KEGG   PATHWAY: panh02020
Entry
panh02020                   Pathway                                
Name
Two-component system - Pseudomonas anuradhapurensis
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
panh02020  Two-component system
panh02020

Other DBs
GO: 0000160
Organism
Pseudomonas anuradhapurensis [GN:panh]
Gene
HU763_024190  phoR; phosphate regulon sensor histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
HU763_024185  phoB; phosphate regulon transcriptional regulator PhoB [KO:K07657]
HU763_010175  phosphate ABC transporter substrate-binding/OmpA family protein [KO:K02040]
HU763_013840  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
HU763_024230  phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
HU763_018360  ATP-binding protein [KO:K07637] [EC:2.7.13.3]
HU763_018365  response regulator [KO:K07660]
HU763_001135  HAMP domain-containing protein [KO:K07638] [EC:2.7.13.3]
HU763_001130  ompR; two-component system response regulator OmpR [KO:K07659]
HU763_017470  response regulator transcription factor [KO:K07662]
HU763_018385  HAMP domain-containing protein [KO:K07639] [EC:2.7.13.3]
HU763_018390  response regulator transcription factor [KO:K07661]
HU763_019330  DegQ family serine endoprotease [KO:K04771] [EC:3.4.21.107]
HU763_013450  MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit [KO:K07799]
HU763_013445  MdtB/MuxB family multidrug efflux RND transporter permease subunit [KO:K07788]
HU763_013440  efflux RND transporter permease subunit [KO:K07789]
HU763_008775  heavy metal sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
HU763_019295  heavy metal sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
HU763_008780  cinR; two-component system response regulator CinR [KO:K07665]
HU763_019290  heavy metal response regulator transcription factor [KO:K07665]
HU763_014370  sensor histidine kinase N-terminal domain-containing protein [KO:K07645] [EC:2.7.13.3]
HU763_016405  sensor histidine kinase N-terminal domain-containing protein [KO:K07645] [EC:2.7.13.3]
HU763_014375  response regulator [KO:K07666]
HU763_016410  response regulator transcription factor [KO:K07666]
HU763_017085  flagellin FliC [KO:K02406]
HU763_016940  RNA polymerase sigma factor FliA [KO:K02405]
HU763_016915  flagellar motor protein [KO:K02556]
HU763_021975  motA; flagellar motor stator protein MotA [KO:K02556]
HU763_016115  sensor histidine kinase KdpD [KO:K07646] [EC:2.7.13.3]
HU763_016110  response regulator [KO:K07667]
HU763_016130  kdpA; potassium-transporting ATPase subunit KdpA [KO:K01546]
HU763_016125  kdpB; potassium-transporting ATPase subunit KdpB [KO:K01547] [EC:7.2.2.6]
HU763_016120  kdpC; potassium-transporting ATPase subunit KdpC [KO:K01548]
HU763_016135  kdpF; K(+)-transporting ATPase subunit F [KO:K01545]
HU763_019375  sensor histidine kinase N-terminal domain-containing protein [KO:K07649] [EC:2.7.13.3]
HU763_019380  response regulator [KO:K07774]
HU763_019400  tripartite tricarboxylate transporter permease [KO:K07793]
HU763_019395  tripartite tricarboxylate transporter TctB family protein [KO:K07794]
HU763_019390  tripartite tricarboxylate transporter substrate binding protein [KO:K07795]
HU763_000350  COX15/CtaA family protein [KO:K02259] [EC:1.17.99.9]
HU763_000005  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
HU763_018315  mprF; bifunctional lysylphosphatidylglycerol flippase/synthetase MprF [KO:K14205] [EC:2.3.2.3]
HU763_010040  OprD family porin [KO:K18093] [EC:3.4.21.-]
HU763_014115  OprD family porin [KO:K18093] [EC:3.4.21.-]
HU763_018280  OprD family porin [KO:K18093] [EC:3.4.21.-]
HU763_023835  OprD family porin [KO:K18093] [EC:3.4.21.-]
HU763_006210  sensor histidine kinase [KO:K19609] [EC:2.7.13.3]
HU763_006205  response regulator transcription factor [KO:K19610]
