KEGG   PATHWAY: otu03013
Entry
otu03013                    Pathway                                
Name
Nucleocytoplasmic transport - Onthophagus taurus (bull-headed dung beetle)
Description
The exchange of molecules between the nucleus and cytoplasm is mediated through nuclear pore complexes (NPCs) embedded in the nuclear envelope. The NPC is composed of highly conserved, distinct structural modules: the inner pore ring, the cytoplasmic and nuclear rings as well as the cytoplasmic filaments and the nuclear basket. Nuclear transport receptors (e.g. importins and exportins) mediate translocation of cargos through the NPC. Cargo proteins harbouring a nuclear export signal (NES) bind to exportins and Ran-GTP to form an export complex in the nucleoplasm. Nuclear export of bulk mRNA is provided by the non-karyopherin transport proteins TAP-p15 in a Ran-GTP-independent manner. Several EJC factors are known to function in mRNA export.
Class
Genetic Information Processing; Translation
Pathway map
otu03013  Nucleocytoplasmic transport
otu03013

Other DBs
GO: 0050658
Organism
Onthophagus taurus (bull-headed dung beetle) [GN:otu]
Gene
111425970  aladin-like [KO:K14320]
111413592  myb-like protein I [KO:K14321]
111417606  nucleoporin GLE1 [KO:K18723]
111424336  DEAD-box helicase Dbp80 [KO:K18655] [EC:5.6.2.7]
111420929  mRNA export factor [KO:K14298]
111414275  mRNA export factor-like [KO:K14298]
111425433  nuclear pore complex protein Nup98-Nup96 [KO:K14297]
111414684  nuclear pore complex protein Nup214-like [KO:K14317]
111415411  nuclear pore complex protein Nup88 [KO:K14318]
111417708  ranBP2-like and GRIP domain-containing protein 4 isoform X1 [KO:K12172] [EC:2.3.2.-]
111426872  ran GTPase-activating protein 1 [KO:K14319]
111426373  SUMO-conjugating enzyme UBC9-B [KO:K10577]
111420223  small ubiquitin-related modifier 3 [KO:K12160]
111417113  nuclear pore complex protein Nup160 homolog [KO:K14303]
111421434  nuclear pore complex protein Nup85 [KO:K14304]
111415072  protein SEC13 homolog [KO:K14004]
111420159  nuclear pore complex protein Nup107 [KO:K14301]
111424606  nuclear pore complex protein Nup133 [KO:K14300]
111419637  nucleoporin SEH1 [KO:K14299]
111420284  nucleoporin Nup43 [KO:K14305]
111414567  nucleoporin Nup37 [KO:K14302]
111419517  protein ELYS [KO:K25129]
111429157  nuclear pore glycoprotein p62 [KO:K14306]
111415600  probable nucleoporin Nup58 [KO:K14307]
111421355  nucleoporin p54 [KO:K14308]
111416905  nuclear pore complex protein Nup205 [KO:K14310]
111425621  nucleoporin NUP188 homolog [KO:K14311]
111413510  nuclear pore complex protein Nup155 [KO:K14312]
111422686  nuclear pore complex protein Nup93-like [KO:K14309]
111417478  nucleoporin NUP53 [KO:K14313]
111428556  nucleoporin NDC1 [KO:K14315]
111423902  nuclear pore membrane glycoprotein 210 isoform X1 [KO:K14314]
111415427  Krueppel homolog 2 [KO:K20724]
111418040  nucleoprotein TPR [KO:K09291]
111414420  nuclear pore complex protein Nup50 [KO:K14295]
111418028  nuclear pore complex protein Nup153 isoform X1 [KO:K14296]
111420644  importin subunit alpha-5 [KO:K15043]
111427682  importin subunit alpha-3 [KO:K23583]
111420716  importin subunit alpha-7 [KO:K15042]
111428014  importin subunit beta isoform X1 [KO:K14293]
111425688  transportin-1 [KO:K18752]
111414524  transportin-3 [KO:K15436]
111418039  importin-4-like [KO:K20221]
111414705  importin-5 [KO:K20222]
111419301  importin-7 [KO:K20223]
111425449  importin-9 [KO:K20224]
111423968  importin-11 [KO:K25201]
