KEGG   PATHWAY: pic00260
Entry
pic00260                    Pathway                                
Name
Glycine, serine and threonine metabolism - Scheffersomyces stipitis
Description
Serine is derived from 3-phospho-D-glycerate, an intermediate of glycolysis [MD:M00020], and glycine is derived from serine. Threonine is an essential amino acid, which animals cannot synthesize. In bacteria and plants, threonine is derived from aspartate [MD:M00018].
Class
Metabolism; Amino acid metabolism
Pathway map
pic00260  Glycine, serine and threonine metabolism
pic00260

Module
pic_M00018  Threonine biosynthesis, aspartate => homoserine => threonine [PATH:pic00260]
pic_M00020  Serine biosynthesis, glycerate-3P => serine [PATH:pic00260]
pic_M00338  Cysteine biosynthesis, homocysteine + serine => cysteine [PATH:pic00260]
pic_M00621  Glycine cleavage system [PATH:pic00260]
Other DBs
GO: 0006544 0006563 0070178 0006566
Organism
Scheffersomyces stipitis [GN:pic]
Gene
PICST_30154  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PICST_33517  IFG3; D-aspartate oxidase [KO:K00273] [EC:1.4.3.3]
PICST_35359  [KO:K20498] [EC:4.3.1.18]
PICST_36392  SER1; 3-phosphoserine transaminase [KO:K00831] [EC:2.6.1.52]
PICST_36951  LPD1; FAD flavoprotein [KO:K00382] [EC:1.8.1.4]
PICST_38956  [KO:K15918] [EC:2.7.1.31]
PICST_40365  PSP1; phosphoserine phosphatase activity [KO:K01079] [EC:3.1.3.3]
PICST_44075  [KO:K00830] [EC:2.6.1.44 2.6.1.45 2.6.1.51]
PICST_48292  GPM1.2; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PICST_51913  CHO1; phosphatidylserine synthase [KO:K17103] [EC:2.7.8.8]
PICST_52102  YDF1; serine dehydrogenase [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PICST_53135  [KO:K00306] [EC:1.5.3.1 1.5.3.7]
PICST_54974  [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PICST_55523  AMO1; peroxisomal copper amine oxidase [KO:K00276] [EC:1.4.3.21]
PICST_57619  HOM6; homoserine dehydrogenase [KO:K00003] [EC:1.1.1.3]
PICST_57912  DAO1; D-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
PICST_63574  [KO:K20498] [EC:4.3.1.18]
PICST_65754  THR4; threonine synthase [KO:K01733] [EC:4.2.3.1]
PICST_67292  SHM2; serine hydroxymethyltransferase [KO:K00600] [EC:2.1.2.1]
PICST_69242  HOM3; aspartate kinase (L-aspartate 4-P- transferase) [KO:K00928] [EC:2.7.2.4]
PICST_69669  TRP5; tryptophan synthetase [KO:K01694] [EC:4.2.1.20]
PICST_70394  GPM1.1; phosphoglycerate mutase [KO:K01834] [EC:5.4.2.11]
PICST_71203  GLY2; threonine aldolase [KO:K01620] [EC:4.1.2.48]
PICST_74130  GLY1; threonine aldolase [KO:K01620] [EC:4.1.2.48]
PICST_75530  GCV3; H-protein subunit of glycine cleavage system [KO:K02437]
PICST_75631  GCV2; Glycine cleavage system protein [KO:K00281] [EC:1.4.4.2]
PICST_77227  CYS4; cystathionine beta-synthase [KO:K01697] [EC:4.2.1.22]
PICST_77247  CYS3; cystathionine gamma-lyase [KO:K01758] [EC:4.4.1.1]
PICST_78806  SHM1; Serine hydroxymethyltransferase, mitochondrial precursor (Serine methylase) [KO:K00600] [EC:2.1.2.1]
PICST_80053  YIM4; NADP(+)-dependent dehydrogenase acts on serine, L-allo-threonine, and other 3-hydroxy acids [KO:K16066] [EC:1.1.1.381 1.1.1.-]
PICST_83340  DAO2; d-amino acid oxidase [KO:K00273] [EC:1.4.3.3]
PICST_83560  GCV1; Aminomethyl transferase [KO:K00605] [EC:2.1.2.10]
PICST_83878  AMO2; copper-containing amine oxidase [KO:K00276] [EC:1.4.3.21]
PICST_83915  ILV1; threonine deaminase [KO:K01754] [EC:4.3.1.19]
PICST_85224  THR1; homoserine kinase [KO:K00872] [EC:2.7.1.39]
PICST_87754  SER3; 3-phosphoglycerate dehydrogenase, serine biosynthesis [KO:K00058] [EC:1.1.1.95 1.1.1.399]
PICST_89195  HOM2; threonine and methionine pathway [KO:K00133] [EC:1.2.1.11]
PICST_89623  HEM1; 5-aminolevulinate synthase, mitochondrial precursor (5-aminolevulinic acid synthase) (Delta-aminolevulinate synthase) (Delta-ALA synthetase) [KO:K00643] [EC:2.3.1.37]
Compound
C00011  CO2
C00014  Ammonia
C00022  Pyruvate
C00037  Glycine
C00048  Glyoxylate
C00049  L-Aspartate
C00065  L-Serine
C00078  L-Tryptophan
C00097  L-Cysteine
C00101  Tetrahydrofolate
C00109  2-Oxobutanoate
C00114  Choline