HU763_000790  LytTR family DNA-binding domain-containing protein [KO:K08083]
HU763_020330  UDP-glucose/GDP-mannose dehydrogenase family protein [KO:K00066] [EC:1.1.1.132]
HU763_005725  response regulator transcription factor [KO:K07684]
HU763_013765  HAMP domain-containing protein [KO:K07675] [EC:2.7.13.3]
HU763_008000  response regulator [KO:K07677] [EC:2.7.13.3]
HU763_008010  response regulator [KO:K07677] [EC:2.7.13.3]
HU763_007995  response regulator [KO:K07687]
HU763_006200  response regulator [KO:K07678] [EC:2.7.13.3]
HU763_015800  uvrY; UvrY/SirA/GacA family response regulator transcription factor [KO:K07689]
HU763_013760  response regulator transcription factor [KO:K07689]
HU763_006700  csrA; carbon storage regulator CsrA [KO:K03563]
HU763_015135  csrA; carbon storage regulator CsrA [KO:K03563]
HU763_017315  csrA; carbon storage regulator CsrA [KO:K03563]
HU763_006665  carbon storage regulator [KO:K03563]
HU763_008490  transporter substrate-binding domain-containing protein [KO:K07679] [EC:2.7.13.3]
HU763_012830  transporter substrate-binding domain-containing protein [KO:K07679] [EC:2.7.13.3]
HU763_018435  transporter substrate-binding domain-containing protein [KO:K07679] [EC:2.7.13.3]
HU763_008495  response regulator transcription factor [KO:K07690]
HU763_018445  response regulator transcription factor [KO:K07690]
HU763_019055  response regulator transcription factor [KO:K07690]
HU763_012825  response regulator transcription factor [KO:K07690]
HU763_011440  beta-lactamase [KO:K01467] [EC:3.5.2.6]
HU763_003020  response regulator transcription factor [KO:K27077]
HU763_009725  spore coat U domain-containing protein [KO:K27078]
HU763_009710  spore coat U domain-containing protein [KO:K27078]
HU763_009700  spore coat U domain-containing protein [KO:K27078]
HU763_009705  spore coat U domain-containing protein [KO:K27078]
HU763_009695  spore coat U domain-containing protein [KO:K27078]
HU763_009715  molecular chaperone [KO:K07346]
HU763_007980  fimbrial biogenesis outer membrane usher protein [KO:K07347]
HU763_015060  fimbrial biogenesis outer membrane usher protein [KO:K07347]
HU763_019520  Flp family type IVb pilin [KO:K02651]
HU763_019525  Flp family type IVb pilin [KO:K02651]
HU763_019530  Flp family type IVb pilin [KO:K02651]
HU763_019505  cpaB; Flp pilus assembly protein CpaB [KO:K02279]
HU763_019500  type II and III secretion system protein family protein [KO:K02280]
HU763_019475  AAA family ATPase [KO:K02282]
HU763_019470  CpaF family protein [KO:K02283] [EC:7.4.2.8]
HU763_019465  type II secretion system F family protein [KO:K12510]
HU763_019460  type II secretion system F family protein [KO:K12511]
HU763_005820  [protein-PII] uridylyltransferase [KO:K00990] [EC:2.7.7.59]
HU763_022690  glnL; nitrogen regulation protein NR(II) [KO:K07708] [EC:2.7.13.3]
HU763_022695  ntrC; nitrogen regulation protein NR(I) [KO:K07712]
HU763_008920  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_012210  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_017235  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_017685  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_022675  glnA; type I glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
HU763_023475  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_023480  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_024085  glutamine synthetase family protein [KO:K01915] [EC:6.3.1.2]
HU763_020980  sigma-54 dependent transcriptional regulator [KO:K07713]
HU763_012075  TIGR00366 family protein [KO:K02106]
HU763_003060  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
HU763_009110  acetyl-CoA C-acyltransferase [KO:K00626] [EC:2.3.1.9]
HU763_010435  acetyl-CoA C-acyltransferase family protein [KO:K00626] [EC:2.3.1.9]
HU763_020625  acetyl-CoA C-acetyltransferase [KO:K00626] [EC:2.3.1.9]