111427124  importin-13 [KO:K25202]
111427161  snurportin-1 isoform X1 [KO:K13151]
111425041  exportin-1 [KO:K14290]
111424395  exportin-2 [KO:K18423]
111424021  exportin-4-like [KO:K25203]
111424985  exportin-5 [KO:K14289]
111426521  exportin-6 isoform X1 [KO:K25204]
111428130  exportin-7 [KO:K18460]
111429232  GTP-binding nuclear protein Ran [KO:K07936]
111413874  elongation factor 1-alpha [KO:K03231]
111415997  elongation factor 1-alpha 2-like [KO:K03231]
111420528  phosphorylated adapter RNA export protein [KO:K14291]
111417129  nuclear cap-binding protein subunit 1 [KO:K12882]
111427955  nuclear cap-binding protein subunit 2 [KO:K12883]
111428411  60S ribosomal export protein NMD3 [KO:K07562]
111418135  RNA-binding protein 8A [KO:K12876]
111421513  protein mago nashi [KO:K12877]
111425102  protein CASC3 isoform X1 [KO:K14323]
111424787  eukaryotic initiation factor 4A-III [KO:K13025] [EC:5.6.2.7]
111419543  apoptotic chromatin condensation inducer in the nucleus isoform X1 [KO:K12875]
111429467  histone deacetylase complex subunit SAP18 [KO:K14324]
111426124  RNA-binding protein with serine-rich domain 1-B [KO:K14325]
111420602  pinin-like [KO:K13114]
111413738  pinin-like [KO:K13114]
111427623  THO complex subunit 4-A [KO:K12881]
111425200  polyadenylate-binding protein, cytoplasmic and nuclear-like [KO:K12881]
111413339  regulator of nonsense transcripts 1 homolog [KO:K14326] [EC:5.6.2.5 5.6.2.3]
111428775  regulator of nonsense transcripts 2 [KO:K14327]
111428513  regulator of nonsense transcripts 3B-like [KO:K14328]
111426367  nuclear RNA export factor 1-like [KO:K14284]
111415295  nuclear RNA export factor 1-like [KO:K14284]
111420536  NTF2-related export protein [KO:K14285]
111414668  ATP-dependent RNA helicase WM6 [KO:K12812] [EC:5.6.2.7]
111427667  serine/arginine repetitive matrix protein 1 [KO:K13171]
111426183  partner of Y14 and mago [KO:K14294]
111426641  THO complex subunit 1 [KO:K12878]
111415789  THO complex subunit 2 [KO:K12879]
111426239  THO complex subunit 5 homolog A [KO:K13174]
111425877  THO complex subunit 6 [KO:K13175]
111416071  THO complex subunit 7 homolog [KO:K13176]
111428690  THO complex subunit 3 [KO:K12880]
Reference
PMID:16777596
  Authors
Tran EJ, Wente SR
  Title
Dynamic nuclear pore complexes: life on the edge.
  Journal
Cell 125:1041-53 (2006)
DOI:10.1016/j.cell.2006.05.027
Reference
PMID:15519698
  Authors
Rodriguez MS, Dargemont C, Stutz F
  Title
Nuclear export of RNA.
  Journal
Biol Cell 96:639-55 (2004)
DOI:10.1016/j.biolcel.2004.04.014
Reference
PMID:18313922
  Authors
Palancade B, Doye V
  Title
Sumoylating and desumoylating enzymes at nuclear pores: underpinning their unexpected duties?
  Journal
Trends Cell Biol 18:174-83 (2008)
DOI:10.1016/j.tcb.2008.02.001
Reference
PMID:15901496
  Authors
Reed R, Cheng H
  Title
TREX, SR proteins and export of mRNA.
  Journal
Curr Opin Cell Biol 17:269-73 (2005)
DOI:10.1016/j.ceb.2005.04.011
Reference
PMID:16314458
  Authors
Tange TO, Shibuya T, Jurica MS, Moore MJ
  Title
Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core.
  Journal
RNA 11:1869-83 (2005)
DOI:10.1261/rna.2155905
Reference
PMID:28673770
  Authors
Beck M, Schirmacher P, Singer S
  Title
Alterations of the nuclear transport system in hepatocellular carcinoma - New basis for therapeutic strategies.
  Journal
J Hepatol 67:1051-1061 (2017)
DOI:10.1016/j.jhep.2017.06.021
Related
pathway
otu03015  mRNA surveillance pathway
KO pathway
ko03013   
LinkDB

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