KEGG   PATHWAY: paes03070
Entry
paes03070                   Pathway                                
Name
Bacterial secretion system - Pseudomonas aeruginosa SCV20265
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
paes03070  Bacterial secretion system
paes03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas aeruginosa SCV20265 [GN:paes]
Gene
SCV20265_0822  putative outer membrane protein [KO:K12340]
SCV20265_5637  Type I secretion outer membrane protein, TolC precursor [KO:K12340]
SCV20265_5223  Outer membrane efflux family protein [KO:K12340]
SCV20265_3691  yscF; Type III secretion cytoplasmic protein YscF [KO:K03221]
SCV20265_3714  Type III secretion spans bacterial envelope protein YscO [KO:K04056]
SCV20265_3715  Type III secretion protein YscP [KO:K04057]
SCV20265_3709  Type III secretion protein SctX [KO:K04059]
SCV20265_3693  yscC; Type III secretion outermembrane pore forming protein YscC [KO:K03219]
SCV20265_3712  Type III secretion outermembrane contact sensing protein YopN [KO:K04058]
SCV20265_3687  yscJ; Type III secretion bridge between inner and outermembrane lipoprotein YscJ [KO:K03222]
SCV20265_3717  Type III secretion inner membrane protein YscR [KO:K03226]
SCV20265_3718  Type III secretion inner membrane protein YscS [KO:K03227]
SCV20265_3719  Type III secretion inner membrane protein YscT [KO:K03228]
SCV20265_3720  Type III secretion inner membrane protein YscU [KO:K03229]
SCV20265_3707  lcrD; Type III secretion inner membrane channel protein LcrD [KO:K03230]
SCV20265_3713  Flagellum-specific ATP synthase FliI [KO:K03224] [EC:7.4.2.8]
SCV20265_3716  Type III secretion inner membrane protein YscQ [KO:K03225]
SCV20265_3685  yscL; Type III secretion cytoplasmic protein YscL [KO:K03223]
SCV20265_4832  General secretion pathway protein D [KO:K02453]
SCV20265_3529  General secretion pathway protein D / Type II secretion outermembrane pore forming protein (PulD) [KO:K02453]
SCV20265_1943  General secretion pathway protein D [KO:K02453]
SCV20265_4838  General secretion pathway protein C [KO:K02452]
SCV20265_3530  General secretion pathway protein C [KO:K02452]
SCV20265_1944  General secretion pathway protein C [KO:K02452]
SCV20265_4830  General secretion pathway protein F [KO:K02455]
SCV20265_2573  General secretion pathway protein F / Type II secretory pathway, component PulF [KO:K02455]
SCV20265_1946  General secretion pathway protein F [KO:K02455]
SCV20265_4836  General secretion pathway protein G [KO:K02456]
SCV20265_2576  General secretion pathway protein G [KO:K02456]
SCV20265_2577  putative type II secretion system protein [KO:K02456]
SCV20265_1947  General secretion pathway protein G [KO:K02456]
SCV20265_4839  General secretion pathway protein H [KO:K02457]
SCV20265_1948  General secretion pathway protein H [KO:K02457]
SCV20265_4837  General secretion pathway protein I [KO:K02458]
SCV20265_2578  General secretion pathway protein I [KO:K02458]
SCV20265_1949  General secretion pathway protein I [KO:K02458]
SCV20265_4840  General secretion pathway protein J [KO:K02459]
SCV20265_2579  Type II secretory pathway, pseudopilin PulG [KO:K02459]
SCV20265_1950  General secretion pathway protein J [KO:K02459]
SCV20265_4835  General secretion pathway protein K [KO:K02460]
SCV20265_1951  General secretion pathway protein K [KO:K02460]
