protein 3 isoform X1 [KO:K14556]
118671870  UTP6; U3 small nucleolar RNA-associated protein 6 homolog isoform X1 [KO:K14557]
118676854  PWP2; periodic tryptophan protein 2 homolog isoform X1 [KO:K14558]
118679192  MPHOSPH10; U3 small nucleolar ribonucleoprotein protein MPP10 [KO:K14559]
118676187  IMP3; U3 small nucleolar ribonucleoprotein protein IMP3 [KO:K14560]
118649909  IMP4; U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
118653592  U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
118657705  TCOF1; treacle protein [KO:K14562]
118659307  FBLL1; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1 [KO:K14563] [EC:2.1.1.-]
118674480  FBL; rRNA 2'-O-methyltransferase fibrillarin [KO:K14563] [EC:2.1.1.-]
118662826  NOP56; nucleolar protein 56 [KO:K14564]
118661462  NOP58; nucleolar protein 58 isoform X1 [KO:K14565]
118650390  SNU13; NHP2-like protein 1 [KO:K12845]
118653892  DKC1; H/ACA ribonucleoprotein complex subunit DKC1 isoform X1 [KO:K11131] [EC:5.4.99.-]
118658193  NHP2; H/ACA ribonucleoprotein complex subunit 2 [KO:K11129]
118672995  GAR1; H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
118649280  NOP10; H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
118673611  H/ACA ribonucleoprotein complex subunit 3-like [KO:K11130]
118660153  H/ACA ribonucleoprotein complex subunit 3 [KO:K11130]
118658102  FCF1; rRNA-processing protein FCF1 homolog isoform X1 [KO:K14566]
118667215  U3 small nucleolar RNA-associated protein 14 homolog A-like [KO:K14567]
118654050  UTP14A; U3 small nucleolar RNA-associated protein 14 homolog A [KO:K14567]
118656184  DROSHA; ribonuclease 3 isoform X1 [KO:K03685] [EC:3.1.26.3]
118652149  EMG1; ribosomal RNA small subunit methyltransferase NEP1 isoform X1 [KO:K14568] [EC:2.1.1.260]
118669435  ribosomal RNA small subunit methyltransferase NEP1-like [KO:K14568] [EC:2.1.1.260]
118670211  BMS1; ribosome biogenesis protein BMS1 homolog isoform X1 [KO:K14569]
118665150  NAT10; RNA cytidine acetyltransferase isoform X1 [KO:K14521] [EC:2.3.1.-]
118667510  RCL1; RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
118670665  POP1; ribonucleases P/MRP protein subunit POP1 [KO:K01164] [EC:3.1.26.5]
118655461  RPP38; ribonuclease P protein subunit p38 [KO:K14523] [EC:3.1.26.5]
118674491  POP4; ribonuclease P protein subunit p29 [KO:K03538] [EC:3.1.26.5]
118678642  POP5; ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
118667371  RPP25L; ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
118660498  RPP25; ribonuclease P protein subunit p25 [KO:K14525] [EC:3.1.26.5]
118655734  POP7; ribonuclease P protein subunit p20 [KO:K14527] [EC:3.1.26.5]
118669971  RPP30; ribonuclease P protein subunit p30 isoform X1 [KO:K03539] [EC:3.1.26.5]
118677258  RPP40; ribonuclease P protein subunit p40 [KO:K14530] [EC:3.1.26.5]
118658882  REXO1; RNA exonuclease 1 homolog isoform X1 [KO:K14570] [EC:3.1.-.-]
118673675  LOW QUALITY PROTEIN: RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
118678621  LOW QUALITY PROTEIN: RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
118660336  RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
118660733  LOW QUALITY PROTEIN: RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
