KEGG   PATHWAY: pic00290
Entry
pic00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Scheffersomyces stipitis
Class
Metabolism; Amino acid metabolism
Pathway map
pic00290  Valine, leucine and isoleucine biosynthesis
pic00290

Module
pic_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:pic00290]
pic_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:pic00290]
pic_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:pic00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Scheffersomyces stipitis [GN:pic]
Gene
PICST_83915  ILV1; threonine deaminase [KO:K01754] [EC:4.3.1.19]
PICST_30154  predicted protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PICST_54974  predicted protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PICST_68659  LEU1; 3-isopropylmalate dehydratase [KO:K01702] [EC:4.2.1.33]
PICST_68561  LEU2; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
PICST_44973  ILV2; acetolactate synthase [KO:K01652] [EC:2.2.1.6]
PICST_80460  ILV6; acetolactate synthase regulatory subunit [KO:K01653] [EC:2.2.1.6]
PICST_78299  ILV5; mitochondrial ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
PICST_75802  ILV3; dihydroxyacid dehydratase [KO:K01687] [EC:4.2.1.9]
PICST_84005  BAT2; branched-chain amino acid transaminase [KO:K00826] [EC:2.6.1.42]
PICST_34985  predicted protein [KO:K00826] [EC:2.6.1.42]
PICST_68770  LEU4; 2-isopropylmalate synthase (Alpha-isopropylmalate synthase) (Alpha-IPM synthetase) [KO:K01649] [EC:2.3.3.13]
PICST_89189  LEU6; Alpha-isopropylmalate synthase/homocitrate synthase (LEU4) [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
pic00260  Glycine, serine and threonine metabolism
pic00280  Valine, leucine and isoleucine degradation
pic00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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