HU763_001220  GHKL domain-containing protein [KO:K10125] [EC:2.7.13.3]
HU763_019555  sensor histidine kinase [KO:K10125] [EC:2.7.13.3]
HU763_001215  sigma-54 dependent transcriptional regulator [KO:K10126]
HU763_019560  sigma-54 dependent transcriptional regulator [KO:K10126]
HU763_008345  dicarboxylate/amino acid:cation symporter [KO:K11103]
HU763_009325  C4-dicarboxylate transporter DctA [KO:K11103]
HU763_018355  dicarboxylate/amino acid:cation symporter [KO:K11103]
HU763_004805  RNA polymerase factor sigma-54 [KO:K03092]
HU763_003365  pilin [KO:K02650]
HU763_000465  PAS domain-containing protein [KO:K11383] [EC:2.7.13.3]
HU763_000470  algB; sigma-54-dependent response regulator transcription factor AlgB [KO:K11384]
HU763_010405  protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
HU763_017200  cheR; protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
HU763_012520  PAS domain-containing protein [KO:K13924] [EC:2.1.1.80 3.1.1.61]
HU763_001465  methyl-accepting chemotaxis protein [KO:K03406]
HU763_001480  methyl-accepting chemotaxis protein [KO:K03406]
HU763_003070  methyl-accepting chemotaxis protein [KO:K03406]
HU763_004130  PAS domain S-box protein [KO:K03406]
HU763_006430  methyl-accepting chemotaxis protein [KO:K03406]
HU763_007265  methyl-accepting chemotaxis protein [KO:K03406]
HU763_008585  methyl-accepting chemotaxis protein [KO:K03406]
HU763_009295  mcpA; methyl-accepting chemotaxis protein McpA [KO:K03406]
HU763_011380  mcpP; methyl-accepting chemotaxis protein McpP [KO:K03406]
HU763_012835  PAS domain-containing methyl-accepting chemotaxis protein [KO:K03406]
HU763_013335  methyl-accepting chemotaxis protein [KO:K03406]
HU763_018155  methyl-accepting chemotaxis protein [KO:K03406]
HU763_019725  methyl-accepting chemotaxis protein [KO:K03406]
HU763_020735  methyl-accepting chemotaxis protein [KO:K03406]
HU763_022520  methyl-accepting chemotaxis protein [KO:K03406]
HU763_022525  methyl-accepting chemotaxis protein [KO:K03406]
HU763_023890  methyl-accepting chemotaxis protein [KO:K03406]
HU763_008545  methyl-accepting chemotaxis protein [KO:K03776]
HU763_009330  methyl-accepting chemotaxis protein [KO:K03776]
HU763_017560  methyl-accepting chemotaxis protein [KO:K03776]
HU763_016895  chemotaxis protein CheW [KO:K03408]
HU763_016900  chemotaxis protein CheW [KO:K03408]
HU763_016925  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
HU763_016935  chemotaxis response regulator CheY [KO:K03413]
HU763_010410  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
HU763_016920  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
HU763_004225  chemotaxis protein [KO:K03415]
HU763_008635  chemotaxis protein CheV [KO:K03415]
HU763_017205  chemotaxis protein CheV [KO:K03415]
HU763_022370  methyl-accepting chemotaxis protein [KO:K02660]
HU763_022375  chemotaxis protein CheW [KO:K02659]
HU763_022365  Hpt domain-containing protein [KO:K06596]
HU763_022385  response regulator [KO:K02657]
HU763_022380  pilH; twitching motility response regulator PilH [KO:K02658]
HU763_022360  chemotaxis protein CheW [KO:K06598]
HU763_005585  methyltransferase domain-containing protein [KO:K13486]
HU763_005575  methyl-accepting chemotaxis protein [KO:K13487]
HU763_005580  chemotaxis protein CheW [KO:K13488]
HU763_005590  chemotaxis protein CheW [KO:K13489]
HU763_005595  hybrid sensor histidine kinase/response regulator [KO:K13490]
HU763_005600  chemotaxis response regulator protein-glutamate methylesterase [KO:K13491] [EC:3.1.1.61]
HU763_005605  wspR; Wsp signal transduction system regulator diguanylate cyclase WspR [KO:K11444] [EC:2.7.7.65]
HU763_009690  GAF domain-containing protein [KO:K11354] [EC:2.7.13.3]
HU763_011230  dctP; C4-dicarboxylate TRAP substrate-binding protein DctP [KO:K11688]