118669434  LOW QUALITY PROTEIN: RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
118664303  REXO2; oligoribonuclease, mitochondrial [KO:K13288] [EC:3.1.-.-]
118674964  XRN1; 5'-3' exoribonuclease 1 isoform X1 [KO:K12618] [EC:3.1.13.-]
118662618  XRN2; 5'-3' exoribonuclease 2 isoform X1 [KO:K12619] [EC:3.1.13.-]
118669407  LOW QUALITY PROTEIN: nucleolar GTP-binding protein 1-like [KO:K06943]
118672769  GTPBP4; nucleolar GTP-binding protein 1 [KO:K06943]
118675845  GNL2; LOW QUALITY PROTEIN: nucleolar GTP-binding protein 2 [KO:K14537]
118667997  GNL3; guanine nucleotide-binding protein-like 3 isoform X1 [KO:K14538]
118653870  GNL3L; guanine nucleotide-binding protein-like 3-like protein isoform X1 [KO:K14538]
118678838  NVL; nuclear valosin-containing protein-like isoform X1 [KO:K14571]
118660383  MDN1; midasin isoform X1 [KO:K14572]
118666438  RBM28; RNA-binding protein 28 isoform X1 [KO:K14573]
118674374  NOB1; RNA-binding protein NOB1 isoform X1 [KO:K11883]
118653021  RAN; GTP-binding nuclear protein Ran [KO:K07936]
118668964  XPO1; exportin-1 isoform X1 [KO:K14290]
118676573  NMD3; 60S ribosomal export protein NMD3 isoform X1 [KO:K07562]
118649015  NXF1; nuclear RNA export factor 1 isoform X1 [KO:K14284]
118653413  nuclear RNA export factor 2-like [KO:K14284]
118653414  NXF3; LOW QUALITY PROTEIN: nuclear RNA export factor 3 [KO:K14284]
118653416  nuclear RNA export factor 2-like [KO:K14284]
118653418  LOW QUALITY PROTEIN: nuclear RNA export factor 2-like [KO:K14284]
118653419  nuclear RNA export factor 2-like [KO:K14284]
118654141  NXT2; NTF2-related export protein 2 isoform X1 [KO:K14285]
118663506  NXT1; NTF2-related export protein 1 [KO:K14285]
118663512  NTF2-related export protein 1-like [KO:K14285]
118663543  EIF6; eukaryotic translation initiation factor 6 [KO:K03264]
118675137  ribosome maturation protein SBDS-like [KO:K14574]
118655876  SBDS; ribosome maturation protein SBDS [KO:K14574]
118659675  EFL1; elongation factor-like GTPase 1 isoform X1 [KO:K14536] [EC:3.6.5.-]
118676156  LSG1; large subunit GTPase 1 homolog isoform X1 [KO:K14539] [EC:3.6.1.-]
118657977  SPATA5; ATPase family protein 2 homolog isoform X1 [KO:K14575]
118669356  LOW QUALITY PROTEIN: ATPase family protein 2 homolog [KO:K14575]
118663304  LOW QUALITY PROTEIN: ATPase family protein 2 homolog [KO:K14575]
118656966  AK6; adenylate kinase isoenzyme 6 isoform X1 [KO:K18532] [EC:2.7.4.3]
118676185  RIOK1; serine/threonine-protein kinase RIO1 isoform X1 [KO:K07178] [EC:2.7.11.1]
118656019  RIOK2; serine/threonine-protein kinase RIO2 isoform X1 [KO:K07179] [EC:2.7.11.1]
118679148  small nucleolar RNA U3 [KO:K14483]
118657535  small nucleolar RNA U3 [KO:K14483]
118672596  small nucleolar RNA U3 [KO:K14483]
118672597  small nucleolar RNA U3 [KO:K14483]
118654940  small nucleolar RNA U3 [KO:K14483]
118660918  small nucleolar RNA U3 [KO:K14483]
118677763  small nucleolar RNA U3 [KO:K14483]
118652174  small nucleolar RNA U3 [KO:K14483]
118677764  small nucleolar RNA U3 [KO:K14483]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
mmyo03010  Ribosome
KO pathway
ko03008   
LinkDB

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