SCV20265_4834  General secretion pathway protein L [KO:K02461]
SCV20265_1952  General secretion pathway protein L [KO:K02461]
SCV20265_4833  General secretion pathway protein M [KO:K02462]
SCV20265_1953  General secretion pathway protein M [KO:K02462]
SCV20265_4831  General secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
SCV20265_5930  Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [KO:K02454] [EC:7.4.2.8]
SCV20265_1945  General secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
SCV20265_4486  Conjugative transfer ATPase PilQ in PFGI-1-like cluster [KO:K02454] [EC:7.4.2.8]
SCV20265_1178  Protein-export membrane protein SecD [KO:K03072]
SCV20265_1179  Protein-export membrane protein SecF [KO:K03074]
SCV20265_0685  Preprotein translocase subunit SecE [KO:K03073]
SCV20265_0718  Preprotein translocase secY subunit [KO:K03076]
SCV20265_1177  Preprotein translocase subunit YajC [KO:K03210]
SCV20265_6309  Inner membrane protein translocase component YidC, long form [KO:K03217]
SCV20265_4977  Protein export cytoplasm protein SecA ATPase RNA helicase [KO:K03070] [EC:7.4.2.8]
SCV20265_0389  Signal recognition particle receptor protein FtsY [KO:K03110]
SCV20265_5801  Protein export cytoplasm chaperone protein (SecB, maintains protein to be exported in unfolded state) [KO:K03071]
SCV20265_1262  Signal recognition particle, subunit Ffh SRP54 [KO:K03106] [EC:3.6.5.4]
SCV20265_5740  tatA; Twin-arginine translocation protein TatA [KO:K03116]
SCV20265_5741  tatB; Twin-arginine translocation protein TatB [KO:K03117]
SCV20265_5742  tatC; Twin-arginine translocation protein TatC [KO:K03118]
SCV20265_5029  Type IV secretion system protein VirD4 [KO:K03205] [EC:7.4.2.8]
SCV20265_2139  Type IV secretion system protein VirD4 [KO:K03205] [EC:7.4.2.8]
SCV20265_3909  VgrG protein [KO:K11904]
SCV20265_5990  VgrG protein [KO:K11904]
SCV20265_0093  VgrG protein [KO:K11904]
SCV20265_0097  VgrG protein [KO:K11904]
SCV20265_2563  VgrG protein [KO:K11904]
SCV20265_0269  VgrG protein [KO:K11904]
SCV20265_5762  VgrG protein [KO:K11904]
SCV20265_2945  VgrG protein [KO:K11904]
SCV20265_1759  VgrG protein [KO:K11904]
SCV20265_3907  Secreted protein Hcp [KO:K11903]
SCV20265_5991  Secreted protein Hcp [KO:K11903]
SCV20265_2951  Putative cytoplasmic protein USSDB7A [KO:K11903]
SCV20265_0270  Secreted protein Hcp [KO:K11903]
SCV20265_0087  Uncharacterized protein ImpD [KO:K11903]
SCV20265_3745  Type VI secretion lipoprotein/VasD [KO:K11906]
SCV20265_0081  Type VI secretion lipoprotein VasD [KO:K11906]
SCV20265_2958  IcmF-related protein [KO:K11891]
SCV20265_3742  IcmF-related protein [KO:K11891]
SCV20265_0078  IcmF-related protein [KO:K11891]
SCV20265_2957  Inner membrane protein DotU [KO:K11892]
SCV20265_3743  Outer membrane protein ImpK/VasF [KO:K11892]
SCV20265_0079  Outer membrane protein ImpK [KO:K11892]
SCV20265_2947  ClpB protein [KO:K11907]
SCV20265_3749  ClpB protein [KO:K11907]
SCV20265_0092  ClpB protein [KO:K11907]
SCV20265_0075  Serine/threonine protein kinase PpkA [KO:K11912] [EC:2.7.11.1]
SCV20265_0082  Uncharacterized protein ImpI/VasC [KO:K11913]
SCV20265_3741  Protein serine/threonine phosphatase PrpC, regulation of stationary phase [KO:K11915] [EC:3.1.3.16]
SCV20265_0076  Phosphoprotein phosphatase PppA [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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