HU763_011235  TRAP transporter small permease [KO:K11689]
HU763_011240  dctM; C4-dicarboxylate TRAP transporter large permease protein DctM [KO:K11690]
HU763_017060  fleQ; transcriptional regulator FleQ [KO:K10941]
HU763_017055  PAS domain-containing protein [KO:K10942] [EC:2.7.13.3]
HU763_017050  sigma-54 dependent transcriptional regulator [KO:K10943]
HU763_019170  sensor histidine kinase [KO:K17060] [EC:2.7.13.3]
HU763_019175  sigma-54 dependent transcriptional regulator [KO:K17061]
HU763_019165  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
HU763_019160  ABC transporter permease subunit [KO:K10002]
HU763_019155  amino acid ABC transporter permease [KO:K10003]
HU763_019150  glutamate/aspartate ABC transporter substrate-binding protein [KO:K10001]
HU763_002055  crp; cAMP-activated global transcriptional regulator CRP [KO:K10914]
HU763_014855  glsB; glutaminase B [KO:K01425] [EC:3.5.1.2]
HU763_004675  sensor histidine kinase [KO:K15011] [EC:2.7.13.3]
HU763_004680  response regulator transcription factor [KO:K15012]
HU763_020175  petA; ubiquinol-cytochrome c reductase iron-sulfur subunit [KO:K00411] [EC:7.1.1.8]
HU763_020170  cytochrome bc complex cytochrome b subunit [KO:K00412]
HU763_020165  cytochrome c1 [KO:K00413]
HU763_016470  ccoN; cytochrome-c oxidase, cbb3-type subunit I [KO:K00404] [EC:7.1.1.9]
HU763_016490  ccoN; cytochrome-c oxidase, cbb3-type subunit I [KO:K00404] [EC:7.1.1.9]
HU763_016475  ccoO; cytochrome-c oxidase, cbb3-type subunit II [KO:K00405]
HU763_016495  ccoO; cytochrome-c oxidase, cbb3-type subunit II [KO:K00405]
HU763_016480  cbb3-type cytochrome c oxidase subunit 3 [KO:K00407]
HU763_016500  cbb3-type cytochrome c oxidase subunit 3 [KO:K00407]
HU763_016485  ccoP; cytochrome-c oxidase, cbb3-type subunit III [KO:K00406]
HU763_016505  ccoP; cytochrome-c oxidase, cbb3-type subunit III [KO:K00406]
HU763_020700  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
HU763_020695  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
HU763_022065  TolC family outer membrane protein [KO:K12340]
HU763_012090  polysaccharide biosynthesis/export family protein [KO:K01991]
HU763_007630  low molecular weight phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
HU763_007225  wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) [KO:K01791] [EC:5.1.3.14]
HU763_022785  GNAT family N-acetyltransferase [KO:K13061] [EC:2.3.1.184]
HU763_001630  RNA polymerase sigma factor [KO:K23514]
HU763_000665  sigma-70 family RNA polymerase sigma factor [KO:K23514]
HU763_003710  sigma-70 family RNA polymerase sigma factor [KO:K23514]
HU763_001625  FecR family protein [KO:K07165]
HU763_003705  FecR domain-containing protein [KO:K07165]
HU763_004570  FecR family protein [KO:K07165]
HU763_020475  FecR domain-containing protein [KO:K07165]
HU763_005065  FecR domain-containing protein [KO:K07165]
HU763_013320  FecR family protein [KO:K07165]
HU763_000660  FecR family protein [KO:K07165]
HU763_007525  response regulator [KO:K20973] [EC:2.7.13.3]
HU763_016185  response regulator [KO:K20974] [EC:2.7.13.3]
HU763_013800  PAS domain-containing hybrid sensor histidine kinase/response regulator [KO:K20975] [EC:2.7.13.3]
HU763_017005  Hpt domain-containing protein [KO:K20976]
HU763_017010  fused response regulator/phosphatase [KO:K20977]
HU763_017015  STAS domain-containing protein [KO:K20978]
HU763_017215  flgM; flagellar biosynthesis anti-sigma factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
  Authors
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Related
pathway
panh00190  Oxidative phosphorylation
panh00550  Peptidoglycan biosynthesis
panh00910  Nitrogen metabolism
panh02030  Bacterial chemotaxis
panh02040  Flagellar assembly
panh03070  Bacterial secretion system
KO pathway
ko02020   
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