C00143  5,10-Methylenetetrahydrofolate
C00168  Hydroxypyruvate
C00188  L-Threonine
C00197  3-Phospho-D-glycerate
C00213  Sarcosine
C00258  D-Glycerate
C00263  L-Homoserine
C00300  Creatine
C00430  5-Aminolevulinate
C00441  L-Aspartate 4-semialdehyde
C00546  Methylglyoxal
C00576  Betaine aldehyde
C00581  Guanidinoacetate
C00631  2-Phospho-D-glycerate
C00719  Betaine
C00740  D-Serine
C00986  1,3-Diaminopropane
C01005  O-Phospho-L-serine
C01026  N,N-Dimethylglycine
C01102  O-Phospho-L-homoserine
C01242  [Protein]-S8-aminomethyldihydrolipoyllysine
C01888  Aminoacetone
C02051  Lipoylprotein
C02291  L-Cystathionine
C02737  Phosphatidylserine
C02972  Dihydrolipoylprotein
C03082  4-Phospho-L-aspartate
C03194  (R)-1-Aminopropan-2-ol
C03232  3-Phosphonooxypyruvate
C03283  L-2,4-Diaminobutanoate
C03508  L-2-Amino-3-oxobutanoic acid
C05519  L-Allothreonine
C06231  Ectoine
C06442  N(gamma)-Acetyldiaminobutyrate
C16432  5-Hydroxyectoine
C19929  N(alpha)-Acetyl-L-2,4-diaminobutyrate
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:11823218
  Authors
Kuhlmann AU, Bremer E.
  Title
Osmotically regulated synthesis of the compatible solute ectoine in Bacillus pasteurii and related Bacillus spp.
  Journal
Appl Environ Microbiol 68:772-83 (2002)
DOI:10.1128/AEM.68.2.772-783.2002
Reference
PMID:10473374
  Authors
Canovas D, Borges N, Vargas C, Ventosa A, Nieto JJ, Santos H.
  Title
Role of Ngamma-acetyldiaminobutyrate as an enzyme stabilizer and an intermediate in the biosynthesis of hydroxyectoine.
  Journal
Appl Environ Microbiol 65:3774-9 (1999)
DOI:10.1128/AEM.65.9.3774-3779.1999
Reference
PMID:17636255
  Authors
Bursy J, Pierik AJ, Pica N, Bremer E.
  Title
Osmotically induced synthesis of the compatible solute hydroxyectoine is mediated by an evolutionarily conserved ectoine hydroxylase.
  Journal
J Biol Chem 282:31147-55 (2007)
DOI:10.1074/jbc.M704023200
Reference
PMID:16707670
  Authors
Garcia-Estepa R, Argandona M, Reina-Bueno M, Capote N, Iglesias-Guerra F, Nieto JJ, Vargas C.
  Title
The ectD gene, which is involved in the synthesis of the compatible solute hydroxyectoine, is essential for thermoprotection of the halophilic bacterium Chromohalobacter salexigens.
  Journal
J Bacteriol 188:3774-84 (2006)
DOI:10.1128/JB.00136-06
Reference
PMID:15470257
  Authors
Arevalo-Rodriguez M, Pan X, Boeke JD, Heitman J
  Title
FKBP12 controls aspartate pathway flux in Saccharomyces cerevisiae to prevent toxic intermediate accumulation.
  Journal
Eukaryot Cell 3:1287-96 (2004)
DOI:10.1128/EC.3.5.1287-1296.2004
Reference
PMID:7639721
  Authors
Rees WD, Hay SM
  Title
The biosynthesis of threonine by mammalian cells: expression of a complete bacterial biosynthetic pathway in an animal cell.
  Journal
Biochem J 309 ( Pt 3):999-1007 (1995)
DOI:10.1042/bj3090999
Reference
PMID:11341914
  Authors
Jacques SL, Nieman C, Bareich D, Broadhead G, Kinach R, Honek JF, Wright GD
  Title
Characterization of yeast homoserine dehydrogenase, an antifungal target: the invariant histidine 309 is important for enzyme integrity.
  Journal
Biochim Biophys Acta 1544:28-41 (2001)
DOI:10.1016/S0167-4838(00)00203-X
Reference
PMID:15520012
  Authors
Chen X, Jhee KH, Kruger WD
  Title
Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine.
  Journal
J Biol Chem 279:52082-6 (2004)
DOI:10.1074/jbc.C400481200
Related
pathway
pic00010  Glycolysis / Gluconeogenesis
pic00020  Citrate cycle (TCA cycle)
pic00230  Purine metabolism
pic00250  Alanine, aspartate and glutamate metabolism
pic00270  Cysteine and methionine metabolism
pic00290  Valine, leucine and isoleucine biosynthesis
pic00300  Lysine biosynthesis
pic00330  Arginine and proline metabolism
pic00460  Cyanoamino acid metabolism
pic00470  D-Amino acid metabolism
pic00564  Glycerophospholipid metabolism
pic00600  Sphingolipid metabolism
pic00620  Pyruvate metabolism
pic00630  Glyoxylate and dicarboxylate metabolism
pic00640  Propanoate metabolism
pic00680  Methane metabolism
pic00860  Porphyrin metabolism
pic00920  Sulfur metabolism
KO pathway
ko00260   

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